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Differential Antibacterial Effects of Chiral Co_(3)O_(4)

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Chemical Research in Chinese Universities 2024年第6期40卷 1134-1140页

作者： sun Jia SONG Shanshan GUO Caoyu LIU Liqiang sun maozhong KUANG Hua XU Chuanlai GUO Lingling State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122P.R.China International Joint Research Laboratory for Biointerface and Biodetection School of Food Science and TechnologyJiangnan UniversityWuxi 214122P.R.China

With the global spread of antimicrobial resistance,it is imperative to satisfy the need to develop novel antibacterial ***,we synthesized chiral Co_(3)O_(4) nanoparticles (NPs) with obvious bactericidal *** was found that the circular dichroism (CD) spectra of L-Co_(3)O_(4) NPs and D-Co_(3)O_(4) NPs exhibited perfect mirror image ***,the survival rate of primary uterine fibroblast (PCS) cells reached above 90% by co-culturing with chiral Co_(3)O_(4) ***,the chiral Co_(3)O_(4) NPs showed obvious killing ability on Gram-positive (Staphylococcus aureus);Gram-negative (Escherichia coli O157:H7) bacteria both in vitro and in ***,D-Co_(3)O_(4) NPs showed better antibacterial *** studies confirmed that the level of reactive oxygen species level generated by D-Co_(3)O_(4) NPs was higher than that of L-Co_(3)O_(4) ***,the synthesized D-Co_(3)O_(4) NPs have the potential to become a kind of novel antibacterial nanomaterials.

关键词： Chiral material Antibacterial property Co_(3)O_(4) Antimicrobial resistance

A multi-colloidal gold immunochromatography assay for rapid and simultaneous detection of 13 herbicides

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Nano Research 2024年第9期17卷 8368-8376页

作者： Qianqian Lu Xinxin Xu Aihua Qu Liqiang Liu Yuzhe Li maozhong sun Chuanlai Xu Hua Kuang International Joint Research Laboratory for Biointerface and Biodetection and School of Food Science and TechnologyJiangnan UniversityWuxi 214122China China National Center for Food Safety Risk Assessment Beijing 100021China

Herbicide residues in agricultural products can have adverse effects on the environment and human health,therefore,there is an urgent need to establish a sensitive,rapid,and wide-ranging detection *** this study,haptens of phenylurea herbicides(PUs)and sulfonylurea herbicides(SUs)were analyzed and designed based on computational simulation techniques,and two high-performance broad-spectrum monoclonal antibodies against PUs and SUs were *** this basis,a multi-colloidal gold immunochromatography assay(multi-CGIA)was developed to simultaneously detect 13 herbicides in *** visual limit of detection(vLOD)for PUs including diuron,chlortoluron,neburon,chlorbromuron,and linuron was 1-2μg/*** vLOD for SUs including metsulfuron methyl,ethametsulfuron-methyl,sulfometuron-methyl,tribenuron methyl,cinosulfuron,triasulfuron,chlorimuron-ethyl,and chlorsulfuron was 2-10μg/*** results of real sample determination indicated that the multi-CGIA is accurate,stable,and reliable,and adaptable to on-site preliminary screening of actual samples.

关键词： phenylurea herbicides sulfonylurea herbicides monoclonal antibody immunochromatographic assay wheat

Metabolic profile of chiral cobalt oxide nanoparticles in vitro and in vivo

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Nano Research 2021年第7期14卷 2451-2455页

作者： Si Li Liwei Xu Meiru Lu maozhong sun Liguang Xu Changlong Hao Xiaoling Wu Chuanlai Xu Hua Kuang International Joint Research Laboratory for Biointerface and Biodetection Jiangnan UniversityWuxi 214122China State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China

In this study,we investigated the in vivo behaviors of chiral cobalt oxide nanoparticles(Co_(3)O_(4) NPs)stabilized with D-or L-cysteine(denoted D-or L-NPs,respectively),as representative chiral metal oxide *** Co_(3)O_(4) NPs exerted no observable cytotoxicity within the tested dose *** D-NPs and L-NPs were internalized by dendritic cells through caveola-dependent endocytosis,and L-NPs entered the cells faster than ***,a metabolic analysis indicated that chiral L-NPs had the same effect on the level of bile acids in the liver as D-NPs,which is attributed to the almost equal amount of farnesoid X receptor(FXR)induced by the chiral *** study suggests that low chiroptical activity nanomaterials would not affect the metabolism and kinetics under physiological conditions even if there is some difference in their transport.

