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Therapeutic potential of Calotropis gigantea extract against invasive pulmonary aspergillosis:In vitro and in vivo study

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Asian Pacific Journal of Tropical Biomedicine 2022年第6期12卷 243-252页

作者： Enas M.Ali manal A.Alfwuaires Gehan M.Badr Department of Biological Sciences Faculty of ScienceKing Faisal UniversityP.O.Box 380Al-Ahsa 31982Saudi Arabia Department of Botany and Microbiology Faculty of ScienceCairo UniversityCairo 12613Egypt Department of Zoology Faculty of ScienceAin Shams UniversityCairo11566Egypt

Objective:To characterize the antifungal activity of methanolic leaf extract of Calotropis gigantea alone or in combination with amphotericin B against invasive pulmonary aspergillosis in ***:GC/MS was used for analysis of active constituents of Calotropis gigantea *** germination assay and broth micro-dilution method were used to determine antifungal potential of Calotropis gigantea/amphotericin B against Aspergillus *** mice were randomly assigned into 5 groups:group 1 was neutropenic(control);group 2 was infected with Aspergillus fumigatus;group 3 was infected with Aspergillus fumigatus,and treated with Calotropis gigantea extract;group 4 was infected with Aspergillus fumigatus and treated with amphotericin B;group 5 was infected with Aspergillus fumigatus and treated with both Calotropis gigantea extract and amphotericin *** lung tissues were histopathologically *** burden and gliotoxin concentration were evaluated in lung ***,superoxide dismutase,and malondialdehyde content were determined in lung ***,tumor necrosis factor-alpha,interleukin-1,and interleukin-17 were also estimated by the sandwich enzyme-linked immuno-sorbent ***:Calotropis gigantea/amphotericin B had a minimum inhibitory concentration and minimum fungicidal concentration of 80 and 160μg/mL,respectively,for Aspergillus ***,Calotropis gigantea/amphotericin B significantly reduced lung fungal burden by 72.95%and inhibited production of gliotoxin in lung tissues from 6320 to 1350μg/g *** gigantea/amphotericin B reduced the oxidative stress of the lung via elevating the activity of antioxidant enzymes and decreasing the levels of lipid *** activity and the production of pro-inflammatory cytokines were also significantly *** electron microscopy revealed deteriorations in the hyphae ultrastructure in Calotropis gigantea/amphotericin B trea

关键词： Aspergillus fumigatus Antifungal Invasive pulmonary aspergillosis Calotropis gigantea Amphotericin B Mice

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Mathematical Morphology View of Topological Rough Sets and Its Applications

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Computers, Materials & Continua 2023年第3期74卷 6893-6908页

作者： Ibrahim Noaman Abd El Fattah El Atik Tamer Medhat manal E.Ali Department of Mathematics Faculty of Science and Arts in Al-MandaqAl-Baha UniversityKingdom of Saudi Arabia Department of Mathematics Faculty of ScienceTanta UniversityTantaEgypt Department of Electrical Engineering Faculty of EngineeringKafrelsheikh UniversityKafrelsheikh33516Egypt Department of Physics and Engineering Mathematics Faculty of EngineeringKafrelsheikh UniversityKafrelsheikh33516Egypt

This article focuses on the relationship between mathematical morphology operations and rough sets,mainly based on the context of image retrieval and the basic image correspondence *** morphological procedures and set approximations in rough set theory have some clear *** initiatives have been made to connect rough sets with mathematical *** significant publications have been written in this *** attempt to show a direct connection between mathematical morphology and rough sets through relations,a pair of dual operations,and neighborhood *** sets are used to suggest a strategy to approximatemathematicalmorphology within the general paradigm of soft computing.A single framework is defined using a different technique that incorporates the key ideas of both rough sets and mathematical *** paper examines rough set theory from the viewpoint of mathematical morphology to derive rough forms of themorphological structures of dilation,erosion,opening,and *** newly defined structures are applied to develop algorithm for the differential analysis of chest X-ray images from a COVID-19 patient with acute pneumonia and a health *** algorithm and rough morphological operations show promise for the delineation of lung occlusion in COVID-19 patients from chest *** foundations of mathematical morphology are covered in this *** that,rough set theory ideas are taken into account,and their connections are ***,a suggested image retrieval application of the concepts from these two fields is provided.

