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Isolated peritoneal lymphomatosis defined as post-transplant lymphoproliferative disorder after a liver transplant: A case report

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World Journal of Clinical Cases 2019年第24期7卷 4299-4306页

作者： Hong Beum Kim Ran Hong Yung Sub na Woo Young Choi Sang Gon Park Hee Jeong Lee Department of Premedical Course Chosun University School of MedicineGwangju 501-717South Korea Department of Pathology Chosun University Hospital365 Pilmun-daeroDong-guGwangju 501-717South Korea Department of Internal Medicine PulomonologyChosun University HospitalGwangju 501-717South Korea Department of Plastic and Reconstructive Surgery Chosun University HospitalGwangju 501-717South Korea Department of Internal Medicine Hemato-oncologyChosun University HospitalGwangju 501-717South Korea MD PhDDepartment of HematoOncologyChosun University Hospital365 Pilmun-daeroDong-guGwangju 501-717South Korea

BACKGROUND Post-transplant lymphoproliferative disorder(PTLD) is a fatal complication of solid organ transplantation or allogenic hematopoietic stem cell transplantation that is associated with immunosuppressive therapy. Potential manifestations are diverse, ranging from reactive lymphoid hyperplasia to high-grade *** is usually of B-cell origin and associated with epstein-Barr virus(EBV)infection. Herein, we describe a case of PTLD involving the peritoneal *** has been only case of PTLD as a diffuse large B-cell lymphoma(DLBCL) in the *** SUMmarY The patient was a 62-year-old man who had been receiving immunosuppressive therapy with tacrolimus since undergoing a liver transplant 15 years prior. He reported that he had experienced abdominal discomfort and anorexia 1 month prior to the current admission. Abdominal pelvic computed tomography(CT)revealed peritoneal and omental mass-like lesions without bowel ***-guided biopsy was performed, and he was histologically diagnosed with EBV-negative DLBCL. Positron emission tomography(PET)-CT depicted peritoneum and omentum involvement only, without any lymphadenopathy or organ masses, including in the gastrointestinal tract. Six cycles of chemotherapy with a "R-CHOP" regimen(rituximab-cyclophosphamide, doxorubicin, vincristine, prednisolone) were administered,and PET-CT performed thereafter indicated complete *** This is the first report of isolated peritoneal lymphomatosis defined as PTLD in a liver transplant recipient.

关键词： Case report Diffuse large B-cell lymphoma epstein-Barr virus infection Posttransplant lymphoproliferative disorder R-CHOP Isolated peritoneal lymphomatosis

Ruxolitinib add-on in corticosteroid-refractory graft-vs-host disease after allogeneic stem cell transplantation:Results from a retrospective study on 38 Chinese patients

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World Journal of Clinical Cases 2020年第6期8卷 1065-1073页

作者： Si-Hua Dang Qin Liu Rong Xie na Shen Shu Zhou Wei Shi Wen Liu Ping Zou Yong You Zhao-Dong Zhong Department of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Department of Oncology Luohe Central HospitalLuohe 462300Henan ProvinceChina Department of Gynecology and Obstetrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina

BACKGROUND Graft-vs-host disease (GVHD) is a major cause of mortality after allogeneic hematopoietic stem cell *** patients have steroid-refractory(SR) *** To evaluate the effect and safety of ruxolitinib add-on in the treatment of patients with SR acute (a) and chronic (c) *** We retrospectively analyzed 38 patients administered ruxolitinib add-on to standard immunosuppressive therapy for SR-aGVHD or SR-cGVHD following allogeneic hematopoietic stem cell *** was administered5-10 mg/d depending on disease severity,patient status,and the use of antifungal *** response rate,time to best response,malignancy relapse rate,infection rate,and treatment-related adverse events were *** The analysis included 10 patients with SR-aGVHD (gradeⅢ/Ⅳ,n=9) and 28patients with SR-cGVHD (moderate/severe,n=24).For the SR-aGVHD and SRcGVHD groups,respectively:Median number of previous GVHD therapies was 2(range:1-3) and 2 (1-4);median follow-up was 2.5 (1.5-4) and 5 (1.5-10) mo;median time to best response was 1 (0.5-2.5) and 3 (1-9.5) mo;and overall response rate was 100%(complete response:80%) and 82.1%(complete response:10.7%) with a response observed in all GVHD-affected *** malignancy relapse rates for the SR-aGVHD and SR-cGVHD groups were 10.0%and 10.7%,*** rates for cytomegalovirus,epstein-Barr virus,and varicella-zoster virus,respectively,were 30.0%,10.0%,and 0%for the SR-aGVHD group and 0%,14.3%,and 7.1%for the SR-cGVHD *** Ruxolitinib add-on was effective and safe as salvage therapy for SR-GVHD.

