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EBV-associated lymphoproliferative disease post-CAR-T cell therapy

Frontiers of Medicine 2024年第2期18卷 394-398页

作者： Shiyuan Zhang Xiaoxi Zhou Shangkun Zhang na Wang Tongcun Zhang Donghua Zhang Qilin Ao Yang Cao Liang Huang Department of Hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Immunotherapy Research Center for Hematologic Diseases of Hubei Province Wuhan430030China Institute of Biology and Medicine College of Life and Health SciencesWuhan University of Science and TechnologyWuhan430081China Department of Pathology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesHaihe Laboratory of Cell EcosystemInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin300020China Tianjin Institutes of Health Science Tianjin301600China

epstein–Barr virus(EBV)-associated lymphoproliferative diseases(EBV-LPDs)are common complications that occur after solid organ transplantation or allogeneic hematopoietic stem-cell transplantation(HSCT).However,their occurrence and treatment post-chimeric antigen receptor-modified T(CAR-T)cell therapy has not been *** patients had been diagnosed with EBV-positive aggressive B-cell lymphoma and experienced relapses after multiple lines of *** receiving CAR-T cell therapy in tandem with autologous HSCT,the patients achieved complete ***,with a median time of 38.5 months after CAR-T cell therapy,B-cell-derived EBV-LPDs were diagnosed,and they were relieved through the administration of immune checkpoint inhibitor or B-cell-depleting ***,our report suggests that EBV-LPDs may represent a long-term adverse event after CAR-T cell therapy,especially in patients who previously had EBV-positive disorders,and they can be resolved by immune normalization strategy or B-cell depleting therapy.

关键词： EBV-associated lymphoproliferative disease chimeric antigen receptor T-cell autologous stem cell transplantation immune checkpoint inhibitor

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N6-methyladenosine methylation regulates the tumor microenvironment of epstein-Barr virus-associated gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2555-2570页

作者： Yu Zhang Fang Zhou Ming-Yu Zhang Li-na Feng Jia-Lun Guan Ruo-nan Dong Yu-Jie Huang Su-Hong Xia Jia-Zhi Liao Kai Zhao Department of Gastroenterology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Institute of Liver and Gastrointestinal Diseases Hubei Key Laboratory of Hepato-Pancreato-Biliary DiseasesTongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Department of Pharmacy Wuhan Fourth HospitalWuhan 430030Hubei ProvinceChina

BACKGROUND N6-methyladenosine(m6A)methylation modification exists in epstein-Barr virus(EBV)primary infection,latency,and lytic *** also modifies EBV latent genes and lytic ***-associated gastric cancer(EBVaGC)is a distinctive molecular subtype of *** hypothesized EBV and m6A methylation regulators interact with each other in EBVaGC to differentiate it from other types of *** To investigate the mechanisms of m6A methylation regulators in EBVaGC to determine the differentiating factors from other types of *** First,The Cancer Gene Atlas and Gene Expression Omnibus databases were used to analyze the expression pattern of m6A methylation regulators between EBVaGC and EBV-negative GC(EBVnGC).Second,we identified Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)functional enrichment of m6A-related differentially expressed *** quantified the relative abundance of immune cells and inflammatory factors in the tumor microenvironment(TME).Finally,cell counting kit-8 cell proliferation test,transwell test,and flow cytometry were used to verify the effect of insulin-like growth factor binding protein 1(IGFBP1)in EBVaGC cell *** m6A methylation regulators were involved in the occurrence and development of *** with EBVnGC,the expression levels of m6A methylation regulators Wilms tumor 1-associated protein,Rna binding motif protein 15B,CBL proto-oncogene like 1,leucine rich pentatricopeptide repeat containing,heterogeneous nuclear ribonucleoprotein A2B1,IGFBP1,and insulin-like growth factor 2 binding protein 1 were significantly downregulated in EBVaGC(Pnal enrichment analyses showed that the immunity pathways were significantly activated and rich in immune cell infiltration in *** with EBVnGC,the infiltration of activated CD4+T cells,activated CD8+T cel

关键词： N6-methyladenosine methylation Tumor microenvironment epstein-Barr virus Gastric cancer Insulin-like growth factor binding protein 1

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Prevalence of bacteria, fungi, and virus coinfections with SARS-CoV-2 Omicron variant among patients with severe COVID-19 in Guangzhou, China, winter 2022

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Biosafety and Health 2024年第2期6卷 92-97页