关键词： Mathematical morphology rough set theory topological spaces COVID-19

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Effect of rare earth on physical properties of Na_(0.5)Bi_(0.5)TiO_(3)system:A density functional theory investigation

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Journal of Rare Earths 2022年第3期40卷 473-481,I0005页

作者： manal Benyoussef Halima Zaari Jamal Belhadi Youssef El Amraoui Hamid Ez-Zahraouy Abdelilah Lahmar Mimoun El Marssi Laboratory of Physics of Condensed Matter(LPMC) University of Picardie Jules VerneScientific Pole80039Amiens Cedex 1France Laboratory of Condensed Matter and Indisciplinary Science(LaMCScI) Faculty of ScienceMohammed V UniversityBP 1014RabatMorocco National School of Arts and Crafts Moulay Ismail University50500MeknesMorocco

Na_(0.5)(Bi_(3/4)RE_(1/4))_(0.5)TiO_(3)(RENBT,RE=Nd,Gd,Dy,and Ho)compounds were investigated in the framework of first-principles calculations using the full potential linearized augmented plane wave(FP-LAPW)method based on the spin-polarized density functional theory implemented in the WIEN2k *** charge density distribution and Ti K-edge X-ray absorption spectra reveal that the RENBT compositions with high polarization values are accompanied by a higher TiO_(6)distortion,DyNBT,and NdNBT *** effect of the rare-earth elements on the polarization is confirmed experimentally with the collection of the hysteresis *** investigation of the electronic properties of the compounds highlights the emergence of a magnetization owing to the 4f orbital effect of the rare-earth ***,the investigation of the chemical ordering shows a short-range chemical ordering for the pure composition and an increased A-site disorder for dysprosium doped NBT *** increased disorder may speak for increased relaxor properties in the RE doped compositions.

关键词： Density functional theory Sodium bismuth titanate Rare earths A-site ordering Ferroelectric properties Magnetization

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Cat Swarm with Fuzzy Cognitive Maps for Automated Soil Classification

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Computer Systems Science & Engineering 2023年第2期44卷 1419-1432页

作者： Ashit Kumar Dutta Yasser Albagory manal Al Faraj Majed Alsanea Abdul Rahaman Wahab Sait Department of Computer Science and Information Systems College of Applied SciencesAlMaarefa UniversityAd DiriyahRiyadh13713Kingdom of Saudi Arabia Department of Computer Engineering College of Computers and Information TechnologyTaif UniversityTaif21944Kingdom of Saudi Arabia Department of Computing Arabeast CollegesRiyadh11583Kingdom of Saudi Arabia Department of Archives and Communication King Faisal UniversityAl AhsaHofuf31982Kingdom of Saudi Arabia

Accurate soil prediction is a vital parameter involved to decide appro-priate crop,which is commonly carried out by the *** an auto-mated soil prediction tool helps to considerably improve the efﬁcacy of the *** the same time,fuzzy logic(FL)approaches can be used for the design of predictive models,particularly,Fuzzy Cognitive Maps(FCMs)have involved the concept of uncertainty representation and cognitive *** other words,the FCM is an integration of the recurrent neural network(RNN)and FL involved in the knowledge engineering *** this aspect,this paper introduces effective fuzzy cognitive maps with cat swarm optimization for automated soil classiﬁca-tion(FCMCSO-ASC)*** goal of the FCMCSO-ASC technique is to identify and categorize seven different types of *** accomplish this,the FCMCSO-ASC technique incorporates local diagonal extrema pattern(LDEP)as a feature extractor for producing a collection of feature *** addition,the FCMCSO model is applied for soil classiﬁcation and the weight values of the FCM model are optimally adjusted by the use of CSO *** exam-ining the enhanced soil classiﬁcation outcomes of the FCMCSO-ASC technique,a series of simulations were carried out on benchmark dataset and the experimen-tal outcomes reported the enhanced performance of the FCMCSO-ASC technique over the recent techniques with maximum accuracy of 96.84%.

