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A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity

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Cellular & Molecular Immunology 2021年第2期18卷 318-327页

作者： Vincent Legros Solène Denolly manon vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto CIRI–Centre International de Recherche en Infectiologie Team EVIRUniv LyonUniversitéClaude Bernard Lyon 1InsermU1111CNRSUMR5308ENS Lyon46 allée d’ItalieF-69007LyonFrance Universitéde Lyon VetAgro SupMarcy-l’ÉtoileFrance Department of Infectious Agents and Hygiene University-Hospital of Saint-EtienneSaint-EtienneFrance Department of Immunology University-Hospital of Saint-EtienneSaint-EtienneFrance CIRI–Centre International de Recherche en Infectiologie Team GIMAPUniv LyonUniversitéClaude Bernard Lyon 1InsermU1111CNRSUMR5308ENS Lyon46 allée d’ItalieF-69007LyonFrance Department of Infectious Diseases University-Hospital of Saint-EtienneSaint-EtienneFrance Department of Occupational Medicine University-Hospital of Saint-EtienneSaint-EtienneFrance Department of Intensive Care and Resuscitation(Réanimation G) University-Hospital of Saint-EtienneSaint-EtienneFrance Laboratoire Interuniversitaire de Biologie de la Motricité Universitéde LyonUniversitéJean MonnetSaint-EtienneFrance Department of Anesthesiology and Critical Care University-Hospital of Saint-EtienneSaint-EtienneFrance

Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for *** this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive *** show that nAb titers correlated strongly with disease severity and with anti-spike IgG ***,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low *** found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other ***,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against ***,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization ***,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted.

关键词： Antibody Pathogenesis Humoral response COVID-19 SARS-CoV-2v

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COVID-19 patient experiences in prehospital pathways:a processual approach using life-events calendar method and state sequence analysis shows detrimental delays

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Family Medicine and Community Health 2024年第1期12卷 45-56页

作者： Romain Lutaud Sebastien Cortaredona Lea Delorme Patrick Peretti-watel Juliette Mirouse manon Borg Lucie Cattaneo Didier Thery Gaetan Gentile Christian Pradier Touitou Irit Philippe Brouqui Sophie Tardieu Michel Carles Stéphanie Gentile Department of General Practice Aix-Marseille UniversityMarseilleFrance ADES MarseilleFrance Institut de Recherche pour le Développement(IRD) MarseilleFrance Assistance Publique-Hôpitaux de Marseille(AP-HM) MarseilleFrance INSERM MarseilleFrance Department of Public Health Archet University HospitalNiceFrance MEPHI MarseilleFrance CEReSS-Health Service Research and Quality of life Center MarseilleFrance Department of Infectious Diseases Centre Hospitalier Universitaire de NiceNiceFrance

Objectives To our best knowledge,no study in France has comprehensively investigated the prehospital history of patients admitted for severe cases of COVID-19.‘Patients’voice is an excellent means to capture data on primary care *** aimed to identify clusters of COVID-19 hospitalised patients with similar prehospital symptom sequences,and to test whether these clusters were associated with a higher risk of poor clinical *** Cross-sectional online survey using life-event *** All patients hospitalised for COVID-19 between September 2020 and May 2021 in the Infectious Disease Departments in Nice and in Marseilles in *** 312 patients responded to the *** outcome measures From the day of symptom onset to the day of hospitalisation,we defined a symptom sequence as the time-ordered vector of the successive symptom grades(grade 1,grade 2,grade 3).State sequence analysis with optimal matching was used to identify clusters of patients with similar symptom *** logistic regressions were performed to test whether these clusters were associated with admission to intensive care unit(ICU)and COVID-19 sequelae after *** Three clusters of symptom sequences were identified among 312 complete prehospital pathways.A specific group of patients(29%)experienced extended symptoms of severe COVID-19,persisting for an average duration of 7.5 days before *** group had a significantly higher probability of being admitted to ICU(adjusted OR 2.01).They were less likely to know a loved one who was a healthcare worker,and more likely to have a lower level of ***,this group of patients,who were more likely to have previously visited the emergency room without exhibiting severe symptoms at that time,may have been inclined to postpone reassessment when their health *** relatives played a decisive role in their *** and relevance This study h

