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Prevalence and hematological indicators of G6PD deficiency in malaria-infected patients

Infectious Diseases of Poverty 2016年第1期5卷 307-312页

作者： manas kotepui Kwuntida Uthaisar Bhukdee PhunPhuech Nuoil Phiwklam Medical Technology Program School of Allied Health Sciences and Public HealthWalailak UniversityNakhon Si Thammarat 80161Thailand Medical Technology Laboratory Phop Phra HospitalPhop Phra DistrictTak Province 63160Thailand

Background:This study aimed to evaluate the prevalence and alteration of hematological parameters in malaria patients with a glucose-6-phosphate dehydrogenase(G6PD)deficiency,in the western region of Thailand,an endemic region for malaria.Methods:Data about patients with malaria hospitalized between 2013 and 2015 were collected.Clinical and sociodemographic characteristics such as age and gender,diagnosis on admission,and parasitological results were mined from medical records of the laboratory unit of the Phop Phra Hospital in Tak Province,Thailand.Venous blood samples were collected at the time of admission to hospital to determine G6PD deficiency by fluorescence spot test and detect malaria parasites by thick and thin film examination.Other data such as complete blood count and parasite density were also collected and analyzed.Results:Among the 245 malaria cases,28(11.4%)were diagnosed as Plasmodium falciparum infections and 217 cases(88.6%)were diagnosed as P.vivax infections.Seventeen(6.9%)patients had a G6PD deficiency and 228(93.1%)patients did not have a G6PD deficiency.Prevalence of male patients with G6PD deficiency was higher than that of female patients(P<0.05,OR=5.167).Among the patients with a G6PD deficiency,two(11.8%)were infected with P.falciparum,while the remaining were infected with P.vivax.Malaria patients with a G6PD deficiency have higher monocyte counts(0.6×10^(3)/μL)than those without a G6PD deficiency(0.33×10^(3)/μL)(P<0.05,OR=5.167).Univariate and multivariate analyses also confirmed that malaria patients with a G6PD deficiency have high monocyte counts.The association between G6PD status and monocyte counts was independent of age,gender,nationality,Plasmodium species,and parasite density(P<0.005).Conclusion:This study showed a prevalence of G6PD deficiency in a malaria-endemic area.This study also supported the assertion that patients with G6PD-deficient red blood cells had no protection against the P.falciparum infection.In addition,malaria patients with a G6PD deficiency had higher m

关键词： Malaria G6PD deficiency Plasmodium falciparum Plasmodium vivax Thailand

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Enhanced in-vitro degradation resistance and cytocompatibility of a thermomechanically processed novel Mg alloy:Insights into the role of microstructural attributes

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Journal of Magnesium and Alloys 2024年第2期12卷 700-725页

作者： Darothi Bairagi Santanu Mandal Mangal Roy manas Paliwal Sumantra Mandal Department of Metallurgical and Materials Engineering Indian Institute of TechnologyKharagpur 721302India

The role of microstructural features on in-vitro degradation and surface film development of a thermomechanically processed Mg-4Zn-0.5Ca-0.8Mn alloy has been investigated employing electrochemical studies,scanning electron microscopy and X-ray photoelectron spectroscopy.The specimen forged at 523 K temperature developed a coarse unimodal microstructure consisting of basal oriented grains,whereas the specimens forged at 623 K and 723 K temperatures exhibited bimodal microstructures containing randomly oriented fine grains and basal oriented coarse grains.The bimodal microstructures exerted higher resistance to corrosion compared to the unimodal microstructure in presence of a protective surface film.The optimum size distribution of fine and coarse grains as well as the prevalence of basal oriented grains led to the lowest anodic current density in the specimen forged at 623 K.The morphology of Ca_(2)Mg_(6)Zn_(3)precipitates governed the cathodic kinetics by controlling the anode to cathode surface area ratio.Despite the specimen forged at 723 K comprised comparatively lower fraction of precipitates than at 623 K,the mesh-like precipitate morphology increased the effective cathodic surface area,leading to enhanced localised corrosion in the former specimen.Optimal microstructural features developed at 623 K forging temperature formed a well-protective surface film with lower Mg(OH)_(2)to MgO ratio,exhibiting distinctly high polarization resistance and superior cytocompatibility in terms of cell-proliferation and cell-differentiation.

