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Left and right ventricular diastolic dysfunction and diastolic heart failure: does one lead to the other?

Journal of Geriatric Cardiology 2009年第1期6卷 3-10页

作者： Faramarz tehrani Anita Phan Ernst R. Schwarz Division of Cardiology Department of Medicine Cedars-Sinai Medical Center and University of California Los Angeles Los Angeles California Division of Cardiology Department of Medicine Cedars-Sinai Medical Center and University of California Los Angeles Los Angeles California Division of Cardiology Department of Medicine Cedars-Sinai Medical Center and University of California Los Angeles Los Angeles California

Background and Objective Diastolic dysfunction of the left ventricle is a mechanical abnormality diagnosed primarily by echocardiogram, and can be distinguished into three separate degrees based on the severity of reduction in passive compliance and active myocardial relaxation. Methods A literature search was performed for basic science studies, clinical studies and major practice guidelines on the subject of diastolic dysfunction and diastolic heart failure. Important findings were analyzed and correlated with regard to clinical relevance. Results Left ventricular diastolic dysfunction appears to compromise exercise tolerance and is believed to contribute to the pathophysiology in patients with diastolic heart failure. In the clinical setting, however, oftentimes no clear distinction is made between echocardiographically diagnosed diastolic dysfunction and diastolic heart failure, and adequate treatment recommendations are sparse and aimed to prevent worsening and progression of clinical symptoms. To date, there is a lack of high powered trials assessing the possible progression rate from echocardiographically diagnosed diastolic dysfunction to the clinical diagnosis of diastolic heart failure. Furthermore, there are no solid indices to assess the degree of severity of diastolic dysfunction or its progression. Pure right ventricular diastolic dysfunction appears to be even less understood and under-recognized, although it may play a role in the development of both right and left heart failure. Currently there are few but interesting data on the possible interaction between ventricles with diastolic dysfunction and the overall affect on the development of heart failure. Conclusions The timeline and progression of diastolic dysfunction to diastolic heart failure have not been well established and warrant further investigation.

关键词： Diastolic dysfunction diastolic heart failure left ventricular dysfunction heart failure cardiomyopathy

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Prevalence and risk factors of avian influenza H9N2 among backyard birds in Iran in 2015

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Asian Pacific Journal of Tropical Medicine 2019年第12期12卷 559-564页

作者： Mohammad Hossein Fallah Mehrabadi Arash Ghalyanchilangeroudi Mohammad Hasan Rabiee Farshad tehrani Razi Vaccine and Serum Research Institute Agricultural ResearchEducation and Extension Organization(AREEO)TehranIran Department of Microbiology and Immunology Faculty of Veterinary MedicineUniversity of TehranTehranIran Division of Epidemiology&Zoonosis Department of Food Hygiene&Quality ControlFaculty of Veterinary MedicineUniversity of TehranTehranIran Department of Health and Management of Poultry Diseases Iranian Veterinary OrganizationTehranIran

Objective: To investigate the prevalence and the risk factors of H9 N2 avian influenza among backyard birds in Iran between October and November 2015. Methods: In this study, a total of 15 500 blood samples and 2 884 cloacal swab samples of backyard birds were collected in villages of Iran between October and November 2015. Then, serum samples were examined with the hemagluttination inhibition test and cloacal swab samples were pooled together and examined by RT-PCR. The samples that had serological titer ≥ 4(log2) and villages that had at least one seropositive sample were considered ***: Out of 559 villages, 526(94.10%) were seropositive for the infection. Among 15 500 serum samples, 7 468(48.18%) samples were seropositive for the infection. The seroprevalence according to species was 54.02% among chickens, 17.59 % among ducks, 18.73% among turkeys, 84.21% among pigeons and 12.15% among ostriches, partridges and pheasants. Based on molecular test, 3.04% villages were positive. The seroprevalence in hot and humid area was less than that in cold and humid area(P<0.05).Conclusions: H9 N2 avian influenza has high seroprevalence among backyard birds of Iran. Therefore, preventive measures such as biosecurity Practices and monitoring should be applied to reduce the prevalence.

