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Efficacy and safety of on demand tadalafil in the treatment of East and Southeast Asian men with erectile dysfunction:a randomized double-blind,parallel,placebo-controlled clinical study

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Asian Journal of Andrology 2006年第6期8卷 685-692页

作者： Wai Chun Andrew Yip Han-Sun Chiang Jesus Benjamin Mendoza Hui-Meng Tan man-kay li Wei Christine Wang Vladimir Kopernicky Department of Surgery Kwong Wah HospitalHong KongChina College of Medicine Fu Jen Catholic UniversityTaipei 24205TaiwanChina Department of Urology National Kidney and Transplant InstituteQuezon City 1100the Philippines Department of Urology Subang Jaya Medical CentreSelangor Darul Ehsan 47500Malaysia Department of Urology National University Hospital119074Singapore lilly Research Laboratories Eli Lilly and CompanyIndianapolisIndiana 46285USA lilly Area Medical Center Vienna 1030Austria

Aim： To assess the efficacy and safety of tadalafil in comparison to a placebo, when taken on demand for 12 weeks by East/Southeast Asian men with erectile dysfunction （ED）, Methods： This multicenter, randomized, double-blind, parallel group, placebo-controlled study was conducted at 17 centers across East and Southeast Asia between August 2002 and February 2003. Men more than 18 years of age with mild to severe ED of various etiologies were randomized to receive a placebo or 20 mg of tadalafil taken as needed （maximum once daily）. Efficacy assessments included the International Index of Erectile Function, the Sexual Encounter Profile diary and Global Assessment Questions. Results： Tadalafil significantly improved erectile function as compared to the placebo （P 〈 0.001）. At the endpoint, the patients receiving 20 mg of tadalafil reported a greater mean per patient percentage of successful intercourse attempts （Sexual Encounter Profile question 3： 70.9% compared to 33.5% in the placebo） and a greater proportion of improved erections （Global Assessment Question： 86.2% compared to 30.1%）. Most （≥3%） treatment emergent adverse events were mild or moderate. The most common treatment emergent adverse events were headache, back pain, dizziness and dyspepsia. Conclusion： Tadalafil was an effective and well-tolerated treatment for ED in East and Southeast Asian men.

关键词： tadalafil phosphodiesterase type 5 inhibitor erectile dysfunction efficacy safety Asian

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Boosting Photocatalytic Performance of Cu-Mn Co-doped CeO_(2) Nanoparticles for Tetracycline Degradation

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 42-48页

作者： XU Rongqi MI Jianxin WANG Shulin XU man ZHU li BAI Lei TANG Dandan LEI Yu Engineering Research Center of Environmental Materials and Membrane Technology of Hubei Province School of Materials Science and EngineeringWuhan Institute of TechnologyWuhan 430205China Shaanxi Coal Chemical Industry Technology Research Institute Co. Ltd.Xi’an 710100China

Cu-Mn co-doped CeO_(2) photocatalyst was successfully synthesized by the sol-gel method to assess its capability in degrading *** and TEM results showed that Cu and Mn were successfully co-doped into CeO_(2) without forming heterostructure,XPS and photoelectrochemical results revealed that Mn ions doping amplified the generation of photo-induced charge carriers,while Cu ions doping significantly facilitated the interfacial charge transfer ***,the optimized Cu3Mn2CeO_(2) nanoparticles exhibited the highest TC removal efficiency,achieved a rate of 78.18%and maintained a stable cycling performance.

关键词： photocatalyst co-doped charge separation water treatment

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TRMT6 and TRMT61A facilitated acute pancreatitis severity via regulation of neutrophil function

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Science China life Sciences 2025年

作者： Yuan Dong li Su Sin man Lam Cen Yan Yalan Deng Guotao Lu Jinkui Yang Guanghou Shui Yingmei Feng Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Department of Science and Development Beijing Youan HospitalCapital Medical University Laboratory for Clinical Medicine Capital Medical University Neuroscience Research Institute Peking University Center of Medical and Health AnalysisPeking University State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of Sciences Pancreatic Center Department of GastroenterologyAffiliated Hospital of Yangzhou UniversityYangzhou University Beijing Key Laboratory of Diabetes Research and Care Department of EndocrinologyBeijing Tongren HospitalCapital Medical University

Dear Editor,Type 2 diabetes mellitus (T2DM) has been identified as a risk factor for increased severity in acute pancreatitis (AP)(Mikóet al,2018).However,to date,no studies have simultaneously included healthy individuals,T2DM patients,and AP patients to investigate which diabetes-associated metabolites are linked to AP severity.

