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Silk-ELR co-recombinamer covered stents obtained by electrospinning

Regenerative Biomaterials 2019年第1期6卷 21-28页

作者： M.Putzu F.Causa manuel parente Israel Gonza´lez de Torre J.C.Rodriguez-Cabello P.A.Netti Dipartimento di Ingegneria Chimica dei Materiali e della Produzione Industriale(DICMAPI)University“Federico II”Piazzale Tecchio 8080125 NaplesItaly Interdisciplinary Research Centre on Biomaterials(CRIB) University of Naples Federico IIPiazzale Tecchio 8080125 NapoliItaly Center for Advanced Biomaterials for Health Care@CRIB Istituto Italiano di TecnologiaLargo Barsanti e Matteucci 5380125 NapoliItaly Conic Vascular via Carlo Maderno 236901 LuganoSwitzerland Technical Proteins NanoBioTechnology S.L. Edificio CTTAPaseo de Belen9A47011 ValladolidSpain Networking Research Center on Bioengineering Biomaterials and Nanomedicine(CIBER-BBN)ValladolidSpain Bioforge Lab University of ValladolidEdificio LUCIAPaseo de Belen1947011 ValladolidSpain

In the field of tissue engineering the choice of materials is of great importance given the possibility to use biocompatible polymers produced by means of biotechnology.A large number of synthetic and natural materials have been used to this purpose and processed into scaffolds using Electrospinning *** materials that could be used for the fabrication of scaffold and degradable membranes,natural polymers such as collagen,elastin or fibroin offer the possibility to design structures strictly similar to the extracellular matrix(ECM).Biotechnology and genetic engineering made possible the advent of a new class of biopolymers called protein-based *** example is represented by the silk-elastin-proteins that combine the elasticity and resilience of elastin with the high tensile strength of silk-fibroin and display engineered bioactive *** this work,we use electrospinning technique to produce a fibrous scaffold made of the corecombinamer *** fibres have been characterized from the morphological point of *** and morphology have been explored using Scanning Electron Microscopy.A thorough study regarding the influence of Voltage,flow rate and distance have been carried out to determine the appropriate parameters to obtain the fibrous mats without defects and with a good distribution of *** has also been in vitro *** the first time we use the co-recombinamer Silk-ELR for the fabrication of a 2.5 angioplasty balloon *** structure could be useful as a coated scaffold for the regeneration of intima layer of vessels.

关键词： electrospinning silk elastin-like-recombinamers tissue engineering

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Prophylactic drains in totally laparoscopic distal gastrectomy:are they always necessary?

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World Journal of Gastroenterology 2022年第3期28卷 399-401页

作者： Tommaso Maria Manzia Alessandro parente Roberta Angelico HPB and Transplant Unit Department of Surgery ScienceUniversity of Rome Tor VergataRome 00133Italy Queen Elizabeth Hospital Liver UnitUniversity of BirminghamBirmingham UK and HPB and Transplant UnitDepartment of Surgery ScienceUniversity of Rome Tor VergataRome 00133Italy

Prophylactic drains have always been a useful tool to detect early complications and prevent postoperative fluid collections,particularly in gastrointestinal ***,the utilization of such drains has been debated,due to mounting evidence that they could be harmful rather than *** on recent published articles,Liu et al reported that the routine use of prophylactic drains in total laparoscopic distal gastrectomy might not be necessary for all ***,we express our opinion regarding this interesting publication.

关键词： Gastric cancer Prophylactic drainage Totally laparoscopic gastrectomy Enhanced recovery after surgery Minimally invasive surgery Early gastric cancer

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Assessment of advanced age candidates for liver transplantation warrants more caution

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World Journal of Transplantation 2022年第2期12卷 24-26页

作者： Alessandro parente Vincenzo Ronca Liver Unit Queen Elizabeth Hospital University Hospital Birmingham NHS Foundation TrustBirmingham B152THUnited Kingdom Centre for Liver and Gastrointestinal Research Institute of Immunology and Immunotherapy University of BirminghamBirmingham B152TTUnited Kingdom

For patients with fulminant liver failure and end-stage liver disease,liver transplantation remains the only effective *** the years,as a result of the ageing population,the average age of liver transplant donors and recipients has increased and currently about one quarter of patients receiving transplantation in the United States are above the age of ***,a study reported that patients aged 65 years or older had lower one-year survival compared to a younger ***,we express our opinion about this interesting publication.

