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Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： maría norte-muñoz maría Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega mar Pérez JoséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz maría Teresa Moreno-Flores marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

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Interplay between mesenchymal stromal cells and the immune system after transplantation: implications for advanced cell therapy in the retina

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Neural Regeneration Research 2024年第3期19卷 542-547页

作者： maría norte-muñoz David García-Bernal Diego García-Ayuso Manuel Vidal-Sanz marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la Salud30120 MurciaSpain Grupo de Investigación Trasplante Hematopoyético y Terapia celular Departamento de Bioquímica e Inmunología.Facultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la Salud30120 MurciaSpain

Advanced mesenchymal stromal cell-based therapies for neurodegenerative diseases are widely investigated in preclinical *** stromal cells are well positioned as therapeutics because they address the underlying mechanisms of neurodegeneration,namely trophic factor deprivation and *** studies have focused on the beneficial effects of mesenchymal stromal cell transplantation on neuronal survival or functional ***,little attention has been paid to the interaction between mesenchymal stromal cells and the host immune system due to the immunomodulatory properties of mesenchymal stromal cells and the long-held belief of the immunoprivileged status of the central nervous ***,we review the crosstalk between mesenchymal stromal cells and the immune system in general and in the context of the central nervous system,focusing on recent work in the retina and the importance of the type of transplantation.

关键词： adaptive immunity cell therapy central nervous system immune system innate immunity mesenchymal stromal cells neuroregeneration preclinical studies retina transplantation

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Mesenchymal stromal cell therapy for damaged retinal ganglion cells, is gold all that glitters?

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Neural Regeneration Research 2019年第11期14卷 1851-1857页

作者： Fernando Lucas-Ruiz Caridad Galindo-Romero David García-Bernal maría norte-munoz Kristy T. Rodríguez-Ramírez Manuel Salinas-Navarro Jose E. Millán-Rivero Manuel Vidal-Sanz marta Agudo-Barriuso Grupo de Oftalmologia Experimental Instituto Murciano de Investigacion Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca)MurciaSpain Department of Talmologia Universidad de MurciaMurciaSpain Unidad de Terapia Celular y Trasplante Hematopoyetico Instituto Murciano de Investigacion Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca)MurciaSpain Department of Medicina Interna Universidad de MurciaMurciaSpain

Mesenchymal stromal cells are an excellent source of stem cells because they are isolated from adult tissues or perinatal derivatives, avoiding the ethical concerns that encumber embryonic stem cells. In preclinical models, it has been shown that mesenchymal stromal cells have neuroprotective and immunomodulatory properties, both of which are ideal for central nervous system treatment and repair. Here we will review the current literature on mesenchymal stromal cells, focusing on bone marrow mesenchymal stromal cells, adipose-derived mesenchymal stromal cells and mesenchymal stromal cells from the umbilical cord stroma, i.e.,Wharton’s jelly mesenchymal stromal cells. Finally, we will discuss the use of these cells to alleviate retinal ganglion cell degeneration following axonal trauma.

关键词： stem cells adipose stem cells umbilical cord bone marrow Wharton's jelly optic nerve axotomy neuroprotection

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Understanding and Forecasting Zonda Wind (Andean Foehn) in Argentina: A Review

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Atmospheric and Climate Sciences 2015年第3期5卷 163-193页

作者： Federico A. norte Instituto Argentino de Nivología Glaciología y Ciencias Ambientales (IANIGLA) CCT-CONICET Mendoza Argentina

This paper focuses on the “state of the art” research of the Argentinian zonda wind at the beginning of 2015. Zonda (similar to foehn) is a strong, warm, very dry wind associated with adiabatic compression upon descending the eastern slopes of the Andes Cordillera in western central Argentina. Particularly, hourly surface meteorological information obtained from the Argentine National Weather Service (Servicio Meteorológico Nacional, SMN) from Mendoza Aero (32?50’S, 68?47’W, 704 m ASL) and San Juan Aero (31?34’S, 68?25’W, 598 m ASL) airport meteorological stations was used. The paper contains a history of zonda research mentioning the principal papers since the 1950s, the characteristics of zonda wind (conceptual model, a classic event, intensities categories) and examples of non-classical episodes. Also zonda dynamics, zonda climatology and forecasting problems are considered. A probabilistic method and the model forecast that are running in operative way are commented. Also the climate impact, air quality and damages caused are mentioned. There has been substantial progress in the understanding of this kind of complex wind during the last years, especially since the last decade, accelerated using different models. This paper has highlighted some of these advances by synthesizing some of the major findings. The probabilistic prediction method developed in the 1980s is still very useful to predict zonda in the cities of San Juan and Mendoza. This as well as the new available tools, such as the eta/PRM and GEM models running operatively (continuously) at PRM (Mendoza Regional Meteorology Program), offered the community the possibility to generate an Early Warning System to warn the population particularly in its severe manifestations. The answer to questions regarding time of onset of the event, place where it will occur first, duration, intensity and offset still poses a great challenge for researchers and forecasters in the region.

