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Changes of anterior segment parameters after horizontal rectus muscles recession versus resection

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Annals of Eye Science 2020年第1期5卷 15-21页

作者： Amani E.Badawi manal ali kasem Tharwat Mokbel Eman A.Awad Mansoura Ophthalmic Center Faculty of MedicineMansoura UniversityMansouraEgypt

Background:To record the corneal,and anterior chamber depth changes after performing recession versus resection of horizontal recti ***:Consecutive patients who underwent isolated lateral rectus muscle recession or resection February 2014 to January 2015 were prospectively *** error(spherical equivalent);K1,K2,and mean k reading,anterior and posterior corneal elevation;and anterior chamber depth were measured(Pentacam)before,1 month,and 3 months after *** who could not maintain reliable fixation and those with a history of eye surgery were ***-and postoperative measurements were compared by analysis of ***:A total of 36 eyes of 23 patients(average age,16 years)were *** muscle recession was performed in 24 eyes;and resection was performed in 12 *** significant changes in mean keratometry of recession group *** anterior elevation,and central anterior chamber depth were significant when both groups are compared at first month after *** became regressive at the end of the third *** a significant change of central anterior elevation ***:In recession group,the mean K was the only statistically significant variable by the first postoperative *** the both groups,the anterior corneal elevation,and central anterior chamber depth revealed a significant difference by the end of the first postoperative *** 3 months,all parameters showed a statistical insignificant difference between the recession and resection groups except the anterior corneal elevation.

关键词： Strabismus cornea parameters anterior chamber Pentacam

Insights into the anorexic mechanism of Khat:an integrated in vivo,ex vivo,and in silico investigations

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Traditional Medicine Research 2024年第10期9卷 36-51页

作者： Ahmed ali Jerah manal Mohamed Elhassan Taha Abdullah Farasani Sivakumar Sivagurunathan Moni Emad Sayed Shaheen Andleeb Khan Ibrahim Abdo Khardali Magbool Oraiby Heyam Mohamed ali Sidahmed Siddig Ibrahim Abdelwahab Department of Medical Laboratory Technology College of Applied Medical SciencesJazan UniversityJazan 45142Saudi Arabia Health Research Centre Jazan UniversityJazan 45142Saudi Arabia Department of Pharmaceutics College of PharmacyJazan UniversityJazan 45142Saudi Arabia Department of Biosciences Faculty of ScienceIntegral UniversityLucknow 226026India Poison Control and Medical Forensic Chemistry Center General Directorate of Health AffairsJazan 45142Saudi Arabia Department of Pharmaceutical Chemistry Faculty of PharmacyAl-Neelain UniversityKhartoum 16458Sudan

Background:Chewing Khat(Catha edulis)releases cathine and cathinone,which may reduce appetite via an unknown *** study investigated the peripheral and central effects of fresh leaves and buds of Catha edulis water extract(CEWE)on appetite biomarkers,gene expression,and body weight,using in vivo,ex vivo,and in silico ***:Rats of both sexes were orally administered CEWE at different doses and durations in three different *** chromatography-mass spectroscopy(LC-MS)-MS was used to detect cathinone and cathine in the murine *** effect of Khat on serotonin receptors was studied in isolated rat fundus *** of the two Khat ligands was performed on G(The 5-hydroxytryptamine-type 2C receptor(5-HT2C)in an agonist-bound active conformation)and H(5-HT2C in an antagonist-bound inactive conformation)proteins to determine which ligands are most likely to act as agonists or ***:Significant differences(P0.05).The expression of the ghrelin and leptin genes was also unaffected,but the expression of the 5-hydroxytryptamine(5-HT)gene decreased(P<0.05)with CEWE *** antagonizes 5-HT receptors in isolated rat fundus *** findings indicated that the khat ligands bound to 5-HT2C *** and cathinone levels in rat plasma were ***:Khat extract may suppress appetite by antagonizing the 5-HT *** research is required to understand its mechanism and potential applications.

关键词： Catha edulis appetite leptin ghrelin 5-hydroxytryptamine molecular docking

Medical clowning in hospitalized children:a meta‑analysis

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World Journal of Pediatrics 2023年第11期19卷 1055-1061页

作者： Rim kasem ali Sliman Noam Meiri Giora Pillar Department of Pediatrics Carmel Medical CenterCarmel Hospital7 Michal St.3436212 HaifaIsrael Technion Faculty of Medicine HaifaIsrael