关键词： Liver transplantation Elderly patients Age in liver transplantation Frailty Transplant assessment Liver transplant outcomes

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Comparison of fusion methods based on DST and DBN in human activity recognition

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控制理论与应用（英文版） 2011年第1期9卷 18-27页

作者： Andrei TOLSTIKOV Jit BISWAS Chris NUGENT Guido parente Institute for Infocomm Research Networking Protocols Department1 Fusionopolis Way#21-01Singapore 138632 School of Computing and Mathematics University of UlsterShore RoadNewtownabbeyBT37 0QBU.K.

Ambient assistive living environments require sophisticated information fusion and reasoning techniques to accurately identify activities of a person under care. In this paper, we explain, compare and discuss the application of two powerful fusion methods, namely dynamic Bayesian networks (DBN) and Dempster-Shafer theory (DST), for human activity recognition. Both methods are described, the implementation of activity recognition based on these methods is explained, and model acquisition and composition are suggested. We also provide functional comparison of both methods as well as performance comparison based on the publicly available activity dataset. Our findings show that in performance and applicability, both DST and DBN are very similar; however, significant differences exist in the ways the models are obtained. DST being top-down and knowledge-based, differs significantly in qualitative terms, when compared with DBN, which is data-driven. These qualitative differences between DST and DBN should therefore dictate the selection of the appropriate model to use, given a particular activity recognition application.

关键词： Dynamic Bayesian networks Dempster-Shafer theory Healthcare monitoring Ambient assisted living Activity recognition

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Routine utilization of machine perfusion in liver transplantation:Ready for prime time?

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World Journal of Gastroenterology 2024年第11期30卷 1488-1493页

作者： Alessandro parente Keyue Sun Philipp Dutkowski AM James Shapiro Andrea Schlegel Department of Surgery Division of TransplantationUniversity of Alberta HospitalEdmonton T6G 2B7Canada Immunity and Inflammation Lerner Research InstituteClevelandOH 44195United States Swiss Hepato-Pancreato-Biliary Center Department of Visceral and Transplantation SurgeryUniversity Hospital ZurichZurich 8091Switzerland Immunity and Inflammation Digestive Disease and Surgery InstituteClevelandOH 44195United States

The last decade has been notable for increasing high-quality research and dramatic improvement in outcomes with dynamic liver *** evidence from numerous randomized controlled trials has been pooled by meta-analyses,providing the highest available evidence on the protective effect of machine perfusion(MP)over static cold storage in liver transplantation(LT).Based on a protective effect with less complications and improved graft survival,the field has seen a paradigm shift in organ *** editorial focuses on the role of MP in LT and how it could become the new“gold standard”.Strong collaborative efforts are needed to explore its effects on long-term outcomes.

关键词： Liver transplantation Machine perfusion Viability assessment Hypothermic oxygenated perfusion Normothermic machine perfusion

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Prediction of ground-borne vibration induced by impact pile driving:numerical approach and experimental validation

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Earthquake Engineering and Engineering Vibration 2023年第4期22卷 921-935页

作者： A.Colaço P.Alves Costa C.Ferreira C.parente J.Fernandez-Ruiz CONSTRUCT-FEUP University of PortoRua Dr.Roberto Frias4200-465 PortoPortugal University of La Coruña Department of Civil EngineeringCampus de Elviña 15071La CoruñaSpain

