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Clinical characteristics and clinicopathological correlations of bilateral breast cancer in China:A multicenter study from Chinese Society of Breast Surgery(CSBrS-006)

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Chinese Journal of Cancer Research 2021年第1期33卷 27-32页

作者： Xuelu Li Yitong Wang Bo pan man Li Jiyue Gao Yi Zhao Zuowei Zhao Chinese Society of Breast Surgery Department of Oncology&Breast Surgery the Second Hospital of Dalian Medical UniversityDalian 116023China department of Oncology Shengjing Hospital of China Medical UniversityShenyang 110004China 不详

Objective:To investigate the clinical characteristics and clinicopathological correlations of bilateral breast cancer(BBC)in ***:Data of 440 patients diagnosed with BBC in 2018 were collected from 33 centers of the Chinese Society of Breast *** characteristics,bilateral tumor characteristics,and comprehensive treatment data were *** between the clinicopathological characteristics of bilateral tumors were ***:The proportion of BBC was 0.22%-3.08%.A total of 33(7.5%)patients had a family history of malignant tumors,304(69.1%)patients had synchronous *** 1(0.2%)patient was *** than half of all patients received concurrent or asynchronous endocrine/chemotherapy,32.5%of all human epidermal growth factor receptor 2(HER2)-positive patients received HER2-targeted therapy,and approximately 21.6%of all patients received *** most common pathological cancer type was invasive ductal cancer(>60%).Approximately 70%of all patients had bilateral hormone receptor(HR)-positive tumors and presented with a single breast *** correlations were found with pathological type,histological grade,locations of tumor,molecular subtype,k.-67 index,tumor site and size of bilateral *** of the subgroup analysis showed more clinicopathological characteristics when synchronous BBC was compared with metachronous ***:In China,the clinicopathological characteristics of bilateral tumors showed significant correlations,and more significant clinicopathological correlations were observed when synchronous BBC was compared with metachronous BBC.

关键词： Adjuvant therapy bilateral breast cancer clinicopathological correlation demographic characteristics

Analysis and simulation of a single-phase seven-level inverter controlled by modified sinusoidal PWM technique

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International Journal of Modeling, Simulation, and Scientific Computing 2021年第4期12卷 120-139页

作者： V.Srinath man Mohan Agarwal D.k.Chaturvedi Department of Electrical Engineering Faculty of Engineering Dayalbagh Educational InstituteAgraIndia

In this paper,a modified sinusoidal pulse width modulation(MSPWM)technique and a modified single-phase H-bridge seven-level inverter is *** switching pulses for the proposed seven-level inverter are generated using a single triangular carrier waveform,a fully rectified sinusoidal signal,and three stepped reference signals(Uref1,Uref2 and Uref3).Using optimization technique,the magnitude of the stepped reference signal is determined so that the total harmonic distortion(THD)of the output voltage waveform is minimum and the fundamental component,RMS value of the voltage is improved for a given modulation index Ma as compared to the sinusoidal pulse width modulation(SPWM).By the implementation of the new scheme,the seven-level of the inverter output voltage level(+Vdc,+2Vdc/3,+Vdc/3,0,−Vdc,−2Vdc/3,−Vdc)is obtained for any given modulation ***,if only two stepped reference signals are used then the inverter will act as a five-level inverter for any modulating index *** proposed MSPWM and seven-level inverter are simulated on MATLAB/SIMULINk.for R,R-L load and on a single-phase capacitor-start and capacitor-start-run Induction Motor.

关键词： Induction motor MATLAB/SIMULINk Seven-level inverter single triangular carrier SPWM stepped reference signals THD

Effect of daily salinity fluctuation on the intraspecific interactions of a euhalophyte(Suaeda salsa)along a salinity gradient

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Journal of Plant Ecology 2022年第1期15卷 208-221页

作者： Hua Ma Li-Juan Cui Wei Li Yu Ning Yin-Ru Lei Xu pan Yi-Fei Wang man-Yin Zhang Institute of Wetland Research Chinese Academy of ForestryBeijing 100091China Beijing k.y Laboratory of Wetland Services and Restoration Institute of Wetland ResearchBeijing 100091China Beijing Hanshiqiao National Wetland Ecosystem Research Station Institute of Wetland ResearchBeijing 101309China Chinese Academy of Forestry Beijing 100091China