关键词： Zonda State of the Art Climatology Forecast Damages Societal Impact

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Combination of hydrotreating and delayed coking technologies for conversion of residue

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Chinese Journal of Chemical Engineering 2023年第11期63卷 209-219页

作者： José A.D.munoz Gabriel Páez Jorge Ancheyta Instituto Mexicano del Petróleo Eje Central Lázaro Cárdenas Norte 152Col.San Bartolo AtepehuacanMéxico City 07730México

Residue conversion by combining catalytic hydrotreating and delayed coking has been evaluated comparatively with both processes *** operating conditions are defined to achieve the greatest economic benefit for upgrading an atmospheric residue from a heavy crude oil.A literature model was adapted to simulate the hydrotreating reactor,and for delayed coking,correlations reported in the literature were *** results with both approaches were employed to calculate the techno-economic feasibility of the combined process *** combination of hydrotreating and delayed coking presented an increase in light fractions of 29% and a reduction in coke production of 47.8%.Based on the calculated net benefit values,it was demonstrated that the combination of hydrotreating and delayed coking is technically and economically better than using each process alone,with highest benefit of 57.7 USD·m^(-3).

关键词： Economic benefit Heavy oil Hydrotreating Delayed coking

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Validation of a Statistical Forecast Model for Zonda Wind in West Argentina Based on the Vertical Atmospheric Structure

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Atmospheric and Climate Sciences 2016年第1期6卷 35-50页

作者： Federico A. norte Silvia Simonelli Instituto Argentino de Nivología Glaciología y Ciencias Ambientales (IANIGLA) CCT-CONICET Mendoza Argentina

Zonda is a strong, warm, very dry wind associated with adiabatic compression upon descending the eastern slopes of the Andes Cordillera in western-central Argentina. This research seeks, first, to validate the skill of a statistical forecast of zonda based on the behavior of the vertical structure of the atmosphere and, second, to describe the climatology of the vertical profile leeward of the Andes. The forecast was built for May-August 1974/1983, and was verified against a series of cases recorded in the Mendoza Aero and San Juan Aero weather stations for May-August 2005/2014. It made use of the Stepwise Discriminant Analysis (SDA) and rawinsonde data from Mendoza Aero as predictors, with the following input variables: surface pressure, temperature, dew point, and the zonal and meridional components of the wind on surface and of the fixed levels up to 200 hPa. The variables selected as predictors by the SDA were: surface pressure, dew point depression at 850 hPa, meridional wind component at 850 hPa, and zonal wind component at 400 hPa. Climatology of the vertical profile of the atmosphere leeward of the Andes was built from daily rawinsonde data from Mendoza Aero for May-August 1974/1983. Zonda markedly influences the atmospheric structure leeward of the Andes in western-central Argentina. Its maximum impact occurs at 850 to 800 hPa, with significant heating and decrease of humidity. Validation of the prediction program considered deterministic and probabilistic forecasts. Contingency tables show that probability of zonda occurrence in the plains is generally overestimated, and false alarm cases are far more frequent than surprise events. The main contribution of this paper is precisely the validation of the prediction model, which ensures forecasters one more tool to improve zonda forecasting;this, in turn, will aid decision-makers when taking steps to ameliorate zonda wind impact.

关键词： Zonda Argentina Statistical Forecast Validation Rawinsonde Climatology

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Circular RNAs in colorectal cancer:Possible roles in regulation of cancer cells

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World Journal of Gastrointestinal Oncology 2017年第2期9卷 62-69页

作者： maría Isabel Taborda Sebastián Ramírez Giuliano Bernal Laboratory of Molecular and Cell Biology of Cancer(Cancer Lab) Department of Biomedical SciencesFaculty of MedicineUniversidad Católica del NorteCoquimbo 1781421Chile

Colorectal cancer(CRC) is the third most commonly diagnosed cancer in the world and the fourth principal cause of cancer deaths worldwide. Currently, there is a lack of low cost and noninvasive screening tests for CRC, becoming a serious health problem. In this context, a potential biomarker for the early detection of CRC has recently gained attention. Circular RNAs(circ RNA), a re-discovered, abundant RNA specie, is a type of noncoding covalent closed RNAs formed from both exonic and intronic sequences. These circular molecules are widely expressed in cells, exceeding the abundance of the traditional linear m RNA transcript. They can regulate gene expression, acting as real sponges for mi RNAs and also regulate alternative splicing or act as transcriptional factors and inclusive encoding for proteins. However, little is known about circ RNA and its relationship with CRC. In this review, we focus on the biogenesis, function and role of these circ RNAs in relation to CRC, including their potential as a new biomarker.

