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possible role of soluble fibrin monomer complex after gastroenterological surgery

World Journal of Gastroenterology 2017年第12期23卷 2209-2216页

作者： Masatoshi Kochi manabu shimomura Takao Hinoi Hiroyuki Egi Kazuaki Tanabe Yasuyo Ishizaki Tomohiro Adachi Hirotaka Tashiro Hideki Ohdan Department of Gastroenterological and Transplant Surgery Applied Life SciencesInstitute of Biomedical and Health SciencesHiroshima University Department of Surgery National Hospital Organization Higashihiroshima Medical Center Department of Surgery Institute for Clinical ResearchNational Hospital Organization Kure Medical Center and Chu-goku Cancer Center Department of Surgery National Hospital Organization Hiroshima-nishi Medical Center

AIM To examine the role of soluble fibrin monomer complex(SFMC) in the prediction of hypercoagulable state after gastroenterological *** We collected data on the clinical risk factors and fibrin-related makers from patients who underwent gastroenterological surgery at Hiroshima University Hospital between April 1, 2014 and March 31, 2015. We investigated the clinical significance of SFMC, which is known to reflect the early plasmatic activation of coagulation, in the view of these fibrin related *** A total of 123 patients were included in the present study. There were no patients with symptomatic VTE. Thirty-five(28%) patients received postoperative anticoagulant therapy. In the multivariate analysis, a high SFMC level on POD 1 was independently associated with D-dimer elevation on POD 7(OR = 4.31, 95%CI: 1.10-18.30, P = 0.03). The cutoff SFMC level was 3.8 μg/ml(AUC = 0.78, sensitivity, 63%, specificity, 89%). The D-dimer level on POD 7 was significantly reduced in high-SFMC patients who received anticoagulant therapy in comparison to highSFMC patients who did *** The SFMC on POD 1 strongly predicted the hypercoagulable state after gastroenterological surgery than the clinical risk factors and the other fibrin related markers.

关键词： Hypercoagulable state Gastroenterological surgery Soluble fibrin monomer complex Venous thromboembolism Anticoagulant therapy

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Abscess in the inguinal hernial sac after peritonitis surgery: A case report

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World Journal of Gastroenterology 2009年第8期15卷 1007-1009页

作者： Satoshi Ikeda Haruka Takeda Masanori Yoshimitsu Takao Hinoi Makoto Yoshida Daisuke Sumitani Yuji Takakura Yasuo Kawaguchi manabu shimomura Masakazu Tokunaga Katsufumi Kawahori Hideki Ohdan Masazumi Okajima Department of Endoscopic Surgery and Surgical Science Graduate School of Biomedical Science Hiroshima University Hiroshima 734-8551 Japan Department of Surgery Division of Frontier Medical Science Programs for Biomedical Research Graduate School of Biomedical Science Hiroshima University Hiroshima 734-8551 Japan

In this paper, we report an extremely rare case of an abscess that developed in the inguinal hernial sac after surgery for peritonitis. A 60-year-old man underwent laparoscopic low anterior resection for rectal cancer. One day after this operation, peritoneal drainage and ileostomy were performed for rectal anastomotic leakage. Five days after the second operation, computed tomography revealed an abscess in the left inguinal hernial sac. Subsequently, hernioplasty and resection of the inflamed sac were performed.

关键词：腹股沟疝腹膜炎手术后病例报告脓肿气囊计算机断层扫描低位前切除

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Bi-predual spaces of generalized Campanato spaces with variable growth condition

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Acta Mathematica Sinica,English Series 2024年

作者： Satoshi YAMAGUCHI Eiichi NAKAI Katsunori shimomura Department of Mathematics Ibaraki University

In this paper we extend the duality(■)*= H1(Rd) to generalized Campanato spaces with variable growth condition Lp,φ(Rd) instead of BMO(Rd). We also extend the characterization of Cc∞omp(Rd)BMO(Rd)by Uchiyama(1978) to ■. Moreover, using this characterization, we prove the boundedness of singular and fractional integral operators on ■.The function space Lp,φ(Rd) treated in this paper covers the case that it is coincide with Lipαon one area, with BMO on another area and with the Morrey space on the other area, for example.