关键词： Graft-vs-host disease Graft-vs-leukemia effect Allogeneic hematopoietic stem cell transplantation Ruxolitinib Treatment Antifungal drugs

Measurements of the ablation-front trajectory and low-mode nonuniformity in direct-drive implosions using x-ray self-emission shadowgraphy

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High Power Laser Science and Engineering 2015年第3期3卷 20-27页

作者： D.T.Michel A.K.Davis W.Armstrong R.Bahr R.epstein V.N.Goncharov M.Hohenberger I.V.Igumenshchev R.Jungquist D.D.Meyerhofer P.B.Radha T.C.Sangster C.Sorce D.H.Froula Laboratory for Laser Energetics University of Rochester

Self-emission x-ray shadowgraphy provides a method to measure the ablation-front trajectory and low-mode nonuniformity of a target imploded by directly illuminating a fusion capsule with laser beams. The technique uses time-resolved images of soft x-rays(>1 ke V) emitted from the coronal plasma of the target imaged onto an x-ray framing camera to determine the position of the ablation front. Methods used to accurately measure the ablation-front radius(δ R= ±1.15 μm), image-to-image timing(δ( t)= ±2.5 ps) and absolute timing(δt= ±10 ps) are *** averaging of the images provides an average radius measurement of δ( Rav)= ±0.15 μm and an error in velocity of δV / V= ±3%. This technique was applied on the Omega Laser Facility [Boehly et al., Opt. Commun. 133, 495(1997)] and the national Ignition Facility [Campbell and Hogan, Plasma Phys. Control. Fusion 41, B39(1999)].

关键词： low mode nonuiformity nuclear fusion self-emission shadowgraphy shell trajectory

空间周期性驱动对双层耦合反应扩散系统中图灵斑图的影响

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物理学报 2022年第9期71卷 356-365页

作者：刘倩田淼范伟丽贾萌萌马凤娜刘富成河北大学物理科学与技术学院保定071002 河北大学环境工程研究所保定071002

周期性驱动是控制斑图最有效的方式之一,因此一直是斑图动力学研究的一大热点.自然界中的斑图形成系统大多是多层耦合的非线性系统,周期性驱动对这些多层耦合系统的作用机理人们还不甚了解.本文通过耦合Brusselator(Bru)系统和Lengyel-E... 详细信息

周期性驱动是控制斑图最有效的方式之一,因此一直是斑图动力学研究的一大热点.自然界中的斑图形成系统大多是多层耦合的非线性系统,周期性驱动对这些多层耦合系统的作用机理人们还不甚了解.本文通过耦合Brusselator(Bru)系统和Lengyel-epstein(LE)系统,并给LE系统施加一个空间周期性驱动来研究外部驱动对多层耦合系统中图灵斑图的影响.研究发现,只要外部驱动与Bru系统的超临界图灵模(内部驱动模)两者中的一个为长波模时,就可以将LE系统中的次临界图灵模激发,3个模式共同作用从而形成具有3个空间尺度的复杂斑图.若外部驱动和内部驱动模均为短波模,则无法激发此系统的本征次临界图灵模,但满足空间共振时也可以产生超点阵斑图.若LE系统的本征模为超临界图灵模,其自发形成的六边形斑图只有在外部驱动强度较大的情况下才能够产生响应,且其空间对称性受到外部驱动波数的影响.