关键词： Magnesium alloy Microstructure Corrosion Electrochemical impedance spectroscopy X-ray photoelectron spectroscopy Cytotoxicity

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Prevalence of and risk factors for severe malaria caused by Plasmodium and dengue virus co-infection: a systematic review and meta-analysis

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Infectious Diseases of Poverty 2020年第5期9卷 120-121页

作者： manas kotepui Kwuntida Uthaisar kotepui Giovanni De Jesus Milanez Frederick Ramirez Masangkay Medical Technology School of Allied Health SciencesWalailak UniversityTha SalaNakhon Si ThammaratThailand 不详

Background:Co-infection with both Plasmodium and dengue virus(DENV)infectious species could have serious and fatal outcomes if left undiagnosed and without timely treatment.The present study aimed to determine the pooled prevalence estimate of severe malaria among patients with co-infection,the risk of severe diseases due to co-infection,and to describe the complications of severe malaria and severe dengue among patients with coinfection.Methods:Relevant studies published between databases between 12 September 1970 and 22 May 2020 were identified and retrieved through a search of the ISI Web of Science,Scopus,and MEDLINE.The pooled prevalence and 95%confidence interval(CI)of severe malaria among patients with Plasmodium and DENV co-infection was estimated with a random-effects model to take into account the between-study heterogeneity of the included studies.The risks of severe malaria and severe diseases due to co-infection were estimated with the pooled odds ratio(OR)and 95%CI with a random-effects model.Results:Of the 5653 articles screened,13 studies were included in the systematic review and meta-analysis.The results demonstrated that the pooled prevalence estimate of severe malaria among patients with co-infection was 32%(95%CI:18-47%,I 2=92.3%).Patients with co-infection had a higher risk of severe diseases than those with DENV mono-infection(odds ratio[OR]=3.94,95%CI:1.96-7.95,I 2=72%).Patients with co-infection had a higher risk of severe dengue than those with DENV mono-infection(OR=1.98,95%CI:1.08-3.63,I 2=69%).The most severe complications found in severe dengue were bleeding(39.6%),jaundice(19.8%),and shock/hypotension(17.9%),while the most severe complications found in severe malaria were severe bleeding/bleeding(47.9%),jaundice(32.2%),and impaired consciousness(7.43%).Conclusions:The present study found that there was a high prevalence of severe malaria among patients with Plasmodium and DENV co-infection.Physicians in endemic areas where these two diseases overlap should recognize that patients wi

关键词： Plasmodium Malaria Dengue Severe complications Severity

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Seasonal Prediction of Indian Summer Monsoon Using WRF: A Dynamical Downscaling Perspective

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Open Journal of Modelling and Simulation 2024年第1期12卷 1-32页

作者： manas Ranjan Mohanty Uma Charan Mohanty Department of Atmospheric and Oceanic Sciences University of California Los Angeles USA Centre for Climate Smart Agriculture Siksha O Anusandhan Deemed to Be University Odisha India

Seasonal forecasting of the Indian summer monsoon by dynamically downscaling the CFSv2 output using a high resolution WRF model over the hindcast period of 1982-2008 has been performed in this study. The April start ensemble mean of the CFSv2 has been used to provide the initial and lateral boundary conditions for driving the WRF. The WRF model is integrated from 1st May through 1st October for each monsoon season. The analysis suggests that the WRF exhibits potential skill in improving the rainfall skill as well as the seasonal pattern and minimizes the meteorological errors as compared to the parent CFSv2 model. The rainfall pattern is simulated quite closer to the observation (IMD) in the WRF model over CFSv2 especially over the significant rainfall regions of India such as the Western Ghats and the central India. Probability distributions of the rainfall show that the rainfall is improved with the WRF. However, the WRF simulates copious amounts of rainfall over the eastern coast of India. Surface and upper air meteorological parameters show that the WRF model improves the simulation of the lower level and upper-level winds, MSLP, CAPE and PBL height. The specific humidity profiles show substantial improvement along the vertical column of the atmosphere which can be directly related to the net precipitable water. The CFSv2 underestimates the specific humidity along the vertical which is corrected by the WRF model. Over the Bay of Bengal, the WRF model overestimates the CAPE and specific humidity which may be attributed to the copious amount of rainfall along the eastern coast of India. Residual heating profiles also show that the WRF improves the thermodynamics of the atmosphere over 700 hPa and 400 hPa levels which helps in improving the rainfall simulation. Improvement in the land surface fluxes is also witnessed in the WRF model.

