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A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity

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Cellular & Molecular Immunology 2021年第2期18卷 318-327页

作者： Vincent Legros Solène Denolly manon vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto CIRI–Centre International de Recherche en Infectiologie Team EVIRUniv LyonUniversitéClaude Bernard Lyon 1InsermU1111CNRSUMR5308ENS Lyon46 allée d’ItalieF-69007LyonFrance Universitéde Lyon VetAgro SupMarcy-l’ÉtoileFrance Department of Infectious Agents and Hygiene University-Hospital of Saint-EtienneSaint-EtienneFrance Department of Immunology University-Hospital of Saint-EtienneSaint-EtienneFrance CIRI–Centre International de Recherche en Infectiologie Team GIMAPUniv LyonUniversitéClaude Bernard Lyon 1InsermU1111CNRSUMR5308ENS Lyon46 allée d’ItalieF-69007LyonFrance Department of Infectious Diseases University-Hospital of Saint-EtienneSaint-EtienneFrance Department of Occupational Medicine University-Hospital of Saint-EtienneSaint-EtienneFrance Department of Intensive Care and Resuscitation(Réanimation G) University-Hospital of Saint-EtienneSaint-EtienneFrance Laboratoire Interuniversitaire de Biologie de la Motricité Universitéde LyonUniversitéJean MonnetSaint-EtienneFrance Department of Anesthesiology and Critical Care University-Hospital of Saint-EtienneSaint-EtienneFrance

Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for *** this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive *** show that nAb titers correlated strongly with disease severity and with anti-spike IgG ***,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low *** found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other ***,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against ***,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization ***,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted.

关键词： Antibody Pathogenesis Humoral response COVID-19 SARS-CoV-2v

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Spinal Analgesia with Intrathecal Morphine versus Conventional Analgesia after Laparoscopic Colectomy: A Retrospective Cohort Study

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Open Journal of Anesthesiology 2024年第7期14卷 159-174页

作者： Lionel Diyamona manon Colin Marc Léone Laurent Zieleskiewicz Joseph Nsiala Wilfrid Mbombo Rachel Mbala Bruno Pastene Chris Nsituavibidila Dan Kankonde Gracia Likinda Jean Claude Mubenga Khazy Anga Noelly Mukuna Christel Isengingo Department of Anaesthesia and Intensive Care University Clinics of Kinshasa University of Kinshasa Kinshasa Democratic Republic of the Congo Department of Anaesthesia and Intensive Care Marseilles Nord Hospital Marseille France General Hospital of Kinshasa ex Mama Yemo Kinshasa Democratic Republic of the Congo Department of Anaesthesia and Intensive Care Monkole Hospital Centre Kinshasa Democratic Republic of the Congo

Objective: Postoperative pain (POP) following abdominal surgery can vary from a few hours to several days. This acute, unrelieved pain can become chronic, requiring patients to take analgesics on an almost daily basis for comfort. Analgesia using general opioids has many side effects and intrathecal morphine is a good alternative. This study was conducted to evaluate the efficacy of intrathecal morphine (ITM) versus conventional analgesia in the management of postoperative pain in colectomy performed by laparoscopic surgery. Methods: Cohort study conducted at the Hôpital Nord in Marseille, from 01 January to 31 July 2021 in patients aged at least 18 years undergoing anaesthesia for scheduled colectomy by laparoscopic surgery. The primary endpoint was postoperative pain intensity and the secondary endpoints were morphine consumption, treatment side effects and length of hospital stay. Statistical analysis was performed using XLSTAT software. Results: We included 193 patients: 131 in the control group (conventional analgesia) and 62 in the ITM group. We observed: a significant decrease in pain (assessed by numerical scale) in favour of the ITM group in the post-anaesthetic care room, i.e. 3 (±4) vs 1 (±2), p 0 and H2: 2 (±2) vs. 1 (±2);p Conclusion: These results suggest that intrathecal morphine (ITM) in laparoscopic colectomy provides effective postoperative analgesia with low morphine consumption, and a reduction in morphine side-effects compared with conventional analgesia.

