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Role of(～(18)F)2-fluoro-2-deoxyglucose positron emission tomography in upper gastrointestinal malignancies

World Journal of Gastroenterology 2011年第46期17卷 5059-5074页

作者： Elizabeth C Smyth manish a shah Department of Gastrointestinal Oncology Weill Cornell Medical CollegeMemorial Sloan-Kettering Cancer Center Department of Gastrointestinal Oncology Weill Cornell Medical CollegeNew York-Presbyterian Hospital

The role of whole-body FDG [(～(18)F)2-fluoro-2-deoxy-glucose] positron emission tomography(PET)scan-ning as an imaging modality in the management of patients with malignancy has evolved enormously over the past two ***-PET has demonstrated signifi cant effi cacy in the staging,prognostication and detection of occult metastatic disease in malignancies of the gastrointestinal tract,in addition to assessment of the response to cytotoxic chemotherapy in a more timely manner than has traditionally been possible by more conventional imaging *** sensitivity and specif icity of FDG-PET for the detection and staging of malignancy depend not only on the site and size of the primary tumor and metastases,but also on histologi-cal cell type,reflecting underlying disparities in glucose *** metabolic response to neo-adjuvant chemotherapy or to chemo-radiotherapy in cancers of the gastro-esophageal junction or stomach has been demonstrated in several prospective studies to correlate signifi cantly with both the histological tumor response to treatment and with consequent improvements in overall *** may offer a future paradigm ofpersonalized treatment based on the PET response to ***-PET has been less successful in efforts to screen for and detect recurrent upper gastro-intestinal malignancies,and in the detection of low vol-ume metastatic peritoneal *** to improve the accuracy of PET include the use of novel radiotrac-ers such as(～(18)F)FLT(3-deoxy-3-fluorothymidine)or 11C-choline,or fusion PET-CT with concurrent high-res-olution computed *** review focuses on the role of FDG-PET scanning in staging and response assessment in malignancies of the upper gastrointesti-nal tract,specif ically gastric,esophageal and pancreas carcinoma.

关键词：正电子发射断层扫描 2-脱氧葡萄糖恶性肿瘤消化道氟代计算机断层扫描代谢反应成像方式

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5%过氧化苯甲酰凝胶、液体清洁剂和保湿剂SPF 30联合治疗痤疮的疗效评价

5%过氧化苯甲酰凝胶、液体清洁剂和保湿剂SPF 30联合治疗痤疮的疗...

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作者： manish Kumar shah 大理大学

学位级别：硕士

客观的结合皮肤护理产品（清洁剂和保湿剂）和过氧化苯甲酰（BPO）治疗痤疮可提高治疗耐受性和依从性。评估BPO 5%凝胶与液体清洁剂和保湿剂SPF 30联合使用后患者的满意度。材料与方法共有100名患者参与了—项开放性研究,其中包括13至3...

客观的结合皮肤护理产品（清洁剂和保湿剂）和过氧化苯甲酰（BPO）治疗痤疮可提高治疗耐受性和依从性。评估BPO 5%凝胶与液体清洁剂和保湿剂SPF 30联合使用后患者的满意度。材料与方法共有100名患者参与了—项开放性研究,其中包括13至30岁的轻度至中度面部痤疮患者。接受BPO 5%凝胶每日—次、液体清洁剂每日两次和保湿剂SPF 30每日—次的患者使用12周。评估包括患者满意度问卷、研究者对改善、病变计数和安全性的总体评估。后果12周后,参与研究的大多数患者对三部分方案总体满意（87%）,自我感觉良好（94%）患者表示皮肤护理产品（清洁剂和保湿剂）有助于皮肤准备治疗（85%）,缓解皮肤瘙痒（81%）,减少刺激（87%）。大多数患者认为液体清洁剂（80%）和保湿剂SPF 30（84%）与BPO 5%凝胶相结合是治疗痤疮的必要部分。治疗耐受性良好。结论BPO 5%凝胶与液体清洁剂和保湿剂SPF 30的组合可使受试者获得高水平的满意度、良好的耐受性和治疗依从性。

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肝细胞癌介入治疗术后磁共振增强扫描与多排计算机断层扫描监测效果的对比

肝细胞癌介入治疗术后磁共振增强扫描与多排计算机断层扫描监测效...