关键词： Soil classiﬁcation intelligent models fuzzy cognitive maps cat swarm optimization fuzzy logic

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Challenge of managing hepatitis B virus and hepatitis C virus infections in resource-limited settings

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World Journal of Hepatology 2022年第7期14卷 1333-1343页

作者： Zeinab Nabil Ahmed Said manal Hamdy El-Sayed Department of Microbiology&Immunology Faculty of Medicine for Girls Al-Azhar UniversityCairoEgypt Department of Pediatrics Faculty of MedicineAin Shams UniversityCairoEgypt

The global burden of hepatitis B virus(HBV)and hepatitis C virus(HCV)infections and coinfection represents a major public health concern,particularly in resource-limited *** of HCV by 2030 has become foreseeable,with effective direct-acting antiviral oral therapies and the availability of affordable generics in low-and-middle-income countries(LMICs).However,access to oral nucleos(t)ide therapy for HBV remains critical and is limited outside the existing global HIV program platforms despite affordable *** of mother-to-child transmission of HBV through scaling up of birth dose implementation in LMICs is essential to achieve the 2030 elimination *** individuals living with HBV and/or HCV in resource-limited settings are unaware of their infection,and with improved access to medications,the most significant barrier remains access to affordable diagnostics and preventive *** coronavirus disease 2019 pandemic interrupted hepatitis elimination programs,albeit offered opportunities for improved diagnostic capacities and raised political awareness of the critical need for strengthening health care services and universal health *** review underpins the HBV and HCV management challenges in resource-limited settings,highlighting the current status and suggested future elimination strategies in some of these *** efforts should continue to improve awareness and political *** resources should be secured to access and implement comprehensive strategies for diagnosis and linkage to care in resource-constrained settings to fulfill the 2030 elimination goal.

关键词： Hepatitis B virus/hepatitis C virus Chronic hepatitis Resource-limited settings HBV and HCV elimination

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Modeling and Analysis of UAV-Assisted Mobile Network with Imperfect Beam Alignment

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Computers, Materials & Continua 2023年第1期74卷 453-467页

作者： Mohamed Amine Ouamri Reem Alkanhel Cedric Gueguen manal Abdullah Alohali Sherif S.M.Ghoneim University of Rennes 1/ADOPNET team at IRISA laboratory Rennes35000France Facultéde Technologie Laboratoire d’Informatique Médicale(LIMED)Universitéde BejaiaBejaia06000Algérie Department of Information Technology College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Information Systems College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Electrical engineering department College of EngineeringTaif University P.O.Box 11099Taif21944Saudi Arabia

With the rapid development of emerging 5G and beyond(B5G),Unmanned Aerial Vehicles(UAVs)are increasingly important to improve the performance of dense cellular *** a conventional metric,coverage probability has been widely studied in communication systems due to the increasing density of users and complexity of the heterogeneous *** recent years,stochastic geometry has attracted more attention as a mathematical tool for modeling mobile network *** this paper,an analytical approach to the coverage probability analysis of UAV-assisted cellular networks with imperfect beam alignment has been *** assumption was considered that all users are distributed according to Poisson Cluster Process(PCP)around base stations,in particular,Thomas Cluster Process(TCP).Using thismodel,the impact of beam alignment errors on the coverage probabilitywas ***,the ProbabilityDensity Function(PDF)of directional antenna gain between the user and its serving base station was ***,association probability with each tier was achieved.A tractable expression was derived for coverage probability in both Line-of-Sight(LoS)andNon-Line-of-Sight(NLoS)condition *** results demonstrated that at low UAVs altitude,beam alignment errors significantly degrade coverage ***,for a small cluster size,alignment errors do not necessarily affect the coverage performance.

