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The frequency of intestinal parasites in puppies from Mexican kennels

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surface defect detection in non-ferromagnetic material using an EMAT

Health（健康） 2010年第11期

作者： Enedina Jiménez-Cardoso Leticia Eligio-García Adrián Cortés-Campos Apolinar Cano Estrada margarita pinto-sagahón Cynthia Noguera-Estrada

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材料科学与工程（中英文版） 2009年第12期3卷 1-10页

作者： sadiq Thomas salah Obayya Domenico pinto Didar Dulay Wam ade v aB al ac handr an Mostafa Darwish school of Electronic and Engineering University of Leeds Leeds LS2 9JT UK Faculty of Advaneed Technology University of Glamorgan Pontypridd CF371DL Wales UK NDT Consultants Limited Coventry CV3 4F J UK school of Engineering and Design Brunel University Uxbridge UB8 3PHUK University of Wales Newport Newport NP18 3QT UK）

Advances in Assessment of Geothermal Resources of south America

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Distance Interventions for Children with sleep Problems: A Review

Natural Resources（自然资源） 2014年第14期 897-913页

作者： Fabio pinto Vieira Valiya Mannathal Hamza

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Journal of Psychological Research 2022年第1期4卷 18-26页

作者： Tatiana Matheus pinto Jéssica de Assis da silva Renatha El Rafihi-Ferreira Edwiges Ferreira de Mattos silvares social and Cognitive Laboratory and Developmental Disorders Program Center for Health and Biological SciencesMackenzie Presbyterian UniversitySao PauloBrazil Ninth of July University Sao PauloBrazil sleep Outpatient Clinic of Psychiatry Institute Clinics Hospital of Sao Paulo Medicine FacultySao PauloBrazil Department of Psychology Institute of PsychologyUniversity of Sao PauloBrazil

sleep problems in childhood are frequent and may cause damage to the children and their families;however,parental orientation appears to be effective in its many new formats,such as the distance *** study aimed to review the literature about behavioral intervention performed by distance to sleep problems in childhood and summarize the main characteristics of such *** were performed up to November 2021 in BVs Psicologia ULAPsI Brasil,sCOPUs,and PsycINFO,using the key words:sleep problems,insomnia,nighttime fears,behavioral intervention,behavioral treatment,treatment,intervention,sleep,behavior,child,children,infant,mobile phones,smartphone,app,telephone,online,internet,*** included 14 *** main results indicate that interventions were implemented between 2 and 12 weeks,the most reported procedure was pre-sleep routines,and semi-presential interventions that required some presential contact were the most *** educational information about sleep through bibliotherapy and telephone contacts were the most used tools to implement the remote component of *** studies indicated improvements on children’s sleep,and secondary results(parental sleep and/or mental health)were also reported among ***,our findings suggest that distance interventions for childhood sleep problems are promising,but future research is still needed.

关键词： sleep problems Distance intervention Children Review

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局部麻醉药对人类神经元的细胞毒性

麻醉与镇痛 2010年第4期6卷 34-45页

作者： Rosalia Perez-Castro sohin Patel Zayra V.Garavito-Aguilar Andrew Rosenberg Esperanza Redo-pinto Jin Zhang Thomas J. J. Blank Fang Xu 周仁龙(译) 杭燕南(校) Department of Anesthesiology New York University. School of Medidne NYU Hospital for Joint Diseases New York New York Department of Anesthesiology NYU Hospital for Joint Diseases New York New York 不详

背景局部麻醉药（LAs）除了能抑制外周神经兴奋性传递作用，对中枢神经系统、心血管系统、神经肌肉接头及细胞代谢还具有毒性作用。手术后多种神经并发症都可归因于LAs的细胞毒性作用，但其作用机制尚不清楚。临床上使用的局部麻醉药浓... 详细信息

