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efficacy of medium-chain fatty acid salts distilled from coconut oil against two enteric pathogen challenges in weanling piglets

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Journal of Animal Science and Biotechnology 2020年第1期11卷 251-267页

作者： Paola López-Colom Lorena Castillejos Agustina Rodríguez-Sorrento Mónica Puyalto Juan JoséMallo Susana maría martín-Orúe Animal Nutrition and Welfare Service Animal and Food Science DepartmentFacultat de VeterinàriaUniversitat Autònoma de BarcelonaBellaterraSpain Norel S.A MadridSpain.

Background:The search for alternatives to antibiotics in pig production has increased the interest in natural resources with antimicrobial properties,such as medium-chain fatty acids(MCFA)as in-feed *** study evaluated the potential of a novel blend of MCFA salts(DIC)from distilled coconut oil with a lauric acid content to reduce enteropathogens and control intestinal diseases around *** experimental disease models were implemented in early-weaned piglets,consisting of two oral challenges:Salmonella Typhimurium(1.2×10~8 CFU)or enterotoxigenic escherichia coli(eTeC)F4(1.5×10~9 CFU).The parameters assessed were:animal performance,clinical signs,pathogen excretion,intestinal fermentation,immune-inflammatory response,and intestinal ***:The Salmonella challenge promoted an acute course of diarrhea,with most of the parameters responding to the challenge,whereas the eTeC F4 challenge promoted a mild clinical course.A consistent antipathogenic effect of DIC was observed in both trials in the hindgut,with reductions in Salmonella *** counts in the cecum(P=0.03)on d 8 post-inoculation(PI)(Salmonella trial),and of enterobacteria and total coliform counts in the ileum and colon(PeTeC F4 trial).When analyzing the entire colonic microbiota(16 S rRNA gene sequencing),this additive tended(P=0.13)to reduce the Firmicutes/Bacteroidetes ratio and enriched Fibrobacteres after the Salmonella *** the eTeC F4 challenge,DIC prompted structural changes in the ecosystem with increases in Dialister,and a trend(P=0.14)to increase the Veillonellaceae *** parameters such as the intestinal fermentation products or serum pro-inflammatory mediators were not modified by DIC supplementation,nor were the histological *** the intraepithelial lymphocyte(IeL)counts were lowered by DIC in animals challenged with Salmonella(P=0.07).With eTeC F4,the IeL counts were higher with DIC on d 8 PI(P=0.08).Conclusions:This study c

关键词： enteric pathogen Gut microbiota Intestinal immunity Medium-chain fatty acids Weaning pig

Intestinal Ca2+ absorption revisited: A molecular and clinical approach

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World Journal of Gastroenterology 2020年第24期26卷 3344-3364页

作者： Vanessa A Areco Romina Kohan Germán Talamoni Nori G Tolosa de Talamoni maría e Peralta López Laboratorio“Dr.Fernando Canas” Cátedra de Bioquímica y Biología MolecularFacultad de Ciencias MédicasINICSA(CONICET-Universidad Nacional de Córdoba)Córdoba 5000Argentina

Ca2+has an important role in the maintenance of the skeleton and is involved in the main physiological *** homeostasis is controlled by the intestine,kidney,bone and parathyroid *** intestinal Ca2+absorption occurs mainly via the paracellular and the transcellular *** proteins involved in both ways are regulated by calcitriol and other hormones as well as dietary *** growth factor 23(FGF-23)is a strong antagonist of vitamin D *** of the intestinal Ca2+movement seems to be vitamin D *** Ca2+absorption changes according to different physiological *** is promoted under high Ca2+demands such as growth,pregnancy,lactation,dietary Ca2+deficiency and high physical *** contrast,the intestinal Ca2+transport decreases with *** stress inhibits the intestinal Ca2+absorption whereas the antioxidants counteract the effects of prooxidants leading to the normalization of this physiological *** pathologies such as celiac disease,inflammatory bowel diseases,Turner syndrome and others occur with inhibition of intestinal Ca2+absorption,some hypercalciurias show Ca2+hyperabsorption,most of these alterations are related to the vitamin D endocrine *** research work should be accomplished in order not only to know more molecular details but also to detect possible therapeutic targets to ameliorate or avoid the consequences of altered intestinal Ca2+absorption.

