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Either transepidermal water loss rates or stratum corneum hydration levels can predict quality of life in children with atopic dermatitis

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Pediatric Investigation 2021年第4期5卷 277-280页

作者： Shan Wang Chunping Shen Mutong Zhao Lei Jiao Jing Tian Yang Wang Lin Ma mao-qiang mao-qiang man Department of Dermatology Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina Dermatology Hospital Southern Medical UniversityGuangzhouChina

Importance:Patients with atopic dermatitis(AD)display compromised epidermal barrier and suffer from poor quality of *** hypothesized that quality of life could reflect in the changes in the epidermal barrier ***:To determine whether the epidermal barrier function correlates with the severity of pruritus and/or life quality in children with ***:A total of 120 children,aged 0-12 years,with moderate AD were *** were topically treated with topical corticosteroids(TCS)and an emollient for 2 *** Eczema Area and Severity Index(EASI),visual analogue scale(VAS)for pruritus severity,the Infant’s Dermatitis Quality of Life Index(IDQOL)and the Children’s Dermatology Life Quality Index(CDLQI)were *** water loss(TEWL)rates,stratum corneum(SC)hydration,and skin surface pH were *** of epidermal barrier function with pruritus,life quality,and EASI were ***:Following 2-week treatments,significant improvements were observed in EASI,TEWL,SC hydration,the VAS of pruritus,as well as DQOL(P<0.001 for all).TEWL positively,while SC hydration negatively correlated with VAS pruritus,DQOL,and EASI(P<0.001).Interpretation:Both TEWL and SC hydration levels can serve as indicators of the severity of pruritus and quality of life in children with AD.

关键词： Atopic dermatitis Transepidermal water loss Hydration Quality of life Pruritus

Efficacy and safety of herbal medicines in treating gastric ulcer:A review

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World Journal of Gastroenterology 2014年第45期20卷 17020-17028页

作者： Wei-Ping Bi Hui-Bin man mao-qiang man Department of Internal Medicine Wendeng Central Hospital Dermatology Service Veterans Affairs Medical Center Department of Dermatology University of California

Gastric ulcer is a common disorder of the digestive *** therapeutic regimens largely rely on Western ***,numerous studies have demonstrated that herbal medicines can effectively treat gastric ulcer in humans and various animal models via divergent *** review updates the efficacy and safety of herbal medicines in treating gastric ulcer,and the mechanisms of their action in humans and animal *** have demonstrated that the efficacy of herbal medicines is comparable or superior to that of drugs such as omeprazole or cimetidine in humans and animal models,and herbal medicines display fewer adverse *** mechanisms by which herbal medicines benefit gastric ulcer include stimulation of mucous cell proliferation,anti-oxidation,and inhibition of gastric acid secretion and H(+)/K(+)-ATPase *** herbal medicines also exhibit antimicrobial *** of herbal medicines could be a valuable alternative to treat gastric ulcer in humans effectively,with few adverse effects.

关键词： Herbal medicines Gastric ulcer Mechanism of action

Precise Asymptotics in Limit Theorems for a Supercritical Branching Process with Immigration in a Random Environment

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Acta Mathematica Sinica,English Series 2024年第8期40卷 1850-1874页

作者： Chun mao HUANG Rui ZHANG Zhi qiang GAO Department of Mathematics Harbin Institute of Technology(Weihai)Weihai 264209P.R.China School of Mathematical Sciences Beijing Normal UniversityBeijing 100875P.R.China

Let(Zn)be a supercritical branching process with immigration in an independent and identically distributed random *** necessary moment conditions,we show the exact convergence rate in the central limit theorem on log Zn and establish the corresponding local limit theorem by using the moments of the natural submartingale and the convergence rates of its *** similar approach and with the help of a change of measure,we also present the so-called integrolocal theorem and integral large deviation theorem to characterize the precise asymptotics of the upper large deviations.

