Simple and customizable method for fabrication of high-aspect ratio microneedle molds using low-cost 3D printing

作     者：Kevin J.Krieger Nicky Bertollo Manita Dangol John T.Sheridan Madeleine M.Lowery Eoin D.O’Cearbhaill 

作者机构：UCD Centre for Biomedical EngineeringUniversity College DublinBelfieldDublin 4Ireland School of Mechanical&Materials EngineeringUniversity College DublinBelfieldDublin 4Ireland School of Electrical&Electronic EngineeringUniversity College DublinBelfieldDublin 4Ireland 

出 版 物：《Microsystems & Nanoengineering》 (微系统与纳米工程（英文）)

年 卷 期：2019年第5卷第1期

页      面：250-263页

核心收录：

学科分类：080503[工学-材料加工工程] 0808[工学-电气工程] 0809[工学-电子科学与技术（可授工学、理学学位）] 0817[工学-化学工程与技术] 08[工学] 0807[工学-动力工程及工程热物理] 0805[工学-材料科学与工程（可授工学、理学学位）] 0802[工学-机械工程] 0811[工学-控制科学与工程] 0702[理学-物理学] 080201[工学-机械制造及其自动化] 

基　　金：This work has been funded through an Irish Research Council Postgraduate Scholarship,a National University of Ireland Travel Studentship,a Marie-Skłodowska-Curie Fellowship(H2020-MSCA-IF-2014/658761) Science Foundation Ireland and the European Regional Development Fund(grant agreement number:13/RC/2073) 

主　　题：needle cost printer 

摘      要：We present a simple and customizable microneedle mold fabrication technique using a low-cost desktop SLA 3D *** opposed to conventional microneedle fabrication methods,this technique neither requires complex and expensive manufacturing facilities nor expertise in *** most low-cost 3D-printed microneedles to date display low aspect ratios and poor tip sharpness,we show that by introducing a two-step“Print&Fillmold fabrication method,it is possible to obtain high-aspect ratio sharp needles that are capable of penetrating *** first the effect of varying design input parameters and print settings,it is shown that printed needles are always shorter than *** decreasing input height,needles also begin displaying an increasingly greater than specified needle base *** factors contribute to low aspect ratio needles when attempting to print submillimeter height *** setting input height tall enough,it is possible to print needles with high-aspect ratios and tip radii of 20–40μ*** tip sharpness is smaller than the specified printer ***,high-aspect ratio sharp needle arrays are printed in basins which are backfilled and cured in a second step,leaving sub-millimeter microneedles exposed resulting microneedle arrays which can be used as male *** female master molds are then formed from the fabricated microneedle *** the molds,both carboxymethyl cellulose loaded with rhodamine B as well as polylactic acid microneedle arrays are produced and their quality examined.A skin insertion study is performed to demonstrate the functional capabilities of arrays made from the fabricated *** method can be easily adopted by the microneedle research community for in-house master mold fabrication and parametric optimization of microneedle arrays.