关键词： Ca2+absorption Transcellular pathway Paracellular pathway Hormones Dietary calcium Physiological conditions Pathological alterations

Protective effect of Sida cordata leaf extract against CCl_4 induced acute liver toxicity in rats

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Asian Pacific Journal of Tropical Medicine 2013年第4期6卷 280-284页

作者： Sunil Mistry kr Dutt J Jena Gayatri College of Pharmacy Gayatri ViharSambalpurOrissa-768200India CMR College of Pharmacy KandlakoyaMedchan RoadHyderabad-501401India Department of Pharmacology VSS Medical CollegeSambalpur University

Objective:To investigate the hepatoprotective potential of Sida cordata（Malvaceae）（***） in experimental rats to validate its traditional ***:Wister albino rats were divided into 6 groups:Croup 1 served as control;CroupⅡserved as hepatotoxic（CCl4 treated） group; CroupⅢ,Ⅳand V served as（100,200 and 400 mg/kg b.w.） *** leaf extract（SCLe） treated groups;CroupⅥserved as positive control（Silymarin） treated *** marker enzymes serum glutamate oxyloacetic transaminase,serum glutamic pyruvic transaminase,pancreatic enzymatic antioxidants superoxide dismutase（SOD）,lipid peroxidation,catalase（CAT）,reduced glutathione（CSH） were measured and compared along with histopathological ***: Obtained results show that the treatment with SCI.e significantly（Pedependently reduced CCl4 induced elevated serum level of hepatic ***, SCLe significantly（up to Peduced the lipid peroxidation in the liver tissue and restored activities of defence antioxidant enzymes CSH,SOD and CAT towards normal levels,which was confirmed by the histopathological ***:The results of this study strongly indicate the protective effect of SCLe against CCl4 induced acute liver toxicity in rats and thereby scientifically support its traditional use.

关键词： Sida cordata Histopathology Hepatoprotective CCl_4

Numerical Integration over Pyramids

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Advances in Applied Mathematics and Mechanics 2013年第3期5卷 309-320页

作者： Chuanmiao Chen Michal krızek Liping Liu Institute of Computer Science Hunan Normal UniversityChangsha 410081HunanChina Institute of Mathematics Academy of SciencesCZ-11567 PragueCzech Republic Department of Mathematical Sciences Lakehead UniversityThunder BayONP7B 5E1Canada Department of Applied Mathematics Anhui Agricultural UniversityHefei230036AnhuiChina

Pyramidal elements are often used to connect tetrahedral and hexahedral elements in the finite element *** this paper we derive three new higher order numerical cubature formulae for pyramidal elements.

关键词： Reference pyramidal element nonlinear systems of algebraic equations Bramble-Hilbert lemma triangular tetrahedral and pyramidal numbers

Root proliferation in native perennial grasses of arid Patagonia,Argentina

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Journal of Arid Land 2014年第2期6卷 195-204页

作者： Yanina A TORReS Carlos A BUSSO Oscar A MONTeNeGRO Leticia ITHURRART Hugo D GIORGeTT Gustavo RODRíGUeZ Diego BeNTIVeGNA Roberto e BReVeDAN Osvaldo A FeRNáNDeZ maría M MUJICA Sandra S BAIONI José eNTíO maría N FIOReTTI Guillermo TUCAT Agronomy Department National University of the South and CERZOS (CONICET) experimental Farm eeA INTA Patagones Ministery of Agrarian Issues Faculty of Agrarian Sciences National University of La Plata