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Preoperative albumin-bilirubin score and liver resection percentage determine postoperative liver regeneration after partial hepatectomy

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World Journal of Gastroenterology 2024年第14期30卷 2006-2017页

作者： Kazuhiro Takahashi Masahiko Gosho Yoshihiro Miyazaki Hiromitsu Nakahashi Osamu shimomura Kinji Furuya Manami Doi Yohei Owada Koichi Ogawa Yusuke Ohara Yoshimasa Akashi Tsuyoshi Enomoto Shinji Hashimoto Tatsuya Oda Department of Gastrointestinal and Hepatobiliary-Pancreatic Surgery University of TsukubaTsukuba 3058-575IbarakiJapan Department of Biostatistics University of TsukubaTsukuba 3058-575IbarakiJapan

BACKGROUND The success of liver resection relies on the ability of the remnant liver to *** of the knowledge regarding the pathophysiological basis of liver regeneration comes from rodent studies,and data on humans are ***,there is limited knowledge about the preoperative factors that influence postoperative *** To quantify postoperative remnant liver volume by the latest volumetric software and investigate perioperative factors that affect posthepatectomy liver *** A total of 268 patients who received partial hepatectomy were *** were grouped into right hepatectomy/trisegmentectomy(RH/Tri),left hepa-tectomy(LH),segmentectomy(Seg),and subsegmentectomy/nonanatomical hepatectomy(Sub/Non)*** regeneration index(RI)and late rege-neration rate were defined as(postoperative liver volume)/[total functional liver volume(TFLV)]×100 and(RI at 6-months-RI at 3-months)/RI at 6-months,*** lower 25th percentile of RI and the higher 25th percentile of late regeneration rate in each group were defined as“low regeneration”and“delayed regeneration”.“Restoration to the original size”was defined as regeneration of the liver volume by more than 90%of the TFLV at 12 months *** The numbers of patients in the RH/Tri,LH,Seg,and Sub/Non groups were 41,53,99 and 75,*** RI plateaued at 3 months in the LH,Seg,and Sub/Non groups,whereas the RI increased until 12 months in the RH/Tri *** to our multivariate analysis,the preoperative albumin-bilirubin(ALBI)score was an independent factor for low regeneration at 3 months[odds ratio(OR)95%CI=2.80(1.17-6.69),P=0.02;per 1.0 up]and 12 months[OR=2.27(1.01-5.09),P=0.04;per 1.0 up].Multivariate analysis revealed that only liver resection percentage[OR=1.03(1.00-1.05),P=0.04]was associated with delayed ***,multivariate analysis demonstrated that the preoperative ALBI score[OR=2.63(1.00-1.05),P=0.02;per 1.

关键词： Liver regeneration Albumin-bilirubin score Liver resection percentage Partial hepatectomy Human Regeneration index

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Perspective on ultrathin layered Ni-doped MoS_(2) hybrid nanostructures for the enhancement of electrochemical properties in supercapacitors

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Journal of Energy Chemistry 2023年第5期80卷 335-349,I0008页

作者： Kamarajar Prakash Santhanakrishnan Harish Shanmugasundaram Kamalakannan Thirumalaisamy Logu Masaru shimomura Jayaram Archana Mani Navaneethan Functional Materials and Energy Devices Laboratory Department of Physics and NanotechnologySRM Institute of Science and TechnologyKattankulathurChennai 603203Tamil NaduIndia Graduate School of Science and Technology Shizuoka University3-5-1 JohokuNaka-KuHamamatsuShizuoka 432-11Japan SPECIFIC Materials Research CentreFaculty of Science and EngineeringSwansea UniversitySwanseaUnited Kingdom Nanotechnology Research Center SRM Institute of Science and TechnologyKattankulathurChennai 603203Tamil NaduIndia

Over the last two decades,extensive study has been done on two-dimensional Molybdenum Sulphide(MoS_(2))due to its outstanding features in energy storage *** MoS_(2)has a lot of active sulphur edges,the presence of inactive surfaces leads to limit conductivity and ***,in this article,we aimed to promote the additional active sites by doping various weight percentages(2%,4%,6%,8%and 10%)of Nickel(Ni)into the MoS_(2)matrix by simple hydrothermal technique,and their doping effects were investigated with the help of Physio-chemical analyses.X-ray diffraction(XRD)pattern,Raman,and chemical composition(XPS)analyses were used to confirm the Ni incorporation in MoS_(2)*** investigations demonstrated that Ni-doped MoS_(2)nanosheets were vertically aligned with enhanced interlayer *** voltammetry,Galvanostatic charge-discharge,and electrochemical impedance spectroscopy investigations were used to characterize the electrochemical *** 6%Ni-doped MoS_(2)electrode material showed better CSPof 528.7 F/g@1 A/g and excellent electrochemical stability(85%of capacitance retention after 10,000 cycles at 5 A/g)compared to other electrode ***,the solid-state asymmetric supercapacitor was assembled using Nidoped MoS_(2)and graphite as anode and cathode materials and analysed the electrochemical properties in the two-electrode *** determine the impact of the Ni-atom on the MoS_(2)surface,firstprinciples computations were ***,it was examined for electronic band structure,the projected density of states(PDOS)and Bader charge transfer analyses.

