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Non-coding RNAs expression in SARS-CoV-2 infection:pathogenesis,clinical significance,and therapeutic targets

Signal Transduction and Targeted Therapy 2024年第1期9卷 55-78页

作者： Xiaoxing Liu Wandi Xiong maosen ye Tangsheng Lu Kai Yuan Suhua Chang Ying Han Yongxiang Wang Lin Lu Yanping Bao Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)100191 BeijingChina Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research Peking University100871 BeijingChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan University570228 HaikouChina Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan Province KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of Sciences650204 KunmingYunnanChina National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence Peking UniversityBeijing 100191China Institute of Brain Science and Brain-inspired Research Shandong First Medical University&Shandong Academy of Medical Sciences250117 JinanShandongChina Department of Neurology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandongChina School of Public Health Peking University100191 BeijingChina

The coronavirus disease 2019(COVID-19)pandemic has been looming globally for three years,yet the diagnostic and treatment methods for COVID-19 are still undergoing extensive exploration,which holds paramount importance in mitigating future *** non-coding RNAs(ncRNAs)display aberrations in the context of ***,microRNAs(miRNAs),long non-coding RNAs(lncRNAs),and circular RNAs(circRNAs)exhibit a close association with viral infection and disease *** this comprehensive review,an overview was presented of the expression profiles of host ncRNAs following SARS-CoV-2 invasion and of the potential functions in COVID-19 development,encompassing viral invasion,replication,immune response,and multiorgan deficits which include respiratory system,cardiac system,central nervous system,peripheral nervous system as well as long ***,we provide an overview of several promising host ncRNA biomarkers for diverse clinical scenarios related to COVID-19,such as stratification biomarkers,prognostic biomarkers,and predictive biomarkers for treatment *** addition,we also discuss the therapeutic potential of ncRNAs for COVID-19,presenting ncRNA-based strategies to facilitate the development of novel *** an in-depth analysis of the interplay between ncRNA and COVID-19 combined with our bioinformatic analysis,we hope to offer valuable insights into the stratification,prognosis,and treatment of COVID-19.

关键词： invasion therapeutic infection

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Ⅱ/Z型Bi_(2)MoO_(6)/Ag_(2)O/Bi_(2)O_(3)异质结可见光催化降解四环素

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无机材料学报 2024年第3期39卷 321-329,I0005-I0008页

作者：叶茂森王耀许冰王康康张胜楠冯建情西安建筑科技大学化学与化工学院西安710055 西北有色金属研究院西安710016

构建异质结能够有效抑制光催化剂中光生电子和空穴的快速复合。本研究采用水热法、煅烧法以及溶剂热法合成了Ⅱ/Z型Bi_(2)MoO_(6)/Ag_(2)O/Bi_(2)O_(3)异质结光催化剂,利用不同研究手段分析材料的组成、形貌以及光电化学性能。结果发现... 详细信息

构建异质结能够有效抑制光催化剂中光生电子和空穴的快速复合。本研究采用水热法、煅烧法以及溶剂热法合成了Ⅱ/Z型Bi_(2)MoO_(6)/Ag_(2)O/Bi_(2)O_(3)异质结光催化剂,利用不同研究手段分析材料的组成、形貌以及光电化学性能。结果发现,复合材料的最佳组成为25%ABOBM(Ag_(2)O/Bi_(2)O_(3)和Bi_(2)MoO_(6)的质量比为1:4)。在可见光照射下25%ABOBM对四环素(TC)的降解效率可达85.6%,明显高于Ag_(2)O/Bi_(2)O_(3)和Bi_(2)MoO_(6),而且三次循环实验后仍具有良好的稳定性。25%ABOBM光催化性能的提高可归因于Ag_(2)O、Bi_(2)O_(3)以及Bi_(2)MoO_(6)之间异质结的构建和特殊形貌的形成。自由基捕获实验和电子顺磁共振谱(EPR)结果表明,h+和·O2-在TC的降解过程中发挥着主要作用,而·OH和1O2发挥着次要作用。实验还探索了相关光催化机理,并利用液相色谱-质谱联用仪(LC-MS)对TC可能的降解路径进行了分析。本研究为双异质结光催化剂的制备及其在有机污染物降解应用方面提供了新的思路。

