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A novel over-sampling method and its application to miRNA prediction

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Journal of Biomedical Science and Engineering 2013年第2期6卷 236-248页

作者： Xuan Tho Dang Osamu Hirose Thammakorn Saethang Vu Anh tran Lan Anh T. Nguyen Tu kien T. Le Mamoru Kubo Yoichi Yamada Kenji Satou Graduate School of Natural Science and Technology Kanazawa University Kanazawa Japan Institute of Science and Engineering Kanazawa University Kanazawa Japan

MicroRNAs (miRNAs) are short (~22nt) non-coding RNAs that play an indispensable role in gene regulation of many biological processes. Most of current computational, comparative, and non-comparative methods commonly classify human precursor micro- RNA (pre-miRNA) hairpins from both genome pseudo hairpins and other non-coding RNAs (ncRNAs). Although there were a few approaches achieving promising results in applying class imbalance learning methods, this issue has still not solved completely and successfully yet by the existing methods because of imbalanced class distribution in the datasets. For example, SMOTE is a famous and general over-sampling method addressing this problem, however in some cases it cannot improve or sometimes reduces classification performance. Therefore, we developed a novel over-sampling method named incre-mental- SMOTE to distinguish human pre-miRNA hairpins from both genome pseudo hairpins and other ncRNAs. Experimental results on pre-miRNA datasets from Batuwita et al. showed that our method achieved better Sensitivity and G-mean than the control (no over- sampling), SMOTE, and several successsors of modified SMOTE including safe-level-SMOTE and border-line-SMOTE. In addition, we also applied the novel method to five imbalanced benchmark datasets from UCI Machine Learning Repository and achieved improvements in Sensitivity and G-mean. These results suggest that our method outperforms SMOTE and several successors of it in various biomedical classification problems including miRNA classification.

关键词： Imbalanced Dataset Over-Sampling SMOTE miRNA Classification

Predicting residue contacts for protein-protein interactions by integration of multiple information

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Journal of Biomedical Science and Engineering 2014年第1期7卷 28-37页

作者： Tu kien T. Le Osamu Hirose Vu Anh tran Thammakorn Saethang Lan Anh T. Nguyen Xuan Tho Dang Duc Luu Ngo Mamoru Kubo Yoichi Yamada Kenji Satou Graduate School of Natural Science and Technology Kanazawa University Kanazawa Japan Institute of Science and Engineering Kanazawa University Kanazawa Japan

Detailed knowledge of interfacial region between interacting proteins is not only helpful in annotating function for proteins, but also very important for structure-based drug design and disease treatment. However, this is one of the most difficult tasks and current methods are constrained by some factors. In this study, we developed a new method to predict residue-residue contacts of two interacting protein domains by integrating information about evolutionary couplings andamino acid pairwise contact potentials, as well as domain-domain interaction interfaces. The experimental results showed that our proposed method outperformed the previous method with the same datasets. Moreover, the method promises an improvement in the source of template-based protein docking.

关键词： Residue-Residue Contacts Domain-Domain Interactions Protein-Protein Interactions Domain Interfaces Residue Co-Evolution Contact Potentials

D-IMPACT: A Data Preprocessing Algorithm to Improve the Performance of Clustering

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Journal of Software Engineering and Applications 2014年第8期7卷 639-654页

作者： Vu Anh tran Osamu Hirose Thammakorn Saethang Lan Anh T. Nguyen Xuan Tho Dang Tu kien T. Le Duc Luu Ngo Gavrilov Sergey Mamoru Kubo Yoichi Yamada Kenji Satou Graduate School of Natural Science and Technology Kanazawa University Kanazawa Japan Institute of Science and Engineering Kanazawa University Kanazawa Japan

In this study, we propose a data preprocessing algorithm called D-IMPACT inspired by the IMPACT clustering algorithm. D-IMPACT iteratively moves data points based on attraction and density to detect and remove noise and outliers, and separate clusters. Our experimental results on two-dimensional datasets and practical datasets show that this algorithm can produce new datasets such that the performance of the clustering algorithm is improved.

关键词： Attraction Clustering Data Preprocessing Density Shrinking

Predicting Βeta-Turns and Βeta-Turn Types Using a Novel Over-Sampling Approach

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Journal of Biomedical Science and Engineering 2014年第11期7卷 927-940页

作者： Lan Anh T. Nguyen Xuan Tho Dang Tu kien T. Le Thammakorn Saethang Vu Anh tran Duc Luu Ngo Sergey Gavrilov Ngoc Giang Nguyen Mamoru Kubo Yoichi Yamada Kenji Satou Graduate School of Natural Science and Technology Kanazawa University Kanazawa Japan Department of Computer Science Hue University of Education Hue Vietnam Institute of Science and Engineering Kanazawa University Kanazawa Japan

β-turn is one of the most important reverse turns because of its role in protein folding. Many computational methods have been studied for predicting β-turns and β-turn types. However, due to the imbalanced dataset, the performance is still inadequate. In this study, we proposed a novel over-sampling technique FOST to deal with the class-imbalance problem. Experimental results on three standard benchmark datasets showed that our method is comparable with state-of-the-art methods. In addition, we applied our algorithm to five benchmark datasets from UCI Machine Learning Repository and achieved significant improvement in G-mean and Sensitivity. It means that our method is also effective for various imbalanced data other than β-turns and β-turn types.