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作者： manish Kumar shah（曼尼）东南大学

学位级别：硕士

背景:随着磁共振(Magnetic Resonance Imaging,MRI)以及新的肝特异性对比剂的使用,对肝细胞癌(HepatocellularCarcinoma,HCC)介入治疗术后的监测可以显著提高复发病灶的敏感性。MRI和CT结合使用可以提高新的、复发的、残存的病灶的检出... 详细信息

背景:随着磁共振(Magnetic Resonance Imaging,MRI)以及新的肝特异性对比剂的使用,对肝细胞癌(HepatocellularCarcinoma,HCC)介入治疗术后的监测可以显著提高复发病灶的敏感性。MRI和CT结合使用可以提高新的、复发的、残存的病灶的检出率。目的:对比Primovist轧塞酸对比剂增强MRI与三个时相的CT扫描对HCC介入治疗术后病人的诊断准确率。材料与方法:这是一个对2010-2017年间的患者进行的回顾性对比研究。总共45例HCC患者入组这项研究,其中41例为连续性的HCC患者(17名女性,24名男性,年龄31-75岁)。所有患者都用64排多排计算机断层扫描(Multidetector Computed Tomography)做了三个时相的CT扫描(动脉期、门静脉期、平衡期),同时也做了轧塞酸增强3.0TMRI。两个影像学检查平均间隔7天。通过图像评估残余或复发病灶,新病灶的证据焦点为病灶-病灶基础。HCC的诊断是依据AASLD2005标准。结果:研究了 45例病灶,其中43例被轧塞酸增强MRI检测为新病灶,38例被CT检测为新病灶。平均病灶检测率轧塞酸增强MRI为(1.42 ± 0.58),CT为(0.96 ±0.82)。配对T检验显示MRI与CT对比有统计学差异(P=0.02)。这表明在肝脏病灶检测方面轧塞酸增强MRI优于CT。结论:由于碘化油的高密度影使CT检测介入术后复发肿瘤较为困难,轧塞酸与高磁场3.0T MRI可以提高肝硬化患者非侵袭性小HCC结节的检出率。该项研究表明MRI轧塞酸增强是一个优于MDCT的影像学检测方法,可以作为肝癌介入治疗后判断肿瘤有无复发的优选检查方法。

关键词：肝细胞癌磁共振成像肝动脉化疗栓塞检测多层计算机断层扫描

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Diabetes mellitus as a consequence of acute severe pancreatitis:Unraveling the mystery

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World Journal of Diabetes 2023年第8期14卷 1212-1225页

作者： manish Manrai Anupam K Singh Chhagan Lal Birda Jimil shah Aditya Dutta Sanjay Kumar Bhadada Rakesh Kochhar Department of Internal Medicine Armed Forces Medical CollegePune 411040MaharashtraIndia Department of Gastroenterology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India Department of Gastroenterology All India Institutes of Medical SciencesJodhpur 342001India Department of Endocrinology Max HospitalNew Delhi 110017India Department of Endocrinology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India

The occurrence of diabetes mellitus(DM)in pancreatitis is being increasingly recognized *** can develop not only with chronic pancreatitis but even after the first episode of acute pancreatitis(AP).The incidence of diabetes after AP varies from 18%to 23%in 3 years and reaches up to 40%over 5 *** exact pathogenesis of diabetes after AP is poorly understood and various mechanisms proposed include loss of islet cell mass,AP-induced autoimmunity,and alterations in the insulin incretin *** factors associated with increased risk of diabetes includes male sex,recurrent attacks of pancreatitis,presence of pancreatic exocrine insufficiency and level of pancreatitic *** of post-pancreatitis DM(PPDM)is often *** includes a trial of oral antidiabetic drugs in mild ***,insulin is required in uncontrolled *** the lack of awareness of this metabolic disorder after AP,this review will evaluate current information on epidemiology,risk factors,diagnosis and management of PPDM and identify the knowledge gaps.

关键词： Post-pancreatitis diabetes Diabetes of exogenous pancreas Endocrine insufficiency Acute pancreatitis Post-pancreatitis diabetes mellitus

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Flow-directed assembly of non-spherical titania nanoparticles into superhydrophilic thin films

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Frontiers of Materials Science 2016年第1期10卷 1-7页

作者： Abhijeet OJHA manish THAKKER Dinesh O. shah Prachi THAREJA Department of Biological Engineering Indian Institute of Technology Gandhinagar Ahmedabad 382424 Gujarat India Department of Instrumentation and Control Engineering Dharmsinh Desai University Nadiad 387001 Gujarat India shah-Schulman Center for Surface Science and Nanotechnology Dharmsinh Desai University Nadiad 387001 Gujarat India Department of Chemical Engineering and Department of Anesthesiology University of Florida Gainesville FL 32608 USA Department of Chemical Engineering Indian Institute of Technology Gandhinagar Ahmedabad 382424 Gujarat India

Superhydrophilic thin films of 21 nm sized non-spherical titania nanoparticles are fabricated from a colloidal suspension by fixed blade flow coating without UV illumination. At a blade angle of a= 36° and a gap of d= 300 μm, hierarchically structured films with increasing surface roughness along with microscopic voids are formed depending on the substrate velocity and the titania volume fraction. Increasing the roughness is shown to be concomitant to an increase in the hydrophilicity, eventually leading to superhydrophilicity or water contact angle less than 5°.