Deep foundations are currently used in engineering practice to solve problems caused by weak geotechnical characteristics of the *** pile driving is an interesting and viable solution from economic and technical points of ***,it is necessary to ensure that the environmental drawbacks,namely ground-borne vibration,are adequately *** this purpose,the authors propose an axisymmetric finite element method-perfectly matched layer(FEM-PML)approach,where the nonlinear behavior of the soil is addressed through an equivalent linear *** the complexity of the problem,an experimental test site was developed and fully *** experimental work comprised in-situ and laboratory soil characterization,as well as the measurement of vibrations induced during pile *** comparison between experimental and numerical results demonstrated a very good agreement,from which it can be concluded that the proposed numerical approach is suitable for the prediction of vibrations induced by impact pile *** experimental database is available as supplemental data and may be used by other researchers in the validation of their prediction models.

关键词： pile driving ground-borne vibrations numerical modeling experimental validation

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Left abdominal mass with carcinosis:Unusual presentation of pancreatic acinar cell carcinoma

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Hepatobiliary & Pancreatic Diseases International 2023年第4期22卷 412-414页

作者： Davide Ciardiello Filomena Urbano Giuseppe Zamboni Nicola Palladino Francesca Bazzocchi Paola parente Oncology Unit Fondazione IRCCS Ospedale Casa Sollievo della SofferenzaViale CappucciniSan Giovanni Rotondo 71013Italy Radiology Unit Fondazione IRCCS Ospedale Casa Sollievo della SofferenzaViale CappucciniSan Giovanni Rotondo 71013Italy Pathology Unit Ospedale Sacro Cuore Don Calabriavai SempreboniNegrar and University of VeronaNegrar 37024VRItaly Abdominal Surgical Unit Fondazione IRCCS Ospedale Casa Sollievo della SofferenzaViale CappucciniSan Giovanni Rotondo 71013Italy Pathology Unit Fondazione IRCCS Ospedale Casa Sollievo della SofferenzaViale CappucciniSan Giovanni Rotondo 71013Italy

Acinar cell carcinoma(ACC)is a rare malignant epithelial neoplasm accounting for 1%-2%of all pancreatic exocrine neoplasm,affecting more frequently man with an age between 50 and 70 *** patients present with nonspecific symptoms,which may give rise to difficulties in clinical diagnosis[1].ACC can manifest with diarrhea,weight loss,abdominal pain and,in up to 10%-15%,with lipase hypersecretion syndrome,characterized by elevated lipase production,diffuse subcutaneous fat necrosis and polyarthralgia[1,2].Biliary obstruction and jaundice are infre-quent clinical manifestations,unlike ductal adenocarcinoma,due to pushing rather than infiltrating growth of ACC.

关键词： abdominal clinical elevated

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Mismatch repair proteins and microsatellite instability in solid pseudopapillary neoplasm of the pancreas

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Hepatobiliary & Pancreatic Diseases International 2019年第5期18卷 491-492页

作者： Claudia Covelli Paola parente Francesco Pepe Pasquale Pisapia Fabiola Fiordelisi Umberto Malapelle UOC di Anatomia Patologica Fondazione Casa Sollievo della SofferenzaViale Cappuccini 171013 San Giovanni RotondoFGItaly Department of Public Health University of Naples Federico ⅡVia Pansini 580131 NapoliItaly

Solid pseudopapillary neoplasms (SPNs) are rare solid pancreatic tumors mainly affecting young women. Despite the high percentage of favorable prognosis, they are considered as low grade malignant neoplasms, and metastases occur in 5%-15% of patients. Almost all SPNs (95%) have somatic activating mutations in the β-catenin gene [1].

