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NIR-enhanced Pt single atom/g-C_(3)N_(4)nanozymes as SOD/CAT mimics to rescue ATP energy crisis by regulating oxidative phosphorylation pathway for delaying osteoarthritis progression

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Bioactive Materials 2024年第6期36卷 1-13页

作者： Jianhui Xiang Xin Yang manli tan Jianfeng Guo Yuting Ye Jiejia Deng Zhangrui Huang Hanjie Wang Wei Su Jianwen Cheng Li Zheng Sijia Liu Jingping Zhong Jinmin Zhao Guangxi Engineering Center in Biomedical Material for Tissue and Organ Regeneration Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed By the Province and MinistryGuangxi Key Laboratory of Regenerative MedicineThe First Affiliated Hospital of Guangxi Medical UniversityNo.6 Shuangyong RoadNanningGuangxi 530021PR China Life Sciences Institute Guangxi Medical UniversityNo.22 Shuangyong RoadNanningGuangxi530021PR China Department of Orthopaedics Trauma and Hand Surgery The First Affiliated Hospital of Guangxi Medical UniversityNo.6 Shuangyong RoadNanningGuangxi530021PR China

Osteoarthritis(OA)progresses due to the excessive generation of reactive oxygen and nitrogen species(ROS/RNS)and abnormal ATP energy metabolism related to the oxidative phosphorylation pathway in the *** active single-atom nanozymes(SAzymes)can help regulate the redox balance and have shown their potential in the treatment of inflammatory *** this study,we innovatively utilised ligand-mediated strategies to chelate Pt^(4+)with modified g-C_(3)N_(4)byπ-πinteraction to prepare g-C_(3)N_(4)-loaded Pt single-atom(Pt SA/C_(3)N_(4))nanozymes that serve as superoxide dismutase(SOD)/catalase(CAT)mimics to scavenge ROS/RNS and regulate mitochondrial ATP production,ultimately delaying the progression of *** SA/C_(3)N_(4)exhibited a high loading of Pt single atoms(2.45 wt%),with an excellent photothermal conversion efficiency(54.71%),resulting in tunable catalytic activities under near-infrared light(NIR)***,the Pt-N_(6) active centres in Pt SA/C_(3)N_(4)formed electron capture sites for electron holes,in which g-C_(3)N_(4)regulated the d-band centre of Pt,and the N-rich sites transferred electrons to Pt,leading to the enhanced adsorption of free radicals and thus higher SOD-and CAT-like activities compared with pure g-C_(3)N_(4)and g-C_(3)N_(4)-loaded Pt nanoparticles(Pt NPs/C_(3)N_(4)).Based on the use of H_(2)O_(2)-induced chondrocytes to simulate ROS-injured cartilage in vitro and an OA joint model in vivo,the results showed that Pt SA/C_(3)N_(4)could reduce oxidative stress-induced damage,protect mitochondrial function,inhibit inflammation progression,and rebuild the OA microenvironment,thereby delaying the progression of *** particular,under NIR light irradiation,Pt SA/C_(3)N_(4)could help reverse the oxidative stress-induced joint cartilage damage,bringing it closer to the state of the normal ***,Pt SA/C_(3)N_(4)regulated the expression of mitochondrial respiratory chain complexes,mainly NDUFV2 of c

关键词： ATP energy crisis Osteoarthritis progression Oxidative phosphorylation pathway Nanozymes

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Role of integrin b1 and tenascin C mediate TGF-SMAD2/3 signaling in chondrogenic differentiation of BMSCs induced by type I collagen hydrogel

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Regenerative Biomaterials 2024年第5期3卷 59-73页

作者： Yuanjun Huang Miao Sun Zhenhui Lu Qiuling Zhong manli tan Qingjun Wei Li Zheng Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration The First Affiliated Hospital of Guangxi Medical UniversityGuangxi Medical UniversityNanning 530021China Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-Constructed by the Province and Ministry First Affiliated Hospital of Guangxi Medical UniversityGuangxi Medical UniversityNanning 530021China Department of Trauma Orthopedic and Hand Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Guangxi Key Laboratory of Regenerative Medicine The First Affiliated Hospital of Guangxi Medical UniversityGuangxi Medical UniversityNanning 530021China Life Science Institute Guangxi Medical UniversityNanning 530021China