作者： Qinghong Fan Mengling Jiang Jun Zhang Guofang Tang Ming Gao Yingfen Wen Xizi Deng Jun Dai Honghao Lai Peng Qian Yaqing Lin Ruiying He Liya Li Yueping Li Zhengtu Li Xuesong Liu Yimin Li na Yu Yun Lan Fengyu Hu Feng Li Institute of Infectious Diseases Guangzhou Eighth People's HospitalGuangzhou Medical UniversityGuangzhou 510440China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of GuangzhouMedicalUniversityGuangzhou510120China Guangzhou Laboratory Guangzhou 510700China

The status of coinfection during the national outbreak of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron BA.5.2 or BF.7 in China in the winter of 2022,which is suspected to contribute substantially to the overloaded severe cases,needs to be *** analyzed the coinfection status of 385 severe patients infected with the Omicron variant in Guangzhou using metagenomic *** found that 317(82.3%)patients were coinfected with at least one additional pathogen(s),including bacteria(58.7%),fungi(27.1%)and viruses(73.5%).Pseudomonas aeruginosa(***)(24.2%),Staphylococcus aureus(***)(14.0%),andKlebsiella pneumoniae(***)(13.4%)ranked as the top three coinfected *** fumigatus(***)(39.5%),Pneumocystis jirovecii(***)(24.4%)andCanidia albicans(***)(22.1%)were the top three coinfected ***-Barr virus(EBV)(63.1%),Human herpesvirus 7(HHV-7)(34.8%),and Herpes simplex virus 1(HSV-1)(32.6%)were the top three coinfected *** note,the detection of multiple coinfections of potential pathogenic bacteria,fungi,and viruses,despite lacking consistent patterns,highlighted a complicated synergistic contribution to disease *** study presents the most comprehensive spectrum of bacterial,fungal,and viral coinfections in Omicron-associated severe coronavirus disease 2019(COVID-19),implying that the coinfection of conditional pathogens might synergistically deteriorate the Omicron infection outcomes.

关键词： SARS-CoV-2 Omicron BA.5.2 Omicron BF.7 Coinfection Severeinfection

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Pulmonary lymphomatoid granulomatosis in a 4-year-old girl:A case report

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World Journal of Clinical Cases 2022年第16期10卷 5380-5386页

作者： Jia-Wei Yao Li Qiu Ping Liang Han-Min Liu Li-na Chen Division of Pediatric Pulmonology Chengdu Women's and Children's Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610091Sichuan ProvinceChina Division of Pediatric Pulmonology and Immunology Key Laboratory of Birth Defects and Related Diseases of Women and ChildrenMinistry of EducationWest China Second University Hospital of Sichuan UniversityNHC Key Laboratory of ChronobiologyChengdu 610041Sichuan ProvinceChina

BACKGROUND Pulmonary lymphomatoid granulomatosis(PLG)is a lymphoproliferative disease associated with epstein-Barr viral infection occurring mainly in adults and rarely in *** is characterized by multiple pulmonary *** diagnosis depends on lung biopsy *** patients are immunodeficient,and it commonly presents in children undergoing chemotherapy for *** report the case of a child with PLG caused by a mutation in the macrophageexpressed gene 1(MPEG1),suggesting possible PLG occurrence in children undergoing treatment for pulmonary nodular *** SUMmarY This study reports a case of PLG without apparent immunodeficiency,suggesting the possibility of this disease occurrence during the treatment of pulmonary nodular lesions in ***,the cause was assumed to be an atypical *** conventional anti-infective treatment,chest computed tomography findings revealed that there were still multiple nodules in the ***,the patient was found to be infected with the epstein-Barr *** examination of the resected lung revealed lymphoproliferative lesions with *** lymphocytes,plasma cells,and histiocytes were observed in the background,although Reed-Sternberg cells were *** staining[CD20(+),CD30(+),and CD3(+)]and EBV-encoded small Rna1/2 in situ hybridization of small lymphocytes revealed approximately 200 cells/high-power *** exon sequencing of the patient revealed a mutation in the *** patient was eventually diagnosed with PLG and transferred to the Department of Pediatric Oncology for bone marrow *** As PLG is rare and fatal,it should be suspected in clinical settings when treatment of initial diagnosis is ineffective.

