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Effects of ultrasonic-assisted extraction on bioactive compounds,volatile flavors and antioxidant activities of vine tea water extracts

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Traditional Medicine Research 2025年第1期10卷 73-81页

作者： Xiao-Long Zhou Wei-Jin Jiang Ji Yu mao-jun yao Yun-Tong Li Hunan Provincial Key Laboratory of Research Resource Mining and High-valued Utilization on Edible&Medicinal PlantCollege of Chemistry and Chemical EngineeringJishou UniversityJishou 416000China Hunan Gaoge Dairy Co. Ltd.Changsha 410000China

Background:Ampelopsis grossedentata,vine tea,which is the tea alternative beverages in *** vine tea processing,a large amount of broken tea is produced,which has low commercial ***:This study investigates the influence of different extraction methods(room temperature water extraction,boiling water extraction,ultrasonic-assisted room temperature water extraction,and ultrasonic-assisted boiling water extraction,referred to as room temperature water extraction(RE),boiling water extraction(BE),ultrasonic assistance at room temperature water extraction(URE),and ultrasonic assistance in boiling water extraction(UBE))on the yield,dihydromyricetin(DMY)content,free amino acid composition,volatile aroma components,and antioxidant properties of vine tea ***:A notable influence of extraction temperature on the yield of vine tea extracts(P<0.05),with BE yielding the highest at 43.13±0.26%,higher than that of RE(34.29±0.81%).Ultrasound-assisted extraction significantly increased the DMY content of the extracts(P<0.05),whereas DMY content in the RE extracts was 59.94±1.70%,that of URE reached 66.14±2.78%.Analysis revealed 17 amino acids,with L-serine and aspartic acid being the most abundant in the extracts,nevertheless ultrasound-assisted extraction reduced total free amino acid *** chromatography-mass spectrometry analysis demonstrated an increase in the diversity and quantity of compounds in the vine tea water extracts obtained through ultrasonic-assisted ***,69 and 68 volatile compounds were found in URE and UBE extracts,which were higher than the number found in RE and BE *** vitro,antioxidant activity assessments revealed varying antioxidant capacities among different extraction methods,with RE exhibiting the highest DPPH scavenging rate,URE leading in ABTS•+free radical scavenging,and BE demonstrating superior ferric ion reducing antioxidant ***:The findings suggest that extraction methods signi

关键词： vine tea dihydromyricetin ultrasonic-assisted extraction volatile aroma components

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欧洲中世纪大学的课程设置

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黑龙江科学 2019年第11期10卷 15-17页

作者：毛钧瑶哈尔滨师范大学

欧洲中世纪大学作为现代大学的源头,其课程设置不仅对当时大学的教学和社会有着巨大的影响,也为现代大学的课程设置提供了借鉴。文章详实地介绍了欧洲中世纪大学课程内容、欧洲中世纪大学的课程结构、欧洲中世纪大学的课程特征以及欧洲... 详细信息

欧洲中世纪大学作为现代大学的源头,其课程设置不仅对当时大学的教学和社会有着巨大的影响,也为现代大学的课程设置提供了借鉴。文章详实地介绍了欧洲中世纪大学课程内容、欧洲中世纪大学的课程结构、欧洲中世纪大学的课程特征以及欧洲中世纪大学课程设置对现代大学建设的影响与启示。

关键词：欧洲中世纪大学课程设置

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草莓园土壤中重金属含量的研究与评价

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现代农业科技 2016年第19期 181-182,184页

作者：毛慧姚军吴晶江苏省泰州市环境监测中心站江苏泰州225300 江苏省土壤有机物重点实验室泰州市环境保护局海陵分局

以草莓园为代表进行土壤重金属的研究,并与土壤本底值进行对比,发现该草莓园土壤中汞含量超过了土壤环境质量二级标准限值,镉元素已经接近土壤本底值的最高限度,其他铅、铬、镍、铜、锌、硒、钴、钒、锑等元素含量基本符合国家二级土壤... 详细信息

以草莓园为代表进行土壤重金属的研究,并与土壤本底值进行对比,发现该草莓园土壤中汞含量超过了土壤环境质量二级标准限值,镉元素已经接近土壤本底值的最高限度,其他铅、铬、镍、铜、锌、硒、钴、钒、锑等元素含量基本符合国家二级土壤环境质量标准对土壤环境要求。通过对草莓园土壤中重金属的研究,为当地草莓业的可持续发展和草莓园生态环境质量的改善提供参考。

关键词：草莓园土壤重金属土壤本底值评价

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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao yao-Wen Chang Hong-Yu Tang Chun-mao Yuan jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao Yue Lin Gen Wei jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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A breakthrough of printable mesoscopic perovskite solar cells

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Science China Materials 2025年第1期 307-308页

作者： Zhiyi yao Zhijun Ning School of Physical Science and Technology Shanghai Tech University

High-performance solar cells based on low-cost wet coating methods are the much-anticipated technology for the next generation of photovoltaics. Perovskite solar cells (PSCs) provide a fascinating choice because their...

