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Grounded theory qualitative approach from Foucault's ethical perspective:Deconstruction of patient self-determination in the clinical setting

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World Journal of Clinical Cases 2021年第28期9卷 8312-8326页

作者： jesús Molina-Mula nursing and Physiotherapy Department University of Balearics IslandPalma 07122Illes BalearsSpain

This paper aims to explain the construction of the autonomous subject from Foucault's ethical perspective for the qualitative analysis of interprofessional relationships,patient-professional relationships,and moral ethics *** tried to break loose from the self,which is merely the result of a biopol-itical subjectivation and constituted an interpersonal *** this,different elements involved in the decision-making capacity of patients in a clinical setting were ***,the context in which decision-making occurs has been explained,distinguishing between traditional practices involved in self-care and the more modern conceptions that make certain possible ***,an attempt is made to explain the formation of the medicalisation of society using the transformations of what Foucault called"techniques of the self".Finally,the ethical framework for a subject's"self-creation",insisting more on the exercises of self-subjectivation,reinforcing the ethics of the self by itself,the"care of the self",has been *** role of the patient is understood as an autonomous subject to the extent that the clinical institution and the professionals involved comprehend how the patient’s autonomy in the clinical environment is *** these elements could generate grounded theory on the qualitative methodology of this *** current ethical model based on universal principles is not useful to provide a capacity for patients decision-making,relegating to the background their opinions and ***,a new ethical perspective emerges that aims to return the patient to the fundamental axis of attention.

关键词： Decision making Personal autonomy Foucault Principle-based Ethics Bioethics,Qualitative methodology,Grounded theory

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Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

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neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： Mackenzie M.spicer Jianqi Yang Daniel Fu Alison n.DeVore marisol Lauffer nilufer s.Atasoy Deniz Atasoy Rory A.Fisher Department of neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in Molecular Medicine University of Iowa Carver College of MedicineIowa CityIAUSA neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein signaling 6(RGs6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel RGs6fl/fl;APP_(sWE) mice and used retroviral approaches to examine the impact of RGs6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(sWE) mice restored their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished by RGs6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(sWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGs6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGs6-expressing ***,RGs6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(sWE) mice,identifying RGs6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(RGs6)

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Experimental study on lightweight expanded clay at particle level:Breakage of isolated grains

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第7期15卷 1846-1858页

作者： Elías Roces-Alonso Jose Estaire Miriam martín-Ruiz jesús González-Galindo ETs de Ingenieros de Caminos Universidad Politécnica de MadridSpain Laboratorio de Geotecnia CEDEXMadridSpain

In this study,more than 1500 particles of lightweight expanded clay aggregate(LECA)are individually loaded up to breakage,following different patterns of contact(from 2 to 7)using a purpose-built ***,a statistical model for predicting the number of fragments into which a grain breaks as a function of the number of contacts and their diameter is *** number of fragments is found to follow a statistical binomial-type distribution function that depends on the number of *** addition,a model based on Bayesian networks,capable of assessing the number of fragments and their size(measured as normalized weight)as a function of the number of contacts,is *** proposed method is applicable when performing discrete element method(DEM)simulations on granular media in which grain breakage plays a relevant role.

关键词： Lightweight expanded clay aggregate(LECA) Grain fragmentation Grain breakage Biaxial grain load

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Effect of femtosecond laser-assisted lens surgery on the optic nerve head and the macula

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International Journal of Ophthalmology(English edition) 2019年第6期12卷 961-966页

作者： Josefina Renones de Abajo Beatriz Estévez Jorge jesús maría González martín Humberto Carreras Díaz Juan Francisco Loro Ferrer Alfonso Antón López Eurocanarias Oftalmológica Las Palmas de Gran Canaria 35004Spain Universidad de Las Palmas de Gran Canaria(ULPGC) Las Palmas de Gran Canaria 35001Spain Department of Research Hospital Universitario de Gran Canaria Doctor NegrínLas Palmas de Gran Canaria 35019Spain Universidad Internacional de Cataluna(UIC) Barcelona 08195Spain Institut Catalàde Retina(ICR) Barcelona 08017Spain Parc de salut mar Barcelona 08024Spain

