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Comparative effectiveness of adipose-derived mesenchymal stromal cells in the management of knee osteoarthritis:A meta-analysis

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World Journal of Orthopedics 2023年第1期14卷 23-41页

作者： Sathish Muthu Sandesh C Patil Naveen Jeyaraman Madhan Jeyaraman Prakash Gangadaran Ramya Lakshmi rajendran Eun Jung Oh Manish Khanna Ho Yun Chung Byeong-Cheol Ahn Department of Orthopaedics Government Medical College and HospitalDindigul 624001Tamil NaduIndia Department of Biotechnology School of Engineering and TechnologySharda UniversityGreater Noida 201310Uttar PradeshIndia Jeyaraman Research AssociateOrthopaedic Research GroupCoimbatore 641045Tamil NaduIndia Indian Stem Cell Study Group Association Lucknow 226001Uttar PradeshIndia Department of Orthopaedic Rheumatology Dr.RML National Law UniversityLucknow 226012Uttar PradeshIndia ACS Medical College&Hospital Dr MGR Educational and Research InstituteChennai 600056Tamil NaduIndia BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents Department of Biomedical SciencesSchool of MedicineKyungpook National UniversityDaegu 41944South Korea Department of Nuclear Medicine School of MedicineKyungpook National UniversityDaegu 41944South Korea Department of Plastic and Reconstructive Surgery CMRIKyungpook National UniversityKyungpook National University HospitalDaegu 41944South Korea Department of Plastic and Reconstructive Surgery School of MedicineKyungpook National UniversityDaegu 41944South Korea Department of Nuclear Medicine Kyungpook National University HospitalDaegu 41944South Korea

BACKGROUND Osteoarthritis(OA)is the most common joint disorder,is associated with an increasing socioeconomic impact owing to the ageing *** To analyze and compare the efficacy and safety of bone-marrow-derived mesenchymal stromal cells(BM-MSCs)and adipose tissue-derived MSCs(AD-MSCs)in knee OA management from published randomized controlled trials(RCTs).METHODS Independent and duplicate electronic database searches were performed,including PubMed,EMBASE,Web of Science,and Cochrane Library,until August 2021 for RCTs that analyzed the efficacy and safety of AD-MSCs and BM-MSCs in the management of knee *** visual analog scale(VAS)score for pain,Western Ontario McMaster Universities Osteoarthritis Index(WOMAC),Lysholm score,Tegner score,magnetic resonance observation of cartilage repair tissue score,knee osteoarthritis outcome score(KOOS),and adverse events were *** was performed on the R-platform using OpenMeta(Analyst)***-one studies,involving 936 patients,were *** one study compared the two MSC sources without patient randomization;hence,the results of all included studies from both sources were pooled,and a comparative critical analysis was *** At six months,both AD-MSCs and BM-MSCs showed significant VAS improvement(P=0.015,P=0.012);this was inconsistent at 1 year for BM-MSCs(P<0.001,P=0.539),and AD-MSCs outperformed BM-MSCs compared to controls in measures such as WOMAC(P<0.001,P=0.541),Lysholm scores(P=0.006;P=0.933),and KOOS(P=0.002;P=0.012).BM-MSC-related procedures caused significant adverse events(P=0.003)compared to AD-MSCs(P=0.673).CONCLUSION Adipose tissue is superior to bone marrow because of its safety and consistent efficacy in improving pain and functional *** trials are urgently warranted to validate our findings and reach a consensus on the ideal source of MSCs for managing knee OA.