关键词： Branching process with immigration random environment central limit theorem large deviation

Topical Applications of Thiosulfinate-Enriched Allium sativum Extract Accelerates Acute Cutaneous Wound Healing in Murine Model

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Chinese Journal of Integrative Medicine 2020年第11期26卷 812-818页

作者： Juan Luis Santiago Eva Maria Galan-Moya Jose Ramon Munoz-Rodriguez Miguel Angel de la Cruz-Morcillo Francisco Javier Redondo-Calvo Ignacio Gracia-Fernandez Peter M.Elias Jose manuel Perez-Ortiz mao-qiang man Dermatology Service Hospital General Universitario de Ciudad RealCiudad Real(13004)Spain Translational Research Unit Hospital General Universitario de Ciudad RealCiudad Real(13004)Spain Translational Oncology Laboratory Centro Regional de Investigaciones BiomedicasUniversidad de Castilla-La ManchaAlbacete(02008)Spain Instituto de Tecnologia Quimica y Medioambiental Universidad de Castilla-La ManchaCiudad Real(13004)Spain Dermatology Service Vetera ns Affairs Medical Centerand Department of DermatologyUniversity of CaliforniaSan FranciscoCA(94121)USA Dermatology Hospital Southern Medical UniversityGuangzhou(510091)China

Objective To determine whether topical applications of thiosulfinate-enriched Allium sativum extract(TASE)can accelerate acute cutaneous wound healing(WH)in a murine *** Keratinocyte viability and in vitro wound closure were assessed in keratinocyte *** of topical TASE(0.5μg/mL of allicin in 97%ethanol)on acute cutaneous WH were determined in a murine model of acute cutaneous *** mice were alternately assigned to the vehicle-and TASE-treated groups(n=6 per group).Expression levels of mRNA for keratinocyte differentiation marker-related proteins(filaggrin,loricrin and involucrin)and lipid synthetic enzymes(elongation of very long chain fatty acids protein 4(ELOVL4),fatty acid synthase(FA2H),3-hydroxy-3-methyl-glutaryl-coenzyme A reductase(HMGCoA),and serine palmitoyltransferase(SPT))were assessed using real-time quantitative polymerase chain reaction on day 3 and 8 after wounding,while transepidermal water loss(TEWL)rates were measured in wounded *** TASE accelerated WH both in vivo(40%vs.22%reduction in wound area,Pmanage acute cutaneous WH.

关键词： Allium sativum thiosulfinate wound healing permeability barrier keratinocytes proliferation

Accurate simulations of pure-viscoacoustic wave propagation in tilted transversely isotropic media

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Petroleum Science 2024年第2期21卷 866-884页

作者： qiang mao Jian-Ping Huang Xin-Ru Mu Ji-Dong Yang Yu-Jian Zhang Geosciences Department China University of Petroleum(East China)Qingdao266580ShandongChina Pilot National Laboratory for Marine Science and Technology(Qingdao) Qingdao266207ShandongChina

Forward modeling of seismic wave propagation is crucial for the realization of reverse time migration(RTM) and full waveform inversion(FWI) in attenuating transversely isotropic media. To describe the attenuation and anisotropy properties of subsurface media, the pure-viscoacoustic anisotropic wave equations are established for wavefield simulations, because they can provide clear and stable wavefields. However, due to the use of several approximations in deriving the wave equation and the introduction of a fractional Laplacian approximation in solving the derived equation, the wavefields simulated by the previous pure-viscoacoustic tilted transversely isotropic(TTI) wave equations has low accuracy. To accurately simulate wavefields in media with velocity anisotropy and attenuation anisotropy, we first derive a new pure-viscoacoustic TTI wave equation from the exact complex-valued dispersion formula in viscoelastic vertical transversely isotropic(VTI) media. Then, we present the hybrid finite-difference and low-rank decomposition(HFDLRD) method to accurately solve our proposed pure-viscoacoustic TTI wave equation. Theoretical analysis and numerical examples suggest that our pure-viscoacoustic TTI wave equation has higher accuracy than previous pure-viscoacoustic TTI wave equations in describing q P-wave kinematic and attenuation characteristics. Additionally, the numerical experiment in a simple two-layer model shows that the HFDLRD technique outperforms the hybrid finite-difference and pseudo-spectral(HFDPS) method in terms of accuracy of wavefield modeling.

关键词： Pure-viscoacoustic TTI wave equation Attenuation anisotropy Seismic modeling Low-rank decomposition method

Mechanistic study of lipid metabolism disorders in diabetic kidney disease treated with GLQMP based on network pharmacology,molecular docking and in vitro experiments

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Traditional Medicine Research 2024年第2期9卷 42-51页

作者： Shu-man Liu Zi-Jie Yan man Xiao Yi-qiang Xie College of Traditional Chinese Medicine Hainan Medical UniversityHaikou 571199China Key Laboratory of Biochemistry and Molecular Biology Hainan Medical UniversityHaikou 571199China.