关键词： Influenza H9N2 Iran Backyard birds

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The research and development on the antioxidants in prevention of diabetic complications

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Asian Pacific Journal of Tropical Medicine 2016年第9期9卷 801-808页

作者： Mohammad Rahimi-Madiseh Afsaneh Malekpour-tehrani Mahmoud Bahmani Mahmud Rafieian-kopaei Medical Plants Research Center Shahrekord University of Medical Sciences Department of Social Medicine Shahrekord University of Medical Sciences Faculty of Medicine and Clinical Microbiology Research Center

Diabetes mellitus can damage the eyes,kidneys,nerves and *** and macrovascular disorders are the leading causes of morbidity and mortality in diabetic *** can increase the indicators of lipid peroxidation and oxidative stress in which free radicals have the main role in the pathogenesis of these ***,antioxidants which combat oxidative stress should be able to prevent and repair free radicals induced *** free radicals contribute to kidney damage,atherosclerosis,diabetes,heart disease,nephrotoxicity and hepatotoxicity; however,clinical trials do not uniquely confirm a substantial impact on diabetic *** seems that antioxidants in vegetables,fruits and grains help preventing diabetes complications; however,there is little evidence that taking single antioxidants such as vitamin E or vitamin C protect these *** findings about combination antioxidants are also complicated and not entirely *** this review paper we tried to present the role of oxidative stress on microvascular complications of type2 diabetes *** objective of this paper is to review the new findings about the role of various antioxidants on prevention and treatment of diabetes mellitus as well as its complications including retinopathy,nephropathy and neuropathy.

关键词： Diabetic Nephropathy Natural antioxidants Diabetes complications Nephropathy Neuropathy Retinopathy

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Synthesis and antibacterial activity of Schiff bases of 5-substituted isatins

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Chinese Chemical Letters 2016年第2期27卷 221-225页

作者： Kamaleddin Haj Mohammad Ebrahim tehrani Maryam Hashemi Maryam Hassan Farzad Kobarfard Shohreh Mohebbi Department of Medicinal Chemistry School of PharmacyZanjan University of Medical SciencesZanjanlran Department of Pharmaceutical Biotechnology School of PharmacyZanjan University of Medical SciencesZanjanIran Department of Medicinal Chemistry School of PharmacyShahid Beheshti University of Medical SciencesTehranIran Phytochemistry Research Center Shahid Beheshti University of Medical SciencesTehranIran

Based on the existing reports on the bioactive isatin derivatives, a number of Schiff bases were synthesized by reacting 5-substituted isatins with bioactive amines/hydrazides and their structures were confirmed using spectroscopic methods such as NMR, IR and mass spectrometry. Furthermore, Nbenzylation of isatin followed by the Schiff base formation furnished a new series of compounds（11a-13c） which allowed the analysis of the effect of isatin N-substitution on the bioactivity of the resulting compounds. The antibacterial activity of the synthesized derivatives was evaluated using a microtiter plate method on a series of gram positive and gram negative bacterial strains. Compounds 2d, 3b, 5c and 6a were among the most potent derivatives against Pseudomonas aeruginosa（MIC = 6.25 μg/m L）.Analysis of the structure-activity relationship showed that the incorporation of（thio）urea-based Schiff bases lead to more potent derivatives with a broader spectrum of antibacterial activity. In addition,highly lipophilic compounds such as 11a-12c did not show any measurable antibacterial activity, which implies that an optimal lipophilicity might be an important requirement for the antibacterial activity of the studied isatins. Finally, the finding that hydantoin derivatives of N-benzylisatins（13a-13c） still exhibit some antibacterial activity prompted us to consider exploring the bioactivity of more diverse derivatives of isatin-aminohydantoin Schiff bases（compounds 1a-1d） in our future studies.

关键词： Synthesis Isatin Schiff base Hydantoin Antibacterial

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Nucleon/nuclei polarized structure function,using Jacobi polynomials expansion

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Chinese Physics C 2010年第9期34卷 1534-1537页

作者： A.Mirjalili M.M.Yazdanpanah F.Taghavi-Shahri S.Atashbar tehrani Physics Department Yazd University School of Particles and Accelerators Institute for Research in Fundamental Sciences (IPM) Physics Department Kerman Shahid Bahonar University

We use the constituent quark model to extract polarized parton distributions and finally polarized nucleon structure *** to limited experimental data which do not cover whole （x,Q 2 ） plane and to increase the reliability of the fitting,we employ the Jacobi orthogonal polynomials *** will be possible to extract the polarized structure functions for Helium,using the convolution of the nucleon polarized structure functions with the light cone moment *** results are in good agreement with available experimental data and some theoretical models.

关键词： perturbative QCD nucleon and nuclei structure function jacobi polynomials

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Critical involvement of circular RNAs in virus-associated cancers

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Genes & Diseases 2023年第6期10卷 2296-2305页

作者： Arghavan Zebardast Tayebeh Latifi Moein shirzad Golnaz Goodarzi Saeed Ebrahimi Fana Sadra Samavarchi tehrani Yousef Yahyapour Department of Virology School of Public HealthTehran University of Medical SciencesTehran ***Iran Cellular and Molecular Biology Research Center Health Research InstituteBabol University of Medical SciencesBabol 47176Iran Department of Clinical Biochemistry School of MedicineTehran University of Medical SciencesTehran ***Iran Student Scientific Research Center Tehran University of Medical SciencesTehran ***Iran Infectious Diseases and Tropical Medicine Research Center Health Research InstituteBabol University of Medical SciencesBabol 47176Iran