关键词： Mesenchymal stromal cell Adipose tissue-derived mesenchymal stromal cell Bone-marrow derived mesenchymal stromal cell Cartilage regeneration Knee osteoarthritis Meta-analysis Efficacy Safety

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Carvacrol attenuates N-nitrosodiethylamine induced liver injury in experimental Wistar rats

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Food Science and Human Wellness 2015年第2期4卷 66-74页

作者： Balan Rajan rajendran Ravikumar Thandavamoorthy Premkumar Thiruvengadam Devaki Department of Biochemistry Guindy CampusUniversity of MadrasChennai 600025TNIndia

Carvacrol is a main constituent in the essential oils of countless aromatic plants including Origanum Vulgare and Thymus vulgari,which has been assessed for substantial pharmacological *** recent years,notable research has been embarked on to establish the biological actions of Carvacrol for its promising use in clinical *** present study is an attempt to reveal the protective role of Carvacrol against NNitrosodiethylamine(DEN)induced hepatic injury in male Wistar albino *** is an egregious toxin,present in numerous environmental factors,which enhances chemical driven liver damage by inducing oxidative stress and cellular *** of DEN(200 mg/kg bodyweight,I.P)to rats results in elevated marker enzymes(in both serum and tissue).Carvacrol(15 mg/kg body weight)suppressed the elevation of marker enzymes(in both serum and tissue)and augmented the antioxidants *** hoisted activities of Phase I enzymes and inferior activities of Phase II enzymes were observed in DEN-administered animals,whereas Carvacrol treated animals showed improved near normal *** observations also support the protective role of Carvacrol against DEN induced liver *** outcome from our findings intimate that Carvacrol might be beneficial in attenuating toxin induced liver damage.

关键词： protective damage rats

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Natural Products Diversity of Marine Ascidians(Tunicates;Ascidiacea)and Successful Drugs in Clinical Development

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Natural Products and Bioprospecting 2017年第1期7卷 1-111页

作者： Satheesh Kumar Palanisamy N.M.rajendran Angela Marino Department of Chemical BiologicalPharmaceutical and Environmental ScienceUniversity of Messina98166 MessinaItaly Key Laboratory of Engineering Plastics and Beijing National Laboratory for Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing 100190China

This present study reviewed the chemical diversity of marine ascidians and their pharmacological applications,challenges and recent developments in marine drug discovery reported during 1994–2014,highlighting the structural activity of compounds produced by these *** date only 5%of living ascidian species were studied from\3000 species,this study represented from family didemnidae(32%),polyclinidae(22%),styelidae and polycitoridae(11–12%)exhibiting the highest number of promising *** to 580 compound structures are here discussed in terms of their occurrence,structural type and reported biological ***-cancer drugs are the main area of interest in the screening of MNPs from ascidians(64%),followed by anti-malarial(6%)and remaining *** approved ascidian compounds mechanism of action along with other compounds status of clinical trials(phase 1 to phase 3)are discussed here *** review highlights recent developments in the area of natural products chemistry and biotechnological approaches are emphasized.

关键词： Cancer Cytotoxicity Diversity Metabolites Pharmacology

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Germline polymorphisms of circadian genes and gastric cancer predisposition

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Cancer Communications 2020年第5期40卷 234-238页

作者： Senthilkumar rajendran Clara Benna Alberto Marchet Donato Nitti Simone Mocellin Department of Surgery Oncology and Gastroenterology University of PadovaPadua 35128Italy First Surgical Clinic Padova University HospitalPadua 35128Italy Multidisciplinary Day-surgery Unit Padova University HospitalPadua 35128Italy Surgical Oncology Unit Veneto Institute of Oncology IOV-IRCCSPadua 35128Italy

Dear Editor,Gastric cancer represents a remarkable disease burden worldwide,ranking among the first five tumor types in incidence and mortality[1].Germline DNA variation has been extensively investigated in terms of predisposition to sporadic gastric cancer,which represents more than 90%of all cases[2].Currently available evidence shows that the fraction of disease burden that can be attributable to known risk polymorphisms is small(<20%)[2].Single germline variations of circadian genes(also called clock genes)have been associated with the predisposition of different tumor types[3].The circadian clock is a timetracking rhythmic biological system with a periodicity of about 24 hours that enables organisms to anticipate environmental changes and allow them to modify their behavior and physiological functions in the most efficient *** rhythms are controlled by proteins encoded by circadian genes,which have been discovered in all studied ***,the disruption of these rhythms has been linked with risk of different diseases including *** regards to the latter,a growing wealth of evidence supports the potential tumor suppressor role of the biological clock[3,4].

