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绿色合成与催化(英文) 2023年第2期4卷 173-176页

作者： manickam deepa Selvarasu Uthayanila Kannan Mariyammal Ramasamy ShanmugaPriya Sivasankar Koppala Manivannan Karthikeyan Parasuraman Karthikeyan PG and Research Department of Chemistry Pachaiyappas College Campus University of MadrasChennai 600030India Department of Chemistry Pachaiyappas College for Women CampusUniversity of MadrasKanchipuram 631501India Department of Chemistry Dhanalakshmi Srinivasan College of Arts and Science for WomenPreambular 621212India Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences(SIMATS)Chennai 602105India

We reported solvent-free and recoverable heterogeneous iron functionalised imidazolium-based ionic liquid for the reduction of nitroarene derivatives in the presence of formic acid under greener ***,the experimental result shows that the iron complex could be an extremely resourceful,high rate and reusable catalyst for a different nitroarene substrate.

关键词： Formic acid Reduction Heterogeneous catalyst Iron complex Ionic liquid

Enhanced Mechanism for Link Failure Rerouting in Software-Defined Exchange Point Networks

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Computers, Materials & Continua 2024年第9期80卷 4361-4385页

作者： Abdijalil Abdullahi Selvakumar manickam Department of Information Technology SIMAD UniversityMogadishu630Somalia National Advanced IPv6 Centre Universiti Sains MalaysiaPulua Pinang11800Malaysia

Internet Exchange Point(IXP)is a system that increases network bandwidth *** exchange points facilitate interconnection among network providers,including Internet Service Providers(ISPs)andContent Delivery Providers(CDNs).To improve service management,Internet exchange point providers have adopted the Software Defined Network(SDN)*** implementation is known as a Software-Defined Exchange Point(SDX).It improves network providers’operations and ***,performance issues still exist,particularly with multi-hop *** issues include switch memory costs,packet processing latency,and link failure recovery *** paper proposes Enhanced Link Failure Rerouting(ELFR),an improved mechanism for rerouting link failures in software-defined exchange point *** proposed mechanism aims to minimize packet processing time for fast link failure recovery and enhance path calculation efficiency while reducing switch storage overhead by exploiting the Programming Protocol-independent Packet Processors(P4)*** paper presents the proposed mechanisms’efficiency by utilizing advanced algorithms and demonstrating improved performance in packet processing speed,path calculation effectiveness,and switch storage management compared to current *** proposed mechanism shows significant improvements,leading to a 37.5%decrease in Recovery Time(RT)and a 33.33%decrease in both Calculation Time(CT)and Computational Overhead(CO)when compared to current *** study highlights the effectiveness and resource efficiency of the proposed mechanism in effectively resolving crucial issues inmulti-hop software-defined exchange point networks.

关键词： Link failure recovery Internet exchange point software-defined exchange point software-defined network multihop topologies

Benzydamine hydrochloride ameliorates ethanol-induced inflammation in RAW 264.7 macrophages by stabilizing redox homeostasis

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Asian Pacific Journal of Tropical Biomedicine 2024年第2期14卷 73-81,I0006-I0009页

作者： Tiasha Dasgupta Venkatraman manickam Department of Biomedical Sciences School of Biosciences and TechnologyVellore Institute of TechnologyVellore 632014Tamil NaduIndia

Objective:To evaluate the protective effect of benzydamine hydrochloride against ethanol-induced oxidative stress and inflammation in RAW 264.7 ***:RAW 264.7 macrophages were treated with ethanol(100 mM)and benzydamine hydrochloride(7.5μM).The imflammatory status was confirmed by measuring pro-(TNF-αand IL-6)and anti-inflammatory(IL-10)cytokines through ELISA and RT-PCR *** oxygen species generation and mitochondrial membrane potential were investigated to study the protective role of benzydamine hydrochloride against ethanol-induced oxidative *** detection was also investigated using flow cytometry and acridine orange/ethidium bromide ***:Benzydamine hydrochloride significantly decreased the secretion of TNF-αand IL-6,as well as the generation of reactive oxygen species inside the cells,thereby stabilizing the mitochondrial membrane potential and reducing DNA *** ethanol-induced cellular necrosis was also reversed by the administration of benzydamine ***:Benzydamine hydrochloride ameliorates ethanol-induced cell apoptosis and inflammation in RAW macrophages.