关键词： Bi_(2)MoO_(6) Ag_(2)O Bi_(2)O_(3) 光催化降解四环素异质结

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Understanding and modeling human traits and diseases:Insights from the comparative genomics resources of Zoonomia

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The Innovation 2023年第4期4卷 5-6页

作者： maosen ye Deng-Feng Zhang Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650201China Kunming College of Life Science University of Chinese Academy of SciencesKunming 650204China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650204China National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility) Kunming Institute of ZoologyChinese Academy of SciencesKunming 650107China KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunming 650201China

Understanding the genetic architecture of complex human traits and diseases is one of the major aims of biomedical *** research,such as genome-wide association studies(GWASs)of large-scale,wellphenotyped cohorts,has identified tens of thousands of genomic variants associated with human traits and *** remaining challenge is how to translate the statistical association of genomic loci to biological mechanisms and clinical strategies.

关键词： diseases clinical translate

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Detection of Persistent Organochlorine Pollutants in Eggs of Antarctic Seabirds Based on Gas Chromatography and Their Ecological Environment Significance

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Meteorological and Environmental Research 2016年第1期7卷 48-51,54页

作者： ye maosen Zhang Rongbao Chen Lihong Lin Bo Zheng Fangqin Lu Bing ye Xinrong Key Laboratory of Engineering Oceanography Second Institute of OceanographyState Oceanic Administration

By using internal standard method based on gas chromatography-electron capture detector （GC-ECD）, the contents of persistent or- ganochlorine pollutants polychorinated biphenyls （PCBs） and organochlorine pesticides （OCPs） in eggs of seabirds （ Catharacta Ionnbergi, Cathar- acta maccormicki, Pygoscelis papua and Macronectes giganteus） breeding on King George Island, Antarctica were detected, and their ecological environment significance was discussed. The results showed that the recovery of various compounds ranged from 68.6% to 90.8% ; relative stand- ard deviation （RSD） was 3.6%, and the lowest detection limits of PCBs and OCPs were 0.8 - 16 and 2 - 12 pg respectively, which could meet the demands for the residue analysis of trace persistent organochlorine pollutants in the eggs of Antarctic seabirds. The contents of PCBs, DDTs, HCB and HCHs in the eggs of Antarctic seabirds were 0.5 -515.5, 2.0 -304.4,0.5 -70.5, and 0.5 -2.0 ng/g respectively. In addition, the accumula- tion of PCBs and OCPs in the skuas was enhanced gradually through the food chain. The maximums of persistent organochlorine pollutants ap- peared in the eggs of C. Ionnbergi, followed by the eggs of C. maccomicki. The detection of OCPs and PCBs in the eggs of Antarctic seabirds was not interfered by other compounds containing chlorine, showing that the extraction, purification and detection method was suitable for the analysis of OCPs and PCBs in the eggs of Antarctic seabirds and has high sensitivity and reliability.

关键词： Gas chromatography Eggs of Antarctic penguins and skuas Persistent organochlorine pollutants China

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Monitoring and Evaluation of Present Situation of Environmental Quality in the Sea Area near the Aojiang Estuary in Wenzou

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Meteorological and Environmental Research 2017年第3期8卷 57-61,66页

作者： ye maosen Yang Dan Zhang Rongbao Xu Hengtao Zhang Haisheng Yao Dongping ye Xinrong Key Laboratory of Engineering Oceanography Second Institute of OceanographyState Oceanic Administration Second Institute of Oceanography State Oceanic Administration Key Laboratory of Marine Ecosystem and Biogeochemistry State Oceanic Administration

Based on the monitoring results of environmental quality in the sea area near the Aojiang estuary in Wenzou during 2010-2012,the present situation of environmental quality in the sea area was analyzed and evaluated. The results show that p H,DO,CODMn,petroleum,and heavy metals( Cu,Pb,Zn,Cd,Hg,As and Cr) in the sea area near the Aojiang estuary did not exceed the second-class standard of Seawater Quality Standard( GB 3097-1997),but both inorganic nitrogen and reactive phosphate in the sea area exceeded the second-class standard seriously,and the water quality of the sea area was in an eutrophic state; domestic sewage and fertilizer loss were the main sources of nitrogen and phosphorus. The standard index of most evaluation factors of sediment quality except for Zn was smaller than 1,meeting the demands of sediment quality for environmental protection.

