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A Selection Process as a Game

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management Studies 2018年第6期6卷 531-535页

作者： manuel alberto m.ferreira maria Cristina Peixoto de matos Instituto Universitário de Lisboa(ISCTE-IUL) LisbonPortugal Instituto Politecnico de Viseu(IPV)-Escola Superior deTecnologia e Gestao de Viseu(ESTGV) ViseuPortugal

The aim of this paper is to exemplify how to solve the problem of selecting a candidate up to his/her acceptance trough game *** originality this paper proposes is how this problem will be approached:It will be treated as a single game which is made up of two parts,going as far as to state that the payoffs in the first part of the game will be the mediators of the second part of the game.

关键词： selection process game theory two-part game code form

RPLP0/TBP are the most stable reference genes for human dental pulp stem cells under osteogenic differentiation

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World Journal of Stem Cells 2024年第6期16卷 656-669页

作者： Daniel B ferreira Leticia m Gasparoni Cristiane F Bronzeri Katiucia B S Paiva Laboratory of Extracellular matrix Biology and Cellular Interaction Department of AnatomyInstitute of Biomedical SciencesUniversity of São PauloSão Paulo 05508-000São PauloBrazil

BACKGROUND Validation of the reference gene(RG)stability during experimental analyses is essential for correct quantitative real-time polymerase chain reaction(RT-qPCR)data ***,in an unreliable way,several studies use genes involved in essential cellular functions[glyceraldehyde-3-phosphate dehydro-genase(GAPDH),18S rRNA,andβ-actin]without paying attention to whether they are suitable for such experimental conditions or the reason for choosing such ***,such studies use only one gene when minimum Information for Publication of Quantitative Real-Time PCR Experiments guidelines recom-mend two or more *** impacts the credibility of these studies and causes dis-tortions in the gene expression *** tissue engineering,the accuracy of gene expression drives the best experimental or therapeutical *** cultivated DPSCs under two conditions:Undifferentiated and osteogenic dif-ferentiation,both for 35 *** evaluated the gene expression of 10 candidates for RGs[ribosomal protein,large,P0(RPLP0),TATA-binding protein(TBP),GAPDH,actin beta(ACTB),tubulin(TUB),aminolevulinic acid synthase 1(ALAS1),tyro-sine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,zeta(YWHAZ),eukaryotic translational elongation factor 1 alpha(EF1a),succinate dehydrogenase complex,subunit A,flavoprotein(SDHA),and beta-2-micro-globulin(B2m)]every 7 d(1,7,14,21,28,and 35 d)by *** data were analysed by the four main algorithms,ΔCt method,geNorm,NormFinder,and BestKeeper and ranked by the RefFinder *** subdivided the samples into eight *** All of the data sets from clonogenic and osteogenic samples were analysed using the RefFinder *** final ranking showed RPLP0/TBP as the two most stable RGs and TUB/B2m as the two least stable *** theΔCt method or NormFinder analysis showed TBP/RPLP0 as the two most stable ***,geNorm analysis showed RPLP0/EF1αin the first *** algorithms’two least stab

关键词： Dental pulp stem cells Reference gene Housekeeping gene Endogenous gene Osteogenic differentiation RefFinder

Reproductive Biology of a Blue-tail Skinks(Plestiodon)Population from a Temperate Forest,East-central Puebla,méxico

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Asian Herpetological Research 2024年第3期15卷 183-193页

作者： manuel FERIA-ORTIZ Isaías hazarmabeth SALGADO-UGARTE museo de Zoología Facultad de Estudios Superiores ZaragozaUniversidad Nacional Autónoma de MéxicoIztapalapaMéxico Laboratorio de Biometría y Biología Pesquera Facultad de Estudios Superiores ZaragozaUniversidad Nacional Autónoma de MéxicoIztapalapaMéxico