Background:In this study,we used network pharmacology and molecular docking combined with vitro experiments to explore the potential mechanism of action of Gualou Qumai pill(GLQMP)against ***:We screened effective compounds and drug targets using Chinese medicine systemic pharmacology database and analysis platform and Chinese medicine molecular mechanism bioinformatics analysis tools;and searched for DKD targets using human online Mendelian genetics and gene *** potential targets of GLQMP for DKD were obtained through the intersection of drug targets and disease *** software was applied to build herbal medicine-active compound-target-disease networks and analyze them;protein-protein interaction networks were analyzed using the STRING database platform;gene ontology and Kyoto Encyclopedia of Genes and Genomes were used for gene ontology and gene and genome encyclopedia to enrich potential targets using the DAVID database;and the AutoDock Vina 1.1.2 software for molecular docking of key targets with corresponding key *** vitro experiments were validated by CCK8,oil red O staining,TC,TG,RT-qPCR,and Western ***:Through network pharmacology analysis,a total of 99 potential therapeutic targets of GLQMP for DKD and the corresponding 38 active compounds were obtained,and 5 core compounds were *** constructing the protein-protein interaction network and performing network topology analysis,we found that PPARA and PPARG were the key targets,and then we molecularly docked these two key targets with the 38 active compounds,especially the 5 core compounds,and found that PPARA and PPARG had good binding ability with a variety of *** vitro experiments showed that GLQMP was able to ameliorate HK-2 cell injury under high glucose stress,improve cell viability,reduce TC and TG levels as well as decrease the accumulation of lipid droplets,and RT-qPCR and Western blot confirmed that GLQMP was able to promote the expressi

关键词： Gualou Qumai pill diabetic kidney disease disorder of lipid metabolism network pharmacology molecular docking

Comparative transcriptome analysis between rhesus macaques(Macaca mulatta) and crab-eating macaques(M. fascicularis)

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Zoological Research 2024年第2期45卷 299-310页

作者： Yu-Xiang mao Yamei Li Zikun Yang Ning Xu Shilong Zhang Xuankai Wang Xiangyu Yang qiang Sun Yafei mao Institute of Neuroscience State Key Laboratory of NeuroscienceCenter for Excellence in Brain Science&Intelligence TechnologyChinese Academy of SciencesShanghai 200031China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Shanghai 201210China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Genetic Evolution&Animal Models Chinese Academy of SciencesKunmingYunnan 650201China Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric DisordersMinistry of EducationShanghai Jiao Tong UniversityShanghai 200030China Zhiyuan College Shanghai Jiao Tong UniversityShanghai 200240China Center for Genomic Research International Institutes of MedicineFourth Affiliated HospitalZhejiang UniversityYiwuZhejiang 322000China

Understanding gene expression variations between species is pivotal for deciphering the evolutionary diversity in phenotypes. Rhesus macaques(Macaca mulatta, MMU)and crab-eating macaques(M. fascicularis, MFA) serve as crucial nonhuman primate biomedical models with different phenotypes. To date, however, large-scale comparative transcriptome research between these two species has not yet been fully explored. Here, we conducted systematic comparisons utilizing newly sequenced RNA-seq data from84 samples(41 MFA samples and 43 MMU samples)encompassing 14 common tissues. Our findings revealed a small fraction of genes(3.7%) with differential expression between the two species, as well as 36.5% of genes with tissue-specific expression in both macaques. Comparison of gene expression between macaques and humans indicated that 22.6% of orthologous genes displayed differential expression in at least two tissues. Moreover,19.41% of genes that overlapped with macaque-specific structural variants showed differential expression between humans and macaques. Of these, the FAM220A gene exhibited elevated expression in humans compared to macaques due to lineage-specific duplication. In summary,this study presents a large-scale transcriptomic comparison between MMU and MFA and between macaques and humans. The discovery of gene expression variations not only enhances the biomedical utility of macaque models but also contributes to the wider field of primate genomics.

