Prevalence of Epstein-Barr virus infection and characteristics of lymphocyte subsets in newly onset juvenile dermatomyositis
作者机构：Department of RheumatologyImmunology and AllergyChildren’s HospitalZhejiang University School of Medicine57#Zhu Gan RoadHangzhou 310000China Department of PathologyChildren's HospitalZhejiang University School of MedicineHangzhouChina
出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)
年 卷 期：2021年第17卷第2期
页 面：205-209页
核心收录：
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100202[医学-儿科学] 10[医学]
基 金：This work was supported by Zhejiang Medical and Health Science and Technology Project(No.2017KY440)
主 题：Epstein-barr virus Juvenile dermatomyositis Lymphocytes
摘 要：Background The underlying etiology of juvenile dermatomyositis(JDM)is unknown.T cell deficiency as well as Epstein-Barr virus(EBV)infection had been suspected to be involved in the pathogenesis,but it has been poorly evaluated in JDM *** This study described the traits of T and B lymphocyte subsets in newly onset JDM patients and the incidence of EBV infection in JDM patients compared with match *** developed JDM patients from 2014 to 2018 were included in the *** with different markers(CD3+,CD3+CD4+,CD3+CD8+,CD3-CD19+and CD3-CD16+CD56+)were tested with flow cytometry in the first admission or after 6 months of *** analysis was conducted to compare the EBV infection in the group of JDM patients and *** We observed that JDM patients had higher positive rate of Epstein-Barr nuclear antigen-immunoglobulin G(IgG)(P0.0001)as well as EBV capsid antigen-IgG(P0.05)than normal ***3-CD16+CD56+lymphocyte was found to be extremely low in early stage of JDM patients,but increased after 6 months of treatment(P=0.0091).Conclusions The level of CD3-CD16+CD56+cells may associate with the clinical course of *** may act as an environmental factor predisposing patients to the development of JDM.
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