关键词： Pulmonary lymphomatoid granulomatosis Child epstein-Barr virus Lymphoproliferative disease Leukemia Case report

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宏基因组二代测序在异基因造血干细胞移植后耶氏肺孢子菌肺炎诊断中的意义

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中华血液学杂志 2024年第1期45卷 62-67页

作者：符蓉林韧范志平黄芬许娜宣丽黄怡霏刘慧赵珂王治香蒋玲戴敏孙竞刘启发南方医科大学南方医院血液科南方医科大学血液病研究所广东省血液系统疾病临床医学研究中心广州510515

目的评估宏基因组二代测序(mNGS)对异基因造血干细胞移植(allo-HSCT)患者耶氏肺孢子菌肺炎(PJP)的诊断价值。方法纳入2019年6月至2023年8月南方医科大学南方医院血液科allo-HSCT后疑似肺感染并接受肺泡灌洗液病原学检测的98例患者,比较m... 详细信息

目的评估宏基因组二代测序(mNGS)对异基因造血干细胞移植(allo-HSCT)患者耶氏肺孢子菌肺炎(PJP)的诊断价值。方法纳入2019年6月至2023年8月南方医科大学南方医院血液科allo-HSCT后疑似肺感染并接受肺泡灌洗液病原学检测的98例患者,比较mNGS与常规方法、实时定量PCR(RQ-PCR)对PJP的诊断效能。结果12例患者最终诊断为PJP(确诊11例、临床诊断1例)。确诊患者中1例为常规方法和RQ-PCR检测均阳性,10例仅RQ-PCR阳性。12例患者mNGS均检出耶氏肺孢子菌。mNGS诊断PJP的敏感性为100%,高于常规方法(8.3%,P=0.001),与RQ-PCR(91.6%)相当(P=1.000)。75%的PJP患者为肺混合感染,合并EB病毒和巨细胞病毒最为常见。mNGS检出混合感染8例,RQ-PCR检出5例,常规方法未检出(P=0.008)。结论mNGS在allo-HSCT患者PJP诊断中具有良好的敏感性,在混合感染病原检测方面具有优势,可作为常规检测方法及RQ-PCR的有效补充。

关键词：耶氏肺孢子菌肺炎异基因造血干细胞移植宏基因组二代测序

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A lipid-based LMP2-mRna vaccine to treat nasopharyngeal carcinoma

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nano Research 2023年第4期16卷 5357-5367页

作者： Mengran Guo Xing Duan Xingchen Peng Zhaohui Jin Hai Huang Wen Xiao Qian Zheng Yongqi Deng na Fan Kepan Chen Xiangrong Song Department of Critical Care Medicine Department of Clinical PharmacyFrontiers Science Center for Disease-related Molecular NetworkState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu 610000China West China School of Pharmacy Sichuan UniversityChengdu 610000China

nasopharyngeal carcinoma(NPC)is a serious and highly invasive epithelial malignancy that is closely associated with epstein‒Barr virus(EBV).Due to the lack of therapeutic vaccines for NPC,we selected EBV latent membrane protein 2(LMP2)as a preferable targeting antigen to develop a lipid-based LMP2-mRna(mLMP2)***-length mLMP2 expressing LMP2 was first synthesized using an in vitro transcription method and then encapsulated into(2,3-dioleacyl propyl)trimethylammonium chloride(DOTAP)-based cationic liposomes to obtain the mRna vaccine(LPX-mLMP2).The cell assays showed that the antigenpresenting cells were capable of highly efficient uptake of LPX-mLMP2 and expression of ***2 could subsequently be presented to form the peptide-major histocompatibility complex(pMHC).Furthermore,LPX-mLMP2 could accumulate in the spleen,express antigens,promote the maturation of dendritic cells and stimulate antigen-specific T-cell responses in *** dramatically inhibited the tumor growth of the LMP2-expressing tumor model after three doses of ***,the proliferation of antigen-specific T cells in the tumor site made a good sign for the promise of mRna vaccines in virus-induced ***,we provided a newly developed antigen-encoding mRna vaccine with advantages against *** also demonstrated that mRna vaccines are attractive candidates for cancer immunotherapy.

关键词： mRna vaccine latent membrane protein 2(LMP2) nasopharyngeal carcinoma epstein-Barr virus(EBV) tumorinfiltrating lymphocytes

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新疆地区292例经典霍奇金淋巴瘤与EB病毒感染的相关性研究与分析

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诊断病理学杂志 2024年第5期31卷 391-395页

作者：于靖雯李君娜马文梅薛晶崔文丽新疆医科大学第一附属医院病理科乌鲁木齐830000

目的探讨新疆地区经典霍奇金淋巴瘤(CHL)与EB病毒感染的相关性,分析EB病毒感染与经典霍奇金淋巴瘤的临床病理学特征及预后的关系。方法回顾性分析2010-01—2023-04;新疆医科大学第一附属医院有详细临床病理资料的CHL患者,复阅HE及免... 详细信息