关键词： Ni-doped MoS_(2) Supercapacitor Cyclic voltammetry Specilic surface area Specific capacitance Stability

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Evaluation of the sperm DNA fragmentation index in infertile Japanese men by in-house flow cytometric analysis

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Asian Journal of Andrology 2022年第1期24卷 40-44页

作者： Akiyoshi Osaka Hiroshi Okada Sae Onozuka Takashi Tanaka Toshiyuki Iwahata Yukihito shimomura Yoshitomo Kobori Kazutaka Saito Kouhei Sugimoto Department of Urology Dokkyo Medical University Saitama Medical Center2-1-50 MinamikoshigayaKoshigayaSaitama 343-8555Japan International Center for Reproductive Medicine Dokkyo Medical University Saitama Medical Center2-1-50 MinamikoshigayaKoshigayaSaitama 343-8555Japan

Semen analysis has long been used to evaluate male ***,several sperm function tests have been *** those,the sperm DNA fragmentation index(DFI),which describes the status of the sperm DNA,is thought to be a suitable parameter for evaluating male ***,there have been no large-scale studies on the sperm DFI of Japanese ***,we investigated the feasibility of using an in-house flow cytometry-based sperm DFI analysis based on the sperm DNA fragmentation test of sperm chromatin structure assay(SCSA)to assess male fertility in *** study enrolled 743 infertile and 20 fertile Japanese *** evaluate reproducibility,inter-and intraobserver precision was analyzed.A receiver operating characteristic curve analysis was used to set a cutoff value for the sperm DFI to identify men who could father children by timed intercourse or intrauterine *** variability of the sperm DFI among fertile volunteers was *** relationship between semen parameters and the sperm DFI was assessed by Spearman’s rho test.A precision analysis revealed good reproducibility of the sperm *** cutoff value of sperm DNA fragmentation in infertile men was 24.0%.Semen volume had no relationship with the sperm *** concentration,sperm motility,total motile sperm count,and percentage of normal-shaped sperm were significantly and negatively correlated with the sperm *** median sperm DFI was smaller in fertile volunteers(7.7%)than that in infertile men(19.4%).Sperm DNA fragmentation analysis can be used to assess sperm functions that cannot be evaluated by ordinary semen analysis.

关键词： DNA fragmentation flow cytometry male infertility semen analysis spermatozoa

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On the Boundary Limits of Monotone Sobolev Functions in Variable Exponent Orlicz Spaces

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Acta Mathematica Sinica,English Series 2013年第3期29卷 461-470页

作者： Toshihide FUTAMURA Tetsu shimomura Department of Mathematics Daido University Department of Mathematics Graduate School of Education Hiroshima University

Our aim in this note is to deal with boundary limits of monotone Sobolev functions with Δu∈Lp（·）logLq（·）（B）for the unit ball B *** p（·） and q（·） are variable exponents satisfying the log-H61der and th... 详细信息

关键词： Monotone Sobolev functions nontangential limits tangential limits LindelSf theorem,variable exponent

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Water-assisted self-sustained burning of metallic single-walled carbon nanotubes for scalable transistor fabrication

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Nano Research 2017年第9期10卷 3248-3260页

作者： Keigo Otsuka Taiki Inoue Yuki shimomura Shohei Chiashi Shigeo Maruyama Department of Mechanical Engineering The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8656 Japan Energy NanoEngineering Lab. National Institute of Advanced Industrial Science and Technology (AIST) 1-2-1 Namiki Tsukuba 305-8564 Japan

