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手持工件打磨作业致职业性手臂振动病流行病学调查

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中国职业医学 2024年第1期51卷 65-69页

作者：潘思玉严茂胜肖斌贾艳霞郑浛君蒋雍建林瀚生王梅广东药科大学公共卫生学院广东广州510310 广东省职业病防治院广东广州510300 山西医科大学公共卫生学院山西太原030001 广州医科大学公共卫生学院广东广州511436

目的探讨手持工件打磨作业致职业性手臂振动病(OHAVD)的影响因素。方法采用方便抽样法,选择某运动器材生产企业的222例OHAVD患者(病例组)、275名手传振动作业工人(接触组)和同企业不从事手传振动作业的243名健康工人(对照组)为研究对象... 详细信息

目的探讨手持工件打磨作业致职业性手臂振动病(OHAVD)的影响因素。方法采用方便抽样法,选择某运动器材生产企业的222例OHAVD患者(病例组)、275名手传振动作业工人(接触组)和同企业不从事手传振动作业的243名健康工人(对照组)为研究对象。对3组人群进行现场职业卫生调查,采用人体振动测量仪检测手传振动的接触水平,计算8 h等能量频率计权振动加速度[A(8)]和累积振动暴露水平(CVEL)。结果接触组和病例组人群手指发冷、麻木、刺痛和振动性白指的检出率均高于对照组(P值均<0.05);病例组人群上述手部症状检出率均高于接触组(P值均<0.05)。病例组人群A(8)和CVEL均高于接触组(P值均<0.05)。二分类logistic回归分析结果显示,年龄和CVEL均是OHAVD的影响因素(P值均<0.05)。限制性立方样条模型显示,接触手传振动人群CVEL水平与罹患OHAVD的风险存在正向非线性的剂量-反应关系(总趋势P<0.01,非线性P<0.01),随着CVEL的增加,罹患OHAVD的发病风险呈递增趋势。结论接触手传振动是OHAVD的危险因素;应及早对接触手传振动人群进行干预,降低振动接触水平,控制振动接触时间。

关键词：手臂振动病手传振动累积振动暴露水平影响因素剂量-反应关系

某电子制造企业工人工作相关肌肉骨骼疾患影响因素分析

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中国工业医学杂志 2024年第4期37卷 335-341页

作者：何雄大谭广辉肖斌林海捷贾宁陈纯烁郭建宇吴君乐王忠旭严茂胜南方医科大学公共卫生学院广东广州510000 惠州市职业病防治院广东省职业病防治院中国疾病预防控制中心职业卫生与中毒控制所职业防护与工效学研究室广州医科大学公共卫生学院

目的了解电子制造企业工人工作相关肌肉骨骼疾患(WMSDs)发生情况及其影响因素。方法采用整群抽样法,选择某电子制造企业515名员工作为研究对象,采用《肌肉骨骼疾患调查问卷》(电子版)调查其WMSDs发生情况和影响因素。结果该电子制造企... 详细信息

目的了解电子制造企业工人工作相关肌肉骨骼疾患(WMSDs)发生情况及其影响因素。方法采用整群抽样法,选择某电子制造企业515名员工作为研究对象,采用《肌肉骨骼疾患调查问卷》(电子版)调查其WMSDs发生情况和影响因素。结果该电子制造企业工人WMSDs总发生率50.1%,以颈、肩部WMSDs发生率较高,分别为23.1%、18.8%。多因素Logistic回归分析显示,女性、身体状况一般、长时间坐位、每周工作41~48 h、颈部大幅度前倾是颈部WMSDs发生的危险因素(P<0.05),休息时间充足为保护因素(P<0.05);身体状况一般、长时间坐位、每次搬运重物≥20 kg、每周工作41~48 h、颈部大幅度前倾是肩部WMSDs发生的危险因素(P<0.05),与同事轮流完成工作、在同一车间完成工作、休息时间充足是肩部WMSDs的保护因素(P<0.05)。结论电子制造企业工人WMSDs发生率较高,以颈、肩部高发,个体特征、工作类型、工作组织及工作姿势均为颈、肩部WMSDs发生的影响因素。电子制造企业可从个人及职业特点出发,采取综合性措施降低工人WMSDs发生风险。

关键词：电子制造工作相关肌肉骨骼疾患(WMSDs) 发生率影响因素

Single cell analysis unveils B cell-dominated immune subtypes in HNSCC for enhanced prognostic and therapeutic stratification

