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Major depressive disorder:hypothesis,mechanism,prevention and treatment

Signal Transduction and Targeted Therapy 2024年第3期9卷 913-944页

作者： Lulu Cui Shu Li Siman Wang xiafang Wu Yingyu Liu Weiyang Yu Yijun Wang Yong Tang maosheng xia Baoman Li Department of Forensic Analytical Toxicology School of Forensic MedicineChina Medical UniversityShenyangChina Liaoning Province Key Laboratory of Forensic Bioevidence Sciences ShenyangChina China Medical University Centre of Forensic Investigation ShenyangChina International Joint Research Centre on Purinergic Signalling/Key Laboratory of Acupuncture for Senile Disease(Chengdu University of TCM) Ministry of Education/School of Health and RehabilitationChengdu University of Traditional Chinese Medicine/Acupuncture and Chronobiology Key Laboratory of Sichuan ProvinceChengduChina Department of Orthopaedics The First HospitalChina Medical UniversityShenyangChina

Worldwide,the incidence of major depressive disorder(MDD)is increasing annually,resulting in greater economic and social ***,the pathological mechanisms of MDD and the mechanisms underlying the effects of pharmacological treatments for MDD are complex and unclear,and additional diagnostic and therapeutic strategies for MDD still are *** currently widely accepted theories of MDD pathogenesis include the neurotransmitter and receptor hypothesis,hypothalamicpituitary-adrenal(HPA)axis hypothesis,cytokine hypothesis,neuroplasticity hypothesis and systemic influence hypothesis,but these hypothesis cannot completely explain the pathological mechanism of *** it is still hard to adopt only one hypothesis to completely reveal the pathogenesis of MDD,thus in recent years,great progress has been made in elucidating the roles of multiple organ interactions in the pathogenesis MDD and identifying novel therapeutic approaches and multitarget modulatory strategies,further revealing the disease features of ***,some newly discovered potential pharmacological targets and newly studied antidepressants have attracted widespread attention,some reagents have even been approved for clinical treatment and some novel therapeutic methods such as phototherapy and acupuncture have been discovered to have effective improvement for the depressive *** this work,we comprehensively summarize the latest research on the pathogenesis and diagnosis of MDD,preventive approaches and therapeutic medicines,as well as the related clinical trials.

关键词： prevention acupuncture hypothesis

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Epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China:a hospital-based retrospective study

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Neural Regeneration Research 2024年第5期19卷 1126-1132页

作者： Hengxing Zhou Yongfu Lou Lingxiao Chen Yi Kang Lu Liu Zhiwei Cai David BAnderson Wei Wang Chi Zhang Jinghua Wang Guangzhi Ning Yanzheng Gao Baorong He Wenyuan Ding Yisheng Wang Wei Mei Yueming Song Yue Zhou maosheng xia Huan Wang Jie Zhao Guoyong Yin Tao Zhang Feng Jing Rusen Zhu Bin Meng Li Duan Zhongmin Zhang Desheng Wu Zhengdong Cai Lin Huang Zhanhai Yin Kainan Li Shibao Lu Shiqing Feng Department of Orthopedics The Second HospitalCheeloo College of MedicineShandong UniversityShandongChina Department of Orthopedics Shandong University Center for OrthopedicsQilu HospitalCheeloo College of MedicineShandong UniversityShandongChina Department of Orthopedics Tianjin Medical University General HospitalInternational Science and Technology Cooperation Base of Spinal Cord InjuryTianjin Key Laboratory of Spine and Spinal CordTianjinChina Faculty of Medicine and Health The Back Pain Research TeamSydney Musculoskeletal HealthThe Kolling InstituteUniversity of SydneySydneyNSWAustralia Department of Spine Surgery Honghui HospitalXi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Burns and Plastic Surgery The Fourth Medical Center of Chinese PLA General HospitalBeijingChina Faculty of Medicine and Health School of Health SciencesUniversity of SydneyNSWAustralia Sydney Spine Institute BurwoodSydneyNSWAustralia Laboratory of Epidemiology Tianjin Neurological InstituteDepartment of NeurologyTianjin Medical University General Hospital&Tianjin Neurological InstituteKey Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous SystemMinistry of Education and Tianjin CityTianjinChina Department of Orthopedics Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Department of Spinal Surgery The Third Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Orthopedics The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Spine Surgery Zhengzhou Orthopedics HospitalZhengzhouHenan ProvinceChina Department of Orthopedic Surgery and Orthopedic Research Institute West China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Orthopedics Xinqiao HospitalArmy Medical UniversityChongqingChina Department of Orthopedics The First Affiliated Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Spinal Surgery Shengj

Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even *** has the largest population of patients with traumatic spinal cord *** studies of traumatic spinal cord injury in China have mostly been regional in scope;national-level studies have been *** the best of our knowledge,no national-level study of treatment status and economic burden has been *** retrospective study aimed to examine the epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China at the national *** included 13,465 traumatic spinal cord injury patients who were injured between January 2013 and December 2018 and treated in 30 hospitals in 11 provinces/municipalities representing all geographical divisions of *** epidemiological and clinical features,treatment status,and total and daily costs were *** in the percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department and cost of care were assessed by annual percentage change using the Joinpoint Regression *** percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department did not significantly change overall(annual percentage change,-0.5%and 2.1%,respectively).A total of 10,053(74.7%)patients underwent *** 2.8%of patients who underwent surgery did so within 24 hours of injury.A total of 2005(14.9%)patients were treated with high-dose(≥500 mg)methylprednisolone sodium succinate/methylprednisolone(MPSS/MP);615(4.6%)received it within 8 *** total cost for acute traumatic spinal cord injury decreased over the study period(-4.7%),while daily cost did not significantly change(1.0%increase).Our findings indicate that public health initiatives should aim at improving hospitals’ability to complete early surgery within 24 ho

关键词： China clinical features costs epidemiology methylprednisolone sodium succinate methylprednisolone retrospective study traumatic spinal cord injury treatment

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医药产业应用信息化管理模式促进转型发展的效果分析

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中国卫生产业 2024年第6期21卷 143-145,149页

作者：夏茂盛龚玺鉴高杨赵天一长春新区管理委员会医药健康产业办公室吉林长春130000 吉林省药品监督管理局综合和规划财务处吉林长春130061 通化师范学院长白山生物种质资源研究院吉林通化134001

目的分析信息化管理模式在医药产业转型发展中应用的效果。方法选取长春新区管理委员会医药健康产业办公室的21名工作人员作为研究对象,2020年1月—2021年12月为常规组,采用常规管理模式;2022年1月—2023年12月为研究组,采用信息化管理... 详细信息

目的分析信息化管理模式在医药产业转型发展中应用的效果。方法选取长春新区管理委员会医药健康产业办公室的21名工作人员作为研究对象,2020年1月—2021年12月为常规组,采用常规管理模式;2022年1月—2023年12月为研究组,采用信息化管理模式,两组的工作人员为同一批员工。比较两组的工作开展质量、工作人员对自身工作满意度、信息化技术应用能力。结果研究组的工作质量评分高于常规组,差异有统计学意义(P均<0.05)。研究组的自身工作满意度评分和信息化技术应用能力评分均高于对照组,差异有统计学意义(P均<0.05)。结论实施信息化管理模式有助于医药产业数字化的转型发展,提高工作开展质量、信息化技术应用能力,以及工作人员对自身工作的满意度。

关键词：信息化管理模式医药产业转型发展效果分析

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Sleep Deprivation Selectively Down-Regulates Astrocytic 5-HT2B Receptors and Triggers Depressive-Like Behaviors via Stimulating P2X7 Receptors in Mice

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Neuroscience Bulletin 2020年第11期36卷 1259-1270页