AIM: To evaluate the effect of femtosecond laser-assisted lens surgery(FLALs;cataract surgery or refractive lens exchange) on the structure of the optic nerve head and the ***: This prospective longitudinal study included healthy eyes undergoing FLALs. Eyes with glaucoma or any other ocular disease that could alter optical coherence tomography results were excluded. Retinal nerve fiber layer(RnFL), Bruch’s membrane opening-minimum rim width(BMO-MRW) and macular thickness(MT) were measured preoperatively, 1 and 6 mo after surgery using spectral-domain optical coherence tomography(sD-OCT). Changes between preoperative and postoperative values were ***: A total of 87 eyes of 46 patients were included in this study. Preoperative RnFL, BMO-MRW and MT in microns(μm) were 100.77±10.39, 330.31±49.99 and 276.30±33.39, respectively. Postoperative RnFL, BMO-MRW and MT were 104.74±11.55, 348.32±54.05 and 279.83±22.65 1 mo after surgery and 102.93±11.17, 343.11±53.4 and 278.90±22.19 6 mo after surgery, respectively;which equals an increase of 3.93%, 5.45% and 1.27%,respectively, 1 mo after surgery, and 2.14%, 3.87% and 0.94% 6 mo after surgery. The differences between the preoperative and the postoperative RnFL and BMO-MRW values were statistically significant(Png MT values, there were not statistically significant differences(P=0.26).COnCLUsIOn: Our study suggests that FLALs does not have a negative impact on the structural status of the optic nerve head in healthy eyes, assessed by sD-OCT. There is a slight increase in the values of RnFL, BMO-MRW and MT 1 mo and 6 mo after surgery.

关键词： femtosecond laser-assisted cataract surgery refractive lens exchange optical coherence tomography optic nerve head macula

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A Comprehensive Review on Human Aichi Virus

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Virologica sinica 2020年第5期35卷 501-516页

作者： Enrique Rivadulla jesús L.Romalde Departamento de Microbiologı´a y Parasitologı´a CIBUSFacultad de Biologı´aUniversidade de Santiago de Compostela15782 SantiagoSpain

Although norovirus,rotavirus,adenovirus and Astrovirus are considered the most important viral agents transmitted by food and water,in recent years other viruses,such as Aichi virus(AiV),have emerged as responsible for gastroenteritis outbreaks associated with different *** belongs to the genus Kobuvirus of the family *** is a virus with icosahedral morphology that presents a single stranded RnA genome with positive sense(8280 nucleotides)and a poly(A)*** was first detected from clinical samples and in recent years has been involved in acute gastroenteritis outbreaks from different world ***,several studies conducted in Japan,Germany,France,tunisia and spain showed a high prevalence of AiV antibodies in adults(between 80%and 99%),which is indicative of a large exposure to this *** aim of this review is to bring together all the discovered information about the emerging pathogen human Aichi virus(AiV),discussing the possibles routes of transmission,new detection techniques and future *** AiV is responsible for a low percentage of gastroenteritis outbreaks,the high seroprevalence shown by human populations indicates an evident role as an enteric *** low percentage of AiV detection could be explained by the fact that the pathogen is more associated to subclinical *** studies will be needed to clarify the real impact of AiV in human health and its importance as a causative gastroenteritis agent worldwide.