Heterogeneity of soil salinity is a prominent environmental characteristic in the intertidal zone of estuaries,affecting the plant growth and the shift of biotic interactions in the salt *** study aims to examine the interactive effects of a salinity gradient and salinity fluctuations on intraspecific interactions of a *** assessed the impact of daily fluctuating salinity on the outcome of intraspecific interactions by cultivating seeds of Suaeda salsa(Chenopodiaceae)in river *** experiment was conducted in a greenhouse with three treatments:daily salinity fluctuations(static and fluctuating salinity),a salinity gradient(200 and 400 mmol L^(−1))and three planting densities(1,2 and 4 plants/pot).First,height and biomass of plants were measured at both the start and end of the ***,the growth indexes and log response ratio of *** were *** outcome of intraspecific interactions of *** shifted from competition in low salinity to facilitation in high salinity,and high conspecific density strengthened the competition and facilitation *** salinity fluctuation did not significantly affect the plant growth and the outcome of intraspecific interactions,but did have a significant influence on belowground *** results suggest that the stress-gradient hypothesis may apply to predicting the variation of the intraspecific relationship of a salt-tolerant species along a salinity gradient,and the magnitude of this variation is density *** findings help us understand how individuals and populations of a euhalophyte species respond to the natural variation or human modification of salinity conditions.

关键词： salinity gradient daily salinity fluctuations euhalophyte intraspecific relationship stress-gradient hypothesis(SGH)

Extensions of PDZ domains as important structural and functional elements

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Protein & Cell 2010年第8期1卷 737-751页

作者： Conan k.Wang Lifeng pan Jia Chen Mingjie Zhang Department of Biochemistry Molecular Neuroscience CenterHong Kong University of Science and TechnologyClear Water BayKowloonHong Kong Esk.tis Institute for Cell and Molecular Therapies Griffith UniversityBrisbaneQld 4111Australia

‘Divide and conquer’has been the guiding strategy for the study of protein structure and *** are divided into domains with each domain having a canonical structural definition depending on its *** this review,we push forward with the interesting observation that many domains have regions outside of their canonical definition that affect their structure and function;we call these regions‘extensions’.We focus on the highly abundant PDZ(PSD-95,DLG1 and ZO-1)*** bioinformatics,we find that many PDZ domains have potential extensions and we developed an openly-accessible website to display our results(http://***/pdzex/).We propose,using well-studied PDZ domains as illustrative examples,that the roles of PDZ extensions can be classified into at least four categories:1)protein dynamics-based modulation of target binding affinity,2)provision of binding sites for macro-molecular assembly,3)structural integration of multi-domain modules,and 4)expansion of the target ligand-binding *** review highlights the potential structural and functional importance of domain extensions,highlighting the significance of look.ng beyond the canonical boundaries of protein domains in general.

关键词： PDZ domain PDZ extensions protein structure

Experimental study on the variation law of coal temperature during excavation in coal mines

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Journal of Coal Science & Engineering(China) 2013年第2期19卷 133-135页

作者： Yi-shan pan Lian-man XU Zhong-Hua LI Guo-Zhen LI School of Mechanics and Engineering Liaoning Technical University Fuxin 123000 China

By testing the temperature of the coal and the stress of the work.ng surface, we got the variation law of coal temperature and coal stress during the excavation. The result shows that the activities of mining affect the coal temperature, the fluctuation of coal temperature and the coal stress is synchronous. During the smooth change of crustal stress, the coal temperature basically k.eps unchanged, when the dynamic phenomenon appears, the coal temperature changes, as well the coal stress. Therefore, we can use the online coal temperature monitoring system to test the coal temperature of the work.ng surface continuously, and it can provide basic information for forecasting coal mine power disaster before it happens.

关键词： coal temperature coal stress coal fracturing gas desorption

Recent Advances in Fatigue Detection Algorithm Based on EEG

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Intelligent Automation & Soft Computing 2023年第3期35卷 3573-3586页

作者： Fei Wang Yinxing Wan man Li Haiyun Huang Li Li Xueying Hou Jiahui pan Zhenfu Wen Jingcong Li School of Software South China Normal UniversityFoShan528225China Pazhou Lab Guangzhou510330China Department of Psychiatry New York University School of MedicineNew York10016USA

Fatigue is a state commonly caused by overwork.d,which seriously affects daily work.and *** to detect mental fatigue has always been a hot spot for researchers to ***(EEG)is considered one of the most accurate and objective *** article investigated the devel-opment of classiﬁcation algorithms applied in EEG-based fatigue detection in recent *** to the different source of the data,we can divide these classiﬁcation algorithms into two categories,intra-subject(within the same sub-ject)and cross-subject(across different subjects).In most studies,traditional machine learning algorithms with artiﬁcial feature extraction methods were com-monly used for fatigue detection as intra-subject ***,deep learn-ing algorithms have been applied to fatigue detection and could achieve effective result based on large-scale ***,it is difﬁcult to perform long-term calibration training on the subjects in practical *** the lack.of large samples,transfer learning algorithms as a cross-subject algorithm could promote the practical application of fatigue detection *** found that the research based on deep learning and transfer learning has gradually increased in recent *** as aﬁeld with increasing requirements,researchers still need to con-tinue to explore efﬁcient decoding algorithms,design effective experimental para-digms,and collect and accumulate valid standard data,to achieve fast and accurate fatigue detection methods or systems to further widely apply.