作者： maosheng xia Zexiong Li Shuai Li Shanshan Liang xiaowei Li Beina Chen Manman Zhang Chengyi Dong Alexei Verkhratsky Dawei Guan Baoman Li Practical Teaching Centre School of Forensic MedicineChina Medical UniversityShenyang 110122China Department of Orthopaedics The First HospitalChina Medical UniversityShenyang 110001China Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUK Department of Forensic Pathology School of Forensic MedicineChina Medical UniversityShenyang 110122China Department of Poison Analysis School of Forensic MedicineChina Medical UniversityShenyang 110122China

Chronic loss of sleep damages health and disturbs the quality of ***-lasting sleep deprivation(SD)as well as sleep abnormalities are substantial risk factors for major depressive disorder,although the underlying mechanisms are not ***,we showed that chronic SD in mice promotes a gradual elevation of extracellular ATP,which activates astroglial P2X7 receptors(P2X7Rs).Activated P2X7Rs,in turn,selectively down-regulated the expression of 5-HT2B receptors(5-HT2BRs)in *** of P2X7Rs induced by SD selectively suppressed the phosphorylation of AKT and FoxO3 a in astrocytes,but not in *** overexpression of FoxO3a in astrocytes inhibited the expression of ***-regulation of 5-HT2BsRs instigated by SD suppressed the activation of STAT3 and relieved the inhibition of Ca2+-dependent phospholipase *** latter cascade promoted the release of arachidonic acid and prostaglandin *** depression-like behaviors induced by SD were alleviated in P2X7R-KO *** study reveals the mechanism underlying chronic SD-induced depression-like behaviors and suggests 5-HT2BRs as a key target for exploring therapeutic strategies aimed at the depression evoked by sleep disorders.

关键词： Astrocyte Sleep deprivation P2X7 receptor 5-HT2B receptor FoxO3a

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Iron Aggravates the Depressive Phenotype of Stressed Mice by Compromising the Glymphatic System

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Neuroscience Bulletin 2020年第12期36卷 1542-1546页

作者： Shanshan Liang Yan Lu Zexiong Li Shuai Li Beina Chen Manman Zhang Binjie Chen Ming Ji Wenliang Gong maosheng xia Alexei Verkhratsky Xu Wu Baoman Li Practical Teaching Center School of Forensic MedicineChina Medical UniversityShenyang 110122China Key Laboratory of the Ministry of Health in Congenital Malformation The Affiliated Shengjing Hospital of China Medical UniversityShenyang 110004China Department of Orthopedics The First HospitalChina Medical UniversityShenyang 110001China Faculty of Biology Medicine and HealthThe University of ManchesterManchesterUK Achucarro Center for Neuroscience IKERBASQUE48011 BilbaoSpain Department of Forensic Pathology School of Forensic MedicineChina Medical UniversityShenyang 110122China

Dear Editor,The pathophysiologic al mechanisms underlying mood disorders including major depressive disorder(MDD)remain to be fully *** is a key component in the development of the central nervous system and iron defi... 详细信息

关键词： impairment Iron lymphatic

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Analytical Solutions for an Isotropic Elastic Half-Plane with Complete Surface Effects Subjected to a Concentrated/Uniform Surface Load

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Acta Mechanica Solida Sinica 2024年第3期37卷 371-384页

作者： xia-Hui Pan School of Civil Engineering Henan Polytechnic UniversityJiaozuo454003China

Within the context of Gurtin-Murdoch surface elasticity theory,closed-form analytical solutions are derived for an isotropic elastic half-plane subjected to a concentrated/uniform surface *** the effects of residual surface stress and surface elasticity are *** stress function method and Fourier integral transform technique are *** solutions are provided in a compact manner that can easily reduce to special situations that take into account either one surface effect or none at *** results indicate that surface effects generally lower the stress levels and smooth the deformation profiles in the *** elasticity plays a dominant role in the in-plane elastic fields for a tangentially loaded half-plane,while the effect of residual surface stress is fundamentally crucial for the out-of-plane stress and displacement when the half-plane is normally *** the remaining situations,combined effects of surface elasticity and residual surface stress should be *** results for a concentrated surface force serve essentially as fundamental solutions of the Flamant and the half-plane Cerruti problems with surface *** solutions presented in this work may be helpful for understanding the contact behaviors between solids at the nanoscale.