Virus-related cancer is cancer where viral infection leads to the malignant transformation of the host's infected cells. Seven viruses (e.g., human papillomavirus (HPV), Epstein–Barr virus (EBV), Kaposi's sarcoma herpesvirus (KSHV), Hepatitis B virus (HBV), Hepatitis C virus (HCV), Human T-lymphotropic virus (HTLV), and Merkel cell polyomavirus (MCV)) that infect humans have been identified as an oncogene and have been associated with several human malignancies. Recently, growing attention has been attracted to exploring the pathogenesis of virus-related cancers. One of the most mysterious molecules involved in carcinogenesis and progression of virus-related cancers is circular RNAs (circRNA). These emerging non-coding RNAs (ncRNAs), due to the absence of 5′ and 3′ ends, have high stability than linear RNAs and are found in some species across the eukaryotic organisms. Compelling evidence has revealed that viruses also encode a repertoire of circRNAs, as well as dysregulation of these viral circRNAs play a critical role in the pathogenesis and progression of different types of virus-related cancers. Therefore, understanding the exact role and function of the virally encoded circRNAs with virus-associated cancers will open a new road for increasing our knowledge about the RNA world. Hence, in this review, we will focus on emerging roles of virus-encoded circRNAs in multiple cancers, including cervical cancer, gastric cancer, Merkel cell carcinoma, nasopharyngeal carcinoma, Kaposi cancer, and liver cancer.

关键词： Cancer Circular RNA Neoplasms Oncogenes Viruses

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Healthy ranges of serum alanine aminotransferase levels in Iranian blood donors

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World Journal of Gastroenterology 2003年第10期9卷 2322-2324页

作者： Mehdi Mohamadnejad Akram Pourshams Reza Malekzadeh Ashraf Mohamadkhani Afsaneh Rajabiani Ali Ali Asgari Seyed Meysam Alimohamadi Hadi Razjooyan mansooreh Mamar-Abadi Digestive Disease Research Center Tehran University of Medical SciencesTehranIran Department of Pathology School of MedicineTehran University of Medical SciencesTehranIran

AIM: The healthy ranges for serum alanine aminotransferase(ALT) levels are less well studied. The aim of this study was to define the upper limit of normal (ULN) for serum ALT levels, and to assess factors associated with serum ALT activity in apparently healthy blood donors. METHODS: A total of 1 939 blood donors were *** measurements were performed for all cases using the same laboratory method. Healthy ranges for ALT levels werecomputed from the population at the lowest risk for liver disease. Univariate and multivariate analyses were performed to evaluate associations between clinical factors and ALT ***: Serum ALT activity was independently associated with body mass index (BMI) and male gender, but not associated with age. Association of ALT with BMI was more prominent in males than in females. Upper limit of normal for non-overweight women (BMI of less than 25) was 34 U/L,and for non-overweight men was 40 U/***: Serum ALT is strongly associated with sex and BMI. The normal range of ALT should be defined for male and female separately.

关键词： Adolescent Adult Age Distribution Aged Alanine Transaminase Blood Donors Body Mass Index Chemistry, Clinical numerical data Child Female Humans Iran Logistic Models Male Middle Aged Reference Values Sex Distribution

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Fatty liver index vs waist circumference for predicting non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2016年第10期22卷 3023-3030页

作者： Nima Motamed Masoudreza Sohrabi Hossein Ajdarkosh Gholamreza Hemmasi mansooreh Maadi Fatemeh Sima Sayeedian Reza Pirzad Khadijeh Abedi Sivil Aghapour Mojtaba Fallahnezhad Farhad Zamani Department of Social Medicine Zanjan University of Medical Sciences Zanjan 45154 Iran Gastrointestinal and Liver Disease Research Center Iran University of Medical Sciences Tehran 159347 Iran Department of Endocrinology Sari University of Medical Sciences Tehran 159347 Iran Razi Science Researchers Institute Karaj 31976 Iran