Although aligned arrays of semiconducting single-walled carbon nanotubes (s-SWNTs) are promising for use in next-generation electronics owing to their ultrathin bodies and ideal electrical properties, even a small portion of metallic (m-) counterparts causes excessive leakage in field-effect transistors (FETs). To fully exploit the benefits of s-SWNTs for use in large-scale systems, it is necessary to completely eliminate m-SWNTs from as-grown SWNT arrays and thereby obtain purely semiconducting large-area arrays, wherein numerous FETs can be flexibly built. In this study, we performed electrical burning of m-SWNTs assisted by water vapor and polymer coating to eliminate m-SWNTs over a long length for the scalable fabrication of transistors from the remaining s-SWNT arrays. During the electrical-breakdown process, the combination of water vapor and the polymer coating significantly enhanced the burning of the SWNTs, resulting in a self-sustained reaction along the nanotube axis. We found that m-SWNT segments partially remaining on the anode side resulted from one-way burning from the initial breakdown position, where Joule-heating-induced oxidation first occurred. The s-SWNT-enriched arrays obtained were used to fabricate multiple FETs with a high on-off current ratio. The results indicate the advantages of this approach over conventional electrical breakdown for the large-scale purification of s-SWNTs.

关键词： single-walled carbon nanotubes field-effect transistor selective removal electrical breakdown one-way burning

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Establishment of a function embodiment knowledge base for supporting service design

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Science China(Information Sciences) 2012年第5期55卷 1008-1018页

作者： NEMOTO Yutaro AKASAKA Fumiya CHIBA Ryosuke shimomura Yoshiki Department of System Design Tokyo Metropolitan University

In service engineering,a service is represented as a functional structure that satisfies customer *** entities and their activities are associated with a functional structure as a way to accomplish a *** this phase,it is important for service designers to have broad knowledge,since entities that construct a service include both human and physical ***,the extent of the designer's knowledge is the key to the enhancement of design ***,few tools to support designers in the embodiment phase have been *** this paper,for the purpose of constructing a function embodiment knowledge base in service design,the representational form of knowledge is proposed,and a prototype system of function embodiment knowledge base is *** function embodiment knowledge is collected from multiple service cases using the prototype system,and the effectiveness of knowledge base is discussed.

关键词： service engineering service design design knowledge management embodiment knowledge base

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Biomimetic Riblets Inspired by Sharkskin Denticles： Digitizing, Modeling and Flow Simulation

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Journal of Bionic Engineering 2018年第6期15卷 999-1011页

作者： Mariko Miyazaki Yuji Hirai Hiroshi Moriya Masatsugu shimomura Akihiro Miyauchi Hao Liu Hitachi Ltd. 832-2 Horiguchi Hitachinaka Ibaraki 312-0034 Japan Chitose Institute of Science and Technology 758-65 Bibi Chitose Hokkaido 066-8655 Japan Tokyo Medical Dental University 2-3-10 Kanda-Surugadai Chiyodaku Tokyo 101-0062 Japan Chiba University 1-33 Yayoi-cho Inage-ku Chiba 263-8522 Japan

While sharkskin surface roughness in terms of denticle morphology has been hypothesized but remains yet controversial to be capable of achieving turbulent flow control and drag reduction, sharkskin-inspired ＂riblets＂ have been reported to be an effective biomimetic design. Here we address an integrated study of biomimetic riblets inspired by sharkskin denticles by combining 3D digitizing and mod- eling of＂fresh＂ denticles and computational fluid dynamic modeling of turbulent flows on a rough surface with staggered denticles and hound-tooth-patterned grooves. Realistic microstructures of denticles in five shark species of Galapagos, great white, whitetip reef, blacktip reef, and hammerhead sharks were first measured and digitized in three fold：（1） 2D imaging of lubricated sharkskin in a wet state by means of a ＂nano-suit＂ technique with a Field-Emission Scanning Electron Microscope （FE-SEM）; （2） 3D structures of sharkskin denticles with a micro-focus X-ray CT; and （3） single denticles of the five shark species in a 3D manner with 3D-CAD. The denticles at mid-body location in the five species were observed to have a structure of five non-uniform-ridges （herein termed ＂non-uniform grooves＂） with Angles Of Inclination （AOI） ranging over 20° - 32°. Hydrodynamics associated with the unique five-ridge denticles were then in- vestigated through modeling turbulent flow past a denticle-staggered skin surface. We further constructed a biomimetic riblet model inspired by the non-uniform grooves and investigated the hydrodynamic effects of height-to-spacing ratios of mid-ridge and side-ridges. Our results indicate that the morphological non-uniformity in sharkskin denticles likely plays a critical role in passively controlling local turbulent flow and point to the potential of denticle-inspired biomimetic riblets for turbulent-flow control in aquatic vehicles as well as other fluid machinery.

关键词： sharkskin denticles biommetic riblets 3D digitizing computational fluid dynamics

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