关键词： Circular RNA Colorectal cancer Gene regulation CircRNA Non-coding RNAs Long non-coding RNA Circularization

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Adaptive Fault Detection Based on Neural Networks and multiple Sampling Points for Distribution Networks and Microgrids

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Journal of Modern Power Systems and Clean Energy 2022年第6期10卷 1648-1657页

作者： J.marín-Quintero C.Orozco-Henao A.S.Bretas J.C.Velez A.Herrada A.Barranco-Carlos W.S.Percybrooks Electric and Electronic Engineering Program Universidad Tecnológica de BolívarCartagenaColombia Electrical and Electronic Engineering Department Universidad del NorteBarranquillaColombia Distributed Systems Group Pacific Northwest National LaboratoryGainesvilleUSA

Smart networks such as active distribution network(ADN)and microgrid(MG)play an important role in power system *** design and implementation of appropriate protection systems for MG and ADN must be addressed,which imposes new technical *** paper presents the implementation and validation aspects of an adaptive fault detection strategy based on neural networks(NNs)and multiple sampling points for ADN and *** solution is implemented on an edge *** are used to derive a data-driven model that uses only local measurements to detect fault states of the network without the need for communication *** sampling points are used to derive a data-driven model,which allows the generalization considering the implementation in physical *** adaptive fault detector model is implemented on a Jetson Nano system,which is a single-board computer(SBC)with a small graphic processing unit(GPU)intended to run machine learning loads at the *** proposed method is tested in a physical,real-life,low-voltage network located at Universidad del norte,*** testing network is based on the IEEE 13-node test feeder scaled down to 220 *** validation in a simulation environment shows the accuracy and dependability above 99.6%,while the real-time tests show the accuracy and dependability of 95.5%and 100%,*** hard-to-derive parameters,the easy-to-implement embedded model highlights the potential for real-life applications.

关键词： Distribution network microgrid adaptive protection intelligent electronic device machine learning

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Intense Visible Photoluminescence from C46H22N8O4KM (M = Co, Fe, Pb) Derivatives Thin Films

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Advances in Materials Physics and Chemistry 2011年第3期1卷 57-63页

作者： maría Elena Sánchez Juan Carlos Alonso Jerry Nathan Reider Faculty of Engineering Anahuac Mexico Norte University Materials Research Institute National Autonomous University of Mexico (UNAM)

Strong visible photoluminescence (PL) at room temperature is obtained from thermal-evaporated thin solid films of Metallophthalocyanine (M = Co, Fe, Pb) and double potassium salt from 1,8 dihydroxyan-thraquinone. The PL of all the investigated samples is observed with the naked eye in a bright background. The deconvolution of the normalized PL spectra shows that each PL spectrum is composed of four emission bands which peak at approximately the same energies of 2.1, 2.2 and 2.4 eV and whose intensities and widths depend upon the structure of the complexes. FTIR and ellipsometry are employed to investigate the structural differences among the films. The optical absorption of the films is also investigated to evaluate the changes in the electronic structure of these metal organic compounds, with respect to other metalphtalocya-nines thin films. Our results suggest that the visible PL comes from radiative transitions between energy lev-els associated to the double potassium salt coordination to the metallic ion in the phthalocyanine.

关键词： Thin Films Optical Properties Photoluminescence

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multiple Indicators&multiple Cause of Public Administration of Zoos in the Sustainable Development Goals

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Journalism and Mass Communication 2024年第5期14卷 279-288页

作者： Leticia maría González Velázquez maría del Rosario Molina Gonzále Gilberto Bermúdez Ruíz Arturo Sánchez Sánchez Rosa maría Rincón Ornelas Lidia Amalia Zallas Esquer Jorge Hernandez Valdés Cruz García Lirios Universidad de Sonora NavojoaMéxico Universidad Anáhuac del norte México Universidad Autónoma de Tlaxcala México Universidad Nacional Autónoma de México MéxicoMéxico Universidad de la Salud de México TolucaMéxico

Zoo management has been approached from its financial guidelines in accordance with the SDGs,but without considering its adjustment to the ***,the objective of this work was to compare the theoretical structure reported in the literature with respect to the observations of this work.A cross-sectional and retrospective study was carried out with a sample of administrative managers linked to zoos committed to the implementation of the *** results suggest that age and gender determine the financial *** relation to the state of the art where dimensions related to learning financial administration are reported,this work suggests that age is a determinant of social responsibility.

关键词： Confirmatory Factor analysis Management Zoo multiple Indicators&multiple Cause SDG`s

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