关键词： admitted likely life

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Development and Evaluation of The Implementation of a Preceptorship Program for The Novice ICU Nurse Intensive Care Unit -A Secondary Publication

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Journal of Clinical and Nursing Research 2024年第3期8卷 158-175页

作者： Annie Perron manon Champagne Abir El-Haouly University of Quebec in Abitibi-Témiscamingue Rouyn-NorandaQC J9X 5E4Canada

This study focused on the development and evaluation of the implementation of a preceptorship program adapted to ICU practice in the Ab.-*** to provide preceptors with tools to support novice *** action research was made possible with the involvement of the centers,preceptors,and novice nurses throughout the development and implementation of the *** approach enabled participants to take ownership of the training content and fully utilize various *** program was implemented throughout the CISSS,where this study was subsequently carried *** novices mentioned that the program reinforced their sense of security and made them feel more equipped to handle complex care *** preceptors said they were better equipped to offer clinical support and novices were better prepared to work in the *** is important to evaluate the development of the novice nurses’skills following their participation in this program and the long-term impact of this preceptorship.

关键词： Preceptorship program Intensive care unit Novice ICU nurses

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Spherical Tropical Geometry:a Survey of Recent Developments

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Acta Mathematica Sinica,English Series 2018年第3期34卷 454-465页

作者： Kiumars KAVEH Christopher manon Department of Mathematics University of PittsburghPittsburghPAUSA Department of Mathematics Univcrsity of KentuckyLexingtonKYUSA

This is a survey of some recent results on spherical tropical geometry.

关键词： Tropical geometry reductive group action spherical variety Grbner theory

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Spinal Analgesia with Intrathecal Morphine versus Conventional Analgesia after Laparoscopic Colectomy: A Retrospective Cohort Study

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Open Journal of Anesthesiology 2024年第7期14卷 159-174页

作者： Lionel Diyamona manon Colin Marc Léone Laurent Zieleskiewicz Joseph Nsiala Wilfrid Mbombo Rachel Mbala Bruno Pastene Chris Nsituavibidila Dan Kankonde Gracia Likinda Jean Claude Mubenga Khazy Anga Noelly Mukuna Christel Isengingo Department of Anaesthesia and Intensive Care University Clinics of Kinshasa University of Kinshasa Kinshasa Democratic Republic of the Congo Department of Anaesthesia and Intensive Care Marseilles Nord Hospital Marseille France General Hospital of Kinshasa ex Mama Yemo Kinshasa Democratic Republic of the Congo Department of Anaesthesia and Intensive Care Monkole Hospital Centre Kinshasa Democratic Republic of the Congo

Objective: Postoperative pain (POP) following abdominal surgery can vary from a few hours to several days. This acute, unrelieved pain can become chronic, requiring patients to take analgesics on an almost daily basis for comfort. Analgesia using general opioids has many side effects and intrathecal morphine is a good alternative. This study was conducted to evaluate the efficacy of intrathecal morphine (ITM) versus conventional analgesia in the management of postoperative pain in colectomy performed by laparoscopic surgery. Methods: Cohort study conducted at the Hôpital Nord in Marseille, from 01 January to 31 July 2021 in patients aged at least 18 years undergoing anaesthesia for scheduled colectomy by laparoscopic surgery. The primary endpoint was postoperative pain intensity and the secondary endpoints were morphine consumption, treatment side effects and length of hospital stay. Statistical analysis was performed using XLSTAT software. Results: We included 193 patients: 131 in the control group (conventional analgesia) and 62 in the ITM group. We observed: a significant decrease in pain (assessed by numerical scale) in favour of the ITM group in the post-anaesthetic care room, i.e. 3 (±4) vs 1 (±2), p 0 and H2: 2 (±2) vs. 1 (±2);p Conclusion: These results suggest that intrathecal morphine (ITM) in laparoscopic colectomy provides effective postoperative analgesia with low morphine consumption, and a reduction in morphine side-effects compared with conventional analgesia.

