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Pipeline Embolization Device for intracranial aneurysms presenting with mass effect:a large Chinese cohort

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Stroke & Vascular Neurology 2024年第1期9卷 50-58页

作者： Yang Zhao Junlin Lu Hongqi Zhang Tianxiao LI Donglei Song Sheng Guan Aisha Maimaitili Yunyan Wang Wenfeng Feng Yang Wang Jieqing Wan Guohua mao Huaizhang Shi Xinjian Yang Jianmin Liu yuanli Zhao Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery Peking University International HospitalBeijingChina Department of Neurosurgery West China HospitalSichuan UniversityChengduSichuanChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Interventional Neuroradiology Zhengzhou University People's HospitalZhengzhouHenanChina Department of Neurosurgery Shanghai Donglei Brain HospitalShanghaiChina Department of Interventional Neuroradiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Department of Neurosurgery The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiangChina Department of Neurosurgery Qilu Hospital of Shandong University QingdaoJinanShandongChina Department of Neurosurgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of Neurosurgery The First Affiliated Hospital of Nanchang UniversityNanchangJiangxiChina Department of Neurosurgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxiChina Department of Neurosurgery The First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Department of Neurosurgery Changhai HospitalNaval Medical UniversityShanghaiChina

Background Unruptured intracranial aneurysm treatment aims to reduce the risk of aneurysm rupture and bleeding,relieves symptoms and improve the quality of life for *** study aimed to assess the safety and efficacy of Pipeline Embolization Device(PED,Covidien/Medtronic,Irvine,CA)treatment for intracranial aneurysms presenting with mass effect in real-world *** We selected patients from the PED in China Post-Market Multi-Center Registry Study with mass effect *** study endpoints included postoperative mass effect deterioration and mass effect relief at follow-up(3–36 months).We conducted multivariate analysis to identify factors associated with mass effect *** analyses by aneurysm location,size and form were also *** This study included 218 patients with a mean age of 54.3±11.8 years and a female predominance of 74.0%(162/218).The postoperative mass effect deterioration rate was 9.6%(21/218).During a median follow-up period of 8.4 months,the mass effect relief rate was 71.6%(156/218).Notably,immediate aneurysm occlusion following treatment was significantly associated with mass effect relief(OR 0.392,95%CI,0.170 to 0.907,p=0.029).Subgroup analysis demonstrated that adjunctive coiling contributed to mass effect relief in cavernous aneurysms,while dense embolism impeded symptom relief in aneurysms<10mm and saccular *** Our data confirmed the efficacy of PED in relieving mass *** findings of this study provide support for endovascular treatment to alleviate mass effect in unruptured intracranial *** registration number NCT03831672.

关键词： aneurysm intracranial Irvine

Salinity fronts shape spatial patterns in zooplankton distribution in Hangzhou Bay

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Acta Oceanologica Sinica 2024年第6期43卷 96-106页

作者： Yepeng Xu Yiqi Wang Lin Zhan Yijun Ou Kangning Jia Ming mao Xuyu Zhu Zhibing Jiang yuanli Zhu Wei Huang Ping Du Jiangning Zeng Lu Shou Feng Zhou Key Laboratory of Marine Ecosystem Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China Key Laboratory of Nearshore Engineering Environment and Ecological Security of Zhejiang Province Hangzhou 310012China State Key Laboratory of Satellite Ocean Environment Dynamics Ministry of Natural ResourcesHangzhou 310012China Nantong Marine Environmental Monitoring Center Ministry of Natural ResourcesNantong 226002China Key Laboratory of Ocean Space Resource Management Technology Ministry of Natural ResourcesHangzhou 310012China Observation and Research Station of Marine Ecosystem in the Yangtze River Delta Ministry of Natural ResourcesZhoushan 316021China

Ocean fronts play important roles in nutrient transport and in the shaping ecological *** zones in small bays are typically small in scale,have a complex structure,and they are spatially and temporally variable,but there are limited data on how biological communities respond to this *** Bay,a mediumsized estuary in China,is an ideal place in which to study the response of plankton to small-scale ocean fronts,because three water masses(Qiantang River Diluted Water,Changjiang River Diluted Water,and the East China Sea current) converge here and form dynamic salinity fronts throughout the *** investigate zooplankton communities,and temperature,salinity and chlorophyll a(Chl a) in Hangzhou Bay in June(wet perio d) and December(dry period) of 2022 and examine the dominant environmental factors that affect zooplankton community spatial *** then match the spatial distributions of zooplankton communities with those of salinity fronts.S alinity is the most important explanatory variable to affect zooplankton community spatial variability during both wet and dry periods,in that it contributes>60% of the variability in community ***,the spatial distributions of zooplankton match well with salinity *** December,with weaker Qiantang River Diluted Water and a stronger secondary Changjiang River Plume,zooplankton communities occur in moderate salinity(MS,salinity range 15.6±2.2) and high salinity(HS,22.4±1.7) regions,and their ecological boundaries closely match the Qiantang River Diluted Water *** June,different zooplankton communities occur in low salinity(LS,3.9±1.0),MS(11.7±3.6) and HS(21.3±1.9) *** the LS region occurs abnormally in the central bay rather than its apex because of the anomalous influence of rising and falling tides during the sampling perio d,the ecological boundaries still match salinity ***-salinity or brackish-water zooplankter taxa are relatively more abunda

关键词： zooplankton spatial distribution salinity fronts Hangzhou Bay

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Increasing resistance and clonal transmission in Shigella sonnei in diarrheal patients between 2002 and 2007 in Beijing

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Increasing resistance and clonal transmission in Shigella so...