关键词：双层反应扩散系统空间周期性驱动图灵斑图空间共振

Diffuse Large B-Cell Lymphoma of the Central Nervous System. Immunophenotype, Clinicopathological Features and Differential Diagnosis

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Open Journal of Pathology 2012年第4期2卷 133-139页

作者： Mónica Belinda Romero-Guadarrama maría Esther Gutiérrez Díaz-Ceballos Fiacro Jiménez-Ponce Samantha Thingen-Velarde Hemathology Service Hospital General de México Mexico City Mexico Mónica Belinda Romero-Guadarrama Neurosurgery Unit Hospital General de México Mexico City Mexico Unit Pathology Hospital General de México Medicine School Autonomous University of Mexico Mexico City Mexico

Background: Diffuse large B-cell lymphomas of the central nervous system (DLBCL CNS) represent less than 1% of all lymphomas and between 2% and 3% of all cerebral tumors. They occur in adults of 60 years of age or more. The objective of this work is to describe the clinical-pathological characteristics, the immunophenotype and the differential diagnosis. Clinical Case: From the files of the surgical pathology unit we found four cases of primary diffuse large B cell lymphoma of the central nervous system in a 6-year period. Three corresponded to women over 47 years of age and the other to a 42-year-old man. The time of evolution was between 2 and 4 months. The symptoms were headache, blurred vision, hemiparesis, and seizures. Localization was in the pineal region, the frontal, parietal regions, and the right thalamus. Morphologically, large lymphoid cells with a diffuse growth pattern and necrosis were observed. Immunohistochemical markers, such as CD 20 and bcl2 were positive, one was positive to CD3. Expression of bcl6 and CD 10 was positive in one case, and MUM-1 was positive in three cases. All the cases were negative for epstein-Barr virus. Conclusions: The diffuse large-B cell lymphoma of the central nervous system is rare. Its average age of presentation is at 60 years or older. The localization is in the pineal, frontal, parietal and thalamic regions. Three cases were originated by activated B lymphocyte (MUM-1 expression) and other from the Germinal Center (GC) (CD 10 expression). The clinical course was bad. The four patients died shortly after the diagnosis.

关键词： Primary Lymphoma Central Nervous System

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4例甲状腺内胸腺癌的临床病理学特征

临床与病理杂志 2022年第11期42卷 2850-2856页

作者：谢闵袁娜孙燃许增祥华东师范大学附属芜湖医院(芜湖市第二人民医院)病理科安徽芜湖241001 皖南医学院病理解剖学教研室安徽芜湖241001

通过回顾性分析4例甲状腺内胸腺癌(intrathyroid thymic carcinoma,ITTC)患者的临床病理学资料及免疫表型特征、EB病毒感染及随访情况,探讨ITTC的临床病理学特征、相关分子机制研究情况、诊断、治疗和预后,以提高对该疾病的认识。4例患... 详细信息

通过回顾性分析4例甲状腺内胸腺癌(intrathyroid thymic carcinoma,ITTC)患者的临床病理学资料及免疫表型特征、EB病毒感染及随访情况,探讨ITTC的临床病理学特征、相关分子机制研究情况、诊断、治疗和预后,以提高对该疾病的认识。4例患者均为女性,年龄为36~63岁,肿瘤最大直径为0.7~3.0 cm。镜下肿瘤具有推挤式边缘,细胞排列呈条索状、巢团状或岛屿状,并可见胸腺肿瘤分叶状结构或胸腺小体样结构。免疫组织化学染色示肿瘤细胞CD5、CD117、CK/pan、CK5/6、p63、p40阳性,Ki-67增殖指数为10%~30%。原位杂交检测EBER结果均为阴性。其中1例合并甲状腺乳头状癌(papillary thyroid carcinoma,PTC),4例均行甲状腺腺叶切除及局部淋巴结清扫术,术后随访10~34个月,均未复发或转移。ITTC为罕见的甲状腺肿瘤,预后尚好,术中冰冻及细针穿刺中诊断难度较大,特别是合并甲状腺其他肿瘤时,易误诊。结合形态学特征及免疫组织化学有助于诊断及鉴别诊断。

关键词：甲状腺内胸腺癌临床病理学免疫表型原位杂交EBER

宏基因组二代测序在伴有中枢神经系统受累儿童噬血细胞综合征中的应用价值

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中国当代儿科杂志 2022年第11期24卷 1226-1230页

作者：张海洋唐茂婷卿露李德渊乔莉娜四川大学华西第二医院儿童重症医学科/出生缺陷与相关妇儿疾病教育部重点实验室四川成都610041

目的探究宏基因组二代测序(metagenomic next-generation sequencing,mNGS)技术检测伴有中枢神经系统受累的噬血细胞综合征患儿颅内EB病毒(epstein-Barr virus,EBV)感染的应用价值及临床意义。方法回顾性分析30例伴有中枢神经系统受累... 详细信息