关键词： Intrathecal Morphine Colectomy Laparoscopy Conventional Analgesia

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几何竞赛,AI逼近人类天才

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环球科学 2024年第9期 44-49页

作者：玛农·比肖夫陶兆巍(译) 不详

国际数学奥林匹克竞赛可能是最高难度的高中数学竞赛,所有参赛者都是中的夜夜者。最近,一位“硅基”44“碳基生命”AI选手在几何题上的表现似乎已逼近人类天才。国际数学奥林匹克竞赛(IMO)可能是世界上最著名的高中数学竞赛。每年,世界... 详细信息

国际数学奥林匹克竞赛可能是最高难度的高中数学竞赛,所有参赛者都是中的夜夜者。最近,一位“硅基”44“碳基生命”AI选手在几何题上的表现似乎已逼近人类天才。国际数学奥林匹克竞赛(IMO)可能是世界上最著名的高中数学竞赛。每年,世界各地的学生都会竞争他们梦寐以求的IMO奖牌。

关键词：高中数学竞赛 IMO 几何题 AI 参赛者国际数学奥林匹克竞赛奖牌逼近

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Investigation of operational parameters for an industrial CFB combustor of coal,biomass and sludge

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China Particuology 2007年第4期5卷 247-254页

作者： manon Van de Velden Jan Baeyens Bill Dougan Alan McMurdo Department of Chemical Engineering University of Birmingham B15 2TT Birmingham United Kingdom UPM-Kymmene Caledonian Paper Ltd.AyrUnited Kingdom

The combustion of coal and/or biomass （sludge, wood waste, RDF, etc.） in a circulating fluidized bed has been a commercial topper for over 20 years, and references to principles and applications are numerous and widespread although few data are presented concerning the operation of large scale CFB-units. The authors studied the CFB-combustion at UPM-Kymmene （Ayr）, a major paper mill relying for its steam production upon the combustion of coal （80-85 %）, wood bark （5-10%） and wastewater treatment sludge （5-10%）. The maximum capacity of the CFB is 58 MWth. A complete diagnostic of the operation was made, and additional tests were performed to assess the operating mode. The plant schematics, relevant dimensions and process data are given. To assess the operation of the UPM-CFB, it is important to review essential design parameters and principles of CFB combustors, which will be discussed in detail to include required data, heat balance and flowrates, operating versus transport velocity, kinetics and conversion （including the possible effect of the Bouduard reaction if carbon is present）. Since the residence time in the riser and the cyclone efficiency determine the burnout of circulating fuel-particles, the UPM-CFB was subjected to a stimulus response technique using nickel oxide as tracer. Results illustrate the efficiency of the cyclone separation and the number of recycle loops for particles of a given size. Results will also be used to assess the cyclone operation and efficiency and to comment upon expected and measured carbon conversion.

关键词： Circulating fluidized bed Combustion Coal Biomass Operation Cyclone

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Cabozantinib and the moving field of systemic treatments in advanced hepatocellular carcinoma

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Hepatobiliary Surgery and Nutrition 2019年第1期8卷 53-55页

作者： manon Allaire Jean Charles Nault Service d’hépato-gastroentérologie et de nutrition CHU Cote de NacreCaenFrance UMR 1149 Centre de Recherche sur l’inflammationFacultéde Médecine BichatParisFrance Service d’hépatologie CHU de jean VerdierBondyFrance UMR 1162 Génomique Fonctionnelle des Tumeurs SolidesInstitut National de la Santéet de la Recherche MédicaleParisFrance

Most of patients with hepatocellular carcinoma(HCC),are diagnosed at an advanced-stage explaining the poor prognosis of this cancer with a median survival without treatment around 8 months(1-3).Currently,two systemic multi-kinase inhibitors with anti-proliferative and antiangiogenic effects are available as first line treatments in advanced *** first one,Sorafenib,was the only available systemic treatment available during one decade and was associated with an improvement of overall survival of around 3 months compared to placebo(4,5).The second one,lenvatinib,showed a similar median overall survival compared to Sorafenib in a non-inferiority phase-3 trial(6).No second line was available during several years due to toxicity or absence of efficacy of the different drugs tested in multicentric phase 3 randomized controlled trials.