关键词： Beta-Turns Beta-Turn Types Class-Imbalance Over-Sampling

Fuzzy Adaptive Control of Networked Control System with Unknown Time-delay

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Fuzzy Adaptive Control of Networked Control System with Unkn...

Hypoglycemic and antioxidant activities of Clerodendrum inerme leaf extract on streptozotocin-induced diabetic models in mice

第三十届中国控制会议

作者： DANG Xuan-kien~1,GUAN Zhi-Hong~1,tran Hoang-Dung~1,LI Tao~2 1.Department of Control Science and Engineering,Huazhong University of Science and Technology,Wuhan 430074,P.R.China 2.Electronics and Information College,Yangtze University,Jingzhou 420400,P.R.China

＜正＞In this paper,we propose a fuzzy adaptive controller design for a class of networked control systems（NCS） with the presence of network induced delay,data packet dropout and unknown time-delay controlled *** mathematical model of Smith predictor,which is combined with fuzzy adaptive controller and fuzzy compensator time-delay,is designed to adjust online its parameters according to the changing of the system’s *** results based on TrueTime Beta2.0 simulation platform demonstrate that our design significantly improves the response of system over unknown time-delay.

关键词： Adaptive Control Fuzzy Adaptive Controller Networked Control System Smith Predictor Unknown Time-Delay

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Chinese Herbal Medicines 2019年第4期11卷 387-393页

作者： Hai Trieu Ly Thi Thu Huong Nguyen Thi Thanh Loan tran Bich Thao Lam Thi Thu Huong Phung Van Minh Le Research Center of Ginseng and Medicinal Materials(CGMM) National Institute of Medicinal MaterialsHo Chi Minh City 700000Viet Nam University of Science Vietnam National UniversityHo Chi Minh City 700000Viet Nam University of Medicine and Pharmacy Ho Chi Minh City 700000Viet Nam NTT Hi-Tech Institute Nguyen Tat Thanh UniversityHo Chi Minh City 700000Viet Nam

Objective:Recently,much attention has been paid to natural product-derived compounds for antidiabetic drug *** recent studies are being focused on clarifying the bioactivity of plants and derived *** aim of the present study was to investigate the anti-oxidant and antidiabetic activities of Clerodendrum inerme leaf extract(CILE)in streptozotocin-induced diabetic ***:*** leaves were analyzed for preliminary phytochemical properties and the content of total phenolic and flavonoid were *** vitro anti-oxidant activity was measured using DPPH ***-induced diabetic model in mice was applied for in vivo study by the effect of CILE at two dose levels(343 and 686 mg/kg b.w.).Results:The results showed that *** leaves contained the major constituents of flavonoids,alkaloids,tannins,triterpenes,and *** exhibited the total polyphenol and flavonoid content with 120.458 mg gallic acid equivalent/g dry weight and 4.494 mg hispidulin equivalent/g dry weight,*** anti-oxidant activity of CILE was expressed with IC50=25.28μg/m *** at the doses of343 mg/kg and 686 mg/kg after 7 d administration exerted a decrease in plasma glucose,protected the liver,kidneys against oxidation stress via increasing glutathione content in the liver,and reduced malondialdehyde content in the liver and *** histological analysis in diabetic mice treated with CILE also showed the pancreaticβ-cells regeneration via increasing the size and number of pancreatic ***:These findings suggested that *** leaves had potent antidiabetic and anti-oxidant *** results provide reliable scientific base,which is the premise for further research and development of CILE as supplements.

关键词： antidiabetic activity anti-oxidant Clerodendrum inerme(L.)Gaertn flavonoids hypoglycemic activity polyphenols

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越南玉米产业发展及市场供需现状分析

南方农业学报 2022年第4期53卷 1186-1192页

作者：吕荣华邹成林唐茂艳陈雷刘淑仪张晓丽曾媛 tran Van Quang 吕佳茗广西农业科学院国际合作处广西南宁530007 广西农业科学院玉米研究所广西南宁530007 广西农业科学院水稻研究所广西南宁530007 越南农业大学越南河内100803 广西大学计算机与电子信息学院广西南宁530004

【目的】掌握越南玉米产业发展历程及现状,为中越两国开展科技合作提供决策参考。【方法】基于越南统计局数据,总结归纳越南玉米发展历程、种植生产、进口贸易及各生态区生产情况,对中越玉米在技术和市场等方面的合作进行展望。【结果... 详细信息

