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Effect of aqueous extract of Murraya koenigii on haematological,hormonal and lipid profile of Albino rats

Journal of Coastal Life Medicine 2015年第11期 901-905页

作者： Sushmita Choudhury manoranjan prasad sinha Department of Zoology Ranchi UniversityRanchi 834008India

Objective:To investigate the effect of aqueous extract of Murraya koenigii leaves on some haematological,hormonal and serum lipid parameters in ***:We evaluated whether oral administration of Murraya koenigii affected the haematological,hormonal and lipid *** 7 days of oral administration of 250 mg/kg and 500 mg/kg body weight,other profiles were ***:The results showed that the extract administered significantly increased(P<0.05)packed cell volume,haemoglobin concentration,red blood cell,mean corpuscular hemoglobin,mean corpuscular hemoglobin concentration,mean corpuscular volume and decreased the platelet count(P<0.05)at the dose of 250 mg/kg and 500 mg/kg body weight when compared with *** extract significantly increased(P<0.05)white blood cell count at all doses administered when compared with *** showed that thyronine and thyroxine were increased,while thyroid stimulating hormone was decreased significantly(P<0.05)at high doses *** recorded data in the present study showed that the testosterone value was reduced significantly(P<0.05)from control *** the extract significantly reduced(P<0.05)the total cholesterol concentration and low density lipoproteins cholesterol concentration in the serum while it had no significant effect on serum high density lipoprotein cholesterol concentration at all doses ***:This study suggests that the extracts may have beneficial effect on serum cholesterol concentration,can act as a stimulant to thyroid functions as well as in anemia and immunity dependent disorders and also as a potent contraceptive.

关键词： Murraya koenigii Haematological Hormonal Serum lipid

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Morbidity Profile and Causes of Mortality in Type 2 Diabetes Patients: Data from a Tertiary Teaching Hospital from Eastern India

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Journal of Diabetes Mellitus 2017年第3期7卷 195-211页

作者： Soumya Ranjan Behera manoranjan Behera Sidhartha Das Bhabani prasad Panda Saroj Kumar Tripathy Purna Chandra Dash Department of Medicine VSS Institute of Medical Sciences and Research Burla Sambalpur Odisha India PG Department of Medicine Faculty of Medicine Sriram Chandra Bhanja Medical College Cuttack Odisha India PG Department of Medicine Sriram Chandra Bhanja Medical College Cuttack Odisha India

Background: Data regarding the prevalence of morbidity and mortality in patients of Type 2 Diabetes Mellitus (T2DM) is scanty in India. Objectives: To determine the prevalence of micro and macro vascular complications, acute metabolic complications, infections, Non Alcoholic Fatty Liver Disease (NAFLD) and cause of mortality in T2DM patients admitted to a tertiary care teaching hospital in Eastern India. Material and Methods: This was a hospital-based prospective study evaluating 150 T2DM patients admitted to a tertiary care institution in Eastern India. Diagnosis of micro and macro vascular complications, infections and NAFLD was made using standard protocols. In case of death, the most probable cause was noted. Results: Out of 150 patients, 14.7% of patients were newly diagnosed T2DM and out of them 41% of patients had vascular complications and 54.5% had infections. Of the total patients, 56% had nephropathy, 20% neuropathy, 17.3% retinopathy, 31.3% CVD, 11.3% CAD, 4.6% acute metabolic complications, 44% infections and 16.6% had NAFLD respectively. Macrovascular events occured earlier than microvascular complications. Multiple logistic regression analysis showed strong association of age, duration of diabetes, serum cholesterol, triglyceride, LDL-C with retinopathy (Regression coefficient β: -0.1086807, 0.4127152, -0.0513393, 0.0146429, 0.0587475;p < 0.05, < 0.001, < 0.05, < 0.05, < 0.05 respectively), while only duration of diabetes was strongly associated with nephropathy and neuropathy (Regression coefficient β: 0.2538751, 0.2261636;p < 0.001 for each). Increasing age was associated with CAD (Regression coefficient β: 0.055392;p β: 0.0055014;p 18.6% patients died due to diabetes related complications. Cardiovascular (CV)-related deaths (CVD+CAD) were most common cause (51.5%: CVD 36.4%, CAD 15.1%) to be followed by infections (27.3%) and then chronic kidney disease (12.1%). Conclusions: This study highlights the high prevalence of vascular complications and in

关键词： Type 2 Diabetes Mellitus Vascular Complications Infections NAFLD Mortality

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