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Temperature Distribution and Heat Saturating Time of Regenerative Heat Transfer

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Journal of Thermal Science 2006年第2期15卷 175-180页

作者： Li JIA ying mao Lixin YANG Department of Power Engineering School of Mechanical and Electronic Control Engineering Beijing Jiaotong University 100044 Beijing China

In this paper, heat transfer of the ceramic honeycomb regenerator was numerically simulated based on the computational fluid dynamics numerical analysis software CFX5. The longitudinal temperature distribution of regenerator and gas were obtained. The variation of temperature with time was discussed. In addition, the effects of some parameters such as switching time, gas temperature at the inlet of regenerator, height of regenerator and specific heat of the regenerative materials on heat saturating time were discussed. It provided primarily theoretic basis for further study of regenerative heat transfer mechanism.

关键词： regenerator numerical simulation heat saturating time high temperature air combustion

Target threat estimation based on discrete dynamic Bayesian networks with small samples

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Journal of Systems Engineering and Electronics 2022年第5期33卷 1135-1142页

作者： YE Fang mao ying LI Yibing LIU Xinrui College of Information and Communication Engineering Harbin Engineering UniversityHarbin 150001China Key Laboratory of Advanced Marine Communication and Information Technology Ministry of Industry and Information TechnologyHarbin Engineering UniversityHarbin 150001China

The accuracy of target threat estimation has a great impact on command *** Bayesian network,as an effective way to deal with the problem of uncertainty,can be used to track the change of the target threat ***,the traditional discrete dynamic Bayesian network(DDBN)has the problems of poor parameter learning and poor reasoning accuracy in a small sample environment with partial prior information *** the finiteness and discreteness of DDBN parameters,a fuzzy k-nearest neighbor(KNN)algorithm based on correlation of feature quantities(CF-FKNN)is proposed for DDBN parameter ***,the correlation between feature quantities is calculated,and then the KNN algorithm with fuzzy weight is introduced to fill the missing *** this basis,a reasonable DDBN structure is constructed by using expert experience to complete DDBN parameter learning and *** results show that the CF-FKNN algorithm can accurately fill in the data when the samples are seriously missing,and improve the effect of DDBN parameter learning in the case of serious sample *** the proposed method,the final target threat assessment results are reasonable,which meets the needs of engineering applications.

关键词： discrete dynamic Bayesian network(DDBN) parameter learning missing data filling Bayesian estimation

The Oncogenesis of Glial Cells in Diffuse Gliomas and Clinical Opportunities

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Neuroscience Bulletin 2023年第3期39卷 393-408页

作者： Qiyuan Zhuang Hui Yang ying mao Department of Neurosurgery Huashan HospitalFudan UniversityShanghai 200040China National Center for Neurological Disorders Huashan HospitalFudan UniversityShanghai 200040China Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration Huashan HospitalFudan UniversityShanghai 200040China Institute for Translational Brain Research Fudan UniversityShanghai 200032China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institute for Translational Brain ResearchInstitutes of Brain ScienceFudan UniversityShanghai 200032China Neurosurgical Institute of Fudan University Shanghai 200032China

Glioma is the most common and lethal intrinsic primary tumor of the *** controversial origins may contribute to its heterogeneity,creating challenges and difficulties in the development of *** the components constituting tumors,glioma stem cells are highly plastic subpopulations that are thought to be the site of tumor *** stem cells/progenitor cells and oligodendrocyte progenitor cells are possible lineage groups populating the bulk of the tumor,in which gene mutations related to cell-cycle or metabolic enzymes dramatically affect this *** approaches have revealed the tumor-promoting properties of distinct tumor cell states,glial,neural,and immune cell populations in the tumor *** between tumor cells and other normal cells manipulate tumor progression and influence sensitivity to ***,we discuss the heterogeneity and relevant functions of tumor cell state,microglia,monocyte-derived macrophages,and neurons in glioma,highlighting their bilateral effects on ***,we describe potential therapeutic approaches and targets beyond standard treatments.