AIM: To determine the discriminatory performance of fatty liver index (FLI) for non-alcoholic fatty liver disease (NAFLD).METHODS: The data of 5052 subjects aged over 18 years were analyzed. FLI was calculated from body mass index, waist circumference (WC), triglyceride, and gamma glutamyl transferase data. Logistic regression analysis was conducted to determine the association between FLI and NAFLD. The discriminatory performance of FLI in the diagnosis of NAFLD was evaluated by receiver operating characteristic analysis. Area under the curves (AUCs) and related confidence intervals were estimated. Optimal cutoff points of FLI in the diagnosis of NAFLD were determined based on the maximum values of Youden’s ***: The mean age of men and women in the study population were 44.8 ± 16.8 and 43.78 ± 15.43, respectively (P = 0.0216). The prevalence of NAFLD was 40.1% in men and 44.2% in women (P < 0.0017). FLI was strongly associated with NAFLD, so that even a one unit increase in FLI increased the chance of developing NAFLD by 5.8% (OR = 1.058, 95%CI: 1.054-1.063, P < 0.0001). Although FLI showed good performance in the diagnosis of NAFLD (AUC = 0.8656 (95%CI: 0.8548-0.8764), there was no significant difference with regards to WC (AUC = 0.8533, 95%CI: 0.8419-0.8646). The performance of FLI was not significantly different between men (AUC = 0.8648, 95%CI: 0.8505-0.8791) and women (AUC = 0.8682, 95%CI: 0.8513-0.8851). The highest performance with regards to age was related to the 18-39 age group (AUC = 0.8930, 95%CI: 0.8766-0.9093). The optimal cutoff points of FLI were 46.9 in men (sensitivity = 0.8242, specificity = 0.7687, Youden’s index = 0.5929) and 53.8 in women (sensitivity = 0.8233, specificity = 0.7655, Youden’s index = 0.5888).CONCLUSION: Although FLI had acceptable discriminatory power in the diagnosis of NAFLD, WC was a simpler and more accessible index with a similar performance.

关键词： Non-alcoholic fatty liver disease Fatty liver index Waist circumference Body mass index Optimal cutoff points Discriminatory performance

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Effect of sex and rearing system on the quality and mineral content of fiber from raeini cashmere goats

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Journal of Animal Science and Biotechnology 2012年第3期3卷 160-165页

作者： Mehrdad Shamsaddini-Bafti Mahnaz Salehi Ali Maghsoudi Ali Mostafa tehrani Farhad Mirzaei Syed Mojtaba Syed Momen Razi Vaccine&Serum Research Institute Kerman Branch 76175KermanIran Animal Science Research Institute of Iran Dehghan Villa 31585KarajIran Department of Agriculture Faculty of Animal ScienceTarbiat Modares University TehranIran 不详

The aim of this study was to compare the quality characteristics and mineral content of the fiber from male and female cashmere goats raised under different management systems. Male and female Raeini cashmere goats （〈1.5 years of age, n=48） were selected from flocks raised at a government breeding station or raised commercially under either rural or nomadic conditions. The staple length, cashmere fiber diameter, coefficient of variation for fiber diameter, percentage of cashmere in a fleece, percentage of guard hair in a fleece and cashmere tenacity averaged 4.6 ±0.1 cm, 18.0 ±0.1 um, 20.9±0.4%, 66.1 ± 1.5%, 33.8± 1.5% and 1.8±0.2 gf/tex, respectively. The sulfur, copper and zinc content of the cashmere averaged 2.8 ± 0.1%, 0.00065 ± 0.00002% and 0.01276 ± 0.00025%, respectively. Rearing method significantly affected staple length, coefficient of variation of fiber diameter, cashmere tenacity and copper content. Males had a higher coefficient of variation of fiber diameter and cashmere tenacity than females （P 〈 0.05）.

关键词： cashmere fiber mineral contents Raeini goat

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Can Social Media be Used to Control Academic Stress?An Application of the Theory of Planned Behavior

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International Journal of Mental Health Promotion 2022年第1期24卷 25-38页

作者： Maliheh Shadi Nooshin Peyman Ali Taghipour Alireza Jafari Hadi tehrani Department of Health Education&Health Promotion School of HealthStudent Research CommitteeMashhad University of Medical SciencesMashhad13131-99137Iran Health Education&Health Promotion Social Determinants of Health Research CenterMashhad University of Medical SciencesMashhad13131-99137Iran Epidemiology Social Determinants of Health Research CenterMashhad University of Medical SciencesMashhad13131-99137Iran Social Determinants of Health Research Center Gonabad University of Medical SciencesGonabadIran

The present study was conducted aiming at investigating the effect of social media-based intervention according to the Theory of Planned Behavior(TPB)to control the academic stress of the *** study comes in two descriptive and quasi-experimental sections in the Academic Year *** order to determine the effect of planned behavioral constructs on stress levels,the descriptive study was conducted on 320 *** quasiexperimental study was organized to determine the effect of a social media-based educational intervention on the TPB on 180 *** collection was conducted through questionnaires of personal information,Gadzella’s Student-Life Stress Inventory,and researcher-made questionnaire based on the TPB,with a confirmed validity and *** predicted 15.1%of the variance of academic stress among students and the perceived behavioral control construct had the most significant effect(p<0.001).The mean score of knowledge and subject norms in the experimental group was significantly increased during the study(p<0.05).The social media intervention could reduce the students’academic stress to some extent and lead to the student’s subject norms development.

关键词： Academic stress social media students

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