背景局部麻醉药（LAs）除了能抑制外周神经兴奋性传递作用，对中枢神经系统、心血管系统、神经肌肉接头及细胞代谢还具有毒性作用。手术后多种神经并发症都可归因于LAs的细胞毒性作用，但其作用机制尚不清楚。临床上使用的局部麻醉药浓度远远大于其抑制离子通道作用的EC50，离子通道阻滞这一单一因素不足以解释LAs诱导细胞死亡的所有原因，因为其他因素也可能参与其中。本研究比较了6种常用局部麻醉药的细胞毒性，并探讨其毒性作用的可能机制。方法将人类sH—sY5Y神经母细胞分别浸泡在6种局部麻醉药中（布比卡因、罗哌卡因、甲哌卡因、利多卡因、普鲁卡因和氯普鲁卡因），通过MTT[3-（4，5-二甲基噻唑-2）-2，5-二苯基四氮唑澳盐]光度计法定量，LIVE／DEAD（钙黄绿素／AM和溴乙啶二聚体-1）荧光成像检测方法定性测量它们的差异。此外采用荧光半胱天冬酶抑制剂（FLICA^TM）测定半胱天冬酶-3／-7的活性测定凋亡活性，同时还研究了局部麻醉药对极化和碳酰胆碱诱导细胞内钙反应的作用。结果（1）用局部麻醉药处理细胞10分钟后，6种局部麻醉药均呈浓度依赖地降低了细胞活性。杀伤力为普鲁卡因≤甲哌卡因〈利多卡因〈氯普鲁卡因〈罗哌卡因〈布比卡因（根据所得LD50，即致50％细胞死亡的浓度）。在所有局部麻醉药中，只有布比卡因和利多卡因随着浓度的增加而能够杀灭所有细胞。（2）布比卡因和利多卡因均激活了半胱天冬酶-3／-7，所需浓度利多卡因高于布比卡因，但布比卡因激活半胱天冬酶的速度较利多卡因迟缓。高浓度利多卡因能立即诱发半胱天冬酶活化，但浓度低于10mM时不产生该作用。（3）普鲁卡因和氯普鲁卡因浓度依赖性地抑制去极化或受体激活诱发的胞浆Ca^2＋反应，并与以往研究中发现的布比卡因、罗哌卡因、甲哌卡因和利多卡因的作用方式相类似。没有一种局部麻醉药能够显著增加基础状态和Ca^2＋诱发的胞浆Ca^2＋浓度变化。结论局部麻醉药导致细胞迅速死亡，主要原因是细胞坏死。利多卡因和布比卡因可以通过延长作用时间或增加浓度来触发细胞凋亡，这些作用可能与手术后神经损伤有关。虽然利多卡因不是本研究模型中毒性最强的局部麻醉药，但是它诱发一过性神经性症状的概率最高，而毒性最高的布比卡因却极少造成一过性神经性症状。这提示不同的局部麻醉药可能通过不同机制，以及作用于神经元以外的其他靶点而产生细胞毒性神经损伤。

关键词：细胞毒性作用局部麻醉药神经元半胱天冬酶-3 人类胞浆Ca^2+ 诱导细胞死亡麻醉药浓度

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79&PARK住宅区

城市环境设计 2019年第2期118卷 198-209页

作者： H?gni Laksáfoss Agata Wozniczka Agne Tamasauskaite Alberto Herzog Borko Nikolic Christin svensson Claudio Moretti Dominic Black Eva seo-Andersen Frederik Wegener Gabrielle Nadeau Jacob Lykkefold Aaen Jaime Peiro suso Jan Magasanik Jesper Boye Andersen Jonas Aars? Larsen Julian Andres Ocampo salazar Karl Johan Nyqvist Karol Bogdan Borkowski Katarina Mácková Katrine Juul Kristoffer Negendahl Lucian Racovitan maria Teresa Fernandez Rojo Max Gabriel pinto Min Ter Lim Narisara Ladawal schr?der Romea Muryn Ryohei Koike sergiu Calacean song He Taylor McNally-Anderson Terrence Chew Thomas sebastian Krall Tiago sá Tobias Vall? s?rensen Tore Banke Laurian Ghinitoiu 朱翰林