关键词： Crab-eating macaques Rhesus macaques Comparative transcriptomics Biomedical models Nonhuman primates RNA-seq Duplicated genes

Efficacy and predictive factors of transarterial chemoembolization combined with lenvatinib plus programmed cell death protein-1 inhibition for unresectable hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1236-1247页

作者： Kun-Peng Ma Jin-Xin Fu Feng Duan mao-qiang Wang Department of Interventional Radiology The Fifth Medical Center of Chinese People's Liberation Army General HospitalBeijing 100853China Chinese People's Liberation Army Medical School Beijing 100853China

BACKGROUND The efficacy and safety of transarterial chemoembolization(TACE)combined with lenvatinib plus programmed cell death protein-1(PD-1)for unresectable hepato-cellular carcinoma(HCC)have rarely been evaluated and it is unknown which factors are related to *** To evaluate the efficacy and independent predictive factors of TACE combined with lenvatinib plus PD-1 inhibitors for unresectable *** This study retrospectively enrolled patients with unresectable HCC who received TACE/lenvatinib/PD-1 treatment between March 2019 and April *** survival(OS)and progression-free survival(PFS)were *** objective response rate(ORR)and disease control rate(DCR)were evaluated in accordance with the modified Response Evaluation Criteria in Solid ***,the prognostic factors affecting the clinical outcome were *** One hundred and two patients were enrolled with a median follow-up duration of 12.63 *** median OS was 26.43 months(95%CI:17.00-35.87),and the median PFS was 10.07 months(95%CI:8.50-11.65).The ORR and DCR were 61.76%and 81.37%,*** patients with Barcelona Clinic Liver Cancer Classification(BCLC)B stage,early neutrophil-to-lymphocyte ratio(NLR)response(decrease),or early alpha-fetoprotein(AFP)response(decrease>20%)had superior OS and PFS than their *** This study showed that TACE/lenvatinib/PD-1 treatment was well tolerated with encouraging efficacy in patients with unresectable *** patients with BCLC B-stage disease with early NLR response(decrease)and early AFP response(decrease>20%)may achieve better clinical outcomes with this triple therapy.

关键词： Transarterial chemoembolization Efficacy Lenvatinib Programmed cell death protein-1 inhibitors Unresectable hepatocellular carcinoma

Molecular template derived ultrathin N-doped carbon layer on cobalt selenide nanobelts for durable and rapid sodium storage

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Nano Research 2024年第9期17卷 8145-8154页

作者： Chuanliang Wei Baojuan Xi Kangdong Tian Xinlu Zhang Quanyan man Keyan Bao Wutao mao Jinkui Feng Shenglin Xiong Key Laboratory of the Colloid and Interface Chemistry Ministry of EducationSchool of Chemistry and Chemical EngineeringSchool of Materials Science and EngineeringShandong UniversityJinan 250100China Resource Environment and Clean Energy Laboratory School of Chemical and Environmental EngineeringJiangsu University of TechnologyChangzhou 213001China

Sodium-ion batteries(SIBs)are an attractive battery system because of similar characteristics to lithium-ion batteries(LIBs)and large Na element ***,exploring stable,high-capacity and high-rate anode materials for SIBs is still challenging ***,diethylenetriamine(DETA)molecular template derived ultrathin N-doped carbon(NC)layer decorated CoSe_(2)nanobelts(CoSe_(2)/NC)are prepared by solvothermal reaction followed by calcination *** CoSe_(2)/NC exhibits large potential as an anode for *** and theoretical calculations reveal that the in situ formed conductive ultrathin NC layer can not only relieve the volume change of CoSe_(2)but also accelerate electron and ion *** addition,the nanobelt structure of CoSe_(2)/NC with abundant exposed active sites can obviously accelerate the electrochemical *** the synergistic effect of special nanobelt structure and NC layer,the rate as well as cycling performances of CoSe_(2)/NC are obviously improved.A superior capacity retention of 94.8%is achieved at 2 A·g^(-1)after 2000 *** using Na3V2(PO4)3 cathodes,the pouch full batteries can work steadily at 0.5 C,verifying the application ***_(2)/NC anodes also exhibit impressive performances in LIBs and potassium-ion batteries(PIBs).

关键词： CoSe2 nanobelts ultrathin N-doped carbon layer sodium-ion batteries anode high rate