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Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-segura Aleksandra Polishchuk Laura Nadal Marta Tomàs Carolina silvera-simón manel M.santafé Maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

searching For(2+1)-dimensional nonlinear Boussinesq equation from(1+1)-dimensional nonlinear Boussinesq equation

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Communications in Theoretical Physics 2023年第7期75卷 58-61页

作者： man Jia s Y Lou school of Physical science and Technology Ningbo UniversityNingbo315211China

A novel(2+1)-dimensional nonlinear Boussinesq equation is derived from a(1+1)-dimensional Boussinesq equation in nonlinear schr?dinger type based on a deformation *** integrability of the obtained(2+1)-dimensional Boussinesq equation is guaranteed by its Lax pair obtained directly from the Lax pair of the(1+1)-dimensional Boussinesq *** of the effects of the deformation,the(2+1)-dimensional Boussinesq equation admits a special travelling wave solution with a shape that can be deformed to be asymmetric and/or multivalued.

关键词： (2+1)-dimensional Boussinesq equation deformation algorithm lax integrable an implicit travelling wave solution

GPIO-Based Continuous sliding Mode Control for Networked Control systems Under Communication Delays With Experiments on servo Motors

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IEEE/CAA Journal of Automatica sinica 2025年第1期 99-113页

作者： Kamal Rsetam Zhenwei Cao Zhihong man Xian-Ming Zhang the school of software and Electrical Engineering Swinburne University of Technology the Department of Automated manufacturing Al Khwarizmi College of Engineering University of Baghdad IEEE

To handle input and output time delays that commonly exist in many networked control systems(NCss), a new robust continuous sliding mode control(CsMC) scheme is proposed for the output tracking in uncertain single input-single-output(sIsO) networked control systems. This scheme consists of three consecutive steps. First, although the network-induced delay in those systems can be effectively handled by using Pade approximation(PA), the unmatched disturbance cames out as another difficulty in the control design. second, to actively estimate this unmatched disturbance, a generalized proportional integral observer(GPIO) technique is utilized based on only one measured state. Third, by constructing a new sliding manifold with the aid of the estimated unmatched disturbance and states, a GPIO-based CsMC is synthesized, which is employed to cope with not only matched and unmatched disturbances, but also networkinduced delays. The stability of the entire closed-loop system under the proposed GPIO-based CsMC is detailedly *** promising tracking efficiency and feasibility of the proposed control methodology are verified through simulations and experiments on Quanser's servo module for motion control under various test conditions.

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Plant Communities and Factors Responsible for Vegetation Pattern in an Alpine Area of the Northwestern Himalaya

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Journal of Mountain science 2011年第6期8卷 817-826页

作者： man s.RANA s.s.sAmanT Y.s.RAWAT Department of Plant science Government Degree College G.B.Pant Institute of Himalayan Environment & Development Department of Botany D.S.B.CampusKumaun University

The study intended to describe the alpine vegetation of a protected area of the northwestern Himalaya and identify the important environmental variables responsible for species *** placed random plots covering different habitats and altitude to record species composition and environmental *** was classified using hierarchical cluster analysis and vegetation-environment relationships were evaluated with Canonical Correspondence *** communities,each in alpine shrub and meadows were delineated and well justified in the ordination *** species for the different communities were *** species richness and diversity were found in community IV among shrub communities and community II among the *** environmental variables explained 61.5% variation in shrub vegetation and 59.8% variation in *** variables explained higher variability (～35%) than spatial variables (～21%) in both shrubs and ***,among the spatial variables and carbon/nitrogen ratio and nitrogen among the soil variables explained maximum *** 40% variations left *** and species diversity among the other variables had significant correlation with ordination *** showed that altitude and C/N ratio played a significant role in species *** sampling efforts and inclusion of other non-studied variables are also suggested for better understanding.

关键词： species diversity Indicator species Environmental variable Ordination Explainedvariation

Extraction,Utilization Pattern and Prioritization of Fuel Resources for Conservation in manali Wildlife sanctuary,Northwestern Himalaya

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Journal of Mountain science 2012年第4期9卷 580-588页

作者： man s.RANA sakshi B.RANA s.s.sAmanT Department of Plant sciences Government CollegeBanjar-Kullu175123Himachal PradeshIndia Department of Plant sciences Government CollegeKullu175101Himachal PradeshIndia G.B.Pant Institute of Himalayan Environment&Development Himachal UnitMohal-Kullu175126Himachal PradeshIndia

Fuelwood is the main source of the energy in mountainous ***,annual wood consumption is very *** on fuelwood resources,and their extraction and availability is very ***,present study was carried out to study the diversity of fuelwood species,annual collection,preference and availability of fuel species in the *** four species(25 trees and 9 shrubs) were extracted for fuel by the *** collection and species preference was highest for Picea smithiana,Cedrus deodara,Indigofera heterantha,Pinus wallchiana and sorbaria tomentosa,*** use index indicating use pressure was highest for ***,***,*** and Abies pindrow,*** native species,some non-native horticultural and agroforestry species such as Malus pumila,***,Celtis australis,*** also being used as *** species showed their availability in eight forest types whereas,population and regeneration status was ***,immediate actions are suggested to sustain current and future demand of *** afforestation of degraded,uncultivated and marginal lands through high quality and preferred fuel species might reduce pressure on wild and selective species.