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FSD1 inhibits glioblastoma diffuse infiltration through restriction of HDAC6-mediated microtubule deacetylation

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Science China life Sciences 2025年

作者： Dake Xiao Haowen Ran lishu Chen Yuanyuan li Yan Cai Songyang Zhang Qinghui Qi Huiran Wu Cheng Zhang Shuailiang Cao Lanjuan Mi Haohao Huang Ji Qi Qiuying Han Haiqing Tu Huiyan li Tao Zhou Fangye li Ailing li Jianghong man Nanhu Laboratory National Center of Biomedical Analysis School of Traditional Chinese Medicine Capital Medical University Department of Neurosurgery General Hospital of Central Theater Command of Chinese PLA School of life and Health Sciences Huzhou College Department of Neurosurgery Beijing Fengtai Hospital Department of Neurosurgery First Medical Center of PLA General Hospital

The infiltration of glioblastoma multiforme(GBM) is predominantly characterized by diffuse spread, contributing significantly to therapy resistance and recurrence of GBM. In this study, we reveal that microtubule deacetylation, mediated through the downregulation of fibronectin type III and SPRY domain-containing 1(FSD1), plays a pivotal role in promoting GBM diffuse infiltration. FSD1 directly interacts with histone deacetylase 6(HDAC6) at its second catalytic domain, thereby impeding its deacetylase activity on α-tubulin and preventing microtubule deacetylation and depolymerization. This inhibitory interaction is disrupted upon phosphorylation of FSD1 at its Ser317 and Ser324 residues by activated CDK5, leading to FSD1 dissociation from microtubules and facilitating HDAC6-mediated α-tubulin deacetylation. Furthermore, increased expression of FSD1 or interference with FSD1 phosphorylation reduces microtubule deacetylation, suppresses invasion of GBM stem cells, and ultimately mitigates tumor infiltration in orthotopic GBM xenografts. Importantly, GBM tissues exhibit diminished levels of FSD1 expression, correlating with microtubule deacetylation and unfavorable clinical outcomes in GBM patients. These findings elucidate the mechanistic involvement of microtubule deacetylation in driving GBM cell invasion and offer potential avenues for managing GBM infiltration.

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温度和水分对寒温带典型森林类型土壤有机碳矿化的影响

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东北林业大学学报 2025年第2期53卷 127-136页

作者：李雪朱宾宾满秀玲东北林业大学哈尔滨150040 内蒙古呼伦贝尔市林业和草原事业发展中心

通过室内模拟试验,分析寒温带典型森林土壤有机碳矿化随温度和水分的变化特征,揭示土壤有机碳矿化影响机制,以期深入探讨气候变暖背景下,温度和水分对寒温带典型森林类型土壤碳循环的影响。采集白桦林和兴安落叶松林0 详细信息

通过室内模拟试验,分析寒温带典型森林土壤有机碳矿化随温度和水分的变化特征,揭示土壤有机碳矿化影响机制,以期深入探讨气候变暖背景下,温度和水分对寒温带典型森林类型土壤碳循环的影响。采集白桦林和兴安落叶松林0

关键词：寒温带白桦林兴安落叶松林土壤有机碳矿化温度敏感性

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Recent Advances in Purely Organic Room Temperature Phosphorescence Polymer

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Chinese Journal of Polymer Science 2019年第4期37卷 383-393,I0006页

作者： man-man Fang Jie Yang Zhen li Institute of Molecular Aggregation Science Tianjin University Department of Chemistry Wuhan University

Room temperature phosphorescence(RTP) has drawn increasing attention for its great potential in practical *** with large molecular weights and long chains tend to form coil, which can endow them with a high degree of possible rigidity and result in the much restricted non-radiative transition. Also, the intertwined structure of polymers could isolate the oxygen and humidity effectively, thus reducing the consumption of triplet excitons. In consideration of these points, organic polymers would be another kind of ideal platform to realize RTP effect. This short review summarized the design strategy of the purely organic room temperature phosphorescence polymers, mainly focusing on the building forms of polymers and the corresponding inherent mechanisms,and also gives some outlooks on the further exploration of this field at the end of this paper.