关键词： chiral metal oxide endocytosis bile acid metabolism

TRIM21-dependent ultrasmall chiral gold nanoparticles for preventing microglia senescence against Alzheimer's disease

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Science China Chemistry 2024年第4期67卷 1360-1372页

作者： Meiru Lu Changlong Hao Liguang Xu Feng Yu Jiwei Jiang Yanli Wang Jun Xu Hua Kuang Chuanlai Xu maozhong sun International Joint Research Laboratory for Biointerface and Biodetection State Key Laboratory of Food Science and ResourcesSchool of Food Science and TechnologyJiangnan UniversityWuxi 214122China Institute of Life Sciences Jiangsu UniversityZhenjiang 212013China Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100050China National Clinical Research Center for Neurological Diseases Beijing 100070China

Tripartite motif 21(TRIM21)is an E3 ubiquitin ligase that shows great promise for protein degradation through ***,ultrasmall chiral gold nanoparticles(D-or L-NPs)modified by D-or L-glutathione ligands were *** conjugated with an NLR family pyrin domain-containing protein 3(NLRP3)antibody(D-NP-a NLRP3 or L-NP-a NLRP3),DNP-a NLRP3 showed effective delivery efficiency of the antibody into microglia and prevented Aβ-mediated microglia senescence,and p16^(ink4a),a marker of senescence,in the microglia was reduced by 90.3%±7.8% while L-NP-a NLRP3 decreased by 48.01%±3.1%.Mechanistic investigations revealed that the D-NP-a NLRP3((1.5±0.3)×10^(7)M^(-1))exhibited sixteen-fold larger binding affinity to transmembrane glycoprotein SLC3A2 than L-type((9.5±2.7)×10^(5)M^(-1)),which led to a high efficiency of antibody delivery and TRIM21-dependent NLRP3 ***,the blood-brain barrier(BBB)-crossing ability of chiral NP-a NLRP3 as well as NLRP3 degradation was demonstrated in *** APP/PS1 Alzheimer's disease(AD)model mice experiments exhibited a reduction of 89.7%±6.8% for the NLRP3 protein and 84.2±7.5% for p16^(ink4a)following the intravenous administration of D-NP-a NLRP3 once a week for 60 ***,the levels of the AD markers Aβ and phosphorylatedTau in the brains were reduced by 86.2%±8.2% and 81.6%±9.1%;these were 2.1-fold and 1.9-fold higher than those treated with L-NP-a NLRP3,*** studies provide a method to rescue AD-like pathologies and prevent senescence.

关键词： chiral gold nanoparticles amyloid-β NLRP3 TRIM21 senescence Alzheimer's disease

Electromagnetic field-enhanced chiral dimanganese trioxide nanoparticles mitigate Parkinson’s disease

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Science China Chemistry 2022年第10期65卷 1911-1920页

作者： Xiuxiu Wang Jing Zhao Weiwei Wang Meiru Lu Aihua Qu maozhong sun Xiaoqing Gao Chen Chen Hua Kuang Chuanlai Xu Liguang Xu International Joint Research Laboratory for Biointerface and Biodetection Jiangnan UniversityWuxi 214122China State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China Wenzhou Institute University of Chinese Academy of SciencesOujiang LaboratoryWenzhou 325001China

The misfolding and aggregation ofα-synuclein(α-syn)is closely associated with Parkinson’s disease(PD).Here,chiral dimanganese trioxide(Mn_(2)O_(3))nanoparticles(NPs)were prepared for PD treatment enhanced by a noninvasive electromagnetic field(MF).The affinity constants of D-NPs towardα-syn monomer(mono)orα-syn fibril were 3.5 times or 5.2 times higher,respectively,than those of L-NPs,and the mechanical force generated by NPs under a MF further promoted the interaction between NPs andα-syn to amplify the difference between L-NPs and *** the synergy effect of the preferentially affinity ability and MF-induced mechanical forces,D-NPs exhibited a better inhibitory efficiency onα-syn fibrillization than ***,after differentially cellular uptake of L-/D-NPs via the caveolin-mediated pathway,as reactive oxygen species(ROS)-scavengers,D-NPs possess higher efficiency in decreasing intracellular ROS level than L-NPs to provide higher cytoprotective efficiency to neuron *** vivo data showed that after treatment with D-NPs under a MF for 60 days,α-syn concentration in the cerebrospinal fluid of PD mice decreased 81%,while dopamine level in the brain of PD mice increased *** findings indicated the potential of utilizing the synergic interplay of chiral NPs and MF for treating disease and opened a new path to explore the nanoscale chirality for regulating the biological effect.