We studied the cycles of reproduction and fat bodies of a blue-tailed skink population of an undescribed species of the Plestiodon brevirostris *** maturity is attained by females and males as they both reach about 59 mm of *** started in June-July,with ovulation occurring during late-October to mid-November,and parturition in *** size varied from two to six,with a mean of 3.86±0.15 embryos in uterus,and showed a positive correlation with female body mass and *** gestation,a significant increase in the average wet mass of embryos in uterus was *** comparison,there were no notable changes in the average dry *** growth data suggest that sexual maturity,both males and females,is reached at 16-17 months of *** and epididymides exhibited maximal weight during *** regression occurred in *** apparently takes place from mid-summer to early *** stored in female fat bodies are used for vitellogenesis and for nutrition during the winter *** males,the stored lipids appear to be used in reproductive activities during the mating season.

关键词： growth litter size minimum size at maturity reproduction Scincidae viviparity

Hematological abnormalities in liver cirrhosis

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World Journal of Hepatology 2024年第9期16卷 1229-1244页

作者： Oscar manuel Fierro-Angulo Joséalberto González-Regueiro Ariana Pereira-García Astrid Ruiz-margáin Fernando Solis-Huerta Ricardo Ulises macías-Rodríguez Department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico 14080Mexico Department of Hematology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico 14080Mexico

Hematological abnormalities are common in cirrhosis and are associated with various pathophysiological *** have documented a prevalence of thrombocytopenia,leukopenia,and anemia in patients with compensated cirrhosis of 77.9%,23.5%,and 21.1%,*** abnormalities carry significant clinical implications,including considerations for invasive procedures,infection risk,bleeding risk,and ***,cirrhosis was believed to predispose patients to bleeding due to alterations observed in classical coagula-tion tests such as prothrombin time,partial thromboplastin time,international normalized ratio,and ***,this understanding has evol-ved,and cirrhosis patients are now also acknowledged as being at a high risk for thrombotic *** in cirrhosis patients presents a complex pheno-type,with procoagulant and anticoagulant abnormalities offsetting each *** multifactorial phenomenon is inadequately reflected by routine laboratory *** complications are more prevalent in decompensated cirrhosis and may correlate with disease *** is primarily associated with portal hypertension,endothelial dysfunction,mechanical vessel injury,dissem-inated intravascular coagulation,endotoxemia,and renal *** review comprehensively outlines hematologic index abnormalities,mechanisms of hemostasis,coagulation,and fibrinolysis abnormalities,limitations of laboratory testing,and clinical manifestations of bleeding and thrombosis in patients with liver cirrhosis.

关键词： Cirrhosis Anemia Leukopenia Thrombocytopenia Coagulopathy Bleeding Thrombosis

Association between lifestyle factors and thyroid function in young euthyroid adults

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Food Science and Human Wellness 2024年第1期13卷 265-275页

作者： Elisa merchan-Ramirez Guillermo Sanchez-Delgado Lucas Jurado-Fasoli Francisco m Acosta manuel munoz-Torres Jose m.Llamas-Elvira Jonatan R Ruiz Sport and Health University Research Institute(imUDS) Faculty of Sports ScienceUniversity of GranadaGranada 18016Spain Pennington Biomedical Research Center Baton Rouge 70808USA Faculty of medicine University of GranadaGranada 18071Spain Turku PET Centre University of TurkuTurku 20500Finland Turku PET Centre Turku University HospitalTurku 20520Finland Biosanitary Research Institute of Granada(Ibs.Granada) Granada 18012Spain CIBERFES Instituto de Salud CarlosⅢMadrid 28029Spain Endocrinology and Nutrition Service University Hospital San CecilioGranada 18016Spain Nuclear medicine Service "Virgen de las Nieves"University HospitalGranada 18014Spain