关键词： Intrathecal Morphine Colectomy Laparoscopy Conventional Analgesia

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Development and Evaluation of The Implementation of a Preceptorship Program for The Novice ICU Nurse Intensive Care Unit -A Secondary Publication

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Journal of Clinical and Nursing Research 2024年第3期8卷 158-175页

作者： Annie Perron manon Champagne Abir El-Haouly University of Quebec in Abitibi-Témiscamingue Rouyn-NorandaQC J9X 5E4Canada

This study focused on the development and evaluation of the implementation of a preceptorship program adapted to ICU practice in the Ab.-*** to provide preceptors with tools to support novice *** action research was made possible with the involvement of the centers,preceptors,and novice nurses throughout the development and implementation of the *** approach enabled participants to take ownership of the training content and fully utilize various *** program was implemented throughout the CISSS,where this study was subsequently carried *** novices mentioned that the program reinforced their sense of security and made them feel more equipped to handle complex care *** preceptors said they were better equipped to offer clinical support and novices were better prepared to work in the *** is important to evaluate the development of the novice nurses’skills following their participation in this program and the long-term impact of this preceptorship.

关键词： Preceptorship program Intensive care unit Novice ICU nurses

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几何竞赛,AI逼近人类天才

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环球科学 2024年第9期 44-49页

作者：玛农·比肖夫陶兆巍(译) 不详

国际数学奥林匹克竞赛可能是最高难度的高中数学竞赛,所有参赛者都是中的夜夜者。最近,一位“硅基”44“碳基生命”AI选手在几何题上的表现似乎已逼近人类天才。国际数学奥林匹克竞赛(IMO)可能是世界上最著名的高中数学竞赛。每年,世界... 详细信息

国际数学奥林匹克竞赛可能是最高难度的高中数学竞赛,所有参赛者都是中的夜夜者。最近,一位“硅基”44“碳基生命”AI选手在几何题上的表现似乎已逼近人类天才。国际数学奥林匹克竞赛(IMO)可能是世界上最著名的高中数学竞赛。每年,世界各地的学生都会竞争他们梦寐以求的IMO奖牌。

关键词：高中数学竞赛 IMO 几何题 AI 参赛者国际数学奥林匹克竞赛奖牌逼近

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Missed colorectal cancers in a fecal immunochemical test-based screening program: Molecular profiling of interval carcinomas

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World Journal of Gastrointestinal Oncology 2022年第11期14卷 2195-2207页

作者： manon van der Vlugt Beatriz Carvalho Joelle Fliers Nahid Montazeri Christian Rausch Esmée J Grobbee manon van Engeland manon C W Spaander Gerrit A Meijer Evelien Dekker Department of Gastroenterology and Hepatology Amsterdam University Medical CenterAmsterdam 1105 AZNetherlands Department of Pathology Netherlands Cancer InstituteAmsterdam 1066 CXNetherlands Biostatistics Unit Department of Gastroenterology and HepatologyAmsterdam University Medical CenterAmsterdam 1105 AZNetherlands Department of Gastroenterology and Hepatology Erasmus MC University Medical CenterRotterdam 3015 CNNetherlands Department of Pathology GROW-School for Oncology and Developmental BiologyMaastricht University Medical CenterMaastricht 6202 AZNetherlands