关键词： Alcohol Benzydamine hydrochloride Inflammation Oxidative stress Apoptosis

The Impact of Heat Treatment and Surface Treatment on Thermal Conductivity of Heat Sinks Made of Aluminium Die Casting Alloys

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Journal of Harbin Institute of Technology(New Series) 2024年第4期31卷 34-41页

作者： Rajesh Kumar manickam Dilip Raja Narayana Department of Mechanical Engineering Vel Tech Rangarajan Dr.Sagunthala R&D Institute of Science and TechnologyChennai 600001Tamil NaduIndia

This research contributes to understand the thermal management capabilities of Plate Fin Heat Sinks(PFHS)fabricated from *** uniqueness in this study is that the heat sinks were exposed to abrasive blasting,heat treatment,and graphene coating,and a full evaluation of the influence of the aforementioned treatments on the thermal management capacities of PFHS was *** PFHS is compared with 1)abrasive blasted and graphene coated heat sink,and 2)heat treated and graphene coated heat *** assess the thermal efficiency of the PFHS variants,a dedicated experimental set up was meticulously *** is noteworthy that a junction temperature of 60℃was assumed as the reference point for the *** results revealed that the charging cycle time which denotes the time required attaining the junction temperature,increased 1.3 times for the sample being abrasive-blasted at 0.5 MPa pressure and graphene-coated for 0.5 mm when the maximum heat input of 45 W is *** low heat input of 15 W is evaluated,the results revealed that there is no significant difference in charging cycle when compared to the untreated heat *** charging cycle time increased 2 times for the sample which is heat-treated at 450℃and graphene-coated for 0.5 mm at heat input of 15 *** finding unequivocally underscores the heightened capacity of the heat treated and graphene coated PFHS made of AlSi10Mg to withstand elevated junction temperatures.

关键词： PFHS abrasive blasting heat treatment graphene

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Sustainable Furfural Biomass Feedstocks Electrooxidation toward Value-Added Furoic Acid with Energy-Saving H_(2) Fuel Production Using Pt-Decorated Co_(3)O_(4) Nanospheres

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Energy & Environmental Materials 2024年第2期7卷 350-358页

作者： Talshyn Begildayeνa Jayaraman Theerthagiri Seung Jun Lee Ahreum Min Gyeong-Ah Kim Siνakumar manickam Myong Yong Choi Department of Chemistry(BK21 FOUR) Core-Facility Center for Photochemistry&NanomaterialsResearch Institute of Natural SciencesGyeongsang National UniversityJinju 52828South Korea Petroleum and Chemical Engineering Faculty of EngineeringUniversiti Teknologi BruneiJalan Tungku Link GadongBandar Seri Begawan BE1410Brunei Darussalam

Here,furfural oxidation was performed to replace the kinetically sluggish O_(2)evolution reaction(OER).Pt-Co_(3)O_(4)nanospheres were developed via pulsed laser ablation in liquid(PLAL)in a single step for the paired electrocatalysis of an H_(2)evolution reaction(HER)and furfural oxidation reaction(FOR).The FOR afforded a high furfural conversion(44.2%)with a major product of 2-furoic acid after a 2-h electrolysis at 1.55 V versus reversible hydrogen electrode in a 1.0-M KOH/50-mM furfural *** Pt-Co_(3)O_(4)electrode exhibited a small overpotential of 290 mV at 10 mA cm^(-2).As an anode and cathode in an electrolyzer system,the Pt-Co_(3)O_(4)electrocatalyst required only a small applied cell voltage of~1.83 V to deliver 10 mA cm^(-2),compared with that of the pure water electrolyzer(OER||HER,~1.99 V).This study simultaneously realized the integrated production of energy-saving H_(2)fuel at the cathode and 2-furoic acid at the anode.

关键词： biomass conversion electrochemical furfural oxidation overall water splitting Pt-Co_(3)O_(4)electrocatalyst pulsed laser ablation in liquid

Integrated Single-cell Multiomic Analysis of HIV Latency Reversal Reveals Novel Regulators of Viral Reactivation

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Genomics, Proteomics & Bioinformatics 2024年第1期22卷 67-88页

作者： manickam Ashokkumar Wenwen Mei Jackson J.Peterson Yuriko Harigaya David M.Murdoch David M.Margolis Caleb Kornfein Alex Oesterling Zhicheng Guo Cynthia D.Rudin Yuchao Jiang Edward P.Browne Department of Medicine University of North Carolina at Chapel HillChapel HillNC 27599USA HIV Cure Center University of North Carolina at Chapel HillChapel HillNC 27599USA Department of Biostatistics University of North Carolina at Chapel HillChapel HillNC 27599USA Department of Microbiology and Immunology University of North Carolina at Chapel HillChapel HillNC 27599USA Department of Genetics University of North Carolina at Chapel HillChapel HillNC 27599USA Department of Medicine Duke UniversityDurhamNC 27708USA Department of Computer Science Duke UniversityDurhamNC 27708USA Department of Statistics Texas A&M UniversityCollege StationTX 77843USA Department of Biology Texas A&M UniversityCollege StationTX 77843USA Department of Biomedical Engineering Texas A&M UniversityCollege StationTX 77843USA

