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Role of(~(18)F)2-fluoro-2-deoxyglucose positron emission tomography in upper gastrointestinal malignancies

Role of(~(18)F)2-fluoro-2-deoxyglucose positron emission tomography in upper gastrointestinal malignancies

作     者:Elizabeth C Smyth Manish A Shah 

作者机构:Department of Gastrointestinal OncologyWeill Cornell Medical CollegeMemorial Sloan-Kettering Cancer Center Department of Gastrointestinal OncologyWeill Cornell Medical CollegeNew York-Presbyterian Hospital 

出 版 物:《World Journal of Gastroenterology》 (世界胃肠病学杂志(英文版))

年 卷 期:2011年第17卷第46期

页      面:5059-5074页

核心收录:

学科分类:1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主  题:Positron emission tomography Gastric cancer Esophageal cancer Pancreas cancer 

摘      要:The role of whole-body FDG [(~(18)F)2-fluoro-2-deoxy-glucose] positron emission tomography(PET)scan-ning as an imaging modality in the management of patients with malignancy has evolved enormously over the past two ***-PET has demonstrated signifi cant effi cacy in the staging,prognostication and detection of occult metastatic disease in malignancies of the gastrointestinal tract,in addition to assessment of the response to cytotoxic chemotherapy in a more timely manner than has traditionally been possible by more conventional imaging *** sensitivity and specif icity of FDG-PET for the detection and staging of malignancy depend not only on the site and size of the primary tumor and metastases,but also on histologi-cal cell type,reflecting underlying disparities in glucose *** metabolic response to neo-adjuvant chemotherapy or to chemo-radiotherapy in cancers of the gastro-esophageal junction or stomach has been demonstrated in several prospective studies to correlate signifi cantly with both the histological tumor response to treatment and with consequent improvements in overall *** may offer a future paradigm ofpersonalized treatment based on the PET response to ***-PET has been less successful in efforts to screen for and detect recurrent upper gastro-intestinal malignancies,and in the detection of low vol-ume metastatic peritoneal *** to improve the accuracy of PET include the use of novel radiotrac-ers such as(~(18)F)FLT(3-deoxy-3-fluorothymidine)or 11C-choline,or fusion PET-CT with concurrent high-res-olution computed *** review focuses on the role of FDG-PET scanning in staging and response assessment in malignancies of the upper gastrointesti-nal tract,specif ically gastric,esophageal and pancreas carcinoma.

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