BACKGROUND For optimizing fecal immunochemical test(FIT)-based screening programs,reducing the rate of missed colorectal cancers(CRCs)by FIT(FIT-interval CRCs)is an important *** of the molecular make-up of these missed lesions could facilitate more accurate detection of all(precursor)*** To compare the molecular make-up of FIT-interval CRCs to lesions that are detected by FIT[screen-detected CRCs(SD-CRCs)].METHODS FIT-interval CRCs observed in a Dutch pilot-program of FIT-based screening were compared to a control group of SD-CRCs in a 1:2 ratio,resulting in 27 FIT-interval CRC and 54 *** analyses included microsatellite instability(MSI),CpG island methylator phenotype(CIMP),DNA sequence mutations and copy number alterations(CNAs).RESULTS Although no significant differences were reached,FIT-interval CRCs were more often CIMP positive and MSI positive(33%CIMP in FIT-interval CRCs vs 21%in SD-CRCs(P=0.274);19%MSI in FIT-interval CRCs vs 12%in SD-CRCs(P=0.469)),and showed more often serrated pathway associated features such as BRAF(30%vs 12%,P=0.090)and PTEN(15%vs 2.4%,P=0.063)*** mutations,a classic feature of the adenoma-carcinoma-sequence,were more abundant in SD-CRCs(68%vs 40%in FIT-interval CRCs P=0.035).Regarding CNAs differences between the two groups;FIT-interval CRCs less often showed gains at the regions 8p11.22-q24.3(P=0.009),and more often gains at 20p13-p12.1(P=0.039).CONCLUSION Serrated pathway associated molecular features seem to be more common in FIT-interval CRCs,while classic adenoma carcinoma pathway associated molecular features seem to be more common in *** indicates that proximal serrated lesions may be overrepresented among FITinterval CRCs.

关键词： Fecal immunochemical test-interval colorectal cancer Mutation analysis Colorectal cancer screening Serrated pathway Adenoma-carcinoma pathway

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Hepatocellular carcinoma with portal invasion,still a place for liver surgery in the era of immunotherapy?

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Hepatobiliary Surgery and Nutrition 2022年第5期11卷 782-784页

作者： Héloïse Giudicelli Claire Goumard manon Allaire Service d’Hépato-Gastroentérologie Hôpital Universitaire Pitié-SalpêtrièreAP-HP Sorbonne UniversitéParisFrance Service de Chirurgie Hépatobiliopancréatique et Transplantation Hépatique Hôpital Universitaire Pitié-SalpêtrièreAP-HP Sorbonne UniversitéParisFrance

Hepatocellular carcinoma(HCC)is a leading cause of cancer death worldwide and is associated with a 5-year overall survival(OS)of 10-15%all stages ***,5-year OS reaches 50-70%when patients are in an early stage and can access curative treatments such as liver transplantation,liver resection(LR)or ***,LR is reserved to very selected patients with adequate performance status,preserved liver function,to be matched with grade of portal hypertension(PHT),sufficient volume of the future liver remnant and acceptable tumor burden(1,2).Worldwide,the definitions of“tumor burden”and vascular invasion vary as illustrated in Tables 1,2,and the impact of portal vein tumoral thrombosis(PVTT)on the choice for HCC treatment is not consensual(1,2).

关键词： treatment invasion matched

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A CuO/TiO_(2)Heterojunction Based CO Sensor with High Response and Selectivity

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Energy & Environmental Materials 2023年第3期6卷 409-416页

作者： Wei Wei Huanhuan Zhang Tiyue Tao Xiaohong Xia Yuwen Bao manon Lourenco Kevin Homewood Zhongbing Huang Yun Gao Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and MinistrySchool of Materials Science&EngineeringHubei UniversityWuhan 430062China

The use of heterojunctions is a promising solution to the problem of cross-sensitivity in gas *** this work,a carbon monoxide sensor based on the CuO/TiO_(2)heterojunction was designed and *** to the good adsorption properties of CuO materials to CO,and the heterojunction interface charge transfer,the CuO/TiO_(2)thin film sensor exhibits high sensitivity to CO at room *** response is as high as 10.8–200 ppm CO,about 10 times its response to H_(2).Interference from H_(2)is greatly reduced by optimizing the structure of the CuO/TiO_(2)*** reliable detection of carbon monoxide with excellent discrimination against H_(2)is of great significance for the development of CO gas sensors.