Despite the success of antiretroviral therapy,human immunodeficiency virus(HIV)cannot be cured because of a reservoir of latently infected cells that evades *** understand the mechanisms of HIV latency,we employed an integrated single-cell RNA sequencing(scRNA-seq)and single-cell assay for transposase-accessible chromatin with sequencing(scATAC-seq)approach to simultaneously profile the transcriptomic and epigenomic characteristics of~125,000 latently infected primary CD4^(+)T cells after reactivation using three different latency reversing *** expressed genes and differentially accessible motifs were used to examine transcriptional pathways and transcription factor(TF)activities across the cell *** identified cellular transcripts and TFs whose expression/activity was correlated with viral reactivation and demonstrated that a machine learning model trained on these data was 75%-79%accurate at predicting viral ***,we validated the role of two candidate HIV-regulating factors,FOXP1 and GATA3,in viral *** data demonstrate the power of integrated multimodal single-cell analysis to uncover novel relationships between host cell factors and HIV latency.

关键词： HIV latency reversal Primary CD4þT cell Single-cell multiomics HIV-regulating factor Machine learning

Impact of phytoconstituents on oral health practices:a post COVID-19 observation

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Food Science and Human Wellness 2024年第5期13卷 2386-2400页

作者： Harsh Kumar Reena Singh Daljeet Singh Dhanjal Chirag Chopra Natália Cruz-Martins Gheyath K.Nasrallah Amin F.Majdalawieh Sivakumar manickam Shahida Anusha Siddiqui Dinesh Kumar Indu Sharma Varun Sharma School of Bioengineering&Food Technology Shoolini University of Biotechnology and Management SciencesSolan 173229India School of Bioengineering and Biosciences Lovely Professional UniversityPunjab 144402India Faculty of Medicine University of PortoPorto 4200-319Portugal Institute for Research and Innovation in Health(i3S) University of PortoPorto 4200-135Portugal Institute of Research and Advanced Training in Health Sciences and Technologies(CESPU) RuaCentral de GandraGandra 4585-116Portugal TOXRUN-Toxicology Research Unit University Institute of Health SciencesCESPUCRLGandra 4585-116Portugal Biomedical Research Center Qatar UniversityDoha 2713Qatar Department of Biomedical Science College of Health SciencesQatar UniversityDoha 2713Qatar Department of Biology Chemistryand Environmental SciencesCollege of Arts and SciencesAmerican University of SharjahSharjah 26666United Arab Emirates Petroleum and Chemical Engineering Faculty of EngineeringUniversiti Teknologi BruneiBandar Seri Begawan BE1410Brunei Campus Straubing for Biotechnology and Sustainability Technical University of MunichStraubing 94315Germany Genetic Heritage Group New York UniversityAbu Dhabi 129188United Arab Emirates Bioinformatics Division NMC Genetics India Pvt.Ltd.Gurugram 122001India

Appropriate oral hygiene significantly reduces the possibility of oral ***,dental caries and periodontal diseases are major oral health issues causing chronic diseases due to poor oral ***,herbal compounds have gained interest in maintaining oral *** of burdock root(Arctium),noni fruit(Morinda citrifolia),and neem leaf(Azadirachta indica)are now used as intracanal medicaments in endodontics and *** amboinicus species and other plants produces essential oil likeβ-caryophyllene,p-cymene,andγ-terpinene can exhibit antibacterial activity;highlighting phytoconstituents plays a vital role in oral *** COVID-19 pandemic highlighted the importance of hygiene and sanitization,to curb *** cavity is among the gateways for virus entry into *** is a potential reservoir of SARS-CoV-2,and there is an increased risk of infection if there is any fissure in the *** enables entry of virus into the vascular system through gingival or periodontal pocket,possibly reaching lung periphery then to lung vessels by interacting with endothelial surface receptors triggering pulmonary vasoconstriction and lung damage due to endothelial *** review aims to draw attention to the possible route of SARS-CoV-2 infection via the oral cavity and the importance of oral hygiene against COVID-19.