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International Journal of Oral Science 2024年第3期16卷 448-459页

作者： Kang Li Caihua Zhang Ruoxing Zhou maosheng Cheng Rongsong Ling Gan Xiong Jieyi Ma yan Zhu Shuang Chen Jie Chen Demeng Chen Liang Peng State Key Laboratory of Oncology in South China Department of Oral and Maxillofacial SurgeryInstitute of Precision MedicineCenter for Translational MedicineThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Institute for Advanced Study Shenzhen UniversityShenzhenChina Hospital of Stomatology Guangdong Provincial Key Laboratory of StomatologyGuanghua School of StomatologySun Yat-Sen UniversityGuangzhouChina Senior Department of Oncology The Fifth Medical Center of PLA General HospitalBeijingChina

Head and neck squamous cell carcinoma(HNSCC)is characterized by high recurrence or distant metastases rate and the prognosis is *** is mounting evidence that tumor-infiltrating B cells(TIL-Bs)have a crucial,synergistic role in tumor ***,little is known about the role TIL-Bs play in immune microenvironment and the way TIL-Bs affect the outcome of immune checkpoint *** single-cell RNA sequencing(scRNA-seq)data from the Gene Expression Omnibus(GEO)database,the study identified distinct gene expression patterns in *** samples were categorized into TIL-Bs inhibition and TIL-Bs activation groups using unsupervised *** classification was further validated with TCGA HNSCC data,correlating with patient prognosis,immune cell infiltration,and response to *** found that the B cells activation group exhibited a better prognosis,higher immune cell infiltration,and distinct immune checkpoint levels,including elevated PD-L1.A prognostic model was also developed and validated,highlighting four genes as potential biomarkers for predicting survival outcomes in HNSCC ***,this study provides a foundational approach for B cells-based tumor classification in HNSCC,offering insights into targeted treatment and immunotherapy strategies.

关键词： prognosis elevated offering

Clinical characteristics and prognosis of triple-negative breast cancer

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The Chinese-German Journal of Clinical Oncology 2009年第8期8卷 471-475页

作者： Hua Cao maosheng yan Shubin Wang Tao Zheng Ruilian Xu Yixin Chen Yajie Liu Department of Medical Oncology Shenzhen People＇s Hospital The Second Clinical Medicine College JinanUniversity Shenzhen 518020 China Department of Radiation Oncology Shenzhen People＇s Hospital The Second Clinical Medicine College JinanUniversity Shenzhen 518020 China

Objective： We investigated the clinical characteristics, and the prognostic factors of triple-negative breast cancer. Methods： 130 triple-negative breast cancer patients were reviewed on clinical characteristics and prognosis. All cases were lack of expression of estrogen receptor, progesterone receptor, and HER2/neu determined by immunohistochemistry. Results： 17.1% of all breast cancer patients （774 cases） were triple-negative breast cancer, and 68.9% of triple-negative breast cancer patients （91 cases） were premenopausal. 53.8% of patients （71 cases） had the tumors with T2 size, and 39.4% of them （52 patients） had lymph node metastasis. The rate of relapse in patients with lymph node metastasis was obviously higher than that in patients without lymph node metastasis （P = 0.001）. The median time of follow-up was 63 months. 33 cases relapsed and 20 patients died. 23 patients had at least two organs metastasis. The 5-year disease-free and overall survival rates were 73.8% and 85.7%. Conclusion： Triple-negative breast cancer patients commonly have high rate of multiple distant metastasis in 2-3 years after treatment. The status of lymph node is the most important prognostic factor. The triple-negative breast caner patients with lymph node metastasis have poor prognosis.

关键词： triple-negative breast cancer clinical characteristics prognosis

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手臂振动病及其防治

中国工业医学杂志 2023年第2期36卷 122-124页

作者：严茂胜广东省职业病防治院/广东省职业病防治重点实验室广东广州510300

手臂振动病(hand-arm vibration disease,HAVD)是公认的职业病之一。近年来,HAVD在我国南方地区金属制造业等行业高发,严重影响企业的正常生产和劳动者的生活质量。本文拟从HAVD的发现、分布特点、临床症状、诊断、防治等方面进行阐述,... 详细信息

手臂振动病(hand-arm vibration disease,HAVD)是公认的职业病之一。近年来,HAVD在我国南方地区金属制造业等行业高发,严重影响企业的正常生产和劳动者的生活质量。本文拟从HAVD的发现、分布特点、临床症状、诊断、防治等方面进行阐述,以期为保护劳动者健康及相关研究提供参考。

