Natural products as a means of overcoming cisplatin chemoresistance in bladder cancer
作者机构：Department of UrologyUniversity of Kansas Medical CenterKansas CityKS 66160USA
出 版 物：《Cancer Drug Resistance》 (癌症耐药（英文）)
年 卷 期：2021年第4卷第1期
页 面：69-84页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Leo and Anne Albert Institute for Bladder Cancer Research U.S. Department of Defense, DOD, (CA190460)
主 题：Cisplatin bladder cancer natural products apoptosis
摘 要：Cisplatin remains an integral part of the treatment for muscle invasive bladder cancer.A large number of patients do not respond to cisplatin-based chemotherapy and efficacious salvage regimens are *** has offered a second line of treatment;however,only approximately 20% of patients respond,and molecular subtyping of tumors indicates there may be significant overlap in those patients that respond to cisplatin and those patients that respond to *** such,restoring sensitivity to cisplatin remains a major hurdle to improving patient *** potential source of compounds for enhancing cisplatin is naturally derived bioactive products such as phytochemicals,flavonoids and *** compounds can activate a diverse array of different pathways,many of which can directly promote or inhibit cisplatin *** purpose of this review is to understand current drug development in the area of natural products and to assess how these compounds may enhance cisplatin treatment in bladder cancer patients.
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