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Immunoregulatory and Anti-cancer Activities of Combination Treatment of Novel Four-Herb Formula and Doxorubicin in 4T1-Breast Cancer Bearing Mice

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Chinese Journal of Integrative Medicine 2024年第4期30卷 311-321页

作者： Lea Ling-Yu kan Ben Chung-Lap Chan Grace Gar-Lee Yue LI Pei-ting Sharon Sze-man Hon HUANG Dan-qi Miranda Sin-man Tsang Clara Bik-San Lau Ping-Chung Leung Chun-Kwok Wong Institute of Chinese Medicine The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants The Chinese University of Hong KongHong KongChina Department of Chemical Pathology The Chinese University of Hong KongHong Kong SARChina China-Australia International Research Centre for Chinese Medicine School of Health and Biomedical SciencesSTEM CollegeRMIT UniversityBundooraVictoriaAustralia Li Dak Sum Yip Yio Chin R&D Centre for Chinese Medicine The Chinese University of Hong Kong SARHong KongChina

Objective To investigate the in vivo immunomodulatory and anti-tumor mechanisms of the combined treatment of novel Four-Herb formula(4HF)and doxorubicin in triple-negative breast cancer(TNBC).Methods Murine-derived triple-negative mammary carcinoma cell line,4T1 cells,was cultured and inoculated into mouse mammary ***-six mice were randomly assigned into 6 groups(n=11 in ench):naive,control,LD 4HF(low dose 4HF),HD 4HF(high dose 4HF),LD 4HF+D(low dose and doxorubicin),and D(doxorubicin).Apart from the naive group,each mouse received subcutaneous inoculation with 5×10^(5)4T1 cells resuspended in 100µL of normal saline in the mammary fat *** from the day of tumor cell inoculation,tumors were grown for 6 *** LD and HD groups received daily oral gavage of 658 and 2,630 mg/kg 4HF,*** LD 4HF+D group received daily oral gavage of 658 mg/kg 4HF and weekly intraperitoneal injection of doxorubicin(5 mg/kg).The D group received weekly intraperitoneal injections of doxorubicin(5 mg/kg).The treatment naive mice received daily oral gavage of 0.2 mL double distilled water and 0.1 mL normal saline via intraperitoneal injection once a *** control group received daily oral gavage of 0.2 mL double-distilled *** treatment period was 30 *** the end of treatment,mice organs were harvested to analyze immunological activities via immunophenotyping,gene and multiplex analysis,histological staining,and gut microbiota *** Mice treated with the combination of 4HF and doxorubicin resulted in significantly reduced tumor and spleen burdens(Pmanipulated gut microbiota to favor the anti-tumor immunological ***,immunosuppressive genes,cytokines,and chemokines such as C-C motif chemokine 2 and interleukin-10 of tumors were significantly downregulated(P<0.05).4HF-doxorubicin combination treatment demonstrated synergetic activities and was most effective

关键词： adjunctivetherapy breast cancer cytokines Chinese medicine tumor microenvironment

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One new species in the genus Bryophaenocladius Thienemann(Chironomidae:Diptera)from China

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Entomotaxonomia 2024年第3期46卷 245-250页

作者： kan DENG Yang XIAO man YANG Zhichao ZHANG Ruilei ZHANG Engineering Research Center of Environmental DNA and Ecological Water Health Assessment Shanghai Ocean UniversityShanghai 201306China Shanghai Universities Key Laboratory of Marine Animal Taxonomy and Evolution Shanghai Ocean UniversityShanghai 201306China

One new species Bryophaenocladius alpinus Deng&Zhang *** described and illustrated based on adult males collected from *** adult males can be distinguished by the third palpomere with a digitiform projection but without sensilla clavata,anal point broad triangular,inferior volsella sub-rectangular-shaped and covered with setae,gonostylus broad triangular,and crista dorsalis welldeveloped.

关键词： Chironominae DNA barcode taxonomy

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3 T MRI定量测量眼眶结构在Graves眼病分期中的诊断价值

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磁共振成像 2024年第5期15卷 61-67页

作者：王嫚沈中原阚宏吴兴旺安徽医科大学第一附属医院放射科合肥230032 安徽医科大学附属阜阳医院核医学科阜阳236000 安徽医科大学附属阜阳医院放射科阜阳236000

目的应用3 T眼眶MRI技术评估Graves眼病(Graves ophthalmopathy,GO)患者泪腺参数与临床活动性评分(clinical activity score,CAS)的相关性。材料与方法前瞻性纳入2020年2月至2023年6月安徽医科大学附属阜阳医院和安徽医科大学第一附属... 详细信息