关键词：手臂振动病(HAVD) 职业病防治

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血管内皮损伤相关蛋白研究进展

中国职业医学 2017年第4期44卷 499-501页

作者：阎蓉严茂胜陈青松广东药科大学公共卫生学院广东广州510224 广东省职业病防治院广东省职业病防治重点实验室 510300

职业性手臂振动病（Hand-arm vibration disease,HAVD）是由于长期从事手传振动作业而引起以手部末梢循环和（或）手臂神经功能障碍为主的疾病,并能引起骨关节-肌肉功能的损伤[1],在我国已列为法定职业病。HAVD血管损伤方面的病理生理... 详细信息

职业性手臂振动病（Hand-arm vibration disease,HAVD）是由于长期从事手传振动作业而引起以手部末梢循环和（或）手臂神经功能障碍为主的疾病,并能引起骨关节-肌肉功能的损伤[1],在我国已列为法定职业病。HAVD血管损伤方面的病理生理机制主要包括血管结构和功能的异常[2],其发生与血管壁（特别是内皮细胞）中的活性物质、神经递质、细胞因子、代谢酶等变化密切相关[3],

关键词：手臂振动病血管内皮损伤类肝素酶小细胞蛋白肌球蛋白轻链整合素黏着斑蛋白

Towards Data-Driving Multi-View Evaluation Framework for Scratch

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Tsinghua Science and Technology 2024年第2期29卷 517-528页

作者： Xiaolin Chai yan Sun yan Gao Department of Computer Science Beijing University of Posts and TelecommunicationBeijing 100876China Intellectual Property Institute Shandong Polytechnic CollegeJining 272067China

As one of the most popular visual programming languages,Scratch has a lot of evaluation around *** evaluation can help programmers understand their projects *** the same time,it can also provide a reference for them to browse other projects in the online *** of the existing evaluations on Scratch are carried from three perspectives:Computational Thinking(CT)ability,visual presentation aesthetics,and code *** them,the assessment of CT and code quality is mainly carried out from the program script,while the evaluation of visual aesthetics is analyzed from the perspective of image sequences generated by project *** single-view evaluation focuses on the performance of a program in a certain aspect and is *** this paper,we propose a multi-view evaluation framework to integrate various evaluations using different *** quantitatively analyze the assessment of different views driven by *** with overall evaluations that represent human opinions,we analyze their differences and *** experiments,we determine the weights of different integration policies,the proposed multi-view evaluation method can generate evaluation results similar to human opinions.

关键词： Scratch Computational Thinking(CT) visual aesthetic static analysis integration policy machine learning

Forward to the Special Topic on“Solving Differential Equations with Deep Learning”

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Journal of Systems Science & Complexity 2024年第2期37卷 389-390页

作者： yan Zhenya Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China

The concept of artificial intelligence(AI)was first presented at the Dartmouth SummerResearch Project on AI hosted by McCarthy and Minsky in *** that,the developmentof AI has experienced ups and downs due to some limited conditions including intelligentcomputing techniques,computer and hardware and software^([1,2]).In particular,with the rapidof deep artificial neural networks,machine learning(ML)and deep learning(DL)techniques^([3,4])have been applied in many fields of science and engineering,including machine translation,image recognition,genomics,scientific computing and atmospheric science,etc^([5]).

关键词： has artificial hardware

高管团队人口统计特征对纺织和信息技术公司经营绩效的影响

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南开管理评论 2006年第6期9卷 61-67页

作者：孙海法姚振华严茂胜中山大学管理学院

运用中国纺织业和信息技术业上市公司的实证数据,本研究发现,高管团队组成特征比CEO个人特征解释更多的企业绩效变异。本研究还发现,公司短期绩效的正相关因素有团队规模和平均任期,公司长期绩效的正相关因素是平均教育水平,公司长期绩... 详细信息

运用中国纺织业和信息技术业上市公司的实证数据,本研究发现,高管团队组成特征比CEO个人特征解释更多的企业绩效变异。本研究还发现,公司短期绩效的正相关因素有团队规模和平均任期,公司长期绩效的正相关因素是平均教育水平,公司长期绩效的负相关因素是团队规模。在信息技术公司,高管团队的平均任期与公司的长期绩效负相关,任期异质性与公司的长期业绩正相关,高管团队平均年龄与企业当期绩效显著负相关。

关键词：高管团队人口统计特征公司绩效异质性