关键词： Dynamical Downscaling Regional and Mesoscale Modeling Diabatic Heating WRF

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Influence of second phase precipitates on mechanical and in-vitro corrosion behaviour of Mg-4Zn-0.5Ca-0.8Mn alloy in optimum homogenized conditions

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Journal of Magnesium and Alloys 2023年第4期11卷 1343-1366页

作者： Darothi Bairagi Partha Duley manas Paliwal Sumantra Mandal Department of Metallurgical and Materials Engineering Indian Institute of Technology Kharagpur721302India

The present study investigates the mechanical and in-vitro corrosion behavior of Mg-4Zn-0.5Ca-0.8Mn alloy in optimum homogenized conditions.The optimization of the homogenization parameters has been carried out employing thermodynamic calculations and kinetic modeling.The model utilizes the inter-diffusivity of the solute elements and predicts that∼6–24 h of homogenization at 633 K effectively redistributes the elements in the Mg matrix.Based on the insights obtained from the simulations,the as-cast Mg-4Zn-0.5Ca-0.8Mn alloy was subjected to homogenization heat treatment process for 6–24h.The microstructural study through optical microscopy and scanning electron microscopy(SEM)revealed that the interconnected network of second phase precipitates substantially dissolve within 24 h,implying adequate homogenization.Moreover,fine Mg-Zn based precipitates with varied morphology and phase fractions also evolved during homogenization treatment,as confirmed through SEM and transmission electron microscopy.In the 12 h homogenized specimen,the highest fraction of uniformly dispersed fine precipitates resulted in the highest strength(∼225 MPa).On the other hand,a substantial disruption in coarse precipitate network and lower aspect ratio of fine Mg-Zn precipitates led to the highest ductility(∼8%)in this specimen.In the 24 h homogenized specimen,the ductility reduced marginally owing to higher aspect ratio of fine precipitates.The immersion and electrochemical tests(viz.,potentiodynamic polarization and electrochemical impedance spectroscopy)carried out in Hank’s solution revealed that the 24 h homogenized specimen exhibits the best corrosion properties.The least fraction of Ca_(2)Mg_(6)Zn_(3)phase with maximum disruption in interconnectivity,in combination with a small fraction of fine equilibrium MgZn_(2)precipitates,resulted in suppression of localized corrosion in this specimen.This promotes the formation of the most stable and compact product layer over the specimen,resulting in the highest corrosion resistance.

关键词： Mg alloy Thermodynamic-kinetic calculation Homogenization EIS Passive film

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A REMARK ON LARGE TIME ASYMTOTICS FOR SOLUTIONS OF A NONHOMOGENEOUS VISCOUS BURGERS EQUATION

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Acta Mathematica Scientia 2023年第3期43卷 1323-1332页

作者： manas Ranjan SAHOO Satyanarayana ENGU Smriti TIWARI School of Mathematical Sciences National Institute of Science Education and ResearchAn OCC of Homi Bhabha National InstituteBhubaneswarKhurdaOdishaP.O.Jatni752050India Department of Mathematics National Institute of TechnologyWarangalTelangana506004India

The existence, uniqueness and regularity of solutions to the Cauchy problem posed for a nonhomogeneous viscous Burger's equation were shown in Chung, Kim and Slemrod [1] by assuming suitable conditions on initial data. Moreover, they derived the asymptotic behaviour of solutions of the Cauchy problem by imposing additional conditions on initial data. In this article, we obtain the same asymptotic behaviour of solutions to the Cauchy problem without imposing additional condition on initial data.

关键词： modified Bessel functions integral equation large time asymptotics convolution of functions

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Surface Roughness Simulation During Rotational-Magnetorheological Finishing of Poppet Valve Profiles

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Nanomanufacturing and Metrology 2022年第3期5卷 259-273页

作者： Manjesh Kumar manas Das Nan Yu Department of Mechanical Engineering Indian Institute of TechnologyGuwahati 781039India School of Engineering The University of EdinburghEdinburgh EH89YLUK Department of Mechanical Engineering SRM University APAndhra Pradesh522502India

Surface finishing is essential for various applications in the aerospace industry.One of the applications is the poppet valve,which is used for leak-proof sealing of high-pressure gases in aerospace gas propulsion engines.The combustion engine also typically employs a poppet valve as an intake and exhaust valve.Nano-finishing a poppet valve is difficult because of its complex narrow profile.The precise nano-finished poppet valve perfectly fits on its seat and reduces hydrocarbon emissions.The rotational-magnetorheological fluid-based finishing process can be used effectively for these complicated surfaces.The polishing agent in this process is magnetorheological fluid,and rheological properties are controlled by a permanent magnet.This article presents the uniform finishing of the poppet valve's narrow ridge profile,which is analyzed through finite element analysis(FEA),wherein the outcomes are uniform shear stress,normal stress,and magnetic flux density distributions along the poppet ridge profile.The study of forces exerting on abrasive grains and surface roughness simulation is also conducted using FEA findings.The experiment is subsequently performed to verify the simulation results for poppet profile polishing.The obtained experimental and simulated surface roughness values are comparable.After the finishing process,the maximum percentage improvement of surface roughness is obtained as 93.71%.The rotational-magnetorheological fluid-based finishing process has high accuracy and reliability for specific applications.