位于G?rdet国家公园边缘,Kullen有意识地塑造了一个尊重且适应环境的形式,并展现出与众不同的社区和壮丽的景色。为直接回应周围环境,建筑的西北和东南角高起至临近周边的高度;而距离公园最远、且本是视野最不好的东北角被拉高以使其拥... 详细信息

位于G?rdet国家公园边缘,Kullen有意识地塑造了一个尊重且适应环境的形式,并展现出与众不同的社区和壮丽的景色。为直接回应周围环境,建筑的西北和东南角高起至临近周边的高度;而距离公园最远、且本是视野最不好的东北角被拉高以使其拥有公园和港口最壮阔的景色。建筑西南角延伸至最远处的G?rdet国家公园;为了在建筑和自然之间创造一个人性化的柔和边缘,西南角被尽可能地压低,变成

关键词：住宅区

2009年加拿大重症甲型H1N1流感患儿病例特点

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中国小儿急救医学 2010年第5期 440-440页

作者： Jouvet PPJ Hutchison J pinto R 杨明首都医科大学附属北京儿童医院

目的描述加拿大重症甲型H1N1流感患儿病例特点,治疗过程和预后情况。设计对2009年4月16日至8月15日收入加拿大9所PICU的重症甲型H1N1流感患儿进行观察性研究。测量指标和主要结果对重症甲型H1N1流感患儿的病例特点进行记录,将确诊病例... 详细信息

目的描述加拿大重症甲型H1N1流感患儿病例特点,治疗过程和预后情况。设计对2009年4月16日至8月15日收入加拿大9所PICU的重症甲型H1N1流感患儿进行观察性研究。测量指标和主要结果对重症甲型H1N1流感患儿的病例特点进行记录,将确诊病例与包含所有甲型H1N1流感住院患儿资料的全国监测数据库进行比较。应用Cox比例风险模型进行风险因素分析。PICU病例队列与全国监测数据进行比较和卡方检验。57例患儿因社区获得性甲型 H1 N1流感住院。70.2%的患儿合并至少1种慢性基础疾病,24.6%的患儿为土著居民。68%的患儿接受机械通气治疗,20例(35.1%)患儿入院第1天发生急性肺损伤,机械通气时间中位数为6d(0～67 d),PICU病死率为7%(4/57)。与非ICU住院患儿比较,PICU患儿合并慢性基础性疾病者更常见(相对风险度1.73)。土著居民并非ICU住院的风险因素。结论因人群对甲型H1N1这种新型流感病毒普遍易感,在疾病首次暴发时,重症病例多见于合并慢性基础性疾病的儿童和土著儿童。重症甲型H1N1流感病例多因严重呼吸衰竭发生缺氧和机械通气时间延长。与季节性流感相比,甲型H1N1流感病例呼吸系统病变发生率较高,程度较重,并未导致病死率增高。

关键词：流感 H1N1 重症儿童急性肺损伤

Temporal trends in areas at risk for concomitant tuberculosis in a hyperendemic municipality in the Amazon region of Brazil

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Infectious Diseases of Poverty 2020年第4期9卷 162-162页

作者： Alexandre Tadashi Inomata Bruce Thais Zamboni Berra Felipe Lima dos santos Yan Mathias Alves Ludmilla Leidianne Limirio souza Antônio Carlos Vieira Ramos Luiz Henrique Arroyo Juliane de Almeida Crispim Ione Carvalho pinto Pedro Fredemir Palha Aline Aparecida Monroe Mellina Yamamura Regina Célia Fiorati Ana Carolina scarpel Moncaio Dulce maria de Oliveira Gomes Ricardo Alexandre Arcêncio Department of Maternal-Infant and Public Health Nursing University of São Paulo at Ribeirão Preto College of NursingRibeirão PretoSão PauloBrazil Department of Nursing Federal University of São CarlosSão CarlosSão PauloBrazil Department of Neurosciences and Behavioral sciences Ribeirão Preto Medical School of the University of São PauloRibeirão PretoSão PauloBrazil Department of Nursing Federal University of CatalãoCatalãoGoiásBrazil Mathematics Department University ofÉvoraÉvoraPortugal