Pappophorum vaginatum is the most abundant C4 perennial grass desirable to livestock in rangelands of northeastern Patagonia, Argentina. We hypothesized that （1） defoliation reduce net primary productivity, and root length density and weight in the native species, and （2） root net primary productivity, and root length density and weight, are greater in P. vaginatum than in the other, less desirable, native species （i.e., Aristida spegazzinfi, A. subulata and Sporobolus cryptandrus）. Plants of all species were either exposed or not to a severe defoliation twice a year during two growing seasons. Root proliferation was measured using the cylinder method. Cylindrical, iron structures, wrapped up using nylon mesh, were buried diagonally from the periphery to the center on individual plants. These structures, initially filled with soil without any organic residue, were dug up from the soil on 25 April 2008, after two successive defoliations in mid-spring 2007. During the second growing season （2008-2009）, cylinders were destructively harvested on 4 April 2009, after one or two defoliations in mid- and/or late-spring, respectively. Roots grown into the cylinders were obtained after washing the soil manually. Defoliation during two successive years did reduce the study variables only after plants of all species were defoliated twice, which supported the first hypothesis. The greater root net primary productivity, root length den- sity and weight in P. vaginatum than in the other native species, in support of the second hypothesis, could help to explain its greater abundance in rangelands of Argentina.

关键词： Aristida species competitive ability Pappophorum vaginatum Sporobolus cryptandrus warm-season perennial grasses

Factors Controlling Low Uranium and Thorium Concentrations in the Cayirhan Bituminous Shales(CBS)in the Beypazari(Ankara)Area,Turkey

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Acta Geologica Sinica(english edition) 2014年第1期88卷 248-252,I0009,I0010,253-259页

作者： Berna Yavuz PeHLIVANLI Sükrü KOC Ali SARI Hilal eNGIN Department of Geological engineering Faculty of Engineering and Architecture Bozok University Department of Geological engineering Faculty of Engineernig Ankara University Graduate School of Natural and Applied Sciences Ankara University

In this study uranium and thorium contents and depositional characteristics of ay rhan bituminous shales（ BS）, west of Ankara（central Anatolia）, are investigated. Samples used were collected from boreholes opened by Park Holding Ltd. A total of 25 samples were taken from bituminous shale levels in boreholes drilled at 6 different locations in the study area. The H rka formation which hosts bituminous shale deposits is a volcanosedimentary sequence and all lithofacies indicate that a lacustrine environment where the water level was continuously changed. In addition to hydrocarbon generation potential, bituminous shales also accumulate significant amount of radioactive elements such as uranium and thorium. The average uranium and thorium concentrations of BS（1.83/2.62 ppm） are much lower than averages of UC, NASK and PAAS（uranium： 2.70/2.66/3.10 ppm; thorium： 8.50/12.30/14.60 ppm）. Low uranium contents in comparison to those of similar lacustrine environments might be attributed to that waters of depositional environment of BS contain low concentration of dissolved uranium and redox conditions were of oxic and dioxic character. Correlation data indicate that U and Th have a similar source and are associated predominantly with clays and phosphates and dominantly with organic material. Radioactive elements in the basin might be derived from Paleozoic granites and metamorphites（e.g. gneiss, schist） which comprise the basement and volcanism which was active in the region throughout the Miocene period. These elements are probably associated with uraniferous phosphate minerals（e.g. autunite, torbernite） which occur in granite, gneiss and schist. BS with average TOC content of 10.96 % shows very good/perfect source rock potential. Positive correlations between Gamma-Ray values and U, Th and K concentrations imply that radioactivity might be originated from these three elements.

关键词： Uranium and Thorium concentrations ay rhan bituminous shales Beypazar area Turkey

Involvement of parathyroid hormone-related peptide in the aggressive phenotype of colorectal cancer cells

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World Journal of Gastroenterology 2021年第41期27卷 7025-7040页

作者： maría Belén Novoa Díaz Pedro Matías Carriere maría Julia martín Natalia Calvo Claudia Gentili Departamento de Biología Bioquímica y FarmaciaUniversidad Nacional del Sur(UNS)-INBIOSUR(CONICET-UNS)Bahía Blanca 8000Buenos AiresArgentina Departamento de Química Universidad Nacional del Sur(UNS)-INQUISUR(CONICET-UNS)Bahía Blanca 8000Buenos AiresArgentina