关键词： Fuelwood Resource Use Index Communities Conservation

Diversity,Distribution and Prioritization of Fodder species for Conservation in Kullu District,Northwestern Himalaya,India

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Journal of Mountain science 2007年第3期4卷 259-274页

作者： s. s. samant man s.ngh manohar Lal shreekar Pant G.B.Pant Institute of Himalayan Environment & Development Himachal UnitMohal-Kullu175 126Himachal PradeshIndia

In the Indian Himalayan Region predominantly rural in character, livestock is one of the main sources of livelihood and integral part of the economy. Livestock mostly rely on fodder from wild. The diversity, distribution, utilization pattern, nativity, endemism, rarity, seasonality of availability, nutritive values, perceived economic values and pressure use index of livestock have not been studied. The present study attempts to enumerate 150 species of fodder representing trees (51 spp.), shrubs (54 spp.) and herbs (45 spp.). Poaceae (19 spp.) and Fabaceae (13 spp.) amongst families and salix (6 spp.), Ficus, Clematis, and Desmodium (5 spp., each) amongst genera are rich in species. Maximum species were found in the 1801 ~ 2600 m zone, and the remaining two zones showed relatively low diversity. Out of the 150 species, 109 are used in summer, 5 winter and 36 throughout year. During rainy season, mostly grasses are used as fodder. Only 83 species are native to the Himalayan region, one species, strobilanthus atropuroureus is endemic and 35 species are near endemic. The nutritive values of the fodder species were reviewed, and economic values and status of the species were also assessed. The pressure use index of the species was calculated on the basis of cumulative values of the utilization pattern, altitudinal distribution, availability, status, nativity and endemism. Amongst the species, Grewia oppositifoilia, Morus serrata, Indigofera heterantha, Quercus leucotrichphora, Ulmus villosa, U. wallichiana and Aesculus indica showed highest PUI indicating high preference and pressure. season wise prioritization of the species for different altitudinal zones has been done. Appropriate strategy and action plan have been suggested for the conservation and management of fodder species.

关键词： Diversity utilization native endemic nutritive and economic value pressure use index prioritization conservation Indian Himalayan Region

Recent Advances in Purely Organic Room Temperature Phosphorescence Polymer

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Chinese Journal of Polymer science 2019年第4期37卷 383-393,I0006页

作者： man-man Fang Jie Yang Zhen Li Institute of Molecular Aggregation science Tianjin University Department of Chemistry Wuhan University

Room temperature phosphorescence(RTP) has drawn increasing attention for its great potential in practical *** with large molecular weights and long chains tend to form coil, which can endow them with a high degree of possible rigidity and result in the much restricted non-radiative transition. Also, the intertwined structure of polymers could isolate the oxygen and humidity effectively, thus reducing the consumption of triplet excitons. In consideration of these points, organic polymers would be another kind of ideal platform to realize RTP effect. This short review summarized the design strategy of the purely organic room temperature phosphorescence polymers, mainly focusing on the building forms of polymers and the corresponding inherent mechanisms,and also gives some outlooks on the further exploration of this field at the end of this paper.

关键词： Room temperature phosphorescence Polymers Non-radiative transition

Optimizing mechanical properties of HIPs fabricated with low-cost desktop 3D printers:investigating the impact of process parameters

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Advances in manufacturing 2024年第2期12卷 379-395页

作者： Jin-Ting Xu Guang-Wei Zhang man-man Chen school of Automotive Engineering Dalian University of TechnologyDalian116024People’s Republic of China

Recently,low-cost desktop three-dimensional(3D)printers,employing the fused deposition modeling(FDM)technique,have gained widespread ***,most users cannot test the strength of printed parts,and little information is available about the mechanical properties of printed high-impact polystyrene(HIPs)parts using desktop 3D *** this study,the user-adjustable parameters of desktop 3D printers,such as crisscross raster orientation,layer thickness,and infill density,were *** experimental plans were designed using the Box-Behnken method,and tensile,3-point bending,and compression tests were carried out to determine the mechanical responses of the printed *** prediction models of the process parameters were regressed to produce the optimal combination of process *** experimental results showcase that the crisscross raster orientation has significant effects on the flexural and compression strengths,but not on the tensile *** an increase in the layer thickness,the tensile,flexural,and compression strengths first decreased and then increased,reaching their minimum values at approximately 0.16 mm layer *** addition,they all increased with an increase of infill *** was demonstrated that when the raster orientation,layer thickness,and infill density were 13.08°/–76.92°,0.09 mm,and 80%,respectively,the comprehensive mechanical properties of the printed HIPs were *** results can help end-users of desktop 3D printers understand the effects of process parameters on the mechanical properties,and offer practical suggestions for setting proper printing parameters for fabricating HIPs parts.

关键词： Desktop three-dimensional(3D)printers Fused deposition modeling(FDM) High-impact polystyrene(HIPs) Process parameters

Optimal Operation of Turbo Blowers serially Connected Using Inlet Vanes

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Journal of Thermal science 2011年第1期20卷 26-31页

作者： Choon-man Jang Plant Research Division Korea Institute of Construction Technology1190 IIsanseo-GuGoyang-Si411-712Korea

Optimal operation of the turbo blowers having an inlet vane has been studied to understand the blowers' operating *** analyze three-dimensional flow field in the turbo blowers serially connected,general analysis code,CFX,is introduced in the present *** turbulence model is employed to estimate the eddy *** the numerical analysis,it is found that the flow rates of the turbo blowers can be controlled at the vane angle between 90 (full open condition) degrees and 60 degrees effectively,because pressure loss rapidly increases below 60 degree of a vane *** also has almost the same values from 90 degrees to 60 degrees of a vane *** is noted that the distorted inlet velocity generated in the small vane angle makes performance deterioration of the turbo blowers due to the local leading edge separation and the following non-uniform blade loading.

关键词： Turbo Blower Inlet Vane Refuse Collection system Efficiency Numerical simulation