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Efficacy comparison between Mathieu combined urethral plate incision and onlay island flap urethroplasty for distal hypospadias in patients with urethral plate stenosis

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Asian Journal of Andrology 2024年第4期26卷 433-438页

作者： Tao Zhang An-Bang Zhu Chang-Kun mao Yong-sheng Cao Department of Urology Anhui Provincial Children’s HospitalHefei 230000China The Fifth School of Clinical Medicine Anhui Medical UniversityHefei 230000China.

The aim of the study was to compare the efficacy of Mathieu combined urethral plate incision(Mathieu-IP)versus onlay island flap urethroplasty in patients with distal hypospadias complicated by urethral *** clinical data of 70 patients with distal hypospadias complicated by urethral plate stenosis treated in the Department of Urology,Anhui Provincial Children’s Hospital(Hefei,China),from May 2019 to May 2022,were retrospectively ***-eight patients underwent Mathieu-IP(Mathieu-IP group)and 32 underwent onlay island flap urethroplasty(Onlay group).Follow-ups at 1 month,6 months,and 12 months postoperatively assessed operative time,complications,urethral meatus morphology,and family *** Mathieu-IP group had significantly shorter operative time(mean±standard deviation[s.d.]:81.58±5.18 min)versus the Onlay group(mean±s.d.:110.75±6.05 min;P0.05).Complications were comparable between the *** Mathieu-IP group resulted in a vertical slit-shaped urethral meatus in 89.5%versus 13.8%in the Onlay group(P<0.05).Family satisfaction with general penile appearance and skin shape showed no significant differences,but the Mathieu-IP group had higher satisfaction with meatal position(P<0.05).Mathieu-IP offers simplicity,safety,and shorter operative time compared to *** the techniques effectively treat urethral plate stenosis in distal hypospadias,with reduced postoperative complications compared to tubularized incised plate ***-IP results in a vertical slit-shaped urethral meatus which enhances urinary stream,indicating its potential for broader adoption.

关键词： longitudinal urethral plate incision Mathieu onlay island flap urethroplasty urethral stenosis

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Fracture geometry and breakdown pressure of radial borehole fracturing in multiple layers

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Petroleum Science 2024年第1期21卷 430-444页

作者： Yu-Ning Yong Zhao-Quan Guo Shou-Ceng Tian Lu-Yao Ma Tian-Yu Wang mao sheng National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China Beijing Petroleum Machinery Company Limited CNPC Engineering Technology R&D Company LimitedBeijing102206China Smart Energy Co. LtdChina Xiongan GroupXiong’an New Area071000HebeiChina

Radial borehole fracturing that combines radial boreholes with hydraulic fracturing is anticipated to improve the output of tight oil and gas *** paper aims to investigate fracture propagation and pressure characteristics of radial borehole fracturing in multiple layers.A series of laboratory experiments with artificial rock samples(395 mm×395 mm×395 mm)was conducted using a true triaxial fracturing *** crucial factors corresponding to the vertical distance of adjacent radial borehole layers(vertical distance),the azimuth and diameter of the radial borehole are *** results show that radial borehole fracturing in multiple layers generates diverse fracture *** types of fractures are identified based on the connectivity between hydraulic fractures and radial *** vertical distance significantly influences fracture propagation perpendicular to the radial borehole *** increase in the vertical distance impedes fracture connection across multiple radial borehole layers and reduces the fracture propagation distance along the radial borehole *** azimuth also influences fracture propagation along the radial borehole *** the azimuth reduces the guiding ability of radial boreholes,which makes the fracture quickly curve to the maximum horizontal stress *** breakdown pressure correlates with diverse fracture geometries *** the fractures connect multi-layer radial boreholes,increasing the vertical distance decreases the breakdown *** the azimuth and increasing the diameter also decrease the breakdown *** extrusion force exists between the adjacent fractures generated in radial boreholes in multiple rows,which plays a crucial role in enhancing the guiding ability of radial boreholes and results in higher breakdown *** research provides valuable theoretical insights for the field application of radial borehole fracturing technology in tight oil and g

关键词： Multi-layer radial boreholes Hydraulic fracturing Fracture propagation Pressure characteristic

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Recent Advances in Deciphering the Mechanisms and Biological Functions of DNA Demethylation

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Chinese Journal of Chemistry 2024年第6期42卷 645-651页