关键词： Sea area near the Aojiang estuary in Wenzou Present situation of environmental quality Monitoring Evaluation Water quality Sediment quality

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A novel missense variant in ACAA1 contributes to early-onset Alzheimer’s disease,impairs lysosomal function,and facilitates amyloid-p pathology and cognitive decline

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Signal Transduction and Targeted Therapy 2021年第9期6卷 2920-2935页

作者： Rongcan Luo Yu Fan Jing Yang maosen ye Deng-Feng Zhang Kun Guo Xiao Li Rui Bi Min Xu Lu-Xiu Yang Yu Li Xiaoqian Ran Hong-Yan Jiang Chen Zhang Liwen Tan Nengyin Sheng Yong-Gang Yao Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan Province and KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnanChina Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnanChina State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingChina Department of Psychiatry The First Affiliated Hospital of Kunming Medical UniversityKunmingChina Division of Mood Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Mental Health Institute of the Second Xiangya Hospital Central South UniverstyChangshaChina Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnanChina CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghaiChina

Alzheimer’s disease(AD)is characterized by progressive synaptic dysfunction,neuronal death,and brain atrophy,with amyloid-p(Ap)plaque deposits and hyperphosphorylated tau neurofibrillary tangle accumulation in the brain tissue,which all lead to loss of cognitive *** mutations in the well-known AD causal genes including APP,PSEN1,and PSEN2 impair a variety of pathways,including protein processing,axonal transport,and metabolic *** we identified a missense variant rs117916664(c.896T>C,***299Ser[p.N299S])of the acetyl-CoA acyltransferase 1(ACM1)gene in a Han Chinese AD family by whole-genome sequencing and validated its association with early-onset familial AD in an independent *** in vitro and in vivo evidence showed that ACAA1 p.N299S contributes to AD by disturbing its enzymatic activity,impairing lysosomal function,and aggravating the Ap pathology and neuronal loss,which finally caused cognitive impairment in a murine *** findings reveal a fundamental role of peroxisome-mediated lysosomal dysfunction in AD pathogenesis.

关键词： Alzheimer amyloid lysosomal

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几种常用食品添加剂对橙汁饮料中V_C稳定性的影响

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食品与发酵工业 2008年第10期34卷 170-173页

作者：钟希琼叶茂森朱敏英佛山科学技术学院食品科学系硕士副教授广东佛山528231

在一定的光、温度、O2和pH条件下,食品中常用的防腐剂、增稠剂、抗氧化剂、营养强化剂对VC稳定性有一定的影响。其中,山梨酸钾、EDTA-Na2、果胶、L-赖氨酸盐酸盐这4种常用的食品添加剂均对VC有一定稳定作用;而且同时使用这4种添加剂时,... 详细信息

在一定的光、温度、O2和pH条件下,食品中常用的防腐剂、增稠剂、抗氧化剂、营养强化剂对VC稳定性有一定的影响。其中,山梨酸钾、EDTA-Na2、果胶、L-赖氨酸盐酸盐这4种常用的食品添加剂均对VC有一定稳定作用;而且同时使用这4种添加剂时,其稳定作用更显著,能明显降低VC-1%HCl溶液、橙汁模拟体系和鲜橙汁中VC的损失率。通过试验,发现其最佳组合是0.5g/kg的山梨酸钾、1.5g/kg的EDTA-Na2、1.5g/kg的果胶、0.5g/kg的L-赖氨酸盐酸盐。

关键词：食品添加剂橙汁 Vc 稳定性

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超深地下连续墙钢筋笼吊装技术研究

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中国水能及电气化 2020年第8期 47-50,58,63页

作者：叶茂森中铁十八局集团第五工程有限公司天津300450

地下连续墙施工过程中,钢筋笼的制作和吊装是关键一环,决定了地下连续墙的整体性和刚度。文章结合具体超深地下连续墙施工实例,探讨了大尺寸钢筋笼制作、吊点设置、吊装方法以及吊装加固等具体施工控制措施。工程实践表明:施工效果良好... 详细信息