关键词： Unmanned aerial vehicles coverage analysis stochastic geometry millimeter wave imperfect beam alignment

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Morphological and Phylogenetic Studies of a Copepod Species, Irodes parupenei Ho and Lin (2007), Infecting Parupeneus rubescens in Saudi Arabia

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Journal of Ocean University of China 2022年第2期21卷 457-464页

作者： DKHIL Mohamed A ALHAFIDH Wejdan AL-QURAISHY Saleh ALOTAIBI Mashael BANAEEM manal ALSALEH Thekra ABDEL-GABER Rewaida Department of Zoology College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia

Dammam City is one of the gorgeous coastal areas in the Arabian Gulf of Saudi *** present study aimed to ex-amine one of the copepod species infecting the rosy goatfish that represents a highly consumed fish species by the local population in the Arabian *** copepod species isolated from the infected fish specimens belong to the family Taeniacanthidae and was iden-tified as Irodes parupenei Ho and Lin(2007),primarily based on its morphological,morphometric,and ultrastructural characteris-tics,especially the structures of the dorsal cephalic area,segmentation of the first antenna,the absence of the maxilliped claw in the fe-male specimens,and the setation and spinulation of the legs 2-4 for the adult females are of great significance in the taxonomic *** 18S rRNA gene sequence was analyzed to ensure the precise identity and exact taxonomic status of the copepod *** result showed that this copepod species belong to Taenicanthidae and closely related to Irodes sauridi(gb|JF781550.1)in the same *** details on the specificity of the goatfish for Irodes species and identifying these parasitic taxa using molecular analysis are given in the present study.

关键词： Taenicanthidae Irodes species goatfish parasite specificity 18S rRNA gene

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Optimal Weighted Extreme Learning Machine for Cybersecurity Fake News Classification

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Computer Systems Science & Engineering 2023年第3期44卷 2395-2409页

作者： Ashit Kumar Dutta Basit Qureshi Yasser Albagory Majed Alsanea manal Al Faraj Abdul Rahaman Wahab Sait Department of Computer Science and Information Systems College of Applied SciencesAlMaarefa UniversityAd DiriyahRiyadh13713Kingdom of Saudi Arabia Department of Computer Science Prince Sultan UniversityRiyadh11586Kingdom of Saudi Arabia Department of Computer Engineering College of Computers and Information TechnologyTaif UniversityTaif21944Kingdom of Saudi Arabia Department of Computing Arabeast CollegesRiyadh11583Kingdom of Saudi Arabia Department of Archives and Communication King Faisal UniversityAl AhsaHofuf31982Kingdom of Saudi Arabia

Fake news and its significance carried the significance of affecting diverse aspects of diverse entities,ranging from a city lifestyle to a country global relativity,various methods are available to collect and determine fake *** recently developed machine learning(ML)models can be employed for the detection and classification of fake *** study designs a novel Chaotic Ant Swarm with Weighted Extreme Learning Machine(CAS-WELM)for Cybersecurity Fake News Detection and *** goal of the CAS-WELM technique is to discriminate news into fake and *** CAS-WELM technique initially pre-processes the input data and Glove technique is used for word embed-ding ***,N-gram based feature extraction technique is derived to gen-erate feature ***,WELM model is applied for the detection and classification of fake news,in which the weight value of the WELM model can be optimally adjusted by the use of CAS *** performance validation of the CAS-WELM technique is carried out using the benchmark dataset and the results are inspected under several *** experimental results reported the enhanced outcomes of the CAS-WELM technique over the recent approaches.

