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Frontiers of Agricultural Science and Engineering 2021年第4期8卷 525-544页

作者： Xiuwei GUO manoj kumar SHUKLA Di WU Shichao CHEN Donghao LI Taisheng DU Center for Agricultural Water Research in China China Agricultural UniversityBeijing 100083China Plant and Environmental Sciences Department New Mexico State UniversityLas CrucesNM 88003USA

Agriculture faces the dual challenges of food security and environmental ***,we investigate current maize production at the field scale,analyze the yield gaps and impacting factors,and recommend measures for sustainably closing yield *** experiment was conducted on a 3.9-ha maize seed production field in arid north-west China,managed with border and drip irrigation,respectively,in 2015 and *** relative yield reached 70%in both ***,drip irrigation saved 227 mm irrigation water during a drier growing season compared with traditional border irrigation,accounting for 44%of the maize evapotranspiration(ET).Yield variability under drip irrigation was12.1%,lower than the 18.8%under border *** line analysis indicates that a relative yield increase of 8%to 10%might be obtained by optimizing the yield-limiting *** density and soil available water content and available nitrogen were the three major factors *** conclusion,closing yield gaps with agricultural sustainability may be realized by optimizing agronomic,irrigation and fertilizer management,using water-saving irrigation methods and using site-specific management.

关键词： boundary line analysis irrigation method precision agriculture spatial variability yield gaps yield-limiting factors

Effect of Flow Field Geometry on Hydrodynamics of Flow in Redox Flow Battery

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Energy Engineering 2022年第1期119卷 201-217页

作者： M.Narendra kumar S.manoj kumar G.C.Vijayakumar K.Kadirgama M.Samykano Krishna Venkatesh H.B.Murlidhara Center for Incubation Innovation Research and Consultancy(CIIRC)Jyothy Institute of TechnologyBangalore560082KarnatakaIndia Department of Mechanical Engineering Jyothy Institute of TechnologyBangalore560082KarnatakaIndia Faculty of Mechanical and Automotive Engineering Technology University Malaysia PahangPahang26600Malaysia Centre for Automotive Engineering Universiti Malaysia PahangPahang26600Malaysia College of Engineering Universiti Malaysia PahangPahang26600Malaysia

This study computationally investigates the hydrodynamics of different serpentine flow field designs for redox flow batteries,which considers the Poiseuille flow in the flow channel and the Darcy flow porous *** Fluid Dynamics(CFD)results of the in-house developed code based on Finite Volume Method(FVM)for conventional serpentine flow field(CSFF)agreed well with those obtained via *** deviation for pressure drop(ΔP)was less than 5.1%for all the flow rates,thus proving the present CFD analysis’s validity on the modified variation of serpentine flow *** serpentine flow field-2(MSFF2)design provided least pressure drop across the channel and maximum velocity penetration across the porous substrate when compared to the other *** increases its wetting ability,which is very important in terms of mass transfer over potential for electrochemical reaction happening in the porous substrate to achieve effective electrochemical cell performance.

关键词： Pressure drop velocity distribution serpentine flow field porous substrate redox flow battery

Modified chitosan hydrogels as drug delivery and tissue engineering systems:present status and applications

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Acta Pharmaceutica Sinica B 2012年第5期2卷 439-449页

作者： Tapan kumar Giri Amrita Thakur Amit Alexander Ajazuddin Hemant Badwaik Dulal Krishna tripathi Rungta College of Pharmaceutical Sciences and Research KurudBhilai 491024India

Chitosan,a natural cationic polysaccharide,is prepared industrially by the hydrolysis of the aminoacetyl groups of chitin,a naturally available marine *** is a non-toxic,biocompatible and biodegradable polymer and has attracted considerable interest in a wide range of biomedical and pharmaceutical applications including drug delivery,cosmetics,and tissue *** primary hydroxyl and amine groups located on the backbone of chitosan are responsible for the reactivity of the polymer and also act as sites for chemical ***,chitosan has certain limitations for use in controlled drug delivery and tissue *** limitations can be overcome by chemical ***,modified chitosan hydrogels have gained importance in current research on drug delivery and tissue engineering *** paper reviews the general properties of chitosan,various methods of modification,and applications of modified chitosan hydrogels.

关键词： Modified chitosan Hydrogels Drug delivery Oral delivery of protein Tissue engineering

An Introduction to Numerical Methods for the Solutions of Partial Differential Equations

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Applied Mathematics 2011年第11期2卷 1327-1338页

作者： manoj kumar Garima Mishra 不详

Partial differential equations arise in formulations of problems involving functions of several variables such as the propagation of sound or heat, electrostatics, electrodynamics, fluid flow, and elasticity, etc. The present paper deals with a general introduction and classification of partial differential equations and the numerical methods available in the literature for the solution of partial differential equations.