关键词： hepatocellular treatment drugs

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Hemostasis testing in patients with liver dysfunction: Advantages and caveats

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World Journal of Gastroenterology 2021年第42期27卷 7285-7298页

作者： Guillaume Nguyen manon Lejeune Benjamin Crichi Corinne Frere Department of Hematology Trousseau HospitalAssistance Publique Hôpitaux de ParisParis 75012France Department of Hematology Pitié-Salpêtrière HospitalAssistance Publique Hôpitaux de ParisParis 75013France Department of Internal Medicine Saint-Louis HospitalAssistance Publique Hôpitaux de ParisParis 75010France Inserm UMRS_1166 Institute of Cardiometabolism and NutritionSorbonne UniversitéParis 75013France

Due to concomitant changes in pro-and anti-coagulant mechanisms,patients with liver dysfunction have a“rebalanced hemostasis”,which can easily be tipped toward either a hypo-or a hypercoagulable *** are often faced with the question whether patients with chronic liver disease undergoing invasive procedures or surgery and those having active bleeding require correction of the hemostasis *** coagulation screening tests,such as the prothrombin time/international normalized ratio and the activated partial thromboplastin time have been demonstrated to have numerous limitations in these patients and do not predict the risk of bleeding prior to high-risk *** introduction of global coagulation assays,such as viscoelastic testing(VET),has been an important step forward in the assessment of the overall hemostasis profile.A growing body of evidence now suggests that the use of VET might be of significant clinical utility to prevent unnecessary infusion of blood products and to improve outcomes in numerous *** present review discusses the advantages and caveats of both conventional and global coagulation assays to assess the risk of bleeding in patients with chronic liver disease as well as the current role of transfusion and hemostatic agents to prevent or manage bleeding.

关键词： Hemostasis Bleeding risk Conventional tests Thrombin generation Viscoelastic tests Hemostatic agents

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Missed colorectal cancers in a fecal immunochemical test-based screening program: Molecular profiling of interval carcinomas

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World Journal of Gastrointestinal Oncology 2022年第11期14卷 2195-2207页

作者： manon van der Vlugt Beatriz Carvalho Joelle Fliers Nahid Montazeri Christian Rausch Esmée J Grobbee manon van Engeland manon C W Spaander Gerrit A Meijer Evelien Dekker Department of Gastroenterology and Hepatology Amsterdam University Medical CenterAmsterdam 1105 AZNetherlands Department of Pathology Netherlands Cancer InstituteAmsterdam 1066 CXNetherlands Biostatistics Unit Department of Gastroenterology and HepatologyAmsterdam University Medical CenterAmsterdam 1105 AZNetherlands Department of Gastroenterology and Hepatology Erasmus MC University Medical CenterRotterdam 3015 CNNetherlands Department of Pathology GROW-School for Oncology and Developmental BiologyMaastricht University Medical CenterMaastricht 6202 AZNetherlands

BACKGROUND For optimizing fecal immunochemical test(FIT)-based screening programs,reducing the rate of missed colorectal cancers(CRCs)by FIT(FIT-interval CRCs)is an important *** of the molecular make-up of these missed lesions could facilitate more accurate detection of all(precursor)*** To compare the molecular make-up of FIT-interval CRCs to lesions that are detected by FIT[screen-detected CRCs(SD-CRCs)].METHODS FIT-interval CRCs observed in a Dutch pilot-program of FIT-based screening were compared to a control group of SD-CRCs in a 1:2 ratio,resulting in 27 FIT-interval CRC and 54 *** analyses included microsatellite instability(MSI),CpG island methylator phenotype(CIMP),DNA sequence mutations and copy number alterations(CNAs).RESULTS Although no significant differences were reached,FIT-interval CRCs were more often CIMP positive and MSI positive(33%CIMP in FIT-interval CRCs vs 21%in SD-CRCs(P=0.274);19%MSI in FIT-interval CRCs vs 12%in SD-CRCs(P=0.469)),and showed more often serrated pathway associated features such as BRAF(30%vs 12%,P=0.090)and PTEN(15%vs 2.4%,P=0.063)*** mutations,a classic feature of the adenoma-carcinoma-sequence,were more abundant in SD-CRCs(68%vs 40%in FIT-interval CRCs P=0.035).Regarding CNAs differences between the two groups;FIT-interval CRCs less often showed gains at the regions 8p11.22-q24.3(P=0.009),and more often gains at 20p13-p12.1(P=0.039).CONCLUSION Serrated pathway associated molecular features seem to be more common in FIT-interval CRCs,while classic adenoma carcinoma pathway associated molecular features seem to be more common in *** indicates that proximal serrated lesions may be overrepresented among FITinterval CRCs.

关键词： Fecal immunochemical test-interval colorectal cancer Mutation analysis Colorectal cancer screening Serrated pathway Adenoma-carcinoma pathway

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