关键词： COVID-19 SARS-CoV-2 Oral Hygiene Microbiota Phytochemicals

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Dry/wet snow mapping based on the synergistic use of dual polarimetric SAR and multispectral data

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Journal of Mountain Science 2019年第6期16卷 1435-1451页

作者： Divyesh VARADE Onkar DIKSHIT Surendar manickam Geoinformatics Department of Civil EngineeringIndian Institute of Technology KanpurKalyanpurKanpur-208016India Department of Civil and Environmental Engineering Duke UniversityDurhamNC-27708-028USA

We propose a multi-sensor multi-spectral and bi-temporal dual-polarimetric Synthetic Aperture Radar(SAR) data integration scheme for dry/wet snow mapping using Sentinel-2 and Sentinel-1 data which are freely available to the research community. The integration is carried out by incorporating the information retrieved from ratio images of the conventional method for wet snow mapping and the multispectral data in two different frameworks. Firstly, a simple differencing scheme is employed for dry/wet snow mapping, where the snow cover area is derived using the Normalized Differenced Snow Index(NDSI). In the second framework, the ratio images are stacked with the multispectral bands and this stack is used for supervised and unsupervised classification using support vector machines for dry/wet snow mapping. We also investigate the potential of a state of the art backscatter model for the identification of dry/wet snow using Sentinel-1 data. The results are validated using a reference map derived from RADARSAT-2 full polarimetric SAR data. A good agreement was observed between the results and the reference data with an overall accuracy greater than 0.78 for the different blending techniques examined. For all the proposed frameworks, the wet snow was better identified. The coefficient of determination between the snow wetness derived from the backscatter model and the reference based on RADARSAT-2 data was observed to be 0.58 with a significantly higher root mean square error of 1.03 % by volume.

关键词： Snow mapping Ratio method Normalized Differenced Snow Index Classification Polarimetric synthetic-aperture radar

Evaluation of Zero and Sub-zero Temperature Tensile and Impact Properties of Quenched and Tempered Steel Weldments

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Journal of Iron and Steel Research International 2016年第11期23卷 1177-1187页

作者： M.BALAKRISHNAN V.BALASUBRAMANIAN M.A.MUTHU manickam Department of Mechanical Engineering M.Kumarasamy College of Engineering(Autonomous)ThalavapalayamKarur 639113Tamil NaduIndia Center for Materials Joining&Research(CEMAJOR) Department of Manufacturing EngineeringAnnamalai UniversityAnnamalainagar 608002Tamil NaduIndia Combat Vehicles Research and Development Establishment(CVRDE) AvadiChennai 600054Tamil NaduIndia

Combat vehicles using armour grade quenched and tempered （Q＆T） steel are needed to be operated under different climatic conditions. However, the properties meeting the room temperature test conditions may not neces-sarily be required to meet the low temperature operating conditions. The influences of shielded metal arc welding （SMAW） process, flux cored arc welding （FCAW） processes and test temperatures below room temperature up to 60℃ on tensile and impact toughness properties of armour grade Q＆T steel welds were reported. The tensile and impact properties of the joints showed incremental trend with respect to the decrement in test temperature up to -40℃ irrespective of the welding processes used. The increment in tensile and impact properties of SMAW and FCAW joints subjected to the low temperature environment is due to plastic strain-induced phase transformation of retained austenite into martensite phase. Among the two processes, SMAW process welded joint showed better tensile and impact properties than its FCAW counterpart joints.

关键词： shielded metal arc welding flux cored arc welding low temperature property microstrncture: hardness

Intrusion Detection Systems Using Blockchain Technology: A Review, Issues and Challenges

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Computer Systems Science & Engineering 2022年第1期40卷 87-112页

作者： Salam Al-E’mari Mohammed Anbar Yousef Sanjalawe Selvakumar manickam Iznan Hasbullah National Advanced IPv6 Centre of Excellence(NAv6) Universiti Sains Malaysia11800 USMPenangMalaysia Computer Sciences Department Northern Border University(NBU)9280 NBUAr’arthe Kingdom of Saudi Arabia

Intrusion detection systems that have emerged in recent decades can identify a variety of malicious attacks that target networks by employing several detection ***,the current approaches have challenges in detecting intrusions,which may affect the performance of the overall detection system as well as network *** the time being,one of the most important creative technological advancements that plays a significant role in the professional world today is blockchain *** technology moves in the direction of persistent revolution and *** is a chain of blocks that covers information and maintains trust between individuals no matter how far apart they ***,blockchain was integrated into intrusion detection systems to enhance their overall *** has also been adopted in health-care,supply chain management,and the Internet of *** uses robust cryptography with private and public keys,and it has numerous properties that have leveraged security’s performance over peer-to-peer networks without the need for a third *** explore and highlight the importance of integrating blockchain with intrusion detection systems,this paper provides a comprehensive background of intrusion detection systems and blockchain ***,a comprehensive review of emerging intrusion detection systems based on blockchain technology is ***,this paper suggests important future research directions and trending topics in intrusion detection systems based on blockchain technology.

关键词： Blockchain intrusiondetectionsystem networksecurity maliciousattacks