Background Medical clowning has been proven effective in reducing pain,anxiety,and stress in many sporadic,usually small-scale *** meta-analysis aims to evaluate the efficiency of medical clowns in reducing pain and anxiety in hospitalized pediatric patients and their parents in different medical *** A thorough literature search was conducted from different databases,and only randomized controlled trials(RCTs)were included with children aged 0 to 18 years old.A total of 18 studies were included,and statistical analysis was performed on the combined *** A total of 912 children(14 studies)showed significantly reduced anxiety when procedures were performed with a medical clown compared with the controls(−0.76 on anxiety score,P<0.001).Preoperative anxiety was lower in 512 children(nine studies)with clown interventions than in the controls(−0.78,P<0.001).The pain scale was completed by 338 participants(six studies),indicating a trend toward reduced pain during procedures performed while the clown was acting compared to controls(−0.49,P=0.06).In addition,medical clown significantly(−0.52,P=0.001)reduced parental anxiety in 489 participants in ten studies;in six of the ten studies,with a total of 380 participants,medical clown significantly reduced parental preoperative anxiety(P=0.02).Conclusion Medical clowns have substantial positive and beneficial effects on reducing stress and anxiety in children and their families in various circumstances in pediatrics.

关键词： Anxiety Medical clown Pain Pediatric patients

Attribute Reduction for Information Systems via Strength of Rules and Similarity Matrix

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Computer Systems Science & Engineering 2023年第5期45卷 1531-1544页

作者： Mohsen Eid Tamer Medhat manal E.ali Department of Mathematics Faculty of ScienceTanta UniversityTantaEgypt Department of Electrical Engineering Faculty of EngineeringKafrelsheikh UniversityKafrelsheikh33516Egypt Department of Physics and Engineering Mathematics Faculty of EngineeringKafrelsheikh UniversityKafrelsheikh33516Egypt

An information system is a type of knowledge representation,and attribute reduction is crucial in big data,machine learning,data mining,and intelligent *** are several ways for solving attribute reduction problems,but they all require a common *** selection of features in most scientific studies is a challenge for the *** working with huge datasets,selecting all available attributes is not an option because it frequently complicates the study and decreases *** the other side,neglecting some attributes might jeopardize data *** this case,rough set theory provides a useful approach for identifying superfluous attributes that may be ignored without sacrificing any significant information;nonetheless,investigating all available combinations of attributes will result in some ***,because attribute reduction is primarily a mathematical issue,technical progress in reduction is dependent on the advancement of mathematical *** the focus of this study is on the mathematical side of attribute reduction,we propose some methods to make a reduction for information systems according to classical rough set theory,the strength of rules and similarity matrix,we applied our proposed methods to several examples and calculate the reduction for each *** methods expand the options of attribute reductions for researchers.

关键词： Rough set reduction strength of rules similarity matrix

Breeding Enrichment of Genetic Variation of Grain Yield and Its Attributes in Bread Wheat under Drought Stress and Well Irrigation

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Phyton-International Journal of Experimental Botany 2022年第12期91卷 2699-2717页

作者： Dina Swelam Abdel Hamid Salem manal Hassan Mohammed ali Wheat Research Department Agricultural Research CenterGiza12619Egypt Agronomy Department Faculty of AgricultureZagazig UniversityZagazig44519Egypt

Drought stress(DS)is one of the most critical environmental abiotic stresses for wheat production in the arid *** of high-yielding genotypes tolerant to DS can play a significant role in mitigation the negative impacts associated with *** the present study,generation means analysis(GMA)was used to study the performance of two crosses under well irrigation(WI)and deficit irrigation[cross I(Line 44×Shandweel-1)and cross II(Line 20×Sakha 93)].Significant differences were observed for days to heading(DH),days to maturity(DM),plant height(PH),spike length(SL),number of spikes per plant(NS/P),number of grains per spike(NG/S),thousand-grain weight(TGW),grain yield per plant(GY/P),and proline content(PC)in the six populations of the two crosses within each irrigation *** II had early maturity and the highest PC,NS/P,TGW,and GY/P regardless of the irrigation *** I showed positive significant relative heterosis and heterobeltiosis for GY/P under the two irrigation *** inheritance of characters of cross I revealed additive,dominant,and epistatic effects,which varied with trait and *** genetic effects predominated in DH,SL,and PC,while non-additive were found in DM,NS/P,NG/S,and GY/***-sense heritability estimates(h^(2) n)were high for DH and PC,moderate to high for PH and SL,moderate for DM,NG/S,NS/P,and TGW,and low for GY/*** on different drought indices the populations BC_(1),BC_(2),F_(1),and P1 of cross II and BC1 of cross I were more tolerant to drought ***,PC,TGW and DH can be used as selection indicators to improve wheat for drought tolerance in early generations and other yield components traits in late *** second cross(Line 20×Sakha 93)shows promise and is of interest to a drought tolerance breeding program,where wheat breeders can use recombinant breeding strategies to construct desirable drought stress *** and path coefficient revealed that TGW and PC were the main