关键词： cancer predisposition Gastric

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Short-term traffic forecasting model: prevailing trendsand guidelines

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Transportation Safety and Environment 2023年第3期5卷 1-19页

作者： Kian Lun Soon Robin Kuok Cheong Chan Joanne Mun-Yee Lim rajendran Parthiban School of Engineering Monash UniversityMalaysiaBandar Sunday 47500Malaysia

The design parameters serve as an integral part of developing a robust short-term traffc forecasting model These parameters include scope determination,input data preparation,output parameters and modelling *** paper takes a further leap to analyse the recent trend of design parameters through a systematic literature review based on peer-reviewed articles up to *** key important findings are summarized along with the challenges of performning short-term traffic ***,this paper offers insights into the next wave of research that contributes significantly to industries.

关键词： design parameters transport and society short term forecasting systematic literature review

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Natural products as a means of overcoming cisplatin chemoresistance in bladder cancer

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Cancer Drug Resistance 2021年第1期4卷 69-84页

作者： Ganeshkumar rajendran John A.Taylor III Benjamin L.Woolbright Department of Urology University of Kansas Medical CenterKansas CityKS 66160USA

Cisplatin remains an integral part of the treatment for muscle invasive bladder cancer.A large number of patients do not respond to cisplatin-based chemotherapy and efficacious salvage regimens are *** has offered a second line of treatment;however,only approximately 20% of patients respond,and molecular subtyping of tumors indicates there may be significant overlap in those patients that respond to cisplatin and those patients that respond to *** such,restoring sensitivity to cisplatin remains a major hurdle to improving patient *** potential source of compounds for enhancing cisplatin is naturally derived bioactive products such as phytochemicals,flavonoids and *** compounds can activate a diverse array of different pathways,many of which can directly promote or inhibit cisplatin *** purpose of this review is to understand current drug development in the area of natural products and to assess how these compounds may enhance cisplatin treatment in bladder cancer patients.

关键词： Cisplatin bladder cancer natural products apoptosis

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Genetic characterization of Stargardt clinical phenotype in South Indian patients using sanger and targeted sequencing

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Eye and Vision 2020年第1期7卷 26-35页

作者： rajendran Kadarkarai Raj Pankaja Dhoble Rupa Anjanamurthy Prakash Chermakani Manojkumar Kumaran Bharanidharan Devarajan Periasamy Sundaresan Department of Genetics Aravind Medical Research Foundation-MaduraiNo.1 Anna NagarMaduraiTamil Nadu 625020India Retina Consultant Department of Vitreo Retinal servicesAravind Eye Hospital-PondicherryPuducherryIndia Department of Paediatrics and Adult strabismus Aravind Eye Hospital-MaduraiMaduraiTamil NaduIndia Department of Bioinformatics Aravind Medical Research Foundation-MaduraiMaduraiTamil NaduIndia

Background:Stargardt disease 1(STGD1;MIM 248200)is a monogenic form of autosomal recessive genetic disease caused by mutation in *** gene has a major role in hydrolyzing N-retinylidene-phosphatidylethanolamine to all-trans-retinal and *** purpose of this study is to identify the frequency of putative disease-causing mutations associated with Stargardt disease in a South Indian ***:A total of 28 clinically diagnosed Stargardt-like phenotype patients were recruited from south *** examination of all patients was carefully carried out by a retina specialist based on the stages of fundus imaging and ERG *** analysis of ABCA4 was performed for all patients using Sanger sequencing and clinical exome ***:This study identified disease-causing mutations in ABCA4 in 75%(21/28)of patients,7%(2/28)exhibited benign variants and 18%(5/28)were negative for the disease-causing ***:This is the first study describing the genetic association of ABCA4 disease-causing mutation in South Indian Stargardt 1 patients(STGD1).Our findings highlighted the presence of two novel missense mutations and an(in/del,single base pair deletion&splice variant)in ***,genetic heterogeneity in ABCA4 mutants requires a larger sample size to establish a true correlation with clinical phenotype.