关键词： Human Aichivirus(AiV) Kobuvirus Picornaviridae Gastroenteritis

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Beacon-Less Geographic Routing in Real Wireless sensor networks

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Journal of Computer science & Technology 2008年第3期23卷 438-450页

作者： Juan A.sánchez Rafael marín-Pérez Pedro M.Ruiz Department of Information and Communications Engineering University of MurciaSpain

Geographic Routing （GR） algorithms require nodes to periodically transmit HELLO messages to allow neighbors to know their positions （beaconing mechanism）. Beacon-less routing algorithms have recently been proposed to reduce the control overheads due to these messages. However, existing beacon-less algorithms have not considered realistic physical layers. Therefore, those algorithms cannot work properly in realistic scenarios. In this paper we present a new beacon-less routing protocol called BOss. Its design is based on the conclusions of our open-field experiments using Tmote-sky sensors. BOss is adapted to error-prone networks and incorporates a new mechanism to reduce collisions and duplicate messages produced during the selection of the next forwarder node. We compare BOss with Beacon-Less Routing （BLR） and Contention-Based Forwarding （CBF） algorithms through extensive simulations. The results show that our scheme is able to *** almost perfect packet delivery ratio （like BLR） while having a low bandwidth consumption （even lower than CBF）. Additionally, we carried out an empirical evaluation in a real testbed that shows the correctness of our simulation results.

关键词： geographic routing beacon-less forwarding performance evaluation real deployment

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Dynamics of canopy-dwelling arthropods under different weed management options,including glyphosate,in conventional and genetically modified insect-resistant maize

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Insect science 2021年第4期28卷 1121-1138页

作者： Esteban García-Ruiz Guillermo Cobos Ismael sánchez-Ramos susana Pascual maría-Cristina Chueca maría-Concepción Escorial Inés santín-Montanyá Íñigo Loureiro Manuel González-núñez Plant Protection Department Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria(INIA)MadridSpain

The use of genetically modified varieties tolerant to herbicides(HT varieties)and resistant to insects(Bt varieties)in combination with application of a broad-spectrum herbicide such as glyphosate could be an effective option for the simultaneous control of weeds and pests in ***,the possible impact of these tools on nontarget arthropods still needs to be *** a field study in central spain,potential changes in populations of canopy-dwelling arthropods in Bt maize under different weed management options,including glyphosate application,were ***-dwelling arthropods were sampled by visual inspection and yellow sticky *** Bt variety had no effect on any group of studied arthropods,except for the expected case of corn borers—the target pests of Bt *** the effects of herbicide regimes,the only observed difference was a lower abundance of Cicadellidae and Mymaridae on yellow sticky traps in plots not treated with pre-emergence *** effect was especially pronounced in a treatment involving two glyphosate *** decrease in Cicadellidae and Mymaridae populations was associated with a higher density of weeds in plots,which may have hindered colonization of the crop by *** differences,however,were only significant in the last year of the *** low likelihood of the use of glyphosate-and herbicide-tolerant varieties for weed control triggering important effects on the nontarget arthropod fauna of the maize canopy is discussed.

关键词： Bt maize canopy-dwelling arthropods GMHT maize glyphosate herbicide management parasitoids

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Boron in Plants: Deficiency and Toxicity

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Journal of Integrative Plant Biology 2008年第10期50卷 1247-1255页

作者： Juan J. Camacho-Cristóbal jesús Rexach Agustín Gonzlez-Fontes Departamento de Fisiología Anatomía y Biología Celular Facultad de Ciencias Experimentales Universidad Pablo de OlavideE-41013 Sevilla Spain

Boron （B） is an essential nutrient for normal growth of higher plants, and B availability in soil and irrigation water is an important determinant of agricultural production. To date, a primordial function of B is undoubtedly its structural role in the ceil wall; however, there is increasing evidence for a possible role of B in other processes such as the maintenance of plasma membrane function and several metabolic pathways. In recent years, the knowledge of the molecular basis of B deficiency and toxicity responses in plants has advanced greatly. The aim of this review is to provide an update on recent findings related to these topics, which can contribute to a better understanding of the role of B in plants.