关键词： carbon monoxide cross-sensitivity gas sensor heterojunction hydrogen

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Synergetic Contributions from the Components of Flexible 3D Structured C/Ag/ZnO/CC Anode Materials for Lithium-Ion Batteries

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Energy & Environmental Materials 2023年第6期6卷 227-235页

作者： Huang Xiao Shuangpeng Li Jiaying Zhou Chenyu Zhao Yi Yuan Xiaohong Xia Yuwen Bao manon Lourenço Kevin Homewood Yun Gao Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and MinistrySchool of Materials Science&EngineeringHubei UniversityWuhan 430062China

Low electronic conductivity and large volume changes during the(de)lithiation process are the two main challenges for ZnO anode materials used for lithium-ion batteries(LIB).Here,a free-standing,flexible,and binder-free LIB electrode composed of ZnO nanorods and carbon cloth(CC)is *** is then decorated with Ag nanoparticles and finally coated by an amorphous carbon layer to form the hybrid electrode:(C@(Ag&ZnO)).The voids among the nanorods are sufficient to accommodate the volume expansion of the ZnO while the flexible CC,which acts as the current collector,relieves the volume change-induced *** Ag nanoparticles are effective in improving the *** composite electrode shows excellent LIB performance with a stable long cycling life over 500 cycles with a reversible capacity of 1093 mAh g^(-1)at a current density of 200 mA g^(-1).It also shows good rate performance with reversible capacity of 517 mAh g^(-1)under a high-current density of 5000 mA g^(-1).In situ Raman spectroscopy is conducted to investigate the contributions of the amorphous carbon layer to the capacity of the whole electrode and the synergy between the CC and ZnO nanorods.

关键词： binder-free in situ Raman spectroscopy lithium-ion batteries ZnO nanorods

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Spherical Tropical Geometry:a Survey of Recent Developments

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Acta Mathematica Sinica,English Series 2018年第3期34卷 454-465页

作者： Kiumars KAVEH Christopher manon Department of Mathematics University of PittsburghPittsburghPAUSA Department of Mathematics Univcrsity of KentuckyLexingtonKYUSA

This is a survey of some recent results on spherical tropical geometry.

关键词： Tropical geometry reductive group action spherical variety Grbner theory

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Coverage rates for diphtheria,tetanus,poliomyelitis,and pertussis age-specific booster recommendations in France:2018 update of the real-world cohort analysis

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Infectious Medicine 2023年第1期2卷 51-56页

作者： Régis Verdier Clarisse Marchal manon Belhassen Marie Le Pannerer Nicole Guiso Robert Cohen Sanofi LyonFrance PELyon(Pharmaco Epidemiology Lyon) LyonFrance Independent Expert ParisFrance UniversitéParis Est IMRB-GRC GEMINICréteilFrance Clinical Research Center(CRC) Centre Hospitalier Intercommunal de CréteilCréteilFrance GPIP Pediatric Infectious Disease GroupFrance ACTIV Pediatric Clinical and Therapeutical Association of the Val de MarneSaint-Maur des FossésFrance UnitéCourt Séjour Petits NourrissonsService de NéonatologieCentre Hospitalier Intercommunal de CréteilCréteilFrance

The French National Immunization Program was updated in 2013 for vaccination against diphtheria,tetanus,per-tussis,and *** previous findings on the evolution of age-specific booster vaccination coverage rates(VCRs)up to 2017 suggested suboptimal vaccination coverages due to the pre-2013 recommendation-residual vaccination *** the current analysis,we evaluated all age-specific booster VCR and distribution of age at vaccination visits in *** this retrospective observational cohort study,the cumulative booster VCRs were updated at all vaccination visits up to 2018 among the people who were eligible for a booster vaccination,using a 1/97th random sample of French national healthcare reimbursement *** cumulative booster VCR for individuals from all age groups increased from 2017 to 2018,except for 85-years-old vaccination *** of the individuals from all age groups were vaccinated(boosted)with a vaccine containing the pertussis *** 2018,sharp peaks corresponding to the recommended ages for booster vaccination visits were observed for individuals aged 6,11 to 13,25,45,and 65 *** study reiterates suboptimal coverages in France and implies the need for booster vaccination throughout life for the protection of the population.

关键词： Booster vaccine DTaP-IPV France Pertussis National Immunisation Programme Vaccination coverage rate

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