关键词： Finite element analysis Nano-finishing Nickel-aluminum bronze alloy Poppet valve Magnetorheological fluid Surfaceroughness simulation

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A review on recent advancements in biodegradable Mg-Ca alloys

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Journal of Magnesium and Alloys 2022年第8期10卷 2094-2117页

作者： manas Ranjan Sahu T.S.Sampath Kumar Uday Chakkingal Department of Metallurgical and Materials Engineering Indian Institute of Technology MadrasChennai 600036India

The binary Mg-Ca alloys are drawing increasing attention as temporary implant materials because of their excellent biocompatibility,biodegradability, and good mechanical properties. However, their applications are limited due to their high degradation rates in the human physiological environment, the consequent release of hydrogen gas, and rapid loss in mechanical properties. Furthermore, biocompatibility depends upon the degradability of the material. Various researchers have demonstrated that these issues can be addressed by control of Ca content, thermo-mechanical processing to obtain suitable microstructures, deposition of surface coatings, etc. In this manuscript, a detailed review of published literature on Mg-Ca alloys is presented. The challenges and future directions of research in this area are also described.

关键词： Mg-Ca alloy Degradation Temporary implant Biocompatibility

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Fatal intracranial bleedings in a viper bite:A case report

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Chinese Journal of Traumatology 2023年第2期26卷 121-124页

作者： Alagarasan Naveen manas Ranjan Sahu Manoj Kumar Mohanty Kimi Soumya Padhi Ashis Patnaik Department of Forensic Medicine&Toxicology All India Institute of Medical Sciences(AMS)BhubaneswarOdishaIndia Department of Neurosurgery Al India Institute of Medical Sciences(AIIMS)BhubaneswarOdishaIndia

Viper bite envenomation represents a significant occupational hazard among agricultural workers in India.The viper bite envenomation is usually suspected when a patient presents with predominant local symptoms at the bitten site,including pain,swelling,and necrosis.Further,systemic findings such as diffuse intravascular coagulation,hypotension,and shock may alert physicians of viper bite envenomation rather than a neurotoxic snake bite.However,cerebral complications are rare in viper bites but may potentially fatal.Central nervous system involvement in a viper bite is either due to neurotoxins or hemorrhagins present in the venom,which may induce cerebral thrombosis,ischemia,infarction,and hemorrhage.Here we present a case of a previously healthy adult male who succumbed to extensive subarachnoid,intracerebral,and intraventricular hemorrhages involving bilateral cerebral hemispheres following viper snake bite envenomation.This report highlights the importance of anticipating cerebral complications in viper bite envenomation,a rare occurrence.It also emphasizes the need for early antisnake venom administration to prevent and control systemic envenomation and its complications.

关键词： Snake bite Viper Intracerebral hemorrhage Subarachnoid hemorrhage Anti-snake venom

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Gaussian Blur Masked ResNet2.0 Architecture for Diabetic Retinopathy Detection

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Computers, Materials & Continua 2023年第4期75卷 927-942页

作者： Swagata Boruah Archit Dehloo Prajul Gupta manas Ranjan Prusty A.Balasundaram School of Electronics Engineering Vellore Institute of TechnologyChennai600127India School of Computer Science and Engineering Vellore Institute of TechnologyChennai600127India Centre for Cyber-Physical Systems Vellore Institute of TechnologyChennai600127India

Diabetic Retinopathy (DR) is a serious hazard that can result inirreversible blindness if not addressed in a timely manner. Hence, numeroustechniques have been proposed for the accurate and timely detection ofthis disease. Out of these, Deep Learning (DL) and Computer Vision (CV)methods for multiclass categorization of color fundus images diagnosed withDiabetic Retinopathy have sparked considerable attention. In this paper,we attempt to develop an extended ResNet152V2 architecture-based DeepLearning model, named ResNet2.0 to aid the timely detection of DR. TheAPTOS-2019 datasetwas used to train the model. This consists of 3662 fundusimages belonging to five different stages of DR: no DR (Class 0), mild DR(Class 1), moderate DR (Class 2), severe DR (Class 3), and proliferativeDR (Class 4). The model was gauged based on ability to detect stage-wiseDR. The images were pre-processed using negative and positive weightedGaussian-based masks as feature engineering to further enhance the qualityof the fundus images by removing the noise and normalizing the images. Upsamplingand data augmentation methods were used to address the skewnessof the original dataset. The proposed model achieved an overall accuracyof 91% and an area under the receiver-operating characteristic curve (AUC)score of 95.1%, outperforming existing Deep Learning models by around 10%.Furthermore, the class-wise F1 score for No DR was 92%, Mild DR was 82%,Moderate DR was 66%, Severe was DR 89% and Proliferative DR was 80%.

关键词： Diabetic retinopathy deep learning transfer learning image processing image classification

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