关键词： Glioma origin Stem/progenitor cell Oncometabolite Immune heterogeneity Neuron-tumor interaction

A Method for Measuring the Structure Complexity of Web Application

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Wuhan University Journal of Natural Sciences 2006年第1期11卷 143-150页

作者： mao Cheng-ying LU Yan-sheng College of Computer Science and Technology Huazhong University of Science and Technology Wuhan 430074Hubei China

The precise and effective measure results of Web applications not only facilitate good comprehension of them, but also benefit to the macro-management of software activities, such as testing, reverse engineering, reuse, etc. The paper exploits some researches on measuring the structure complexity of Web application. Through a deep analysis of the configuration and objects＇ interactions of Web system, two conclusions have been drawn：① A generic Web application consists of static web page, dynamic page, component and database object; ② The main interactions have only three styles, that is static link, dynamic link and call/return relation. Based on analysis and modeling of the content of a Web page （static or dynamic）, complexity measure methods of both control logic of script and nesting of HTML code are further discussed. In addition, two methods for measuring the complexity of inte〉page navigation are also addressed by modeling the inte〉page navigation behaviors of Web application via WNG graph.

关键词： structure complexity measure DD graph,HTree tree WNG graph

Cystic duct cancer: Should it be deemed as a type of gallbladder cancer?

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World Journal of Gastroenterology 2019年第44期25卷 6541-6550页

作者： Tu-Nan Yu ying-ying mao Fang-Qiang Wei Hui Liu Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Department of Epidemiology and Biostatistics Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina Department of Hepatobiliary and Pancreatic Surgery Zhejiang Provincial People’s HospitalHangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina Zhejiang Provincial Key Laboratory of Laparoscopic Technology Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016Zhejiang ProvinceChina

BACKGROUND According to the latest American Joint Committee on Cancer and Union for International Cancer Control manuals,cystic duct cancer(CC)is categorized as a type of gallbladder cancer(GC),which has the worst prognosis among all types of biliary *** hypothesized that this categorization could be verified by using taxonomic *** To investigate the categorization of CC based on population-level *** Cases of biliary cancers were identified from the Surveillance,Epidemiology,and End Results 18 registries *** with routinely used statistical methods,three taxonomic methods,including Fisher’s discriminant,binary logistics and artificial neuron network(ANN)models,were used to clarify the categorizing problem of *** The T staging system of perihilar cholangiocarcinoma[a type of extrahepatic cholangiocarcinoma(EC)]better discriminated CC prognosis than that of *** adjusting other covariates,the hazard ratio of CC tended to be closer to that of EC,although not reaching statistical *** differentiate EC from GC,three taxonomic models were built and all showed good *** ANN model had an area under the receiver operating characteristic curve of *** the three models,the majority(75.0%-77.8%)of CC cases were categorized as *** Our study suggested that CC should be categorized as a type of EC,not *** surgical attitude might be considered in CC cases,to see whether long-term prognosis could be immensely improved like the situation in EC.

关键词： Cystic duct cancer Gallbladder cancer Extrahepatic cholangiocarcinoma Surgical management Taxonomy Categorization

Novel Microglia-based Therapeutic Approaches to Neurodegenerative Disorders

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Neuroscience Bulletin 2023年第3期39卷 491-502页

作者： Lijuan Zhang Yafei Wang Taohui Liu ying mao Bo Peng Department of Neurosurgery Huashan HospitalInstitute for Translational Brain ResearchState Key Laboratory of Medical NeurobiologyMOE Frontiers Center for Brain ScienceFudan UniversityShanghai 200040China Co-innovation Center of Neuroregeneration Nantong UniversityNantong 226001China

prominent immune cells in the central nervous system,microglia constantly monitor the environment and provide neuronal protection,which are important functions for maintaining brain *** the diseased brain,microglia are crucial mediators of neuroinflammation that regulates a broad spectrum of cellular *** this review,we summarize current knowledge on the multifunctional contributions of microglia to homeostasis and their involvement in *** further provide a comprehensive overview of therapeutic interventions targeting microglia in neurodegenerative ***,we propose microglial depletion and subsequent repopulation as promising replacement *** microglial replacement therapy is still in its infancy,it will likely be a trend in the development of treatments for neurodegenerative diseases due to its versatility and selectivity.