目的应用3 T眼眶MRI技术评估Graves眼病(Graves ophthalmopathy,GO)患者泪腺参数与临床活动性评分(clinical activity score,CAS)的相关性。材料与方法前瞻性纳入2020年2月至2023年6月安徽医科大学附属阜阳医院和安徽医科大学第一附属医院确诊的GO患者40例80只眼作为GO组,选取与GO组性别与年龄段匹配的健康人群40例80眼作为对照组。根据CAS评分将GO患者分为活动期GO组、非活动期GO组。分别对三组进行MRI常规图像及读出分段平面回波弥散加权成像(readout segmentation of long variable echo-trains diffusion weighted imaging,RESOLVE DWI)图像采集,横断位T2加权成像脂肪抑脂(T2-weighted imaging fat suppression,T2WI-FS)获得眼球突出度、泪腺突出度,横断位及冠状位T2WI-FS测量获得泪腺最大截面时的长径、短径、面积,记录横断位泪腺表观扩散系数(apparent dispersion coefficient,ADC)平均值。使用SPSS 24.0软件进行统计学分析,Pman’s相关分析泪腺各定量参数与CAS评分的相关性。结果(1)活动期GO组眼球突出度、横断位泪腺各参数,包含泪腺突出度、长径、短径、面积及ADC平均值,均较非活动期GO组、对照组增大,非活动期GO组较对照组升高(P均<0.05)。(2)ROC曲线结果显示,眼球突出度、横断位泪腺面积对GO患者的诊断效能最高(AUC为0.906、0.905),泪腺突出度、横断位泪腺ADC平均值对GO患者也有一定的诊断价值(0.793、0.702)。RESOLVE DWI ADC值预测GO活动性的最佳截断点为1.181×10^(-3)mm^(2)/s,其敏感度高达95.00%,特异度76.30%。(3)眼球突出度(r=0.734,P<0.05)、泪腺突出度(r=0.719,P<0.05)、泪腺ADC值(r=0.742,P<0.05)与CAS呈高度相关。结论横断位泪腺突出度、泪腺DWI ADC平均值可作为GO诊断及分期的重要参考指标。

关键词： Graves眼病泪腺定量测量弥散加权成像磁共振成像

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真空低温烹调技术对肉制品品质的影响研究进展

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食品工业科技 2024年第11期45卷 333-340页

作者：张慢熊晓筱刘俊阚娟千春录金昌海扬州大学食品科学与工程学院江苏扬州225127

真空低温烹调(Sous vide)是在真空条件下进行的一种经严格控制温度和时间的烹调技术。与传统的烹调方法相比,真空低温烹调因能有效减少产品中营养成分的损失,保留食品的原有风味,改善肉制品嫩度等优势而受到大众关注,近几年被广泛研究... 详细信息

真空低温烹调(Sous vide)是在真空条件下进行的一种经严格控制温度和时间的烹调技术。与传统的烹调方法相比,真空低温烹调因能有效减少产品中营养成分的损失,保留食品的原有风味,改善肉制品嫩度等优势而受到大众关注,近几年被广泛研究并应用于肉制品加工。本文主要综述了真空低温烹调技术加工条件和方式的改变对肉制品食用品质的影响,指出适宜的加热温度和时间能提高肉制品风味和嫩度、促进营养物质的保留,且低温长时间加热有助于提高肉类的安全性。同时本文还阐述了真空低温烹调与其他技术联用对产品嫩度和安全性的显著影响,为更好地促进真空低温烹调技术在肉制品精深加工中的应用和实现真空低温烹饪肉制品的工业化生产提供了理论依据。

关键词：真空低温烹调肉制品加工风味营养成分嫩度安全性

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Rupture of a rubber sheet by a cavitation bubble:an experimental study

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Acta Mechanica Sinica 2021年第10期37卷 1489-1497,I0001页

作者： Xing-Yu kan Jia-Le Yan Shuai Li A-man Zhang College of Shipbuilding Engineering Harbin Engineering UniversityHarbin150001China

Dynamics of spark-generated cavitation bubbles near a deformable rubber sheet are experimentally investigated in this *** transient bubble–rubber interaction is captured by high-speed photography,including the expansion and collapse of the bubble,jetting behaviors,large deformation,and rupture of the rubber *** dependence of bubble behaviors and rubber response on two governing parameters(the bubble–rubber stand-off distanceγand the rubber thickness T)are systematically ***,the bubble collapse patterns or jetting directions are categorized into three *** the bubble is initially located at a largeγfrom the rubber sheet,the jet is directed towards the boundary(regime I).Unexpectedly,when the generated bubble is close to the rubber sheet,it develops a jet away from the boundary(regime III).Bubble splitting and the formation of two axial liquid jets directing in opposite directions can only be observed with an intermediateγ(regime II).A phase diagram of the bubble behaviors is given in theγ–T *** a large rubber sheet thickness(e.g.,T=5 mm),only a downward jet is *** the perspective of jet direction,the effect of such a thick rubber sheet on the bubble dynamics is similar to that of a rigid *** that the jet velocity and jet width may be slightly ***,the results reveal that bubble expansion can cause the boundary to *** strong axial jet towards the rubber sheet can damage and even rupture the rubber boundary.A parameter range within which the bubble jetting can rupture the rubber boundary is ***,for a thin rubber sheet(T≤4 mm),the rupture is more likely to occur in regime *** a thick rubber sheet(e.g.,T=5 mm),the rupture can be seen when the jet directly impacts the rubber sheet(regime I).