关键词： Drought generation mean analysis heterosis heritability wheat

Therapeutic potential of Calotropis gigantea extract against invasive pulmonary aspergillosis:In vitro and in vivo study

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Asian Pacific Journal of Tropical Biomedicine 2022年第6期12卷 243-252页

作者： Enas M.ali manal A.Alfwuaires Gehan M.Badr Department of Biological Sciences Faculty of ScienceKing Faisal UniversityP.O.Box 380Al-Ahsa 31982Saudi Arabia Department of Botany and Microbiology Faculty of ScienceCairo UniversityCairo 12613Egypt Department of Zoology Faculty of ScienceAin Shams UniversityCairo11566Egypt

Objective:To characterize the antifungal activity of methanolic leaf extract of Calotropis gigantea alone or in combination with amphotericin B against invasive pulmonary aspergillosis in ***:GC/MS was used for analysis of active constituents of Calotropis gigantea *** germination assay and broth micro-dilution method were used to determine antifungal potential of Calotropis gigantea/amphotericin B against Aspergillus *** mice were randomly assigned into 5 groups:group 1 was neutropenic(control);group 2 was infected with Aspergillus fumigatus;group 3 was infected with Aspergillus fumigatus,and treated with Calotropis gigantea extract;group 4 was infected with Aspergillus fumigatus and treated with amphotericin B;group 5 was infected with Aspergillus fumigatus and treated with both Calotropis gigantea extract and amphotericin *** lung tissues were histopathologically *** burden and gliotoxin concentration were evaluated in lung ***,superoxide dismutase,and malondialdehyde content were determined in lung ***,tumor necrosis factor-alpha,interleukin-1,and interleukin-17 were also estimated by the sandwich enzyme-linked immuno-sorbent ***:Calotropis gigantea/amphotericin B had a minimum inhibitory concentration and minimum fungicidal concentration of 80 and 160μg/mL,respectively,for Aspergillus ***,Calotropis gigantea/amphotericin B significantly reduced lung fungal burden by 72.95%and inhibited production of gliotoxin in lung tissues from 6320 to 1350μg/g *** gigantea/amphotericin B reduced the oxidative stress of the lung via elevating the activity of antioxidant enzymes and decreasing the levels of lipid *** activity and the production of pro-inflammatory cytokines were also significantly *** electron microscopy revealed deteriorations in the hyphae ultrastructure in Calotropis gigantea/amphotericin B trea

关键词： Aspergillus fumigatus Antifungal Invasive pulmonary aspergillosis Calotropis gigantea Amphotericin B Mice

Mathematical Morphology View of Topological Rough Sets and Its Applications

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Computers, Materials & Continua 2023年第3期74卷 6893-6908页

作者： Ibrahim Noaman Abd El Fattah El Atik Tamer Medhat manal E.ali Department of Mathematics Faculty of Science and Arts in Al-MandaqAl-Baha UniversityKingdom of Saudi Arabia Department of Mathematics Faculty of ScienceTanta UniversityTantaEgypt Department of Electrical Engineering Faculty of EngineeringKafrelsheikh UniversityKafrelsheikh33516Egypt Department of Physics and Engineering Mathematics Faculty of EngineeringKafrelsheikh UniversityKafrelsheikh33516Egypt

This article focuses on the relationship between mathematical morphology operations and rough sets,mainly based on the context of image retrieval and the basic image correspondence *** morphological procedures and set approximations in rough set theory have some clear *** initiatives have been made to connect rough sets with mathematical *** significant publications have been written in this *** attempt to show a direct connection between mathematical morphology and rough sets through relations,a pair of dual operations,and neighborhood *** sets are used to suggest a strategy to approximatemathematicalmorphology within the general paradigm of soft computing.A single framework is defined using a different technique that incorporates the key ideas of both rough sets and mathematical *** paper examines rough set theory from the viewpoint of mathematical morphology to derive rough forms of themorphological structures of dilation,erosion,opening,and *** newly defined structures are applied to develop algorithm for the differential analysis of chest X-ray images from a COVID-19 patient with acute pneumonia and a health *** algorithm and rough morphological operations show promise for the delineation of lung occlusion in COVID-19 patients from chest *** foundations of mathematical morphology are covered in this *** that,rough set theory ideas are taken into account,and their connections are ***,a suggested image retrieval application of the concepts from these two fields is provided.