Purpose:The present work examines the associations of dietary habits,sedentarism,physical activity(PA)levels and sleep habits,with thyroid function in young euthyroid ***:A total of 105 young euthyroid adults participated in this cross-sectional *** function was determined in fasting conditions(>6 h).Dietary habits were measured by a food frequency questionnaire and three non-consecutive 24 h recalls,and different dietary intake and patterns were then *** time spent in sedentary,PA levels and sleep habits were objectively measured using a wrist-worn ***:Energy and carbohydrate intake were positively associated with thyroid stimulating hormone(TSH)(β=0.222;R^(2)=0.102;P=0.022 andβ=0.425;R^(2)=0.129;P=0.007,respectively)whereas fat intake was negatively associated with TSH(β=-0.428;R^(2)=0.137;P=0.004).Energy intake was also positively associated with free triiodothyronine(β=0.277;R^(2)=0.137;P=0.004).Further,adherence to the mediterranean diet was negatively related to TSH and free thyroxine(FT4)(β=-0.221;R^(2)=0.113;P=0.020 andβ=-0.268;R^(2)=0.071;P=0.007,respectively).Vigorous-intensity and overall PA were negatively associated with FT4(β=-0.227;R^(2)=0.052;P=0.022 andβ=-0.204;R^(2)=0.042;P=0.041,respectively).In contrast,no associations were found between sleep parameters and thyroid ***:Lifestyle factors such as dietary intake and PA levels seems to be related to thyroid function even in young euthyroid adults.

关键词： Thyroid hormones Dietary intake Sleep Physical activity Euthyroid

Audio Enhancement for Computer Audition—An Iterative Training Paradigm Using Sample Importance

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Journal of Computer Science & Technology 2024年第4期39卷 895-911页

作者： manuel milling Shuo Liu Andreas Triantafyllopoulos Ilhan Aslan Björn W.Schuller Chair of Embedded Intelligence for Health Care and Wellbeing University of AugsburgAugsburg 86159Germany Chair of Health Informatics München rechts der IsarTechnical University of MunichMunich 81675Germany munich Center for machine Learning Munich 80333Germany Huawei Technologies MunichMunich 80992Germany munich Data Science Institute Garching 85748Germany Group on Language Audio and MusicImperial College LondonLondon SW72AZU.K.

Neural network models for audio tasks,such as automatic speech recognition(ASR)and acoustic scene classification(ASC),are susceptible to noise contamination for real-life *** improve audio quality,an enhancement module,which can be developed independently,is explicitly used at the front-end of the target audio *** this paper,we present an end-to-end learning solution to jointly optimise the models for audio enhancement(AE)and the subsequent *** guide the optimisation of the AE module towards a target application,and especially to overcome difficult samples,we make use of the sample-wise performance measure as an indication of sample *** experiments,we consider four representative applications to evaluate our training paradigm,i.e.,ASR,speech command recognition(SCR),speech emotion recognition(SER),and *** applications are associated with speech and nonspeech tasks concerning semantic and non-semantic features,transient and global information,and the experimental results indicate that our proposed approach can considerably boost the noise robustness of the models,especially at low signal-to-noise ratios,for a wide range of computer audition tasks in everyday-life noisy environments.

关键词： audio enhancement computer audition joint optimisation multi-task learning voice suppression

A Chopper Negative-R Delta-Sigma ADC for Audio mEmS Sensors

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Computer modeling in Engineering & Sciences 2022年第2期130卷 607-631页

作者： Jamel Nebhen Pietro m.ferreira College of Computer Engineering and Sciences Prince Sattam bin Abdulaziz UniversityAlkharj11942Saudi Arabia Universit´e Paris-Saclay Centrale SupelecCNRSLaboratory de G´enie Electrique et Electronique de ParisGif-sur-Yvette91192France Sorbonne Universite CNRSLab.de Genie Electrique et Electronique de ParisParis75252France