关键词： superhydrophilicity titania flow coating thin films

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Synthesis,characterization and antimicrobial activity of some new biquinoline derivatives containing a thiazole moiety

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Chinese Chemical Letters 2012年第4期23卷 454-457页

作者： Nirav K.shah Nimesh M.shah manish P.Patel Ranjan G.Patel Department of Chemistry Sardar Patel UniversityVallabh Vidyanagar 388120GujaratIndia

A series of new biquinoline derivatives containing a thiazole moiety were synthesized by a one-pot,base-catalyzed cyclocondensation reaction of 2-chloro-3-formyl quinoline,malononitrile and *** the synthesized compounds were characterized by elemental analysis,FT-IR,~1H NMR and ^（13）C NMR *** the synthesized compounds were screened against three bacterial pathogens,namely Bacillus cereus,*** and Escherichia coli and for antifungal activity against three fungal pathogens,Aspergillus niger,Fusarium oxisporum and Rhizopus using the disc diffusion method.

关键词： Quinoline Multicomponent reaction Thiazole Antimicrobial activity

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Determination of mycophenolic acid in human plasma by ultra performance liquid chromatography tandem mass spectrometry

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Journal of Pharmaceutical Analysis 2014年第3期4卷 205-216页

作者： Vivek Upadhyay Vikas Trivedi Gaurang shah manish Yadav Pranav S.Shrivastav Chemistry Department Kadi Sarva VishwavidyalayaGandhinagar 382015India Department of Chemistry School of SciencesGujarat University

A simple, sensitive and high throughput ultra performance liquid chromatography tandem mass spectrometry method has been developed for the determination of mycophenolic acid in human plasma. The method involved simple protein precipitation of MPA along with its deuterated analog as an internal standard （IS） from 50 mL of human plasma. The chromatographic analysis was done on Acquity UPLC C18 （100mm×2.1mm,1.7μm） column under isocratic conditions using acetonitrile and 10 mM ammonium formate, pH 3.00 （75：25, v/v） as the mobile phase. A triple quadrupole mass spectrometer operating in the positive ionization mode was used for quantitation. In-source conversion of mycophenolic glucuronide metabolite to the parent drug was selectively controlled by suitable optimization of cone voltage, cone gas flow and desolvation temperature. The method was validated over a wide concentration range of 15-15000 ng/mL. The mean extraction recovery for the analyte and IS was 〉95%. Matrix effect expressed as matrix factors ranged from 0.97 to 1.02. The method was successfully applied to support a bioequivalence study of 500 mg mycophenolate mofetil tablet in 72 healthy subjects.

关键词： Mycophenolic acid Mycophenolic acid-d3 UPLC-MS/MS In-source conversion Incurred sample reanalysis

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Plants Used as Antihypertensive

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Natural Products and Bioprospecting 2021年第2期11卷 155-184页

作者： Tarawanti Verma manish Sinha Nitin Bansal Shyam Raj Yadav Kamal shah Nagendra Singh Chauhan I.K.Gujral Punjab Technical University(IKGPTU) JalandharPunjabIndia Laureate Institute of Pharmacy KathogJwalamukhiKangraHimachal PradeshIndia Department of Pharmacology ASBASJSM College of PharmacyBELARoparPunjabIndia Department of Chemistry S.P.Jain College(Veer Kunwar Singh UniversityAra)SasaramBiharIndia Institute of Pharmaceutical Research GLA UniversityNH#2MathuraUttar Pradesh 281406India Drugs Testing Laboratory Avam Anusandhan Kendra 1st Floor Govt.Ayurvedic Hospital BuildingGovt.Ayurvedic College Campus G.E.RoadRaipurChhattisgarh 492010India