关键词： Partial Differential Equations Eigenvalue Finite Difference Method Finite Volume Method Finite Element Method

Anti-cancer effects of sitagliptin,vildagliptin,and exendin-4 on triple-negative breast cancer cells via mitochondrial modulation

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BIOCELL 2022年第12期46卷 2645-2657页

作者： POOJA JAISWAL VERSHA tripathi ANSHUL ASSAIYA DHARMENDRA KASHYAP RAHUL DUBEY ANAMIKA SINGH JANESH kumar HEM CHANDRA JHA RAJESH SHARMA AMIT kumar DIXIT HAMENDRA SINGH PARMAR School of Biotechnology Devi Ahilya UniversityIndore452001India Laboratory of Membrane Protein Biology National Centre for Cell SciencePune411007India Department of Biosciences and Biomedical Engineering Indian Institute of TechnologyIndore452020India Department of Biotechnology IPS AcademyIndore452012India School of Pharmacy Devi Ahilya UniversityIndore452001India Central Council for Research in Ayurvedic Sciences Kolkata263645India

Triple-negative breast cancer(TNBC)cell line MDA-MB-231 is known for Warburg metabolism and defects in *** the other hand,dipeptidyl peptidase-IV(DPP-IV)inhibitors such as sitagliptin and vildagliptin and GLP-1 agonist exendin-4 are known to improve mitochondrial functions as well as biogenesis,but no study has evaluated the influence of these drugs on mitochondrial biogenesis on metastatic breast cancer cell *** have recently reported anticancer effects of 5-aminoimidazole-4-carboxamide riboside on MDA-MB-231 cells via activation of AMP-dependent kinase(AMPK),which activates the downstream transcription factors PGC-1α,PGC-1β,or FOXO1 for mitochondrial biogenesis;above-mentioned incretin-based therapies are also known to activate *** study evaluated the effects of sitagliptin,vildagliptin,and exendin-4 on MDA-MB-231 cells and the underlying changes in mitochondrial biogenesis,were *** with sitagliptin(100μM),vildagliptin(100μM),and exendin-4(10 nM)for 72 h to MDA-MB-231 cells led to a decrease in viability indicated by MTT assay,cell migration by scratch,and transwell migration assays,accompanied with marginal reduction in cell numbers along with the apoptotic appearance,the rate of apoptosis,and decreased lactate content in conditioned *** changes in the cancer phenotype were accompanied by an increase in the mitochondrial DNA to nuclear DNA ratio,increased MitoTracker green and red staining,and increased expression of transcription factors PGC-1α,NRF-1,NRF-2,TFAM,and ***-treatment of cells with these incretin-based drugs followed by 48 h treatment with 1μM doxorubicin increased doxorubicin sensitivity as observed by a decrease in viability by MTT ***,sitagliptin,vildagliptin,and exendin-4 exert their beneficial effects on TNBC cells via an increase in mitochondrial biogenesis that helps to switch Warburg metabolism into anti-Warburg *** response was in the order of:sitagliptin>vildagliptin>ex

关键词： Sitagliptin Vildagliptin Exendin-4 Apoptosis Migration Viability Chemo-sensitivity Mitochondrial biogenesis

Towards Multi-Faceted Test Cases Optimization

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Journal of Software Engineering and Applications 2011年第9期4卷 550-557页

作者： manoj kumar Arun Sharma Rajesh kumar 不详

The target of software engineering is to produce high quality software product at low cost. Software testing is labour-intensive, ambiguous and error prone activity of software development. How to provide cost-effective strategies for software test cases optimization problem such as classification, minimization, selection, and prioritization has been one of the research focuses in software testing for a long time. Many researchers and academicians have addressed the effectiveness/fitness and optimization of test cases, and obtained many interesting results. However, one issue of paramount importance in software testing i.e. the intrinsic imprecise and uncertainty of test cases fitness, fitness parameters, multi-objective optimization, is left unaddressed. Test cases fitness depends on several parameters. Vagueness of fitness of test cases and their fitness parameters have created the uncertainty in test cases optimization. Cost and adequacy values are incorporated into multi-faceted optimization of test cases. This paper argues test cases optimization requires multi-faceted optimization in order to adequately cater realistic software testing. In this paper, authors have identified several parameters for test cases fitness and multiple objectives for test cases optimization. In addition above, authors have formulated the test cases optimization problem in three different ways using multi-faceted concept. These formulations can be used in future by authors and researchers.

关键词： Multi-Faceted Optimization Test Cases Test Data Adequacy Criteria Test Case Fitness

Exact Solution of Second Grade Fluid in a Rotating Frame through Porous Media Using Hodograph Transformation Method

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Journal of Applied Mathematics and Physics 2015年第11期3卷 1443-1453页

作者： Sayantan Sil manoj kumar Department of Physics S.S.L.N.T. Mahila College Dhanbad India Post Graduate Department of Physics Ranchi College Ranchi India

In this paper exact solution for a homogenous incompressible, second grade fluid in a rotating frame through porous media has been provided using hodograph-Legendre transformation method. Results are summarised in the... 详细信息

关键词： Non-Newtonian Fluid Rotating Frame Hodograph Transformation Porous Media Exact Solution

Design and Simulation of Intelligent Optical WDM Switching Node Based on Erlang Traffic Model

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International Journal of Communications, Network and System Sciences 2010年第6期3卷 563-568页

作者： manoj kumar Dutta Vinod kumar Chaubey 不详

In this paper we propose a new architectural switching nodes consisting of two processing nodes that follow Erlang B and Erlang C traffic respectively. The developed model is used to best utilize the given number of output channels to achieve the least blocking probability. An appropriate mathematical model has been further devised and its call blocking probability has been enunciated. Performance of the model has been evaluated for different values of blocking probabilities. It has been observed that the performance of the network is well satisfactory for different design parameters.