目的探究宏基因组二代测序(metagenomic next-generation sequencing,mNGS)技术检测伴有中枢神经系统受累的噬血细胞综合征患儿颅内EB病毒(epstein-Barr virus,EBV)感染的应用价值及临床意义。方法回顾性分析30例伴有中枢神经系统受累的噬血细胞综合征患儿的脑脊液mNGS结果,与脑脊液EBV-Dna定性检测、血清EBV抗体谱检测结果进行比较,以治疗前后血清EBV-Dna拷贝数变化反映针对性治疗效果。结果脑脊液mNGS EBV检测阳性率为100%(30/30),高于脑脊液EBV-Dna定性检测阳性率(10%,3/30;P0.05)。中位mNGS EBV检出序列数为2400,治疗前血清EBV-Dna拷贝数与EBV检出序列数呈中度正相关(rs=0.693,Pna拷贝数越高,脑脊液mNGS EBV检出序列数越高(P<0.05)。结论EBV相关噬血细胞综合征容易诱发EBV感染引起的病毒性脑炎,mNGS可以显著提高脑脊液EBV检测的阳性率,协助临床诊断。

关键词：噬血细胞综合征 EB病毒宏基因组二代测序儿童

CMV和EBV共感染可影响造血干细胞移植患者预后

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检验医学 2023年第8期38卷 760-765页

作者：张娜牛伟华孙媛媛贾玫北京大学人民医院检验科北京100044

目的探讨巨细胞病毒(CMV)和EB病毒(EBV)共感染与造血干细胞移植(HSCT)患者预后的相关性。方法选取2018年1月—2019年1月北京大学人民医院血液科327例接受HSCT的患者,其中CMV和EBV共感染75例(共感染组),CMV或EBV感染165例(单一感染组),CM... 详细信息

目的探讨巨细胞病毒(CMV)和EB病毒(EBV)共感染与造血干细胞移植(HSCT)患者预后的相关性。方法选取2018年1月—2019年1月北京大学人民医院血液科327例接受HSCT的患者,其中CMV和EBV共感染75例(共感染组),CMV或EBV感染165例(单一感染组),CMV和EBV均未感染87例(无感染组)。收集HSCT患者的临床基本资料和移植后CMV、EBV感染情况。采用Kaplan-Meier生存曲线和Cox比例回归分析CMV和EBV共感染是否是HSCT患者预后的危险因素。结果327例患者中,有226例(69.1%)年龄≤40岁。共感染组≤40岁患者所占比例高于>40岁患者(P<0.05)。人白细胞抗原(HLA)匹配方面,共同感染组半相合所占比例高于单一感染组和无感染组(P<0.05)。共感染组、单一感染组、无感染组患者1年总体生存率(OS)分别为86.7%、85.4%、95.4%,差异有统计学意义(P<0.05)。Kaplan-Meier生存曲线分析结果示,CMV和EBV共感染是HSCT术后患者1年OS的危险因素(P<0.05)。Cox比例回归分析结果显示,CMV和EBV共感染、单一感染均是HSCT术后患者1年OS的危险因素[风险比(HR)值分别为12.553、13.108,95%可信区间(CI)分别为1.456~108.230、1.683~102.062,P值分别为0.021、0.014]。结论CMV感染(无论是否伴有EBV感染)可降低HSCT患者术后1年OS。

关键词：巨细胞病毒 EB病毒共感染造血干细胞移植预后

基于交叠影响阈理论的家校企联动教学模式研究

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中阿科技论坛（中英文） 2021年第8期 161-164页

作者：李娜浙江外国语学院浙江杭州310012

家庭、学校与社会协同育人,是当下一项重要的教育课题。如何在课程教学中建立家庭、学校和企业的协同关系,需要进行实证研究。本文基于爱普斯坦提出的交叠影响阈理论,以饭店餐饮管理课程实践研究为例构建了家校企联动教学模式,并提出以... 详细信息

家庭、学校与社会协同育人,是当下一项重要的教育课题。如何在课程教学中建立家庭、学校和企业的协同关系,需要进行实证研究。本文基于爱普斯坦提出的交叠影响阈理论,以饭店餐饮管理课程实践研究为例构建了家校企联动教学模式,并提出以学生为中心的服务体系、开创以亲情为主题的教学内容以及尝试以角色为指标的考核方式等具体实施对策。

关键词：交叠影响阈理论家校企联动(HUE) 饭店餐饮管理课程实践教学