作者： Yang Feng sheng-Jun chen Bi-Feng Yuan Key Laboratory of Aquatic Product Processing Ministry of Agriculture and Rural AffairsNational R&D Center for Aquatic Product ProcessingSouth China Sea Fisheries Research InstituteChinese Academy of Fishery SciencesGuangzhouGuangdong510300 China School of Public Health Research Center of Public HealthRenmin Hospital of Wuhan UniversityWuhan UniversityWuhanHubei430071 China

5-Methylcytosine (5mC) is a dynamic and reversible epigenetic modification in genomic DNA of higher *** has been well-established that the demethylation of 5mC occurs through the ten-eleven translocation (TET)-mediated oxidation of 5mC followed by thymine DNA glycosylase (TDG)-initiated base excision repair (BER).Recent findings also have identified an alternative pathway of DNA *** this pathway,TET enzymes directly oxidize 5mC to form 5-formylcytosine (5fC) or 5-carboxylcytosine (5caC).These modified bases can undergo direct deformylation or decarboxylation,***,DNA demethylation can also occur through the deamination of 5mC and 5hmC,resulting in the production of thymine and 5-hydroxymethyluracil (5hmU),*** DNA demethylation pathways possess critical functional implications and roles in biological *** Recent Advances article will focus on the studies of mechanisms and biological functions of DNA demethylation,shedding light on the reversible nature of the epigenetic modification of 5mC.

关键词： Epigenetics DNA DNA methylation 5-Methylcytosine Demethylation Mechanisms Biological functions C—C bond cleavage Mass spectrometry

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Extraordinary hot extreme in summer 2022 over the Yangtze River basin modulated by the La Nina condition under global warming

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Advances in Climate Change Research 2024年第1期15卷 21-30页

作者： Zhen LIAO Yu-Feng YUAN Yang chen Pan-mao ZHAI State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China

A widespread and prolonged hot extreme hit the Yangtze River basin in summer 2022,with 300 sites established new temperature records and nearly 96%stations endured more than 40 hot *** the perspective of the combination effect of the global warming and La Nina condition,potential mechanisms of the hot extreme were *** a record-breaking hot extreme was caused by an extremely strong and westward-shifted western Pacific subtropical high(WPSH).The global warming effect contributed primarily to the abnormal hot days in the Yangtze River basin,coupled with the modulation of the La Nina *** sea surface temperature anomaly pattern under La Nina condition favored more convection activities over the western Pacific,encouraging an enhanced and westward-extended *** addition,an observation-based attribution analysis indicates that anthropogenic warming may increase the probability of such extensively persistent hot extremeby1.8 times.

关键词： Hot extreme The Yangtze River basin Global warming Tropical Pacific forcing

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Hydrodynamics and OCM reaction performance in a bubbling fluidized bed reactor and a riser reactor

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Particuology 2024年第3期86卷 188-204页

作者： Min Cai Shuangzhu Kong sheng chen Mengxi Liu Chunxi Lu State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing102249China China Special Equipment Inspection and Research Institute Beijing102249China

The reasonable reactor design is of great importance for increasing the C_(2) yield(C2H4 and C2H6)of the oxidative coupling of methane(OCM),and the OCM reactor should remove the heat released in reactions quickly and efficiently and minimize the consecutive reaction of ethylene to carbon *** fluidized bed reactor is characterized by excellent heat transfer,superior mass transport,and large handling capacity,while fewer studies focused on large-scale fluidized bed reactors for the OCM ***,large cold-model experiments and computational fluid dynamics simulations were conducted to investigate hydrodynamics and the OCM reaction performance in a large-scale bubbling fluidized bed(BFB)and a large-scale *** the BFB reactor,consecutive reactions of ethylene are acute because of the strong gas back-mixing,high solids holdup,and non-uniform solids *** the consecutive reactions of ethylene are negligible due to the plug flow structure and low solids holdup in the riser ***,both reactors can achieve isothermal operation for the OCM *** C_(2) selectivity of 45.4% and C_(2) yield of 21.1% are obtained in the riser reactor,increasing by 20.3% and 5.8% individually than that in the BFB *** study provides useful information and reference to the OCM reactor designandcommercialization.