关键词： WDM Networks Erlang Traffic Optical Node Blocking Probability Traffic Fraction

Does endoscopic sclerotherapy in filarial chyluria affect renal function and morphology? A prospective study using dimercaptosuccinic acid renal scan

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Asian Journal of Urology 2019年第4期6卷 359-363页

作者： Bimalesh Purkait Apul Goel Satyawati Deswal Monica Agrawal BhupendraPal Singh manoj kumar Department of Urology King George’s Medical UniversityLucknowUttar PradeshIndia Department of Nuclear Medicine Dr.Ram Manohar Lohia Institute of Medical SciencesLucknowIndia Department of Obstetrics and Gynaecology King George’s Medical UniversityLucknowUttar PradeshIndia

Objective:To look for change in relative renal function and document renal scarring following endoscopic renal pelvic instillation sclerotherapy(RPIS)in patients with chyluria by dimercaptosuccinic acid(DMSA)renal ***:A prospective study was performed between November 2015 and September *** patients with biochemically documented chyluria who underwent RPIS using either 1%-silver nitrate or 0.1%-povidine iodine were *** received either 3-,6-or *** renal scan was performed before and 2e3 months after ***:Of the 34 patients,22 were *** age was 41.08±16.64 years(range,15-70 years).Thirty-two patients(94.1%)responded to therapy while two did not respond even after *** follow-up was 8.94±3.70 *** mean relative renal function(preinstillation)of normal kidney was 50.76%±3.55%while that of affected renal unit(side of instillation)was 49.20%±3.44%(range,43.0%-61.0%).After instillation therapy,the mean relative renal function of normal side was 52.26%±3.57%while that of affected renal unit was 47.50%±3.56%(range,41.0%-54.0%).The relative renal function did not change>5%from the baseline value in any patient except one(in which the differential function increased paradoxically by 12%).Two patients developed renal scar in post-instillation renal ***:Endoscopic sclerotherapy in chyluria is safe and *** relative renal function does not deteriorate by more than 5%.There is a small risk of development of renal *** studies involving larger number of patients are needed to answer this dilemma.

关键词： Chyluria Endoscopic sclerotherapy Dimercaptosuccinic acid renal scan Relative renal function Renal scarring

Effect of Low Level Subchronic Microwave Radiation on Rat Brain

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Biomedical and Environmental Sciences 2016年第12期29卷 858-867页

作者： Pravin Suryakantrao Deshmukh Kanu Megha Namita Nasare Basu Dev Banerjee Rafat Sultana Ahmed Mahesh Pandurang Abegaonkar Ashok kumar tripathi Pramod kumari Mediratta Environmental Biochemistry and Molecular Biology Laboratory Department of Biochemistry.University College of Medical Sciences & G.T.B.Hospital(University of Delhi) Department of Pharmacology University College of Medical Sciences & G.T.B.Hospital(University of Delhi) Centre for Applied Research in Electronics(CARE) Indian Institute of Technology

Objective The present study was designed to investigate the effects of subchronic low level microwave radiation （MWR） on cognitive function, heat shock protein 70 （HSP70） level and DNA damage in brain of Fischer rats. Methods Experiments were performed on male Fischer rats exposed to microwave radiation for 90 days at three different frequencies： 900, 2800, and 2450 MHz. Animals were divided into 4 groups： Group I： Sham exposed, Group I1： animals exposed to microwave radiation at 900 MHz and specific absorption rate （SAR） 5.953 x 10-4 W/kg, Group II1： animals exposed to 1800 MHz at SAR 5.835 x 20-4 W/kg and Group IV： animals exposed to 2450 MHz at SAR 6.672 x 10-4 W/kg. All the animals were tested for cognitive function using elevated plus maze and Morris water maze at the end of the exposure period and subsequently sacrificed to collect brain tissues. HSP70 levels were estimated by ELISA and DNA damage was assessed using alkaline comet assay. Results Microwave exposure at 900-2450 MHz with SAR values as mentioned above lead to decline in cognitive function, increase in HSP70 level and DNA damage in brain. Conclusion The results of the present study suggest that low level microwave exposure at frequencies 900, 2800, and 2450 MHz may lead to hazardous effects on brain.

关键词： Brain Cognitive function Comet assay DNA damage HSP70 Microwave radiation