关键词： Room temperature phosphorescence Polymers Non-radiative transition

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A Multi-Channel CMOS Analog Front-End Interface IC with 157.8 d B Current Detection Dynamic Range

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Chinese Journal of Electronics 2024年第2期33卷 393-402页

作者： Kunyu WANG Wenjing XU Chengbin ZHANG Yanjun YANG man-kay LAW li ZHOU Jie CHEN Ming CHEN Institute of Microelectronics of the Chinese Academy of Science University of Chinese Academy of Sciences Zunyi Normal University Institute of Microelectronics and Dept.of ECE FST University of Macau

A high dynamic range and low-noise CMOS(complementary metal-oxide-semiconductor transistor)front-end interface integrated circuit(IC) with multi-channel detection is presented in this paper. Two different current detection channels, composed of a trans-impedance amplifier(TIA) and an integrator-differentiator TIA, are used to boost the current detection range. A capacitance-coupled instrument amplifier(CCIA) is also included to realize high precision voltage detection. A fourth-order sigma-delta modulator using a second-order loop filter and a second-order noise shaping integral quantizer is adopted to realize effective number of bits above 16 bits. The presented interface IC is implemented in 0.18-μm CMOS process with supply voltage of 3.3 V, and a proto-type electrochemical sensor platform with miniaturized sensor array is developed to verify the functionality of the interface IC. Measurement results indicate that the designed interface IC achieves 157.8 d B current detection dynamic range, and the measured input-referred current noise and voltage noise floor are 1.04 p A and 58.4 n V within 10 k Hz integration bandwidths,respectively.

关键词： Integrated circuits Sigma-delta modulation Semiconductor device measurement Voltage measurement Current measurement Noise Bandwidth

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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai liu Wen-Qiang Xu Ying-Tong Di man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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Fabrication and characteristics of magnesium alloys produced via powder metallurgy

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中国有色金属学会会刊：英文版 2000年第6期10卷 757-760页

作者：曹鹏 LU li man On LAI Department of Mechanical and Production Engineering National University of SingaporeSingapore 119260 State Key Laboratory for Powder Metallurgy Central South UniversityChangsha 410083P.R.China

Magnesium aluminum alloy materials were fabricated via powder metallurgy. Microstructural evolution, thermal stability, tensile properties and fracture mechanism of the hot extruded magnesium alloys were investigated. Microstructural observation revealed that all alloys have fine equiaxed grains due to dynamic recrystallization during hot extrusion with Mg 17 Al 12 precipitating along grain boundaries. The DSC analyses exhibited that because diffusion rate of Al into Mg is slow in solid state sintering process, Al concentration in localized region after sintering is still high enough to cause eutectic reaction. The tensile test showed that 0.2% yield strength, ultimate tensile strength and elastic modulus increase and elongation decrease with increasing Al content. Mg 9%Al obtains the best combination of mechanical properties among the investigated alloys. Fracture surface observation showed ductile fracture to be a dominant failure mode. Abundant dimples and tear ridges are found in the fracture surfaces. Grain boundary weakening results from the precipitate Mg 17 Al 12 caused intergranular cracks during tensile test. [

关键词： magnesium alloys mechanical properties powder metallurgy hot extrusion

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基于隐性句逗号识别的汉语长句机器翻译

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外语学刊 2025年第1期 39-46页

作者：冯文贺李熳佳张文娟广东外语外贸大学外国语言学及应用语言学研究中心语言工程与计算实验室广州510420 广州理工学院计算机科学与工程学院广州510420

长句翻译一直是机器翻译的难题。本文根据汉语中相当数量的逗号和句号可相互转化的特点,提出“隐性句号”和“隐性逗号”概念,并实现其自动识别,以将汉语长句变为短句用于汉英机器翻译。为此,首先通过人工与半监督学习结合方法构建一个... 详细信息

长句翻译一直是机器翻译的难题。本文根据汉语中相当数量的逗号和句号可相互转化的特点,提出“隐性句号”和“隐性逗号”概念,并实现其自动识别,以将汉语长句变为短句用于汉英机器翻译。为此,首先通过人工与半监督学习结合方法构建一个隐性句逗数据集,实现基于预训练模型的隐性句逗识别方法,其中性能最好的Hierarchical BERT作为后续应用模型。进而,实现基于隐性句逗识别的汉英机器翻译方法。在新闻和文学公开翻译测试语料上基于预训练机器翻译模型的实验表明,对于汉语长句的英译,本文方法相比基准翻译的BLEU值整体有所提高,而且在相对稳健机器翻译模型上,呈现为句子越长本文方法效果越明显。

关键词：机器翻译长句翻译隐性句逗号汉语长句逗号识别句内标点

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