关键词： Bubble dynamics Rubber boundary Rupture High-speed photography

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探讨多模态MRI检查对成人MELAS型线粒体脑肌病的诊断价值

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中国CT和MRI杂志 2024年第2期22卷 22-24页

作者：王嫚沈中原阚宏张小艳李飞安徽医科大学附属阜阳医院核医学科安徽阜阳236000 安徽医科大学附属阜阳医院放射科安徽阜阳236000

目的探讨多种功能磁共振成像的联合应用在成人线粒体脑肌病伴乳酸血症和卒中样发作(mitochondrial encephalomyopathy,lactate acidosis and stroke-like episodes,MELAS)中的诊断价值。方法1例MELAS患者,除了CT平扫、常规MRI检查序列,补充了病人MR血管成像(MRA)、DWI、MRS和CASL-PWI的影像资料。结果病灶呈片状不对称分布脑实质,以颞叶、顶叶、枕叶较多;MRI T1序列稍低信号、T2序列稍高信号,FLAIR、DWI信号较高,ADC图显示信号稍偏低。MRA未见病变相应区域血管异常改变;病变可同时累及Willis两支血管供血区。MRS示病灶区乳酸峰升高,MRI平扫无异常信号的脑组织亦出现乳酸峰轻度升高。CASL-PWI显示病变区高灌注。结论多模态核磁共振检查对诊断成人MELAS综合征极大价值。

关键词：线粒体脑肌病伴乳酸血症和卒中样发作多模态磁共振波谱连续动脉自旋标记灌注

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老年男性幕上髓母细胞瘤MR和CT表现的研究

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中国CT和MRI杂志 2024年第5期22卷 38-39页

作者：沈中原王嫚孙明华阚宏安徽医科大学附属阜阳医院放射科安徽阜阳236000 安徽医科大学附属阜阳医院核医学科安徽阜阳236000

本文报道成人幕上髓母细胞瘤1例,老年男性,十几天持续头疼、头晕、反应迟钝入院就诊。CT平扫双侧额叶、胼胝体膝部团块状稍高密度,CT值约45-56Hu,周围环绕片状水肿带。MRI示肿瘤实性部分信号不均,T_(1)WI信号低,T_(2)WI信号混杂,DWI信... 详细信息

本文报道成人幕上髓母细胞瘤1例,老年男性,十几天持续头疼、头晕、反应迟钝入院就诊。CT平扫双侧额叶、胼胝体膝部团块状稍高密度,CT值约45-56Hu,周围环绕片状水肿带。MRI示肿瘤实性部分信号不均,T_(1)WI信号低,T_(2)WI信号混杂,DWI信号较高,ADC等或低信号,瘤周伴水肿;增强扫描见双侧额叶及胼胝体膝部病灶环形明显强化,左侧额叶、基底节区、右侧小脑半球见结节状强化灶。术后病理最终确诊为髓母细胞瘤。

关键词：髓母细胞瘤幕上成人 CT 磁共振

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High mass-loading and binder-free flexible vanadium-based oxide cathode for zinc-ion battery via a bridge of MXene

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Journal of Materials Science & Technology 2023年第12期143卷 84-92页

作者： kan Fang Fei Li Gui-Gen Wang Yi-Lin Liu man-Lin Tan Da-Qiang Zhao Hua-Yu Zhang Jie-Cai Han Shenzhen Key Laboratory for Advanced Materials School of Materials Science and EngineeringHarbin Institute of TechnologyShenzhen 518055China National Key Laboratory of Science and Technology on Advanced Composites in Special Environments Harbin Institute of TechnologyHarbin 150080China Research Institute of Tsinghua University in Shenzhen Shenzhen 518055China