关键词： Oxidative coupling of methane Bubbling fluidized bed reactor Riser reactor Hydrodynamics Isothermal operation

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Inclusions modification by rare earth in steel and the resulting properties: A review

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Journal of Rare Earths 2024年第3期42卷 431-445,I0001页

作者： Xiaoqiang Wang Zhiwei Wu Bing Li Wenxiong chen Jun Zhang Jian mao College of Materials Science and Engineering Sichuan UniversityChengdu610065China chengdu Advanced Metal Materials Industry Technology Research Institute Co. Ltd.Chengdu610303China State Key Laboratory of Metal Material for Marine Equipment and Application Anshan114009China

Rare earth(RE) elements are excellent modifiers for non-metallic inclusions that inevitably appear in steel and affect steel properties. This paper reviews the research status of inclusions modification by RE elements and the changes it cause on steel properties. First, the inclusion changes caused by RE modification are described. Generally, after adding pure RE, the main evolution of inclusions occurs as M →M + RE-Al-O → RE-Al-O + RE_(2)O_(2)S → RE_(2)O_(2)S + RE—S/RE_(2)O_(2)S + RE-O with an increase in the RE content(M represents the inclusions before RE addition). The type of final inclusion obtained after RE modification is related to the relative contents of S and O in the steel. Moreover, fine, regular, and uniformly distributed inclusions can be obtained with appropriate RE addition. However, the effectiveness of inclusions modification by adding both RE and non-RE elements is closely related to the order of their addition. Second, the applications and advantages of thermodynamic calculations in the study of RE-modified inclusions are introduced. Third, the changes in the corrosion resistance, impact properties,and other properties of steel caused by the modification of inclusions by RE are reviewed. Finally, the perspectives and trends of inclusions modified by RE elements in the steel industry are presented.

关键词： Rare earths Inclusions Modification Thermodynamic calculation Properties change

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Theoretical screening of cooperative N-bridged dual-atom sites for efficient electrocatalytic nitrogen reduction with remolding insight

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Nano Research 2024年第4期17卷 3413-3422页

作者： Huimei chen Yan Yang Chi Jiao Zhiwen Zhuo Junjie mao Yan Liu Key Laboratory of Functional Molecular Solids Ministry of EducationCollege of Chemistry and Materials ScienceAnhui Normal UniversityWuhu 241002China

The electrocatalytic nitrogen reduction reaction(e-NRR)is a promising alternative method for the Haber–Bosch ***,it still faces many challenges in searching for high activity,stability,and selectivity catalysts and ascertaining the catalytic mechanism with complete ***,a series of graphene-based N-bridged dual-atom catalysts(M1-N-M2/NC)are systematically investigated via first-principle calculation and a high-throughput screening *** result unveils that N_(2) adsorption on M1-N-M2/NC in bridge-on adsorption mode can effectively break the scaling relationship on single-atom catalysts(SACs).Moreover,V-N-Ru/NC and V-N-Os/NC are systematically screened out as promising e-NRR catalysts,with extremely low limiting potentials of-0.20 and-0.18 V,***,the adsorption site competition between*N_(2) and*H,as well as the competitive twin reactions of hydrogen evolution reaction(HER)on intermediates(N_(n)H_(m))during the e-NRR process,is systematically evaluated to form a remodeling insight for the reactions in mechanism,and the e-NRR of new proposed dual-atom catalysts(DACs)is strategically optimized for its high-efficiency performance potential via our remolding insight in e-NRR *** work provides new ideas and insights for the design and mechanism of e-NRR catalysts and an effective strategy for rapidly screening highly efficient e-NRR catalysts.

关键词： nitrogen reduction dual-atom catalysts high-throughput screening hydrogen evolution reaction density functional theory calculations

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Impact and mechanism of bisphosphonate depressant 1-hydroxypropane-1,1-diphosphonic acid on flotation decalcification of dolomite-rich magnesite ore

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International Journal of Mining Science and Technology 2024年第7期34卷 1017-1032页

作者： Wengang Liu Xudong chen Wenbao Liu Naixu Zhang Yong mao Ying Guo School of Resources&Civil Engineering Northeastern UniversityShenyang 110819China

Given the depletion of high-quality magnesite deposits and the rising demand for high-end magnesium materials,the separation and utilization of high-calcium magnesite ores have become ***,the similar surface properties and solubility of semi-soluble salt-type minerals,pose significant challenges for the utilization of dolomite-rich magnesite *** this study,1-hydroxypropane-1,1-di phosphonic acid(HPDP)was identified for the first time as a high-performance depressant for *** tests,including contact angle measurements,ζ potential analysis,X-ray photoelectron spectroscopy,and atomic force microscopy,were conducted to elucidate the interfacial interaction mechanisms of HPDP on the surfaces of the two minerals at different ***,molecular modeling calculations were used to detail the spatial matching relationship between HPDP and the crystal faces of the two *** was emphasized that HPDP specifically adsorbed onto the dolomite surface by forming calcium phosphonate,ensuring that the dolomite surface remained hydrophilic and ***,it was found that the adsorption strength of HPDP on the mineral surfaces depended on the activity of the metal sites and their spatial *** findings provide a theoretical foundation for the molecular design of flotation reagents for high-calcium magnesite ores.