Hypertension is a critical health problem and worse other cardiovascular *** is mainly of two types:Primary or essential hypertension and Secondary *** is the primary possibility feature for coronary heart disease,stroke and renal vascular *** medicines have been used for millions of years for the management and treatment of hypertension with minimum side *** aim to write this review is to collect information on the anti-hypertensive effects of natural herbs in animal studies and human involvement as well as to recapitulate the underlying mechanisms,from the bottom of cell culture and ex-vivo tissue *** to WHO,natural herbs/shrubs are widely used in increasing order to treat almost all the ailments of the human *** are the regular industrial units for the invention of chemical constituents,they used as immunity booster to enhance the natural capacity of the body to fight against different health prob-lems as well as herbal medicines and food products *** percent population of the world(around 5.6 billion people)consume medicines from natural plants for major health *** review provides a bird’s eye analysis primarily on the traditional utilization,phytochemical constituents and pharmacological values of medicinal herbs used to normalize hypertension *** sabdariffa,Allium sativum,Andrographis paniculata,Apium graveolens,Bidenspilosa,Camel-lia sinensis,Coptis chinensis,Coriandrum sativum,Crataegus spp.,Crocus sativus,Cymbopogon citrates,Nigella sativa,Panax ginseng,Salviaemiltiorrhizae,Zingiber officinale,Tribulus terrestris,Rauwolfiaserpentina,Terminalia arjuna etc.

关键词： Hypertension Antihypertensive herbs Blood pressure Vasodilatation Herbal medicines Blood pressure regulation

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Anti-leukemic and anti-angiogenic effects of D-Limonene on K562-implanted C57BL/6 mice and the chick chorioallantoic membrane model

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Animal Models and Experimental Medicine 2018年第4期1卷 328-333页

作者： Bhavini B.shah Ruma Baksi Kiranj K.Chaudagar manish Nivsarkar Anita A.Mehta Department of Pharmacology L.M.College of Pharmacy Department of Pharmacology and Toxicology B.V.Patel Pharmaceutical Education and Research Development Centre Department of Surgery University of Chicago

Background: D-Limonene, a monoterpene from citrus fruit has been found to have chemopreventive and chemotherapeutic activities in various types of cancers. In this study, we evaluated the in vivo effect of D-Limonene on a K562-induced model of chronic myeloid leukemia(CML) in C57 BL/6 ***: The tail vein injection model of K562 cells in immunocompromised C57 BL/6 mice was developed and evaluated for characteristics of the disease. The mice were treated with D-Limonene and evaluated for haematological parameters. We also evaluated the effect of D-Limonene on angiogenesis using the chick chorioallantoic membrane(CAM) ***: In a complete blood count, a significant dose-dependent reduction in white blood cell, neutrophil and lymphocyte counts, but an elevation in red blood cell count and haemoglobin content was observed with D-Limonene treatment compared to the disease control or untreated group. In the CAM assay, D-Limonene produced a significant dose-dependent reduction in number of blood vessels in treatment groups compared to the vehicle-treated ***: These studies suggest promising anti-leukemic and anti-angiogenic effects of D-Limonene in the treatment of CML.

关键词： angiogenesis C57BL/6 mice chick chorioallantoic membrane chronic myeloid leukemia D-Limonene

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Multi-parametric MRI of the prostate:Factors predicting extracapsular extension at the time of radical prostatectomy

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Asian Journal of Urology 2017年第1期4卷 31-36页

作者： Geoffrey S.Gaunay Vinay Patel Paras shah Daniel Moreira Ardeshir R.Rastinehad Eran Ben-Levi Robert Villani manish A.Vira The Smith Institute for Urology Hofstra Northwell School of MedicineNew Hyde ParkNYUSA Department of Urology Mayo ClinicRochesterMNUSA Department of Urology Icahn School of Medicine at Mount SinaiNew YorkNYUSA Department of Radiology Hofstra Northwell School of MedicineNew Hyde ParkNYUSA

Objective:Extracapsular extension(ECE)of prostate cancer is a poor prognostic factor associated with progression,recurrence after treatment,and increased prostate cancer-related *** staging prior to radical prostatectomy is crucial in avoidance of positive margins and when planning nerve-sparing ***-parametric magnetic resonance imaging(mpMRI)of the prostate has shown promise in this regard,but is hampered by poor *** sought to identify additional clinical variables associated with pathologic ECE and determine our institutional accuracy in the detection of ECE amongst patients who went on to radical ***:mpMRI studies performed between the years 2012 and 2014 were cross-referenced with radical prostatectomy *** properties of ECE as well as additional clinical and biochemical variables to identify pathology-proven prostate cancer ECE were ***:The prevalence of ECE was 32.4%,and the overall accuracy of mpMRI for ECE was 84.1%.Overall mpMRI sensitivity,specificity,positive predictive value,and negative predictive value for detection of ECE were 58.3%,97.8%,93.3%,and 81.5%,*** mpMRI characteristics predictive of pathologic ECE included primary lesion size((20.73±9.09)mm,mean±SD,p<0.001),T2 PIRADS score(p=0.009),overall primary lesion score(p<0.001),overall study suspicion score(p=0.003),and MRI evidence of seminal vesicle invasion(SVI)(p=0.001).

关键词： Prostate cancer Magnetic resonance imaging Staging Prostatectomy Extracapsular extension

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