中华医学会第九次全国检验医学学术会议暨中国医院协会临床...

作者： Qu Fen,Bao Chunmei,Chen Suming,Cui Enbo, Guo Tongsheng,Wang Han,Wang Huan, mao yuanli 302 hospital of PLA

Shigella sonnei has become the dominant serotype causing shigellosis in Asia recent *** this study,we evaluated the antibiotic resistance and potential clonal transmission as well as related risk factors of *** in Beijing *** January 2002 to December 2007,a total of 1,108 Shigella isolates were recovered from diarrhea patients in the 302nd Hospital in *** the frequency

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Combined serum biomarkers in non-invasive diagnosis of non-alcoholic steatohepatitis——Combined biomarkers in NASH non-invasive diagnosis

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Combined serum biomarkers in non-invasive diagnosis of non-a...

第十四届中国体视学与图像分析学术会议

作者： Yang Mei Xu Dongping Liu Yuan Guo Xiaodong Li Wenshu Guo Chaonan Zhang Hongping Gao Yinjie mao yuanli Zhao Jingmin Department of Pathology and Hepatology Beijing 302 Hospital Institute of Infectious Diseases/Liver Failure Medical Center Beijing 302 Hospital Center for Clinical Trial Beijing 302 Hospital Center for Clinical Laboratory Beijing 302 Hospital

Background Non-alcoholic steatoheaptitis(NASH),the critical stage of non-alcoholic fatty liver disease(NAFLD),is of chronic progression and can develop cirrhosis even hepatocellular carcinoma(HCC).However,non-invasive biomarkers for NASH diagnosis remain poorly applied in clinical *** study aims at testing the accuracy of the combination of cytokeratin-18 M30 fragment(CK-18-M30),fibroblast growth factor 21(FGF-21),interleukin 1 receptor antagonist(IL-1 Ra),pigment epithelium-derived factor(PEDF)and osteoprotegerin(OPG)in diagnosing NAFLD and *** 179 patients with biopsy-proven NAFLD were enrolled as training group,91 ageand gender-matched healthy subjects were recruited at the same time as controls.63 otherNAFLD patients were separately collected as validation group.45 alcoholic fatty liver disease(AFLD)patients,50hepatitis B virus(HBV)patients,52 hepatitis C virus(HCV)patients were also *** biomarker levels were measured by enzyme-linked immunosorbent *** Serum levels of CK-18-M30,FGF-21,IL-1Ra and PEDF increased,while OPG decreased in a stepwise fashion in controls,non-NASH NAFLD patients and NASH patients(P<0.01).The area under receiver-operating characteristics curve to diagnose NASH was 0.86 for CK-18-M30,O.89 for},0.89 for IL-1Ra,0.89 for PEDF and 0.89 for ***-18-M30 had 70%negative predictive value(NPV)and 79%positive predictive value(PPV)to diagnose NASH.A 5-step approach measuring CK-18-M30 followed by FGF21,IL-1Ra,PEDF and OPG gradually improved the NPV to 76%and PPV to 85%,which reached80%and 76%respectively in the validation *** Compared to single biomarker,stepwise combination of CK-18-M30,FGF-21,IL-1 Ra,PEDF and OPG can further improve the accuracy in diagnosing NASH.

关键词： Non-alcoholic steatohepatitis Non-invasive diagnosis Combined serum biomarker Accuracy

Combined serum biomarkers in non-invasive diagnosis of non-alcoholic steatohepatitis

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第九届全国生物医学体视学学术会议、第十二届全军军事病理学学术会议、第八届全军定量病理学学术会议

作者： Mei Yang DongPing Xu Yuan Liu Xiaodong Guo Wenshu Li Chaonan Guo Hongping Zhang Yinjie Gao yuanli mao Jingmin Zhao Department of Pathology and Hepatology Beijing 302 Hospital Institute of Infectious Diseases/Liver Failure Medical Center Beijing 302 Hospital Center for Clinical Trial Beijing 302 Hospital Center for Clinical Laboratory Beijing 302 Hospital 中国人民解放军第三O二医院病现研究与诊断中心

Backgroud&Aims:Non-alcoholic steatoheaptitis(NASH),the critical stage of non-alcoholic fatty liver disease(NAFLD),is of chronic progression and can develop cirrhosis and even hepatocellular carcinoma(HCC).Seeking non-invasive biomarkers in diagnosing NASH is a worldwide heated *** study aims at testing the accuracy of the combination of cytokeratin-18 M30 fragment(CK-18-M30),fibroblast growth factor 21(FGF-21),interleukin 1 receptor antagonist(IL-1Ra),pigment epithelium-derived factor(PEDF) and osteoprotegerin(OPG) in diagnosing NAFLD and ***:A large-cohort prospective study was conducted on 242 patients with biopsy-proven NAFLD,randomly divided into NAFLD training group(n=179) and validation group(n=63),and 91 ageand gender-matched healthy subjects as *** biomarker levels were measured by enzyme-linked immunosorbent ***:Serum levels of CK-18-M30,FGF-21,IL-IRa and PEDF increased,while OPG decreased in a stepwise fashion in controls,non-NASH NAFLD patients and NASH patients(P respectively in validation ***:Stepwise combination of CK-18-M30,FGF-21,IL-IRa,PEDF and OPG can greatly improve the accuracy in diagnosing NASH compared to single biomarker,which is worth clinical application.