关键词： Stargardt ABCA4 Macular degeneration Yellow white flecks Mutation detection South Indian population

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Antibacterial activity of selected ethnomedicinal plants from South India

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Asian Pacific Journal of Tropical Medicine 2011年第5期4卷 375-378页

作者： rajendran Darling Anpin Raja Solomon Jeeva Juststella Wilfred Prakash Johnson Marimuthu Antonisamy Varaprasadham Irudayaraj Department of Botany Scott Christian College(Autonomous)Nagercoil-629 003Tamil NaduIndia Centre for Biodiversity and Biotechnology Department of BotanyNesamony Memorial Christian CollegeMarthandam-629 165Tamil NaduIndia Denartment of Botanr Scott Christian College(Autonomous)Naeercoil-629 003Tamil NaduIndia Department of Plant Biology and Plant Biotechnology St.Xavier's College(Autonomous)TirunelveliTamil NaduIndia

Objective:To screen the antimicrobial potential of three ethnomedicinal plants Chassalia curviflora Thw.(***),Cyclea peltata Hook.F.& Thomson(***) and Euphorbia hirta L(***) used in folk medicines in Aarukani hills Kani tribe,Tamil Nadu,India against human bacterial ***:Antibacterial efficacy was performed by disc diffusion method against the pathogens viz.,Escherichia coli(***)(ATCC 35218),Staphylococcus aureus (***)(ATCC 6538),Salmonella typhi(***)(MTCC 733),Proteus vulgaris(***), Proteus mirabilis(***) and Streptococcus pyogenes(***) and incubated for 24 h at 37°***:The maximum degree of antibacterial activity was observed in *** followed by *** *** showed comparatively low degree of antibacterial *** methanolic extract of *** showed the antibacterial activity against three pathogens viz.,***,*** and *** with the inhibition zones 12 mm,10 mm and 9 mm,respectively,hexane extracts of *** also showed the antibacterial activity against two selected pathogens viz.,*** and *** with 15 mm and 12 mm of inhibition *** the three different concentrations(025,0.50 & 0.75 mg/mL) of methanolic extract of C. peltata show the inhibitory effect on the three susceptible bacteria ***,*** and E. coli with the maximum inhibition in the highest concentration(0.75 mg/mL).The methanolic and hexane extracts of *** exhibited the antibacterial activity against only one bacterium each *** and *** with the maximum zone of inhibition 13 and 11 mm respectively. The methanolic and hexane extracts of *** exhibited the antibacterial activity against only one bacterium *** with the maximum zone of inhibition 13 and 11 mm respectively. Conclusions:The present investigation revealed that the ***,*** and *** are potentially good source of antibacterial agents and demonstrates

关键词： Antibacterial Folk medicine Kani tribe

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Vapor and Pressure Sensors Based on Cellulose Nanofibers and Carbon Nanotubes Aerogel with Thermoelectric Properties

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Journal of Renewable Materials 2018年第3期6卷 277-287页

作者： rajendran Muthuraj Abhishek Sachan Mickael Castro Jean-Francois Feller Bastien Seantier Yves Grohens Dupuy de Lôme Research Institute(IRDL) FRE CNRS 3744University of Southern BrittanyRue de Saint Maudé56321 Lorient CedexFrance