Background Although preventable and curable,tuberculosis(TB)still occurs in poor or developing countries,mainly in metropolitan regions of larger *** disease is a serious public health problem,and is directly linked to social *** analyzed temporal trend variations in areas at risk for concomitant TB,and characterized the clinical and epidemiological profiles of cases in a hyperendemic municipality in the Amazon region of *** This ecological study was performed in the municipality of Manaus,in northern *** population comprised cases with concomitant pulmonary and extrapulmonary TB,registered on the Notifiable Diseases Information system(sINAN),between January 1,2009 and December 31,*** risk cluster detection,spatial and spatiotemporal scanning statistical techniques were *** spatial Variation in Temporal Trends(sVTT)approach was used to detect and infer clusters for significantly different time *** Between 2009 and 2018,873 concomitant TB cases were registered in *** using purely spatial scanning statistics,we identified two risk *** relative risk(RR)of the clusters was 2.21(95%confidence interval[CI]:1.57–2.88;P=0.0031)and 2.03(95%CI:1.58–2.58;P=0.0029).Using space-time scanning,we identified a risk cluster with an RR of 3.57(95%CI:2.84–4.41;P=0.014),between 2017 and *** sVTT analyses,three clusters with spatial variations were detected in the significant temporal trends:sVTT 1(P=0.042),sVTT 2(P=0.046)and sVTT 3(P=0.036).Conclusions In Brazil,several TB-determining factors such as race/color,gender,low educational level and low income overlap in needy urban areas and communities,demonstrating that it is unlikely to reach the goals,agreed and launche. with the END TB strategy within the deadlines of international agreements,if there is no reduction in existing inequities determinants and risk of illness in the country.

关键词： Tuberculosis Public health Epidemiology spatial analysis spatio-temporal analysis

Interferon-γ and other inflammatory mediators in cardiomyocyte signaling during Chagas disease cardiomyopathy

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World Journal of Cardiology 2014年第8期6卷 782-790页

作者： Ludmila Rodrigues pinto Ferreira Amanda Farage Frade Monique Andrade Baron Isabela Cunha Navarro Jorge Kalil Christophe Chevillard Edecio Cunha-Neto Laboratory of Immunology Heart Institute (InCor)School of MedicineUniversity of S o Paulo05403-001 S o PauloBrazil Division of Clinical Immunology and Allergy School of MedicineUniversity of S o Paulo05403-001 S?o PauloBrazil Institute for Investigation in Immunology (iii) INCT05403-001 S o PauloBrazil Aix-marseille Université INSERMGIMP UMR_S90613385 MarseilleFrance

Chagas disease cardiomyopathy(CCC), the main consequence of Trypanosoma cruzi(***) infection, is an inflammatory cardiomyopathy that develops in up to 30% of infected individuals. The heart inflammation in CCC patients is characterized by a Th1 T cell-rich myocarditis with increased production of interferon(IFN)-γ, produced by the CCC myocardial infiltrate and detected at high levels in the periphery. IFN-γ has a central role in the cardiomyocyte signaling during both acute and chronic phases of *** infection. In this review, we have chosen to focus in its pleiotropic mode of action during CCC, which may ultimately be the strongest driver towards pathological remodeling and heart failure. We describe here the antiparasitic protective and pathogenic dual role of IFN-γ in Chagas disease.

关键词： Chagas disease Trypanosoma cruzi Interferon-gamma Gene expression Cardiomyopathy