关键词： Surface effects Residual surface stress Surface elasticity Half-plane Analytical solutions

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Computational modelling of gas–liquid–solid multiphase free surface flow with and without evaporation

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Particuology 2024年第7期90卷 218-235页

作者： Huihuang xia Marc Kamlah Institute for Applied Materials(IAM) Karlsruhe Institute of Technology(KIT)Hermann-von Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany

Gas–liquid–solid multiphase systems are ubiquitous in engineering applications,*** printing,spray drying and *** a numerical framework for modelling these multiphase systems is of great *** improved,resolved computational fluid dynamics-discrete element method(CFD-DEM)framework is developed to model the multiphase free surface flow with and without *** improved capillary force model is developed to compute the capillary interactions for partially floating particles at a free *** well-known benchmark cases,namely drag coefficient calculation,the single sphere settling,and drafting-kissing-tumbling of two particles are conducted to validate the resolved CFD-DEM *** turns out that the resolved CFD-DEM model developed in this paper can accurately calculate the fluid–solid interactions and predict the trajectory of solid particles interacting with the liquid *** demonstrations,namely two particles moving along a free surface when the liquid phase evaporates,and particle transport and accumulations inside an evaporating sessile droplet show the performance of the resolved model.

关键词： Capillary force Discrete element method Liquid bridge Particle transport Resolved CFD-DEM Volume of fluid

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Seasonal thermal energy storage using natural structures:GIS-based potential assessment for northern China

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Building Simulation 2024年第4期17卷 561-574页

作者： Yichi Zhang Jianjun xia Midea HVAC Heating&Ventilation Equipment Co. LtdFoshan528311China Building Energy Research Center Tsinghua UniversityBeijing100084China

Seasonal thermal energy storage(STES)allows storing heat for long-term and thus promotes the shifting of waste heat resources from summer to winter to decarbonize the district heating(DH)*** being a promising solution for sustainable energy system,large-scale STES for urban regions is lacking due to the relatively high initial investment and extensive land *** close the gap,this study assesses the potentials of using two naturally available structures for STES,namely valley and ground pit *** on geographical information system(GIS)methods,the available locations are searched from digital elevation model and selected considering several criteria from land uses and construction *** costs of dams to impound the reservoir and the yielded storage capacities are then quantified to guide the choice of suitable *** assessment is conducted for the northern China where DH systems and significant seasonal differences of energy demand *** total,2,273 valley sites and 75 ground pit sites are finally identified with the energy storage capacity of 15.2 billion GJ,which is much larger than the existing DH demand in northern *** results also prove that 682 valley sites can be achieved with a dam cost lower than 20 CNY/m^(3).By conducting sensitivity analysis on the design dam wall height and elevations,the choices of available natural structures are expanded but practical issues about water pressures and constructions are also ***,the identified sites are geographically mapped with nearest urban regions to reveal their roles in the DH *** general,560 urban regions are found with potential STES units and most of them have STES storage capacities larger than their own DH *** novel planning methodology of this study and publicly available datasets create possibilities for the implementations of large-scale STES in urban DH systems.