目的探讨新疆地区经典霍奇金淋巴瘤(CHL)与EB病毒感染的相关性,分析EB病毒感染与经典霍奇金淋巴瘤的临床病理学特征及预后的关系。方法回顾性分析2010-01—2023-04;新疆医科大学第一附属医院有详细临床病理资料的CHL患者,复阅HE及免疫组织化学染色切片,核实诊断和组织分型。结果 EBER:292例CHL阳性率为43.8%(128/292),其中结节硬化型48.6%(89/183)、混合细胞型36.3%(37/102)、淋巴细胞消减型33.3%(2/6)、无富于淋巴细胞型;汉族EB病毒感染率为42.7%(41/96),少数民族54.1%(106/196)。少数民族中结节硬化型的EB病毒感染率最高,为65例(55.1%);EBER阳性患者5年无进展生存率为90.3%,较阴性患者(95.3%)略低。结论新疆地区CHL少数民族中EB病毒感染率较高,尤其是结节硬化型。

关键词： EB病毒经典霍奇金淋巴瘤新疆地区民族感染

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Hexagonal Patterns in the 2-D Lengyel-epstein System

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Journal of Mathematical Research with Applications 2019年第3期39卷 269-276页

作者： Li-na ZHANG Fei XU Department of Mathematics and statistics Northwest Normal University

Some qualitative behaviors of stationary solutions for the 2-D Lengyel-epstein system are considered from the local bifurcation viewpoint in this paper. First, local bifurcation branches of hexagonal stationary solutions are constructed in the special case when the habitat domain is a rectangle. Next, the type of the bifurcation diagram near the bifurcation points is discussed.

关键词： Lengyel-epstein system bifurcation hexagonal patterns

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Prevalence of epstein-Barr virus infection and characteristics of lymphocyte subsets in newly onset juvenile dermatomyositis

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World Journal of Pediatrics 2021年第2期17卷 205-209页

作者： Qi Zheng Kun Zhu Cai-na Gao Yi-Ping Xu Mei-Ping Lu Department of Rheumatology Immunology and AllergyChildren’s HospitalZhejiang University School of Medicine57#Zhu Gan RoadHangzhou 310000China Department of Pathology Children's HospitalZhejiang University School of MedicineHangzhouChina

Background The underlying etiology of juvenile dermatomyositis(JDM)is unknown.T cell deficiency as well as epstein-Barr virus(EBV)infection had been suspected to be involved in the pathogenesis,but it has been poorly evaluated in JDM *** This study described the traits of T and B lymphocyte subsets in newly onset JDM patients and the incidence of EBV infection in JDM patients compared with match *** developed JDM patients from 2014 to 2018 were included in the *** with different markers(CD3+,CD3+CD4+,CD3+CD8+,CD3-CD19+and CD3-CD16+CD56+)were tested with flow cytometry in the first admission or after 6 months of *** analysis was conducted to compare the EBV infection in the group of JDM patients and *** We observed that JDM patients had higher positive rate of epstein-Barr nuclear antigen-immunoglobulin G(IgG)(P<0.0001)as well as EBV capsid antigen-IgG(P<0.05)than normal ***3-CD16+CD56+lymphocyte was found to be extremely low in early stage of JDM patients,but increased after 6 months of treatment(P=0.0091).Conclusions The level of CD3-CD16+CD56+cells may associate with the clinical course of *** may act as an environmental factor predisposing patients to the development of JDM.

关键词： epstein-barr virus Juvenile dermatomyositis Lymphocytes

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中央银行比较研究的政治经济学分析

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政治经济学评论 2016年第3期7卷 144-168页

作者：杰拉尔德.爱泼斯坦王娜张雪琴美国马萨诸塞大学阿默斯特分校经济系中国农业大学马克思主义学院中国人民大学经济学院

本文介绍了对中央银行比较研究进行政治经济学分析的一个马克思—凯恩斯—卡莱斯基模型。该模型表明货币政策由如下四个关键因素所决定:资本—劳动关系、产业资本—金融资本关系、中央银行独立性程度以及该经济体在世界经济中的地位。... 详细信息

本文介绍了对中央银行比较研究进行政治经济学分析的一个马克思—凯恩斯—卡莱斯基模型。该模型表明货币政策由如下四个关键因素所决定:资本—劳动关系、产业资本—金融资本关系、中央银行独立性程度以及该经济体在世界经济中的地位。本文提供的计量经济学证据表明,在经济合作与发展组织(OECD)国家中,具有更多独立性的中央银行、更多投机性的金融市场和对抗性更强的资本—劳动关系的大国,会具有更低的产能利用率。这一证据与本文的模型对政治—经济结构和中央银行政策之间的关系的预测是一致的。

关键词：中央银行货币政策政治经济学

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