In this work,thermally insulating and electrically conductive aerogels were prepared from cellulose nanofibers(CNF)and carbon nanotubes(CNTs)by environmentally friendly freeze-drying *** thermal conductivity of neat CNF aerogel is 24 mW/(m・K)with a density of 0.025 g/*** the addition of CNTs into CNF aerogel,the electrical conductivity was significantly increased while the thermal conductivity was increased to 38 mW/(m・K).Due to these interesting properties,the Seebeck coefficient and the figure of merit(ZT)of the CNF/CNTs aerogels were measured and showed that CNF/CNTs aerogel thermoelectric properties can be *** compressibility and electrical resistance of the CNF/CNTs aerogel highlighted its pressure-responsive property.A set of volatile organic compounds(VOCs)were exposed to aerogels to monitor the resistance *** CNF/CNTs aerogel showed high sensitivity and good response to both nonpolar and polar vapors due to the absorption by both CNF and CNTs *** prepared CNF/CNTs aerogel is therefore a good candidate for thermal insulation,thermoelectric material,VOCs sensing,and pressure-sensing applications.

关键词： CNF/CNTs aerogel thermal conductivity pressure sensing thermoelectric materials VOCs sensing

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Indistinguishable cellular changes in gastric mucosa between Helicobacter pylori infected asymptomatic tribal and duodenal ulcer patients

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World Journal of Gastroenterology 2009年第9期15卷 1105-1112页

作者： Dhira Rani Saha Simanti Datta Santanu Chattopadhyay Rajashree Patra Ronita De Krishnan rajendran Abhijit Chowdhury Thandavaryan Ramamurthy Asish Kumar Mukhopadhyay Division of Histology & Electron microscopy. National Institute of Cholera and Enteric Diseases P 33 CIT Road Scheme XM Beliaghata Kolkata 700010 India School of digestive diseases Institute of Post Graduate Medical Education and Research 244 AJC Bose Road Kolkata 700020 India Division of Bacteriology National Institute of Cholera and Enteric Diseases P 33 CIT Road Scheme XM Beliaghata Kolkata 700010 India Data management Division National Institute of Cholera and Enteric Diseases P 33 CIT Road Scheme XM Beliaghata Kolkata 700010 India

AIM:To investigate the changing pattern of different histological parameters occurring in the stomach tissue of Helicobacter pylori (H pylori) infected tribal populations and duodenal ulcer patients among ethnic Bengalis and correlation of the genotypes of H pylori with different histological *** enrolled into this study between 2002 and 2004. Among them,72 had clinical features of duodenal ulcer (DU) from ethnic Bengali population and 40 were asymptomatic ethnic tribals. Endoscopic gastric biopsy samples were processed for histology,genotyping and rapid urease test. Histologically,haematoxylin and eosin staining was applied to assess the pathomorphological changes and a modified Giemsa staining was used for better detection of H pylori. For intestinal metaplasia,special stainings,i.e. Alcian blue periodic acid-Schiff and high iron diamine-Alcian blue staining,were performed. PCR was performed on bacterial DNA to characterize the presence or absence of virulence-associated genes,like cagA,and distribution of different alleles of vacA and iceA. RESULTS:Intraglandular neutrophil infiltration,a hallmark of activity of gastritis,was present in 34 (94%) of tribals (TRs) and 42 (84%) of DU individuals infected with H pylori. Lymphoid follicles and aggregates,which are important landmarks in H pylori infection,were positive amongst 15 (41%) of TRs and 20 (40%) of DU subjects. Atrophic changes were observed in 60% and 27.7%,respectively,among DU cases and tribals (P > 0.003). Metaplastic changes were detected in low numbers in both groups. Moderate to severe density distribution of H pylori in the gastric mucosa was 63% among TRs,whereas it was 62% in DU subjects. There were no significant differences in the distribution of virulence-associated genes like cagA,vacA and iceA of H pylori strains carried by these two populations. CONCLUSION:Our study showed almost similar distribution of inflammatory cells among asymptomatic tribals and DU Bengali patients. Interes

关键词：胃黏膜幽门螺杆菌感染十二指肠球部溃疡无症状细胞变化 Hpylori 改良Giemsa染色中性粒细胞浸润过碘酸Schiff

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