Does endoscopic sclerotherapy in filarial chyluria affect renal function and morphology? A prospective study using dimercaptosuccinic acid renal scan

作     者：Bimalesh Purkait Apul Goel Satyawati Deswal Monica Agrawal BhupendraPal Singh Manoj Kumar 

作者机构：Department of UrologyKing George’s Medical UniversityLucknowUttar PradeshIndia Department of Nuclear MedicineDr.Ram Manohar Lohia Institute of Medical SciencesLucknowIndia Department of Obstetrics and GynaecologyKing George’s Medical UniversityLucknowUttar PradeshIndia 

出 版 物：《Asian Journal of Urology》 (亚洲泌尿外科杂志（英文）)

年 卷 期：2019年第6卷第4期

页      面：359-363页

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：Chyluria Endoscopic sclerotherapy Dimercaptosuccinic acid renal scan Relative renal function Renal scarring 

摘      要：Objective:To look for change in relative renal function and document renal scarring following endoscopic renal pelvic instillation sclerotherapy(RPIS)in patients with chyluria by dimercaptosuccinic acid(DMSA)renal ***:A prospective study was performed between November 2015 and September *** patients with biochemically documented chyluria who underwent RPIS using either 1%-silver nitrate or 0.1%-povidine iodine were *** received either 3-,6-or *** renal scan was performed before and 2e3 months after ***:Of the 34 patients,22 were *** age was 41.08±16.64 years(range,15-70 years).Thirty-two patients(94.1%)responded to therapy while two did not respond even after *** follow-up was 8.94±3.70 *** mean relative renal function(preinstillation)of normal kidney was 50.76%±3.55%while that of affected renal unit(side of instillation)was 49.20%±3.44%(range,43.0%-61.0%).After instillation therapy,the mean relative renal function of normal side was 52.26%±3.57%while that of affected renal unit was 47.50%±3.56%(range,41.0%-54.0%).The relative renal function did not change5%from the baseline value in any patient except one(in which the differential function increased paradoxically by 12%).Two patients developed renal scar in post-instillation renal ***:Endoscopic sclerotherapy in chyluria is safe and *** relative renal function does not deteriorate by more than 5%.There is a small risk of development of renal *** studies involving larger number of patients are needed to answer this dilemma.