关键词： Cybersecurity cybercrime fake news data classification machine learning metaheuristics

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Intelligent Smart Grid Stability Predictive Model for Cyber-Physical Energy Systems

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Computer Systems Science & Engineering 2023年第2期44卷 1219-1231页

作者： Ashit Kumar Dutta manal Al Faraj Yasser Albagory Mohammad zeid M Alzamil Abdul Rahaman Wahab Sait Department of Computer Science and Information Systems College of Applied SciencesAlMaarefa UniversityAd DiriyahRiyadh13713Kingdom of Saudi Arabia Department of Computer Engineering College of Computers and Information TechnologyTaif UniversityTaif21944Kingdom of Saudi Arabia Department of Archives and Communication King Faisal UniversityAl AhsaHofuf31982Kingdom of Saudi Arabia

A cyber physical energy system(CPES)involves a combination of pro-cessing,network,and physical *** smart grid plays a vital role in the CPES model where information technology(IT)can be related to the physical *** the same time,the machine learning(ML)modelsﬁnd useful for the smart grids integrated into the CPES for effective decision ***,the smart grids using ML and deep learning(DL)models are anticipated to lessen the requirement of placing many power plants for electricity *** this aspect,this study designs optimal multi-head attention based bidirectional long short term memory(OMHA-MBLSTM)technique for smart grid stability predic-tion in *** proposed OMHA-MBLSTM technique involves three subpro-cesses such as pre-processing,prediction,and hyperparameter *** OMHA-MBLSTM technique employs min-max normalization as a pre-proces-sing ***,the MBLSTM model is applied for the prediction of stability level of the smart grids in *** the same time,the moth swarm algorithm(MHA)is utilized for optimally modifying the hyperparameters involved in the MBLSTM *** ensure the enhanced outcomes of the OMHA-MBLSTM technique,a series of simulations were carried out and the results are inspected under several *** experimental results pointed out the better outcomes of the OMHA-MBLSTM technique over the recent models.

关键词： Stability prediction smart grid cyber physical energy systems deep learning data analytics moth swarm algorithm

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Development of new lateral-flow immunochromatographic strip using colloidal gold and mesoporous silica nanoparticles for rapid diagnosis of active schistosomiasis

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Asian Pacific Journal of Tropical Biomedicine 2019年第8期9卷 315-322页

作者： manal Kamel Faten salah Zeinab Demerdash Sara Maher Shimaa Atta Abeer Badr Ahmed Afifi Hanan El Baz Immunology Department Theodor Bilharz Research InstituteKornish El Nil streetGizaEgypt Zoology Department Faculty of ScienceCairo University12613GizaEgypt

Objective: To develop a new sandwich based lateral flow immunochromatographic strip for rapid detection of circulating Schistosoma mansoni antigen in serum and urine samples of patients with active schistosomiasis. Methods: This lateral flow immunochromatographic strip was prepared by using anti-Schistosoma mansoni soluble egg antigen monoclonal antibody conjugated gold nanoparticles (MAb-AuNPs) as antigen-detecting antibody, while crystalline material (MCM)-41-MAb bioconjugate was immobilized at the test line as antigen-capturing antibody. Both antigen capturing and detecting antibodies formed sandwich complexes with circulating Schistosoma mansoni antigen in the positive samples. Sandwich complexes immobilized at the test line gave distinct red color. The assay reliability was examined by using urine and serum samples of 60 Schistosoma mansoni infected patients, 20 patients infected with parasites other than Schistosoma, and 20 healthy individuals as negative controls. Results were compared with those obtained via sandwich enzyme linked immunosorbent assay (ELISA). Results: The detection limit of circulating Schistosoma mansoni antigen by lateral flow immunochromatographic strip was lower (3 ng/mL) than the detection limit by ELISA (30 ng/mL). The sensitivity and specificity of lateral flow immunochromatographic strip in urine samples were 98.3% and 97.5%, respectively compared to 93.5% and 90.0% by ELISA. In serum samples, they were 100.0% and 97.5%, respectively compared to 97.0% and 95.0% by ELISA. The strip test took approximately 10 min to complete. Conclusions: This new lateral flow immunochromatographic strip offers a sensitive, rapid, and field applicable technique for diagnosis of active schistosomiasis.

关键词： Schistosomiasis Nanoparticles Immunochromatographic Monoclonal antibodies

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