关键词： Solid pseudopapillary neoplasms (SPNs) Mismatch repair proteins microsatellite instability

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Characterization of Read/Write Head Shield Asperities in Hard Disk Drives

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Materials Sciences and Applications 2023年第9期14卷 439-457页

作者： Guilherme parente Souza Western Digital Storage Technologies (Thailand) Ltd. Ayutthaya Thailand

A new way to characterize asperities on metallic surfaces at the nanometer scale is proposed. Asperities are often treated using conventional statistical descriptors such as average and root mean square roughness, which do not provide adequate mechanistic insight into surface defect formation and mitigation. The new rationale revolves around developing a mathematical description of the evolution of the area occupied by asperities at each height slice on a topography image, with direct implications on how asperity instances are tracked and their risk of breakage leading to potential exposure and degradation of the metal surface upon thermo-mechanical stresses during the operation of read/write heads is assessed. The technique was shown to be disruptive by surpassing all other surface quality metrics, such as conventional roughness and static area % asperity at 0.5 nm height, in its ability to statistically differentiate surfaces coming from various manufacturing process iterations tailored to produce different surface conditions in the hard disk drive industry. A theoretical formulation proposing that the static asperity technique is fundamentally insufficient, is presented and validated experimentally.

关键词： DLC AFM Surface Characterization Thin Film HDD

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Inflammatory bowel disease in an underdeveloped region of Northeastern Brazil

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World Journal of Gastroenterology 2015年第4期21卷 1197-1206页

作者： José Miguel Luz parente Claudio Saddy Rodrigues Coy Viriato Campelo Mírian Perpétua Palha Dias parente Leonardo Araújo Costa Renata Mendes da Silva Celso Stephan José Murilo Robilotta Zeitune Center for Health Sciences Federal University of Piaui (Universidade Federal do Piauí - UFPI)TeresinaPiauí 64049-550Brazil Department of Surgery School of Medical SciencesState University of Campinas (Universidade Estadual de Campinas)CampinasS?o Paulo 13083-970Brazil Center of Health Sciences State University of Piaui (Universidade Estadual do Piauí - UESPI)TeresinaPiauí 64001-280Brazil Federal University of Piaui (Universidade Federal do Piauí - UFPI) TeresinaPiauí 64049-550Brazil Department of Public Health School of Medical SciencesState University of Campinas (Universidade Estadual de Campinas - Unicamp)CampinasS?o Paulo 13083-970Brazil Department of Internal Medicine School of Medical SciencesState University of Campinas (Universidade Estadual de Campinas - Unicamp)CampinasS?o Paulo 13083-970Brazil

AIM: To evaluate the demographic characteristics and clinical phenotypes of inflammatory bowel disease(IBD) in a geographic area in Northeastern ***: This retrospective study was conducted at the Hospital of the Federal University of Piauí in Northeastern Brazil. Demographic characteristics and clinical phenotypes of IBD were analyzed in relation to the time of diagnostic confirmation, which was defined as the date of disease onset. Data were collected between January 2011 and December 2012 and included all census patients 18 years of age or older during that period for whom there was diagnostic confirmation of Crohn's disease(CD), ulcerative colitis(UC), or unclassified colitis according to the Montreal criteria. We also analyzed the period of time between the onset of clinical manifestations and the diagnosis of IBD(delay in the diagnosis). Statistical analyses included means and standard deviations for numeric variables and the Pearson χ2 adherence test for nominal variables. The annual index occurrence and overall prevalence of IBD at our institution were also calculated, with P values < 0.05 indicating statistical significance. This study was approved by the Institutional Ethics and Research ***: A total of 252 patients with IBD were included, including 152(60.3%) UC patients and 100(39.7%) CD patients. The clinical and demographic characteristics of all patients with IBD showed a female to male ratio of 1.3:1.0 and a mean age of35.2(SD = 14.5) years. In addition, the majority of patients were miscegenated(171, 67.9%), had received higher education(157, 62.4%), lived in urban areas(217, 86.1%), and were under the age of 40 years(97, 62.5%). For patients with CD, according to the Montreal classification, the predominant features present from the onset of disease were an age between 17 and 40 years(A2); colonic disease location(L2); and nonstricturing, nonfistulizing disease behavior(B1). However, approximately one-quarter of all CD patie

关键词： Inflammatory bowel diseases Crohn’s disease Ulcera

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