地下连续墙施工过程中,钢筋笼的制作和吊装是关键一环,决定了地下连续墙的整体性和刚度。文章结合具体超深地下连续墙施工实例,探讨了大尺寸钢筋笼制作、吊点设置、吊装方法以及吊装加固等具体施工控制措施。工程实践表明:施工效果良好,能够对类似工程起到借鉴帮助作用。

关键词：地下连续墙钢筋笼吊装

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基于Moldﬂow的车身后护板微孔发泡注塑工艺多目标优化

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合成树脂及塑料 2024年第3期41卷 44-49页

作者：周纪委王明伟翟剑敏叶星辉杨茂森大连工业大学机械工程与自动化学院辽宁大连116034 山西太钢不锈股份有限公司山西太原030003 浙江凯华模具有限公司浙江台州318020

使用Moldflow软件模拟车身后护板注塑工艺,采用正交试验及灰色关联分析结合熵权法优化注塑工艺参数,并进行了实际试模验证。结果表明:使用微孔发泡注塑成型可实现车身后护板减重及降低翘曲变形量;优化的工艺参数为熔体温度235℃,模具温... 详细信息

使用Moldflow软件模拟车身后护板注塑工艺,采用正交试验及灰色关联分析结合熵权法优化注塑工艺参数,并进行了实际试模验证。结果表明:使用微孔发泡注塑成型可实现车身后护板减重及降低翘曲变形量;优化的工艺参数为熔体温度235℃,模具温度35℃,充填时间3.5 s,充填体积百分比92%,初始气体含量1.2%(w),所制零件总质量为1362.2 g,z方向翘曲变形量为1.006 mm,较采用微孔发泡默认工艺组合分别减少了18.4 g,0.478 mm;采用灰色关联分析结合熵权法对工艺优化能满足产品减重和降低翘曲变形量的要求。

关键词：车身后护板微孔发泡注塑正交试验灰色关联分析熵权法多目标优化

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基于粗糙集法的五指毛桃补骨脂素合成酶基因序列获取与分析

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分子植物育种 2021年第22期19卷 7398-7407页

作者：叶茂森瞿静涛杨琳郑豫刘柄良张君诚三明学院资源与化工学院药用植物开发利用福建省高校工程研究中心融媒体中心三明365000 四川农业大学玉米研究所成都611130

多重比对补骨脂素合成酶(psoralen synthase,PS)基因信息,预测单序列能量最低状态,基于粗糙集法,建立PS保守结构域的氨基酸残基识别体系,获取五指毛桃(Ficus hirta Vahl)的转录本中该Unigene序列信息,并通过生物信息学验证。结果表明,... 详细信息

多重比对补骨脂素合成酶(psoralen synthase,PS)基因信息,预测单序列能量最低状态,基于粗糙集法,建立PS保守结构域的氨基酸残基识别体系,获取五指毛桃(Ficus hirta Vahl)的转录本中该Unigene序列信息,并通过生物信息学验证。结果表明,通过五指毛桃RNA测序得到61287240条高质量读长(Clean reads),注释得到179974条Unigene序列。采用粗糙集法,预测40条PS基因有10个区域的氨基酸序列同源性高。通过转录本比对,获取五指毛桃1751 bp Unigene序列,开放阅读框1533 bp,编码510个氨基酸,属于细胞色素P450超家族的成员,相对分子质量为57.8 kD,等电点为6.48,亚细胞定位于内质网;二级结构α-螺旋、无规则卷曲和延伸连的比例分别为50.39%、33.73%、10.98%。虽然该序列编码的氨基酸与其他植物PS的相似性不高,但与大阿米芹、珊瑚菜等植物PS蛋白的三级结构极为相似,与同为桑科的川桑补骨脂素合成酶序列聚在一支。综上结果验证了基于粗糙集法,建立PS保守结构预测,获取PS的Unigene为五指毛桃PS基因,为基于植物转录组测序,获取目标基因,提供一种保守结构域的氨基酸序列获取方法。

关键词：补骨脂素五指毛桃粗糙集法保守结构域转录组测序

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