This paper presents a proposed low-noise and high-sensitivity Internet of Thing(IoT)system based on an m&NEmS *** IoT device consists of an m&NEmS resistive accelerometer associated with an electronic readout circuit,which is a silicon nanowire and a Continuous-Time(CT)△∑*** first integrator of the△∑ADC is based on a positive feedback DC-gain enhancement two-stage amplifier due to its high linearity and low-noise *** mitigate both the offset and 1/f noise,a suggested delay-time chopper negative-R stabilization technique is applied around the first integrator.A 65-nm CmOS process implements the CT△∑*** supply voltage of the CmOS circuit is 1.2-V while 0.96-mW is the power consumption and 0.1-mm^(2) is the silicon *** m&NEmS microphone and△∑ADC complete circuit are fabricated and *** a working frequency bandwidth of 20-kHz,the measurement results of the proposed IoT system reach a signal to noise ratio(SNR)of ***,it has a measured dynamic range(DR)of 108-dB and a measured signal to noise and distortion ratio(SNDR)of 101.3-dB.

关键词： m&NEmS sensor △∑ ADC chopper negative-R IoT 1/f noise SNR

The challenging management of malignant ureteral obstruction:Analysis of a series of 188 cases

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Current Urology 2024年第1期18卷 34-42页

作者： alberto Artiles medina Inés Laso García Fernando González Tello Sara Álvarez Rodríguez manuel Hevia Palacios marina mata Alcaraz César mínguez Ojeda Fernando Arias Funez Victoria Gómez Dos Santos Francisco Javier Burgos Revilla Department of Urology Hospital Universitario Ramón y CajalMadridSpain Department of Radiology Hospital Universitario Ramón y CajalMadridSpain

Background:malignant ureteral obstruction(mUO)is a common condition that complicates the course of advanced *** aims of this study are to analyze the causes,management,and survival of patients with obstructive nephropathy due to malignant ureteric obstruction and to determine prognostic ***,we studied the complications and outcomes in patients who underwent urinary *** and methods:A retrospective study was conducted on patients with computed tomography-confirmed mUO between January 2016 and November ***,clinical,radiological,laboratory,and management data were *** curves were estimated using the Kaplan-meier method,and univariate and multivariate Cox proportional hazards models were used to test the association between parameters and ***:A total of 188 patients were *** mean age was 69.01 years(SD,14.95 years),and the majority(54.8%)were *** most common mechanism leading to mUO was compression by a pelvic mass(36.9%),and the 3 most frequent tumors causing mUO were prostate(17.6%),bladder(16.5%),and rectal cancer(11.7%).Forty-seven patients(25%)underwent urinary diversion:23(48.9%)underwent double-J stenting and 21(44.7%)underwent percutaneous *** most common reason for urinary diversion was acute kidney injury(53.3%).Recovery of renal function was observed in 55.8%of the patients after urinary *** most frequently identified complications after urinary diversion were urinary tract infection(24.4%),hematuria(17.0%),and urinary sepsis(14.9%).The median survival after hydronephrosis diagnosis was 6.43 months(interquartile range,1.91-14.81 months).In patients who underwent urinary decompression,the median survival after urinary diversion was 8.67 months(interquartile range,2.99-17.28 months).In the multivariate analysis,a lower grade of hydronephrosis and cancer cachexia negatively impacted ***:Cancer patients with mUO have a poor pro

关键词： Hydronephrosis Ureteral obstruction Neoplasms Urinary diversion Survival Prognosis

Verdier quotients of homotopy categories of rings and Gorenstein-projective precovers

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Science China mathematics 2024年

作者： manuel Cortés-Izurdiaga Departamento de matemática Aplicada Universidad de Málaga

Let R be a ring, Proj be the class of all the projective right R-modules, K be the full subcategory of the homotopy category K(Proj) whose class of objects consists of all the totally acyclic complexes, and morK be the class of all the morphisms in K(Proj) whose cones belong to K. We prove that if K(Proj) has enough morK-injective objects, then the Verdier quotient K(Proj)/K has small Hom-sets, and this last condition implies the existence of Gorenstein-projective precovers in mod-R and of totally acyclic precovers in C(mod-R).

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