Cartilage defects may lead to severe degenerative joint *** engineering based on type I collagen hydrogel that has chondrogenic potential is ideal for cartilage ***,the underlying mechanisms of chondrogenic differentiation driven by type I collagen hydrogel have not been fully ***,we explored potential collagen receptors and chondrogenic signaling pathways through bioinformatical analysis to investigate the mechanism of collagen-induced *** showed that the super enhancer-related genes induced by collagen hydrogel were significantly enriched in the TGF-b signaling pathway,and integrin-b1(ITGB1),a receptor of collagen,was highly expressed in bone marrow mesenchymal stem cells(BMSCs).Further analysis showed genes such as COL2A1 and Tenascin C(TNC)that interacted with ITGB1 were significantly enriched in extracellular matrix(ECM)structural constituents in the chondrogenic induction *** of ITGB1 led to the downregulation of cartilage-specific genes(SOX9,ACAN,COL2A1),SMAD2 and TNC,as well as the downregulation of phosphorylation of SMAD2/*** of TNC also resulted in the decrease of cartilage markers,ITGB1 and the SMAD2/3 phosphorylation but overexpression of TNC showed the opposite ***,in vitro and in vivo experiments confirmed the involvement of ITGB1 and TNC in collagen-mediated chondrogenic differentiation and cartilage *** summary,we demonstrated that ITGB1 was a crucial receptor for chondrogenic differentiation of BMSCs induced by collagen *** can activate TGF-SMAD2/3 signaling,followed by impacting TNC expression,which in turn promotes the interaction of ITGB1 and TGF-SMAD2/3 signaling to enhance *** may provide concernful support for cartilage tissue engineering and biomaterials development.

关键词： collagen hydrogel chondrogenic induction integrin b1 tenascin C TGF-SMAD2/3 signaling

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Apolipoprotein E elicits targetdirected miRNA degradation to maintain neuronal integrity

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Neural Regeneration Research 2025年第9期20卷 2577-2578页

作者： Jiazi tan Chin-Tong Ong Temasek Life Sciences Laboratory National University of SingaporeSingapore Department of Biological Sciences National University of SingaporeSingapore

Apolipoprotein E has diverse functions in neurons:Apolipoprotein E(ApoE)is a glycoprotein that primarily regulates lipid metabolism and transport in the central nervous *** are three predominant human ApoE protein isoforms with cysteine and arginine substitutions at amino acid positions 112 and 158 that impact their lipidation and related functions(Flowers and Rebeck,2020).ApoE2 is characterized by Cys112 and Cys158,ApoE3 by Cys112 and Arg158,whereas ApoE4 contains Arg112 and Arg158.

关键词： metabolism glycoprotein maintain

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Copper-catalyzed C–H bond functionalization enabled by programmed alternating current

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Science China Chemistry 2025年第1期68卷 10-11页

作者： Zhoumei tan Kun Xu Chengchu Zeng Beijing Key Laboratory of Environmental and Viral Oncology College of Chemistry and Life Science Beijing University of Technology

Synthetic electrochemistry has been selected as one of the Top Ten Emerging Technologies in Chemistry in 2023 by International Union of Pure and Applied Chemistry (IUPAC)[1]. It has emerged as a sustainable platform for organic synthesis and has exhibited a wide range of applications from academia to industry [2]. However, electrosynthesis has been predominantly performed by using direct current (DC).

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定点突变提高木聚糖酶Umxyn10A的热稳定性

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基因组学与应用生物学 2020年第3期39卷 1137-1142页

作者：邓巧平王龙谭曼利冯家勋刘君梁广西大学生命科学与技术学院亚热带农业生物资源保护与利用国家重点实验室南宁530004

木聚糖酶是微生物半纤维素降解体系中的一种关键酶,被广泛地应用在工业中的多个领域。本研究为了提高木聚糖酶Umxyn10A (ABL73-883.1)的热稳定性,将Umxyn10A与GH 10家族4种耐热木聚糖酶进行多序列同源比对以及三维结构的同源建模分析,... 详细信息

木聚糖酶是微生物半纤维素降解体系中的一种关键酶,被广泛地应用在工业中的多个领域。本研究为了提高木聚糖酶Umxyn10A (ABL73-883.1)的热稳定性,将Umxyn10A与GH 10家族4种耐热木聚糖酶进行多序列同源比对以及三维结构的同源建模分析,选定了Umxyn10A第31位氨基酸位点进行定点突变,将氨基酸Ala (A)突变为Phe (F)。分别将Umxyn10A和Umxyn10AA31F在大肠杆菌中进行重组表达,分析2种重组酶的酶学特性,结果发现,Umxyn10AA31F的最适反应温度为85℃,较野生重组酶提高了5℃;在65℃下的半衰期为105 min,较野生重组酶(15 min)提高了6倍;在70℃下突变重组酶的半衰期为15 min,较野生重组酶(5 min)提高了2倍;与此同时突变重组酶的pH耐受区间较原酶也有一定的增大。结果表明,将第31位氨基酸位点Ala突变为Phe能够显著的提高Umxyn10A的热稳定性。