关键词： Non-alcoholic Steatohepatitis Non-invasive diagnosis Combined serum biomarker Accuracy

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小学“全科阅读”的构想与实践

当代教研论丛 2019年第5期6卷 26-27页

作者：毛园丽浙江省江山实验小学

'全科阅读'以'同一本书'为载体,由学科教师从各自的学科角度组织学生开展相关的阅读引导、交流、展示等主题活动,达到阅读内容与学科知识之间的融会贯通,课堂内外的科学沟通,学科之间的跨界与融合。

关键词：小学全科阅读教学模型跨界与融合

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基于恶性疟原虫富含组氨酸蛋白2抗原诊断方法的研究进展

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国际医学寄生虫病杂志 2014年第6期41卷 369-372页

作者：李波毛远丽解放军军医学院北京100853 解放军第302医院临床检验医学中心北京100039

恶性疟原虫是引起人类疟疾的主要病原体之一，采用基于恶性疟原虫富含组氨酸蛋白2（Plasmodium falciparum ***2）抗原的快速诊断试剂（rapiddiagnostictest，RDT）进行诊断是诊断恶性疟原虫感染的特异性方法，但表达该抗原的pfhrp2基... 详细信息

恶性疟原虫是引起人类疟疾的主要病原体之一，采用基于恶性疟原虫富含组氨酸蛋白2（Plasmodium falciparum ***2）抗原的快速诊断试剂（rapiddiagnostictest，RDT）进行诊断是诊断恶性疟原虫感染的特异性方法，但表达该抗原的pfhrp2基因呈现明显的多态性，甚至表达缺失，导致试剂的灵敏度降低，其临床实用性受到质疑。该文对pfh,p2基因多态性研究及基于PfHRP2抗原的恶性疟原虫诊断试剂评价进行综述，为恶性疟原虫的流行病学研究和临床诊断试剂的选择提供依据。

关键词：恶性疟原虫富含组氨酸蛋白2 快速诊断试剂

肠出血性大肠杆菌O_(157):H_7感染

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传染病信息 2004年第2期17卷 52-53页

作者：曲芬毛远丽解放军第三○二医院北京100039

大肠杆菌O157:H7是肠出血性大肠杆菌(enterohaemorrhagic escherichia coli,EHEC)的一种主要血清型,可引起消化道传播的人畜共患病,临床表现为无症状感染、轻度腹泻、出血性结肠炎(hemorrhagic colitis,HC),溶血性尿毒综合症(hemolytic ... 详细信息

大肠杆菌O157:H7是肠出血性大肠杆菌(enterohaemorrhagic escherichia coli,EHEC)的一种主要血清型,可引起消化道传播的人畜共患病,临床表现为无症状感染、轻度腹泻、出血性结肠炎(hemorrhagic colitis,HC),溶血性尿毒综合症(hemolytic uremics syndrome,HUS),血栓性血小板减少性紫癜(thrombotic thromobocyto penicporpura,TTP).自1982年美国发生首起O157引起的小型暴发后,世界20多个国家有散发或流行的报道,已引起广泛关注.

关键词：肠出血性大肠杆菌 O157:H7 感染病原学致病机制实验室诊断治疗

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硫铝酸盐水泥处理冶金固体废弃物的研究

环境工程 2010年第1期28卷 73-76页

作者：万新张明远周书才毛远礼重庆科技学院重钢集团铁业公司

利用硫铝酸盐水泥作为粘结剂,采用水硬化球团加工工艺,对冶金过程的二次资源进行了成球性能研究。研究结果表明:在70%硫酸渣、20%除尘灰和10%精矿粉原料条件下,添加6.5%的硫铝酸盐水泥和1.2%的复合粘结剂,能够获得粒度组成和强度均较理... 详细信息

利用硫铝酸盐水泥作为粘结剂,采用水硬化球团加工工艺,对冶金过程的二次资源进行了成球性能研究。研究结果表明:在70%硫酸渣、20%除尘灰和10%精矿粉原料条件下,添加6.5%的硫铝酸盐水泥和1.2%的复合粘结剂,能够获得粒度组成和强度均较理想的小球作为烧结料。该项成果的特点是带入原料的S iO2大量减少,水硬化球团养护期大幅度缩短,在重钢集团铁业公司取得了良好的生产效果。

关键词：水硬化球团硫铝酸盐水泥二次资源综合利用