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Simple and customizable method for fabrication of high-aspect ratio microneedle molds using low-cost 3D printing

Microsystems & Nanoengineering 2019年第1期5卷 250-263页

作者： Kevin J.Krieger Nicky Bertollo manita dangol John T.Sheridan Madeleine M.Lowery Eoin D.O’Cearbhaill UCD Centre for Biomedical Engineering University College DublinBelfieldDublin 4Ireland School of Mechanical&Materials Engineering University College DublinBelfieldDublin 4Ireland School of Electrical&Electronic Engineering University College DublinBelfieldDublin 4Ireland

We present a simple and customizable microneedle mold fabrication technique using a low-cost desktop SLA 3D *** opposed to conventional microneedle fabrication methods,this technique neither requires complex and expensive manufacturing facilities nor expertise in *** most low-cost 3D-printed microneedles to date display low aspect ratios and poor tip sharpness,we show that by introducing a two-step“Print&Fill”mold fabrication method,it is possible to obtain high-aspect ratio sharp needles that are capable of penetrating *** first the effect of varying design input parameters and print settings,it is shown that printed needles are always shorter than *** decreasing input height,needles also begin displaying an increasingly greater than specified needle base *** factors contribute to low aspect ratio needles when attempting to print submillimeter height *** setting input height tall enough,it is possible to print needles with high-aspect ratios and tip radii of 20–40μ*** tip sharpness is smaller than the specified printer ***,high-aspect ratio sharp needle arrays are printed in basins which are backfilled and cured in a second step,leaving sub-millimeter microneedles exposed resulting microneedle arrays which can be used as male *** female master molds are then formed from the fabricated microneedle *** the molds,both carboxymethyl cellulose loaded with rhodamine B as well as polylactic acid microneedle arrays are produced and their quality examined.A skin insertion study is performed to demonstrate the functional capabilities of arrays made from the fabricated *** method can be easily adopted by the microneedle research community for in-house master mold fabrication and parametric optimization of microneedle arrays.

关键词： needle cost printer

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