关键词： boron-binding molecules boron transporter cell wall-related genes gene expression nitrogen metabolism,

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Twenty years of population dynamics in European beech-oak forest at their rear range margin anticipate changes in its structure and composition

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Forest Ecosystems 2024年第3期11卷 358-370页

作者： álvaro Rubio-Cuadrado Iciar Alberdi Isabel Canellas Fernando Montes jesús Rodríguez-Calcerrada Rosana López Guillermo G.Gordaliza maría Valbuena-Carabana nikos nanos Ramón Perea Luis Gil Departamento de dinamica y gestion forestal Instituto de Ciencias Forestales(ICIFOR-INIA)CSICCtra.La Coruna km 7.528040MadridSpain Departamento de sistemas y Recursos naturales Escuela Tecnica Superior de Ingeniería de MontesForestal y del Medio NaturalUniversidad Politecnica de Madrid.Ciudad Universitaria s/n28040MadridSpain school of Forestry and natural Environment Aristotle University of ThessalonikiUniversity Campus54124ThessalonikiGreece

There is an increasing interest in restoring degraded forests,which occupy half of the forest *** the forms of restoration,passive restoration,which involves the elimination of degrading factors and the free evolution of natural dynamics by applying minimal or no management,is gaining *** dynamics is difficult to predict due to the influence of multiple interacting factors such as climatic and edaphic conditions,composition and abundance of species,and the successional character of these ***,we study the natural dynamics of a mixed forest located in central spain,which maintained an open forest structure,due to intensive use,until grazing and cutting were banned in the *** most frequent woody species in this forest are Fagus sylvatica,Quercus petraea,Quercus pyrenaica,Ilex aquifolium,sorbus aucuparia,sorbus aria and Prunus avium,with contrasting shade and drought *** species are common in temperate European deciduous forest and are found here near their southern distribution limit,except for *** order to analyze forest dynamics and composition,three inventories were carried out in 1994,2005 and *** results show that,despite the Mediterranean influence,the natural dynamics of this forest has been mainly determined by different levels of shade *** the abandonment of grazing and cutting,*** expanded rapidly due to its lower shade tolerance,whereas after canopy closure and forest densification,shade-tolerant species gained ground,particularly ***,despite its lower drought and late-frost *** the current dynamics continue,*** will overtake the rest of the species,which will be relegated to sites with shallow soils and steep ***,all the multi-centennial beech trees,which are undergoing a rapid mortality and decline process,will disappear.

关键词： Forest succession secondary forest Woodland Mixed forest Competition Recruitment

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Crosslinked hyaluronic acid with liposomes and crocin for management symptoms of dry eye disease caused by moderate meibomian gland dysfunction

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International Journal of Ophthalmology(English edition) 2020年第9期13卷 1368-1373页

作者： José-maría sánchez-González Concepción De-Hita-Cantalejo maría Carmen sánchez-González Department of Physics of Condensed Matter Optics AreaUniversity of SevilleSeville 41012Spain

AIM:To study the effect of uncrosslinked and crosslinked hyaluronic acid combined with other artificial tear components in patients with dry eye caused by moderate meibomian gland ***:Prospective,single-blind,contralateral eye *** eyes(25 patients)were *** selection for each tear type was random,and the eye drop formulations,0.4%uncrosslinked hyaluronic acid and 0.2%galactoxyloglucan(tear A)and 0.15%crosslinked hyaluronic acid,crocin,and liposomes(tear B)were *** determined dosing schedule was three times a day for six weeks,and the study participants underwent a clinical examination before and 45 d after lubricant *** schirmer test,tear breakup time(TBUT)test,and Ocular surface Disease Index(OsDI)questionnaire were applied before and after instillation period with both types of artificial ***:On the schirmer test,a significant improvement was obtained with both tear A(Pnd tear B(Pn the TBUT test,a significant improvement was obtained with tear A(Pnd tear B(PsDI score significantly decreased after instillation period with both artificial tear types(PnCLUsIOn:Uncrosslinked hyaluronic acid combined with other components,such as tamarind seed polysaccharide,and crosslinked hyaluronic acid combined with liposomes and crocin are effective for management symptoms of dry eye disease.

关键词： liposome crosslinked hyaluronic acid meibomian gland dysfunction contact lens dry eye disease

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