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One-step random-walk process of nanoparticles in cement-based materials

Journal of Central South University 2021年第6期28卷 1679-1691页

作者： Ali BAHARI Aref SADEGHI-NIK Elena CERRO-PRADA Adel SADEGHI-NIK mandana roodbari Yan ZHUGE Department of Physics University of MazandaranBabolsarIran Young Researchers and Elite Club Sari BranchIslamic Azad UniversitySariIran Department of Civil Engineering Universidad Politécnica de MadridMadridSpain Department of Civil Engineering University of South AustraliaAdelaideAustralia

Efficient modelling approaches capable of predicting the behavior and effects of nanoparticles in cement-based materials are required for conducting relevant *** the microstructural characterization of a cement-nanoparticle system,this paper investigates the potential of cell-based weighted random-walk method to establish statistically significant relationships between chemical bonding and diffusion processes of nanoparticles within cement ***_(0.5)C_(0.5)O_(3)(LSCO)nanoparticles were employed to develop a discrete event system that accounts for the behavior of individual cells where nanoparticles and cement components were expected to *** stochastic model is based on annihilation(loss)and creation(gain)of a bond in the *** model considers both chemical reactions and transport mechanism of nanoparticles from cementitious cells,along with cement hydration *** approach may be useful for simulating nanoparticle transport in complex 2D cement-based materials systems.

关键词： Markov chain Monte Carlo random-walk method Fokker-Planck equation LaSr_(0.5)C_(0.5)O_(3)(LSCO) cement nanoparticle incorporation

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A simple method for inducing nonalcoholic steatohepatitis with fibrosis

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Animal Models and Experimental Medicine 2019年第4期2卷 282-290页

作者： Leyla Yahaghi Azadeh Ebrahim-Habibi Nasim Hayati-roodbari Shiva Irani Parichehreh Yaghmaei Department of Biology Science and Research BranchIslamic Azad UniversityTehranIran Biosensor Research Center Endocrinology and Metabolism Molecular-Cellular Sciences InstituteTehran University of Medical SciencesTehranIran Endocrinology and Metabolism Research Center Tehran University of Medical SciencesTehranIran

Background: Nonalcoholic fatty liver disease(NAFLD) is increasingly occurring in sedentary people, and may progress to NASH and hepatocellular carcinoma. It is essential to design affordable animal models for the study of various diseases, including fatty liver, which was the aim of the study. In this study, a high-fat diet was devised that triggers NASH’s animal model quickly and easily. High-fat diet(HFD) was used both with intra-mouth oral gavage and in combination with animal ***: Twenty-four male C57 BL/6 J mice were divided into HFD and ND groups, which received a high-fat diet and a normal diet, respectively. At the end of the experiment(fourth week of treatment), body and liver weights, biochemical parameters, PPAR-α gene expression and histopathologic characteristics of the liver were ***: During 4 weeks, body weight of mice did not show a significant increase in the HFD group compared to the ND group, while weight gain of the liver was significant. Histological assessment of the HFD group’s liver confirmed NASH symptoms. In the HFD group, HDL-c, SOD, catalase, FRAP, adiponectin, and PPAR-α decreased significantly, and lipid profiles, hepatic enzymes, MDA, leptin, and TNF-α showed a significant increase compared to the ND ***: Our high-fat diet has successfully induced all aspects of NASH with fibrosis in 4 weeks, and with low cost.

关键词： animal model nonalcoholic fatty liver disease(NAFLD) nonalcoholic steatohepatitis(NASH) PPAR‐α

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