关键词： electromagnetic field chiral dimanganese trioxide nanoparticles mitigate Parkinson’s Disease

Chiral Cu_(x)Co_(y)S Supraparticles Ameliorate Parkinson’s Disease

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CCS Chemistry 2022年第7期4卷 2440-2451页

作者： Baimei Shi Aihua Qu Weiwei Wang Meiru Lu Zhuojia Xu Chen Chen Changlong Hao maozhong sun Liguang Xu Chuanlai Xu Hua Kuang International Joint Research Laboratory for Biointerface and Biodetection Jiangnan UniversityWuxiJiangsu 214122 State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxiJiangsu 214122

Protein aggregation causes alpha-synuclein(α-syn)to change from its original physiological role to a pathological state,which is a potential pathogenic mechanism in Parkinson’s disease(PD).Chiral _(L/D)-Cu_(x)Co_(y)S supraparticles(_(L/D)-SPs)with a circular dichroism value of 35 mdeg at 805 nm were fabricated using a simple wet-chemical *** _(L/D)-SPs prevented the α-syn monomers from forming fibrils and triggered the α-syn fibrils to turn into monomers under 808 nm near-infrared(NIR)*** living MN9D cells,D-SPs reduced cellular damage,neuronal functional deficits,and neuron loss caused by α-syn fibrils after NIR spectroscopy treatment within 10 min to prevent α-syn ***,the reactive oxygen species produced by _(D)-SPs were 1.42 times higher than those produced by _(L)-*** vivo experiments showed that _(D)-SPs had a protective effect on neuron damage caused by α-syn aggregate deposition,reduced the symptoms in a mouse model of PD,and restored cognitive *** NIR light treatment,the amount of α-syn in a mouse model of PD decreased by more than 67.5%.At the same time,_(D)-SPs gradually decomposed into small nanoparticleswithin 60 days and were excreted through the blood-brain *** discovery paves theway for the treatment of neurodegenerative diseases using chiral SPs under NIR light irradiation.

关键词： chirality Cu_(x)Co_(y)S supraparticles α-synuclein Parkinson’s disease

Chiral Semiconductor Nanoparticles for Site-Selective Photoinduced Cleavage of DNA phosphodiester bond

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Chiral Semiconductor Nanoparticles for Site-Selective Photoi...

DNA Driven Nanoassemblies for Bioapplication

中国化学会第十四届全国生物无机化学学术会议

作者：匡华 sun maozhong XU Liguang MA Wei XU Chuanlai State Key Laboratory of Food Science and Technology Jiangnan University

＜正＞Inorganic nanomaterials with tunable sizes and surface chemistries can form multifunctional biomimetic nanozymes, and have therefore been extensively studied[1]. However, no nanomaterial-based sequence-specific ...

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DNA Driven Nanoassemblies for Bioapplication

第七届全国物理无机化学学术会议

作者： Hua Kuang Liguang Xu Wei Ma Xiaoling Wu maozhong sun Si Li Chuanlai Xu International Joint Research Laboratory for Biointerface and Biodetection State Key Lab of Food Science and Technology and School of Food Science and Technology Jiangnan University

DNA-based nanostructure self-assemblies have been proposed for specific geometric control in the material *** the present study,we established core-satellite structures in which the gold nano rods(NR)dimer(core)and the chlorin e6(Ce6)-attached upconversion nanoparticles(UCNPs:NaGdF:Yb,Er)(satellite)were assembled through complementary base *** the core-satellite

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手性纳米材料:生物成像、生物传感与治疗

高等学校化学学报 2022年第12期43卷 328-338页

作者：卢美如张宏宇石百媚孙茂忠徐丽广胥传来匡华江南大学食品科学与技术国家重点实验室无锡214122

手性无机纳米结构不仅形貌和结构可调控、易于表面功能化修饰,而且光学性质独特,在生物领域的应用上展现了很大的优异性.本文综述了近年来手性纳米技术在生物医学领域的研究进展,重点介绍了手性金属和手性半导体纳米结构的合成策略、圆... 详细信息

手性无机纳米结构不仅形貌和结构可调控、易于表面功能化修饰,而且光学性质独特,在生物领域的应用上展现了很大的优异性.本文综述了近年来手性纳米技术在生物医学领域的研究进展,重点介绍了手性金属和手性半导体纳米结构的合成策略、圆二色效应、光手性机制及在生物成像、生物传感、肿瘤以及神经退行性疾病等医学领域的应用.手性纳米材料的研究丰富了生物化学的纳米技术手段,促进了肿瘤等重大疾病诊断与治疗技术的进步,推动了手性在生命科学中的发展,鼓励了研究者对这一新兴领域的持续探索与挑战.

关键词：手性纳米结构生物成像生物传感治疗