关键词： seasonal thermal energy storage geographical information system district heating water reservoir

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Minimum mass-entransy dissipation profile for one-way isothermal diffusive mass-transfer process with mass-resistance and massleakage

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Science China(Technological Sciences) 2024年第8期67卷 2427-2435页

作者： CHEN LinGen xia ShaoJun Institute of Thermal Science and Power Engineering Wuhan Institute of TechnologyWuhan 430205China School of Mechanical Electrical EngineeringWuhan Institute of TechnologyWuhan 430205China School of Power Engineering Naval University of EngineeringWuhan 430033China

As a new concept,mass-entransy is one of the twins in the core of entransy *** can describe mass-transfer ability for masstransfer processes(MTPes),just as thermal-entransy for describing heat-transfer ***,mass-entransy dissipation can be utilized to evaluate the loss of mass-transfer *** mass-entransy dissipation(MMED) is utilized to optimize one-way isothermal diffusive MTPes with mass-leakage and mass-transfer law(g ∝ Δ(c),where c means concentration).For a given net amount of mass-transferred key components at the low-concentration side,optimality-condition for the MMED of isothermal diffusive MTPes is obtained by using the *** of the amount of mass-transferred and mass-leakage on optimal results are analyzed,and the obtained optimization profiles are compared with those for MTP profiles of constant-concentration-difference(c_1-c_2=const) and constant-concentration-ratio(c_1/c_2=const).The product of square of key-component-concentration(KCC) difference between high-and low-concentration sides and inert component concentration at high-concentration side for the MMED of the MTP with no mass-leakage is a constant,and the optimal relationship of the KCCs between high-and low-concentration sides with mass-leakage is significantly different from the *** mass-leakage is relatively small,the MTP with c_1-c_2=const strategy is superior to that with c_1/c_2=const strategy,and the latter is superior to the former with an increase in mass-leakage.A combination of mass-entransy concept,finite-time thermodynamics,and averaged-optimization-method is a meaningful tool for optimizing MTPes.

关键词： diffusive mass-transfer-law mass-leakage one-way isothermal mass-transfer minimum mass-entransy dissipation finite-time thermodynamics averaged-optimization-method

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Regional features of pollen R-values in China

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Science China Earth Sciences 2024年第1期67卷 295-308页

作者： Jie xia Jian NI College of Life Sciences Zhejiang Normal UniversityJinhua 321004China Jinhua Mountain Observation and Research Station for Subtropical Forest Ecosystems Jinhua 321004China

Establishing a quantitative relationship between modern pollen and vegetation remains a pivotal but intricate pursuit within the field of Quaternary *** R-value,a well-established and traditional metric characterized by its simplicity and direct applicability,serves to calibrate the nonlinear disparities between surface pollen and modern *** study entails the construction of a comprehensive pollen R-value dataset for China derived from R-values published between 1987 and *** dataset,compiled after rigorous screening,calibration,and standardization processes,encompasses 898 modern pollen sampling sites and 2115 pollen R-value data entries,encapsulating 152 pollen taxa spanning 65 families and 113 *** the extracted R-values yielded the following insights:(1)A macrospatial analysis validates previously established knowledge at a site-specific ***,pollen R-value variations across China are statistically *** two-thirds of pollen taxa exhibit underrepresentation(e.g.,Taxodiaceae,Corylus,Nitraria,Tamarix,Cyperaceae,Poaceae,and Fabaceae),while the remaining one-third display overrepresentation(e.g.,Pinus,Picea,Betula,Ephedra,Chenopodiaceae,and Artemisia).The degree of underrepresentation surpasses that of overrepresentation,and the representation patterns of Castanea,Quercus,Polygonaceae,and Asteraceae are contingent upon vegetation types.(2)Pollen R-values follow distinct spatial distribution patterns within *** the woody vegetation region of eastern China,R-values progressively decline from north to south,correlating with rising temperatures and ***,in herbaceous vegetation regions of northern and western China,R-values decrease from east to west and from northeast to southwest,corresponding to increased ***,pollen R-values manifest variation contingent on pollen taxa,vegetation types,and climatic regions,even differing for the same taxa across varying

关键词： Pollen R-value Modern pollen-vegetation relationship Regional pattern Variability Paleovegetation reconstruction

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