关键词：木聚糖酶热稳定性定点突变

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载气种类对微波CVD合成碳纳米管阵列生长的影响

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化工新型材料 2015年第8期43卷 146-148页

作者：符冬菊叶利强曾燮榕马清陈建军檀满林深圳清华大学研究院深圳518057 深圳市特种功能材料重点实验室深圳大学深圳518060

以乙炔为碳源气体,采用微波辅助化学气相沉积法低温合成高纯度的垂直定向碳纳米管阵列。研究了分别以氮气和氩气为载气对碳纳米管阵列形貌结构的影响,并用扫描电子显微镜、透射电镜和拉曼光谱等手段对碳纳米管形貌与结构进行观察和分析... 详细信息

以乙炔为碳源气体,采用微波辅助化学气相沉积法低温合成高纯度的垂直定向碳纳米管阵列。研究了分别以氮气和氩气为载气对碳纳米管阵列形貌结构的影响,并用扫描电子显微镜、透射电镜和拉曼光谱等手段对碳纳米管形貌与结构进行观察和分析。结果表明:以氮气为载气合成的碳纳米管阵列纯度较高,直径分布均匀。并对碳纳米管阵列在微波场下的生长机理进行分析探讨。

关键词：定向碳纳米管阵列微波结构电子显微分析

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Aerodynamic Optimization and Flow Mechanism for a Compressor Cascade at Low Reynolds Number

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Journal of Thermal Science 2025年第1期34卷 92-109页

作者： LI Lin ZHANG Jianshe CHEN Caiyan tan Wei ZHANG Yanfeng Key Laboratory of Light-Duty Gas-Turbine Institute of Engineering ThermophysicsChinese Academy of Sciences University of Chinese Academy of Sciences National Key Laboratory of Science and Technology on Advanced Light-duty Gas-turbine

Low-Reynolds-number effect is an important factor affecting the performance of compressors and other main components of high-altitude long-endurance unmanned aerial *** improve the flow condition and reduce flow loss under the condition of high altitude and low Reynolds number(Re),this paper proposes an optimization process based on a surrogate model,which combines the class-shape transformation method(CST),the Latin hypercube sampling(LHS) method,the light gradient-boosting machine algorithm(LightGBM),and a genetic algorithm(GA) to optimize a high-subsonic compressor *** surrogate model is verified to be accurate and can be used in the optimization *** accuracy of the GA is higher than the other algorithms under common test *** optimization results are verified by numerical simulation,and the flow differences before and after optimization are compared,especially the flow within the boundary *** changing the blade shape,the optimization process adjusts the loading distribution to delay the transition of the optimized blade on the suction surface,which changes the turbulent reattachment in the laminar separation bubble(LSB) into laminar ***,the mixing loss induced by the turbulent reattachment of the LSB and the wake loss of turbulent separation at the trailing edge are significantly reduced,and the performance of the compressor profile is finally *** addition,turbulent separation of the optimized profile is delayed reducing the range of the wake region on the suction *** this optimization process,the reduction of total pressure loss coefficient at Re of 2.5×10～5,3.5×10～5,and 4.5×10～5 are 16.32%,20.76%,and 22.16%,respectively.

关键词： Reynolds number

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Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao tan Junling Lü Chunchi Zhang Dong Liang Lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

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Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu Hong-Wei Li Jian-Hong Shi tan Li Wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

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Recent advances of metal vacancies in energy and environmental catalysis:Synthesis,characterization,and roles

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Green Energy & Environment 2025年第1期10卷 84-108页

作者： Long Sun Shunzheng Zhao Sirui Gao Ronghui Zhu Yiran tan Xiaolong tang Honghong Yi School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing100083China Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollutants Beijing100083China

With the ongoing depletion of fossil fuels,energy and environmental issues have become increasingly critical,necessitating the search for effective ***,being one of the hallmarks of modern industry,offers a promising avenue for ***,the question of how to significantly enhance the performance of catalysts has gradually drawn the attention of *** engineering,a commonly employed and effective approach to improve catalyst activity,has become a significant research focus in the catalysis field in recent *** vacancies have received extensive attention due to their simple ***,exploration of metal vacancies has remained stagnant for a considerable period,resulting in a scarcity of comprehensive reviews on this ***,based on the latest research findings,this paper summarizes and consolidates the construction strategies for metal vacancies,characterization techniques,and their roles in typical energy and environmental catalytic ***,it outlines potential challenges in the future,aiming to provide valuable references for researchers interested in investigating metal vacancies.

关键词： Metal vacancies Catalysis Construction strategies Characterization techniques Roles

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