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GCT系统在机组瞬态下的响应及故障处理

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科技视界 2017年第1期 359-360页

作者：赵昌兴许海峰毛耀军中核核电运行管理有限公司浙江海盐314300

本文介绍了GCT系统的基本功能,并结合其工作原理,对一些瞬态工况进行了分析,重点论述了在满功率停机不停堆工况下,GCT121VV未正常开启时调节系统的响应过程。并从机组控制的角度对操纵员的如何进行故障处理进行了探讨。

关键词： GCT控制原理故障瞬态响应

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Highly conductive and stable iodine doped argyrodite electrolyte for all-solid-state lithium batteries

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Journal of Energy Chemistry 2025年第1期100卷 50-58页

作者： Gaozhan Liu Jing Zhang Jing Yang Jinghui Chen Xingyue Xiao Xiayin yao Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Lithium argyrodites with high ionic conductivity and low cost are considered as one of the most prospective solid electrolytes for all-solid-state lithium ***,the poor chemical stability and compatibility with lithium metal limit their ***,Li5.4PS4.4Cl1.4I0.2solid electrolyte with high ionic conductivity of 11.49 m S cm-1and improved chemical stability is synthesized by iodine *** ultra-thin Li5.4PS4.4Cl1.4I0.2membrane with thickness of 10μm can be obtained by wet coating process,exhibiting a high ionic conductivity of 2.09 mS cm-1and low areal resistance of 1.17Ω***,iodine doping could in-situ form LiI at the lithium/electrolyte interface and improve the critical current density of Li5.4PS4.4Cl1.6from 0.8 to 1.35 mA *** resultant LiCoO2/Li5.4PS4.4Cl1.4I0.2/Li battery shows excellent cycling stability at 1 C,with a reversible specific capacity of 110.1 mA h g-1and a retention of 80.5% after 1000 *** addition,the assembled LiCoO2/Li5.4PS4.4Cl1.4I0.2membrane/Li pouch cell delivers an initial discharge capacity of 110.4 mA h g-1and 80.5% capacity retention after 100 cycles.

关键词： Argyrodite electrolytes Iodine doping Ionic conductivity Stability All-solid-state lithium battery

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黄土高原小流域综合治理效益多维灰色动态评价

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农业系统科学与综合研究 2005年第2期21卷 156-160页

作者：贾宁凤段建南陈焕伟李旭霖毛俊耀中国农业大学资源和环境学院湖南农业大学资源环境学院湖南长沙410128 莱阳农学院农学系山东莱阳265200 山西省河曲县国土资源局山西河曲036500

构建了黄土高原小流域综合治理效益评价指标体系,以砖窑沟流域为例,选择1989、1998、2010年3个时期,采用多维灰色评估模型进行小流域综合治理效益评价。结果表明,高灰类和低灰类的土地面积均为上升趋势,但高灰类上升缓慢,中灰类呈迅速... 详细信息

构建了黄土高原小流域综合治理效益评价指标体系,以砖窑沟流域为例,选择1989、1998、2010年3个时期,采用多维灰色评估模型进行小流域综合治理效益评价。结果表明,高灰类和低灰类的土地面积均为上升趋势,但高灰类上升缓慢,中灰类呈迅速下降趋势。同时,划分了综合治理效益发展趋势类型,即高稳定型、低稳定型、上升型、下降型和不稳定型,其中低稳定型和下降型的发展趋势成为流域的主要类型。今后的黄土高原小流域综合治理应采取新思路、新策略。图3,参13。

关键词：综合治理效益指标体系砖窑沟流域多维灰色评估模型

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Glycolytic dysregulation in Alzheimer's disease:unveiling new avenues for understanding pathogenesis and improving therapy

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Neural Regeneration Research 2025年第8期20卷 2264-2278页

作者： You Wu Lijie Yang Wanrong Jiang Xinyuan Zhang Zhaohui yao Department of Geriatrics Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Alzheimer's disease poses a significant global health challenge owing to the progressive cognitive decline of patients and absence of curative *** current therapeutic strategies,primarily based on cholinesterase inhibitors and N-methyl-Daspartate receptor antagonists,offer limited symptomatic relief without halting disease progression,highlighting an urgent need for novel research directions that address the key mechanisms underlying Alzheimer's *** studies have provided insights into the critical role of glycolysis,a fundamental energy metabolism pathway in the brain,in the pathogenesis of Alzheimer's *** in glycolytic processes within neurons and glial cells,including microglia,astrocytes,and oligodendrocytes,have been identified as significant contributors to the pathological landscape of Alzheimer's *** changes impact neuronal health and function,thus offering promising targets for therapeutic *** purpose of this review is to consolidate current knowledge on the modifications in glycolysis associated with Alzheimer's disease and explore the mechanisms by which these abnormalities contribute to disease onset and *** focus on the pathways through which glycolytic dysfunction influences Alzheimer's disease pathology should provide insights into potential therapeutic targets and strategies that pave the way for groundbreaking treatments,emphasizing the importance of understanding metabolic processes in the quest for clarification and management of Alzheimer's disease.

关键词： Alzheimer’s disease glial cells glycolysis neuronal metabolism pathogenesis therapeutic targets

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