关键词： Microglia Neuroinflammation Multifunction Microglial replacement Neurodegeneration

Current status of human adenovirus infection in China

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World Journal of Pediatrics 2022年第8期18卷 533-537页

作者： Nai‑ying mao Zhen Zhu Yan Zhang Wen‑Bo Xu NHC Key Laboratory of Medical Virology and Viral Diseases WHO WPRO Regional Reference Laboratory of Measles and RubellaChinese Center for Disease Control and PreventionMeasles Laboratory in National Institute for Viral Disease Control and Prevention155#Changbai RoadChangping DistrictBeijing 102206China

Background Outbreaks of severe,acute hepatitis among children have recently attracted global *** pathogen causing the outbreak remains unknown,but there is growing evidence that it may be associated with human adenovirus(HAdV).Data sources A review of adenovirus-related clinical studies,epidemiological studies,etiological studies,and case reports was conducted by reviewers *** HAdV can cause a wide variety of clinical *** the Mainland of China,HAdV infection accounts for 5.8%–13%of patients with acute respiratory infections,and these infections are mainly caused by species B,C,and E of *** acute conjunctivitis,39.8%–74.9%of sporadic cases were infected by B and D species of *** of keratoconjunctivitis and pharyngoconjunctival fever related to HAdV infection could be found throughout the *** pediatric patients with acute gastroenteritis,HAdV-41 was the predominant HAdV type,followed by HAdV species B and *** types of HAdV,including HAdV-5,HAdV-7,HAdV-1,and HAdV-2,have previously been reported as potential pathogens associated with HAdV hepatitis in immunocompromised ***,few HAdV-related hepatitis cases have been reported in China to *** There are no systematic surveillance and clinical studies on HAdV hepatitis in ***,it is imperative to establish a nationwide HAdV virological surveillance system to collect relevant clinical,epidemiological and virological surveillance data and risk factor information as soon as possible to assess the potential risk of HAdV hepatitis among children.

关键词： Acute respiratory tract infections Conjunctivitis Gastroenteritis Human adenovirus Hepatitis Unknown etiology

Effects of Drying Processes on the Antioxidant Properties in Sweet Potatoes

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Agricultural Sciences in China 2010年第10期9卷 1522-1529页

作者： YANG Jing CHEN Jin-feng ZHAO Yu-ying mao Lin-chun Department of Food Science and Nutrition College of Biosystem Engineering and Food Science Zhejiang University Hangzhou 310029 P.R. China

The effects of different drying methods （hot-air drying, microwave drying and vacuum-freeze drying） on the antioxidant activity and antioxidants in sweet potato （lpomoea batatas L. Lain.） tubers were investigated to determine the potential drying process. Sweet potato tubers were cut into 5 mm thick slices, steamed at 100℃ for 10 rain, then dried in either hotair, microwave, or vacuum-freeze. The dried sweet potatoes in microwave possessed the highest antioxidant activity, while the lowest activity was observed in hot-air dried samples. The phenolic contents were positively correlated with scavenging activity and reducing power of DPPH^＋. The microwave drying retains the highest antioxidant activity with the highest content of phenolic compounds in dried sweet potatoes. β-carotene and ascorbic acid showed minor contribution to the antioxidant activity in dried sweet potatoes.

关键词： sweet potato (lpomoea batatas L. Lam.) drying antioxidant activity antioxidants

Immunoproteomic Assay of Antigenic Surface Proteins in Streptococcus equi ssp. zooepidemicus

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Agricultural Sciences in China 2011年第7期10卷 1096-1105页

作者： mao ying FAN Hong-jie ZHOU Yong-hua LU Cheng-ping Key Laboratory of Animal Disease Diagnostic and Immunology Ministry of Agriculture/College of Veterinary Medicine Nanjing Agricultural University Nanjing 210095 P.R.China Jiangsu Institute of Parasitic Diseases Wuxi 214064 P.R.China

Streptococcus equi ssp. zooepidemicus （S. zooepidemicus） is a zoonotic pathogen with worldwide distribution. Lacking suitable vaccine and virulent maker is still bottleneck to control this infection. An immunoproteomic approach has been used to screen the membrane-associated and cell wall-associated proteins of S. zooepidemicus isolate in China CY to discover vaccine candidate antigens and therapeutic agents. Finally, 11 membrane-associated proteins, and 13 cell wall-associated proteins were successfully identified. BLAST （***） results also indicated that nucleotide sequences of majority identified proteins shared high homology （60%） with S. zooepidemicus, except for AC1-3, AC5, AC8, and AC13. Moreover, genes for 7 of the identified proteins were detected from CY; compared with ST171, 3 of them （AM1, AM8 and AC11） were only found in virulent strains （CY）. All of the proteins identified in this study remain not to be reported in S. zooepidemicus. Some of the proteins serve a vital role in the immune system and reproduction of host species according to available data, while the functions of the rest were seldom researched.

关键词： membrane-associated proteins (MAP) cell wall-associated proteins (CP) immunoproteomics S. zooepidemicus