Colorectal cancer(CRC)remains one of the leading causes of mortality from malignant diseases *** general terms,CRC presents high heterogeneity due to the influence of different genetic and environmental factors;also,the neoplastic cells are strongly influenced by the extracellular matrix and several surrounding cells,known together as the tumor microenvironment(TMe).Bidirectional communication takes place between the tumor and the TMe through the release of autocrine and paracrine *** hormone-related peptide(PTHrP)is a cytokine secreted by a wide variety of tissues and is able to regulate several cellular functions both in physiological as well as in pathological *** exerts its effects as a paracrine/autocrine factor,although its mode of action is mainly *** has been shown that this peptide is expressed by several tumors and that the tumor secretion of PTHrP is responsible for the malignant humoral *** years ago,when our research group started studying PTHrP effects in the experimental models derived from intestinal tumors,the literature available at the time addressing the effects of PTHrP on colorectal tumors was limited,and no articles had been published regarding to the paracrine action of PTHrP in CRC *** on this and on our previous findings regarding the role of PTH in CRC cells,our purpose in recent years has been to explore the role of PTHrP in *** analyzed the behavior of CRC cells treated with exogenous PTHrP,focalizing in the study of the following events:Survival,cell cycle progression and proliferation,migration,chemoresistance,tumor-associated angiogenesis,epithelial to mesenchymal transition program and other events also associated with invasion,such us the induction of cancer stem cells *** work summarizes the major findings obtained by our investigation group using in vitro and in vivo CRC models that evidence the participation of PTHrP in the acquisition of an aggressiv

关键词： Parathyroid hormone-related protein Colorectal cancer Tumor biomarkers Neoplastic processes Drug resistance Tumor microenvironment

elastic Smart Contracts in Blockchains

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Ieee/CAA Journal of Automatica Sinica 2021年第12期8卷 1901-1912页

作者： Schahram Dustdar Pablo Fernández Josémaría García Antonio Ruiz-Cortés Distributed Systems Group Vienna University of TechnologyWien 1040Austria Smart Computer Systems Research and engineering Lab Research Institute of Computer EngineeringUniversity of SevillaSevilla 41012Spain

In this paper,we deal with questions related to blockchains in complex Internet of Things(IoT)-based *** ecosystems are typically composed of IoT devices,edge devices,cloud computing software services,as well as people,who are decision makers in scenarios such as smart *** decisions related to analytics can be based on data coming from IoT sensors,software services,and ***,they are typically based on different levels of abstraction and *** poses a number of challenges when multiple blockchains are used together with smart *** work proposes to apply our concept of elasticity to smart contracts and thereby enabling analytics in and between multiple blockchains in the context of *** propose a reference architecture for elastic Smart Contracts and evaluate the approach in a smart city scenario,discussing the benefits in terms of performance and self-adaptability of our solution.

关键词： Blockchain elasticity Internet of Things(IoT) smart cities smart contracts virtual chains

Posttranscriptional Control of Gene expression and Role of Small RNAs in Streptococcus mutans

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Advances in Microbiology 2018年第2期8卷 138-160页

作者： Jaroslaw e.król Center for Advanced Microbial Processing Department of Microbiology and ImmunologyDrexel University College of MedicinePhiladelphiaPAUSA

Streptococcus mutansis a key contributor to the formation of biofilms associated with dental caries disease. Living in the oral environment and developing of disease require tight gene regulation. In bacteria, gene expression is most commonly regulated at the level of transcription initiation. This control involved interactions of specific DNA sequences with regulatory proteins. A second mechanism of control of gene expression is mediated at the RNA level by several mechanisms and is generally called posttranscriptional regulation. These mechanisms include cis- and trans-acting small, non-coding RNAs, RNA-binding proteins, riboswitches, thermosensors, RNases, and Type I toxin-antitoxin systems, and may result in changes in RNA stability, efficiency of ribosome binding, translation initiation, and transcript secondary structures. Here I review the posttranscriptional regulation in S. mutans.

关键词： Dental Carries Gene Regulation Antisense Therapy