Flexible zinc-ion batteries(ZIBs)are promising power sources for portable devices due to their high safety and low production ***,the low mass-loading and limited areal capacity of cathode materials are the major problems blocking the practicability of ***,a high mass-loading and binder-free flexible vanadium oxide(MCV@CC)cathode with a large areal capacity was fabricated via the bridge effect of *** functional MXene bridge induces the growth of the vanadium oxide active layer on the carbon cloth(CC)flexible *** binder-free cathode can reduce the electrochemically inactive weight of the whole electrode,which enhances the energy density of ***,the MCV@CC cathode(mass-loading of∼7 mg cm^(−2))delivers a desirable areal capacity(2.36 mAh cm^(−2))and good cycling stability(capacity retention of 86.1%after 1200 cycles at 10 mA cm^(−2)).Moreover,several ex-situ characterization results indicate that the reaction mechanism upon battery cycling is based on the reversible Zn^(2+)/H^(+)(de)intercalation in the vanadium oxide ***,the assembled quasi-solid-state MCV@CC//Zn flexible battery exhibits decent performance at different bending *** a bridge effect strategy sheds light on the construction of high mass-loading flexible electrodes for ZIBs applications.

关键词： Zinc-ion batteries Vanadium oxide MXene bridge High mass-loading Flexible electrode

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Prevalence and clinical implications of polypharmacy and potentially inappropriate medication in elderly patients with heart failure: results of six months' follow-up

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Journal of Geriatric Cardiology 2023年第7期20卷 495-508页

作者： man LI Na WEI Han-Yu SHI Xue-Jiao JING Xiao-Hong kan Hai-Qing GAO Yun-Ling XIAO Department of Geriatric Medicine Qilu Hospital of Shandong UniversityJinanShandongChina Key Laboratory of Cardiovascular Proteomics of Shandong Province Qilu Hospital of Shandong UniversityJinanShandongChina

OBJECTIVES To investigate the prevalence of polypharmacy and potentially inappropriate medication(PIM)in elderly patients with heart failure(HF)and their impact on readmission and *** We conducted a study of 274 participants aged 60 years or older with *** prevalence of polypharmacy(defined as the use of five or more medications)was calculated,and the 2019 American Geriatrics Society Beers criteria were applied to access *** and PIMs were characterized at admission and discharge,and changes in prescriptions during hospitalization were *** impact of polypharmacy and PIM on readmission and mortality were *** The median age of this study population was 68 years *** median number of prescribed drugs was 7 at admission and 10 at *** discharge,99.27%of all patients were taking five or more *** incidence of composite endpoint and cardiovascular readmission increased with the number of polypharmacy within 6 *** use of guideline-directed medical therapy reduced the incidence of composite endpoint events and cardiovascular readmission,while the use of noncardiovascular medications increased the composite endpoint *** frequency of PIMs was 93.79%at *** incidence of composite endpoint events increased with the number of PIMs.“PIMs in older adults with caution”increased cardiovascular readmission and“PIMs based on kidney function”increased cardiovascular *** comorbidities were associated with cardiovascular mortality or non-cardiovascular *** Polypharmacy and PIM were highly prevalent in elderly patients with HF,and their use was associated with an increased risk of composite endpoint events,readmission and ***-cardiovascular medications,“PIMs in older adults with caution”,“PIMs based on kidney function”and several comorbidities were important factors associated with hospital readmission and *** findings highlight the importance

关键词： medication patients drugs

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重症肌无力的分子靶向药物治疗研究进展

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华西医学 2024年第5期39卷 818-824页

作者：袁曼阚鸿姣陈云娜赵开杰孙秀亭张晓燕甘肃中医药大学第一临床医学院兰州730000 中国人民解放军联勤保障部队第九四〇医院神经内科兰州730050 西北民族大学医学部兰州730030

重症肌无力(myasthenia gravis, MG)是常见的抗体介导的、细胞免疫依赖及补体参与的神经-肌肉接头免疫疾病。其治疗主要包括药物治疗(症状性治疗、非特异性免疫抑制治疗、靶向免疫治疗)、免疫调节(静脉注射用人免疫球蛋白与血浆置换)及... 详细信息

重症肌无力(myasthenia gravis, MG)是常见的抗体介导的、细胞免疫依赖及补体参与的神经-肌肉接头免疫疾病。其治疗主要包括药物治疗(症状性治疗、非特异性免疫抑制治疗、靶向免疫治疗)、免疫调节(静脉注射用人免疫球蛋白与血浆置换)及胸腺切除术。随着对MG治疗研究的不断深入,靶向B细胞、补体系统及新生儿Fc受体等特异性免疫调节成为目前治疗MG的研究热点。与传统免疫抑制剂相比,MG患者对新型生物制剂耐受性较好,现就MG靶向治疗相关药物的研究进行阐述,并总结其在MG治疗中的疗效及安全性,旨在寻找更多的治疗方案。

关键词：重症肌无力新生儿Fc受体细胞因子补体

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