关键词： Depressant Interfacial mechanism Magnesite Dolomite DFT Decalcification

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Impacts of multi-foulings on salinity gradient energy conversion process in negatively charged conical nanochannels

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Science China(Technological Sciences) 2024年第6期67卷 1714-1726页

作者： mao RuiJie chen Xi ZHOU RuHong LONG Rui LIU ZhiChun LIU Wei School of Energy and Power Engineering Huazhong University of Science and TechnologyWuhan430074China China-EU Institute for Clean and Renewable Energy Huazhong University of Science and TechnologyWuhan430074China School of Mechanical Science and Engineering Huazhong University of Science and TechnologyWuhan430074China

Membrane fouling inevitably occurs during nanofluidic reverse ***,the impact of multi-fouling on the energy conversion performance of negatively charged conical nanochannels under asymmetrical configurations is systematically *** results reveal that in Configuration I,where a high-concentration solution is applied at the tip side,at small concentration ratios,multiple foulings reduce the electric *** Configuration II,where a low-concentration solution is applied at the tip side,multiple foulings near the base side contribute to the electric *** fouling that formed near the lowconcentration entrance diminished the electric power and energy conversion ***-fouling lowered the electrical power consumption by 69.27%and 99.94%in Configurations I and II,*** Configuration I,the electric power first increased with increasing fouling surface charge density,reached its maximum value,and thereafter *** Configuration II,the electric power first decreased with increasing fouling surface charge density,reached its minimum value,and thereafter *** negative or positive charge densities of fouling contribute to the electric power and energy conversion efficiency.

关键词： conical nanochannel fouling nanofluidic reverse electrodialysis salinity gradient energy

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Cortical activity in patients with high-functioning ischemic stroke during the Purdue Pegboard Test:insights into bimanual coordinated fine motor skills with functional near-infrared spectroscopy

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Neural Regeneration Research 2024年第5期19卷 1098-1104页

作者： Siyun chen Mengchai mao Guangyue Zhu Yufeng chen Yuqi Qiu Bin Ye Dongsheng Xu The Second Rehabilitation Hospital of Shanghai ShanghaiChina College of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina School of Statistics East China Normal UniversityShanghaiChina The Third Rehabilitation Hospital of Shanghai ShanghaiChina Tongji University ShanghaiChina Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine ShanghaiChina

After stroke,even high-functioning individuals may experience compromised bimanual coordination and fine motor dexterity,leading to reduced functional *** arm training has been proposed as a promising intervention to address these ***,the neural basis of the impairment of functional fine motor skills and their relationship to bimanual coordination performance in stroke patients remains unclear,limiting the development of more targeted *** address this gap,our study employed functional near-infrared spectroscopy to investigate cortical responses in patients after stroke as they perform functional tasks that engage fine motor control and ***-four high-functioning patients with ischemic stroke(7 women,17 men;mean age 64.75±10.84 years)participated in this cross-sectional observational study and completed four subtasks from the Purdue Pegboard Test,which measures unimanual and bimanual finger and hand *** found significant bilateral activation of the sensorimotor cortices during all Purdue Pegboard Test subtasks,with bimanual tasks inducing higher cortical activation than the assembly ***,patients with better bimanual coordination exhibited lower cortical activation during the other three Purdue Pegboard Test ***,the observed neural response patterns varied depending on the specific *** the unaffected hand task,the differences were primarily observed in the ipsilesional *** contrast,the bilateral sensorimotor cortices and the contralesional hemisphere played a more prominent role in the bimanual task and assembly task,*** significant correlations were found between cortical activation and unimanual tasks,no significant correlations were observed with bimanual *** study provides insights into the neural basis of bimanual coordination and fine motor skills in high-functioning patients after stroke,highlighting task-dependent neural resp

关键词： bilateral arm training bimanual coordination cortical activity fine motor dexterity functional near-infrared spectroscopy(fNIRS) high-functioning Purdue Pegboard Test stroke

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