【目的】掌握越南玉米产业发展历程及现状,为中越两国开展科技合作提供决策参考。【方法】基于越南统计局数据,总结归纳越南玉米发展历程、种植生产、进口贸易及各生态区生产情况,对中越玉米在技术和市场等方面的合作进行展望。【结果】越南从事玉米育种研究较晚,品种引入,国外品种引进对越南玉米育种和生产发展起重要作用,越南玉米种植面积、单产和总产量自20世纪80年代以来逐年上升,目前种植面积在100万ha左右,总产量在500万t左右,2014年以来呈现逐年下滑趋势。从生态区域来看种植主要集中在北部丘陵山区,2019年北部种植面积61.97万ha,占全越南玉米1/3以上;从省份来看种植面积较大省份有山罗省、多乐省、义安省和清化省,产量来较大省份是多乐省、山罗省、同奈省、清化省、义安省、嘉莱省和得农省;从南北区域来看种植面积和产量主要集中在北部;从栽培条件来看,东南部、九龙江平原和西原地区玉米单产最高,单产较高省份是同塔、坚江、安江和同奈。越南生产的玉米约60%用于食用和生产酒精,40%用于生产饲料。越南生产的玉米满足不了本国需求,需从美国、印度等国进口大量玉米,年进口量100万~180万t,且80%为转基因玉米。种植品种主要有单交玉米GS9989(A380)、VN5885、TC 14-1,鲜食糯玉米品种VN556、甜玉米品种20(DL20)青料饲料两用玉米VS71品种。玉米草地贪夜蛾是危害中越两国迁飞性害虫;同时越南玉米生产中存在品种单一、优良品种匮乏、栽培技术落后制约其玉米产业的发展。【建议】我国相关机构部门应加强与越南玉米研究所和越南农业大学等农业研究部门合作;加大示范推广我国优良玉米品种;在越南登记经示范适用玉米品种;与企业合作将适宜品种出口到越南,加强与东盟国家合作。

关键词：玉米越南农业生态区种植面积栽培技术

Flood Hazard Mapping at Long Xuyen Quadrangle in2015 Using Geographic Information System and RemoteSensing Technologies

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Journal of Environmental Science and Engineering(B) 2019年第5期8卷 197-203页

作者： Nguyen Thi Hong Diep tran Huu Duy Phan Kieu Diem Nguyen Thi Be Nam Nguyen Thi ThanhHuong Land Resources Department College of Environment and Natural ResourcesCan Tho UniversityCan Tho 940000Vietnam The Southwest Information and Appraisal Corporation(SIAC) Cantho 94000Vietnam Department of Natural Resources and Environment in kien Giang Province Kien Giang 920000Vietnam Forest Ecology and Environment Department Faculty of Agriculture and ForestryTay Nguyen UniversityDakLak 630000Vietnam

In recent year,the flooding has occurred with high frequency at LXQ(Long Xuyen Quadrangle)areas of Mekong Delta,*** was considered as a major natural disaster which has effects on the physic and spirit in people’s life in this *** research aims to generate a flood hazard map and assess the flood situation at LXQ in *** MNDWI(Modification of Normalized Difference Water Index)extracting from Sentinel-2 image was used to map the flood extent at LXQ during rainy season in *** statistics method estimated correlation coefficient between flooding spatial distribution and hydrological stations on SPSS(Statistical Product and Services Solutions)*** results showed that the severe flood occurred from August to December in *** were about 47.6%and 28.2%of the total areas that were inundated in October and August,*** correlation between inundated areas and water level at Ha Tien and Chau Doc hydrological stations was 0.73 and 0.65(p<0.01),*** derived information was very essential and valuable for local managers in making decision on responding and mitigating to the flood disaster.

关键词： Flood distribution MNDWI LXQ correlation coefficient

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越南坚江省华人的天后圣母信仰考察

妈祖文化研究 2021年第4期 1-5页

作者： [越南]阮福才阮福勇阮顺贵陈氏金黄同塔政治学校越南同塔93000 同塔大学越南同塔93000 坚江师范专科学校越南坚江83000

宗教信仰在越南,尤其是在南部坚江省华人华侨的文化与生活中扮演着一个非常重要的角色。他们奉祀许多神灵,如关圣帝君、本头公、天后圣母(妈祖)等。本文通过田野调查与访问,对越南坚江省华人的天后圣母信仰在精神生活中的地位、祭祀仪... 详细信息

宗教信仰在越南,尤其是在南部坚江省华人华侨的文化与生活中扮演着一个非常重要的角色。他们奉祀许多神灵,如关圣帝君、本头公、天后圣母(妈祖)等。本文通过田野调查与访问,对越南坚江省华人的天后圣母信仰在精神生活中的地位、祭祀仪式以及历史本源、演进过程等作初步探讨。

关键词：越南坚江省华人天后圣母信仰妈祖文化