关键词： EEG fatigue detection deep learning machine learning transfer learning

Identification of Mucilage Cavity as a Significant Microscopic Characteristic Existing in Phloem Instead of Pith of Radix et Rhizoma Rhei

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Wuhan University Journal of Natural Sciences 2008年第2期13卷 239-246页

作者： TANG Jun FENG Yibin TONG Yao JIA Ruirui SY Laik.ng R. Y. k. man School of Chinese Medicine The University of Hong Kong HongKong China College of Pharmacy Wuhan University Wuhan 430072 HubeiChina Department of Pharmacology The University of Hong Kong HongKong China

The morphologic and microscopic features of Radix et Rhizoma Rhei were studied. The study verified that the mucilage cavities did exist in phloem of rhizomes and roots or abnormal vascular bundles. Also, they were in similar distribution in three species of Radix et Rhizoma Rhei. The diagnostic characteristic for microscopic identification was found to be the similar distribution of abnormal vascular bundles in pith of rhizomes in all three species. And the appearance of the crude drug varied more depending on the plants＇ geographical origin and different preliminary treatment on the spot of collection than on the species differences. Our findings, having not been delineated clearly so far in the previous reports, are helpful for clarifying current descriptions in different literatures or standards and mak. a full understanding on microscopic and macroscopic identification of Radix et Rhizoma Rhei.

关键词： Radix et Rhizoma Rhei microscopic identification mucilage cavity abnormal vascular bundle

Novel travelling wave structures:few-cyclepulse solitons and soliton molecules

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Communications in Theoretical Physics 2021年第2期73卷 23-29页

作者： Zitong Chen man Jia School of Physical Science and Technology Ningbo UniversityNingbo 315211China

We discuss a fifth order k.V(FOk.V)equation via a novel travelling wave method by introducing a back.round *** show that the back.round term plays an essential role in finding new abundant travelling wave structures,such as the soliton induced by negative back.round,the periodic travelling wave excited by the positive back.round,the few-cycle-pulse(FCP)solitons with and without back.round,the soliton molecules excited by the *** FCP solitons are first obuained for the FOk.V equation.

关键词： New travelling method a fifth order k.V equation solitons induced by back.round few-cycle-pulse solitons soliton molecules

Next-generation sequencing technology for the diagnosis of Pneumocystis pneumonia in an immunocompetent female:A case report

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World Journal of Clinical Cases 2023年第18期11卷 4425-4432页

作者： Jing-Ji Huang Song-Song Zhang man-Li Liu En-Yu Yang Yu pan Jing Wu The Second Clinical Medical College Guizhou University of Traditional Chinese MedicineGuiyang 550000Guizhou ProvinceChina Intensive Care Unit Guizhou Provincial People's HospitalGuiyang 550000Guizhou ProvinceChina

BACk.ROUND Pneumocystis pneumonia(PCP)is a serious fungal infection usually seen in patients with human immunodeficiency virus,and it is more frequently found and has a high fatality rate in immunocompromised ***,it rarely occurs in immunocompetent ***,the clinical diagnosis of this pathogen is made more difficult by the difficulty of obtaining accurate microbiological evidence with routine *** case reports a PCP patient with normal immune function who was diagnosed through next-generation sequencing(NGS).CASE SUMMARY A 23-year-old female who had no special disease in the past was admitted to the hospital with a persistent fever and *** on the initial examination results,the patient was diagnosed with bipulmonary pneumonia,and empirical broad-spectrum antibiotic therapy was ***,due to the undetermined etiology,the patient's condition continued to *** was transferred to the intensive care unit because of acute respiratory *** the diagnosis of Pneumocystis jirovecii infection through NGS in bronchoalveolar lavage fluid and treatment with trimethoprim/sulfamethoxazole and caspofungin,the patient gradually recovered and had a good *** This case emphasizes that,for patients with normal immune function the possibility of PCP infection,although rare,cannot be *** plays an important role in the diagnosis of refractory interstitial pneumonia and acute respiratory failure.

关键词： Pneumocystis pneumonia Pneumocystis jirovecii Next-generation sequencing Immunocompetent Trimethoprim/Sulfamethoxazole Case report