关键词： Mathematical morphology rough set theory topological spaces COVID-19

Optimization of Coronavirus Pandemic Model Through Artificial Intelligence

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Computers, Materials & Continua 2023年第3期74卷 6807-6822页

作者： manal M.Alqarni Arooj Nasir Dumitru Baleanu ali Raza Tahir Nawaz Cheema Nauman Ahmed Muhammad Rafiq Umbreen Fatima Emad E.Mahmoud Department of Mathematics College of SciencesKing Khalid UniversityAbha61413Saudi Arabia Baqai Medical University Karachi75340Pakistan Shalamar Medical and Dental College Lahore54000Pakistan Department of Mathematics Cankaya UniversityBalgatAnkara06530Turkey Department of Medical Research China Medical UniversityTaichung40402TaiwanChina Institute of Space Sciences Magurele-Bucharest077125Romania Department of Mathematics Govt.Maulana Zafar Ali Khan Graduate College WazirabadPunjab Higher Education Department(PHED)Lahore54000Pakistan Department of Mathematics University of GujratGujrat52200Pakistan Department of Mathematics and Statistics The University of LahoreLahore54590Pakistan Department of Mathematics Faculty of Science and TechnologyUniversity of Central PunjabLahore54000Pakistan Department of Computer Science University of LahoreLahore54590Pakistan Department of Mathematics and Statistics College of ScienceTaif UniversityP.O.Box11099Taif21944Saudi Arabia

Artificial intelligence is demonstrated by machines,unlike the natural intelligence displayed by animals,including *** intelligence research has been defined as the field of study of intelligent agents,which refers to any system that perceives its environment and takes actions that maximize its chance of achieving its *** techniques of intelligent computing solve many applications of mathematical *** researchworkwas designed via a particularmethod of artificial neural networks to solve the mathematical model of *** representation of the mathematical model is made via systems of nonlinear ordinary differential *** differential equations are established by collecting the susceptible,the exposed,the symptomatic,super spreaders,infection with asymptomatic,hospitalized,recovery,and fatality *** generation of the coronavirus model’s dataset is exploited by the strength of the explicit Runge Kutta method for different countries like India,Pakistan,Italy,and many *** generated dataset is approximately used for training,validation,and testing processes for each cyclic update in Bayesian Regularization Backpropagation for the numerical treatment of the dynamics of the desired *** performance and effectiveness of the designed methodology are checked through mean squared error,error histograms,numerical solutions,absolute error,and regression analysis.

关键词： Coronavirus model artificial techniques analysis

Interobserver reliability of computed tomography angiography in the assessment of ruptured intracranial aneurysm and impact on patient management

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World Journal of Radiology 2023年第6期15卷 201-215页

作者： ali H Elmokadem Basma Abdelmonaem Elged Ahmed Abdel Razek Lamiaa Galal El-Serougy Mohamed ali kasem Mohamed ali EL-Adalany Department of Radiology Mansoura UniversityMansoura 35516Egypt Department of Neurosurgery Mansoura UniversityMansoura 35516Egypt

BACKGROUND Aneurysmal subarachnoid hemorrhage is an emergency that can lead to a high mortality rate and many severe *** is critical to make a rapid radiological evaluation of ruptured intracranial aneurysms(RIAs)to determine the appropriate surgical *** To assess the reliability of computed tomography angiography(CTA)in assessing different features of ruptured intracranial aneurysm and its impact on patient *** The final cohort of this study consisted of 146 patients with RIAs(75 male and 71 female)who underwent cerebral *** age ranged from 25 to 80,and the mean age±SD was 57±8.95 *** readers were asked to assess different features related to the aneurysm and perianeurysmal ***-observer agreement was measured using kappa *** data extracted from non-contrast computed tomography and CTA were considered to categorize the study population into two groups according to the recommended therapeutic *** The inter-observer agreement of both reviewers was excellent for the detection of aneurysms(K=0.95,P=0.001),aneurysm location(K=0.98,P=0.001),and(K=0.98,P=0.001),morphology(K=0.92,P=0.001)and margins(K=0.95,P=0.001).There was an excellent interobserver agreement for the measurement of aneurysm size(K=0.89,P=0.001),neck(K=0.85,P=0.001),and dome-to-neck ratio(K=0.98,P=0.001).There was an excellent inter-observer agreement for the detection of other aneurysm-related features such as thrombosis(K=0.82,P=0.001),calcification(K=1.0,P=0.001),bony landmark(K=0.89,P=0.001)and branch incorporation(K=0.91,P=0.001)as well as perianeurysmal findings including vasospasm(K=0.91,P=0.001),perianeurysmal cyst(K=1.0,P=0.001)and associated vascular lesions(K=0.83,P=0.001).Based on imaging features,87 patients were recommended to have endovascular treatment,while surgery was recommended in 59 patients.71.2%of the study population underwent the recommended *** CTA is a reproducible promising

关键词： Computed tomography angiography Intracranial aneurysm Subarachnoid hemorrhage Intracranial hemorrhage Observer variation