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V0405 Dra:A New Deep and Low Mass Ratio Contact Binary with Extremely Fast Decrease in the Orbital Period

Research in Astronomy and Astrophysics 2024年第6期24卷 287-293页

作者： Chao-Yue Li Lin-Qiao Jiang Jie Zheng Yi-man Liu Xiao-Yu Long Min Sun Han-Lu Zhang Xiao-man tian School of Science Leshan Normal UniversityLeshan 614000China Center for Applied Optics Research Leshan Normal UniversityLeshan 614000China Key Laboratory of Detection and Application of Space Effect in Southwest Sichuan Leshan 614000China CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Aeronautics Shandong Jiaotong UniversityJinan 250000China

V0405 Dra is a W UMa-type binary *** on the TESS data,we have conducted an orbital period study and performed a light curve analysis for the *** orbital period study reveals that the O-C curve for V0405 Dra exhibits secular decrease at an extremely high rate of d P/dt=-2.71×10^(-6)day year^(-1),along with periodic variations characterized by an amplitude of A_(3)=0.0032 day and a period of P_(3)=1.413 *** orbital periodic change is possibly due to the light-travel time effect resulting from an additional third body in the system,for which we estimate a minimum mass of M_(3)=0.77M_(⊙).By employing the 2013 version of the Wilson-Devinney(W-D)method to synthesize a light curve,we derived photometric solutions indicating that V0405 Dra is a new deep(f=68.7%)and low-mass ratio(q=0.175)contact *** fast decrease in its orbital period is likely caused by mass transfer from the more massive primary star to the less massive secondary star,or due to angular momentum *** further mass transfer and loss of angular momentum,the binary will gradually evolve into a tighter contact configuration,eventually leading to a merger into a single star,following the evolutionary paths suggested for such deep and low mass ratio contact binaries.

关键词： (stars:)binaries(including multiple):close (stars:)binaries:eclipsing stars:individual(V0405 Dra)

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儿童肺部侵袭性曲霉菌感染的诊治进展

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中国实用儿科杂志 2024年第2期39卷 103-107页

作者：田曼南京医科大学附属儿童医院呼吸科江苏南京210008

曲霉菌属在自然界中广泛分布,温湿度适宜时,曲霉菌可长成菌丝并产生分生孢子,通过空气传播定植于人体呼吸道中。当宿主免疫功能低下时,则易出现与致病性曲霉菌相关的疾病,多数表现为肺部受累,即侵袭性肺曲霉病(invasive pulmonary asper... 详细信息

曲霉菌属在自然界中广泛分布,温湿度适宜时,曲霉菌可长成菌丝并产生分生孢子,通过空气传播定植于人体呼吸道中。当宿主免疫功能低下时,则易出现与致病性曲霉菌相关的疾病,多数表现为肺部受累,即侵袭性肺曲霉病(invasive pulmonary aspergillosis,IPA)。与成人患者相比,儿童IPA患者的影像学表现多不典型,目前血清学标志物相关研究尚不充分,对儿童IPA的诊断较为困难。同时,儿童安全的抗真菌用药仍有待探究。该文就儿童IPA的流行病学、致病机制、临床表现、诊断技术以及治疗等方面进行概述。

关键词：儿童侵袭性肺曲霉病诊断治疗

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中国反避税法规是否遏制了外资企业的避税行为?——基于工业行业数据的经验研究

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经济体制改革 2024年第4期 151-160页

作者：薛漫天东南大学经济管理学院江苏南京210096

依据中国工业行业层面数据,使用连续型双重差分方法,评估2008年以来中国发布的反避税法规对于外资企业避税行为的遏制作用。研究发现:2008年两税合一改革明显增强了外资企业的避税动机,同期生效的各项反避税法规没有能够完全遏制其避税... 详细信息

依据中国工业行业层面数据,使用连续型双重差分方法,评估2008年以来中国发布的反避税法规对于外资企业避税行为的遏制作用。研究发现:2008年两税合一改革明显增强了外资企业的避税动机,同期生效的各项反避税法规没有能够完全遏制其避税行为。具体而言,税制改革前享受优惠税率的外资企业更倾向于通过各种避税手段降低税前利润;随着企业所得税过渡优惠政策的逐步退出,外资企业的避税动机也逐步增强。2016、2017年生效的反避税法规在一定程度上遏制了外资企业利用资本弱化和知识产权交易避税的行为。同期发生的国际金融危机和中美贸易摩擦不影响上述结论。在新发展格局下,在华外资企业的利润将更多地来源于中国本地市场,完善避税法规体系的重要性进一步凸显。

关键词：反避税法规外资企业税基侵蚀资本弱化

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FOXO1 reshapes neutrophils to aggravate acute brain damage and promote late depression after traumatic brain injury

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Military Medical Research 2024年第4期11卷 521-542页

作者： Mi Zhou Yang-Wu-Yue Liu Yu-Hang He Jing-Yu Zhang Hao Guo Hao Wang Jia-Kui Ren Yi-Xun Su Teng Yang Jia-Bo Li Wen-Hui He Peng-Jiao Ma man-tian Mi Shuang-Shuang Dai Department of Biochemistry and Molecular Biology School of Basic MedicineArmy Medical UniversityChongqing 400038China Research Center for Nutrition and Food Safety Chongqing Key Laboratory of Nutrition and HealthInstitute of Military Preventive MedicineArmy Medical UniversityChongqing 400038China Department of Neurosurgery Daping HospitalArmy Medical UniversityChongqing 400042China Department of Trauma and Emergency Southwest HospitalArmy Medical UniversityChongqing 400038China Department of Histology and Embryology Chongqing Key Laboratory of NeurobiologyBrain and Intelligence Research Key Suyixun Laboratory of Chongqing Education CommissionArmy Medical UniversityChongqing 400038China Research Center Seventh Affiliated Hospital of Sun Yat-Sen UniversityShenzhen 518107GuangdongChina

Background:Neutrophils are traditionally viewed as first responders but have a short onset of action in response to traumatic brain injury(TBI).However,the heterogeneity,multifunctionality,and time-dependent modulation of brain damage and outcome mediated by neutrophils after TBI remain poorly ***:Using the combined single-cell transcriptomics,metabolomics,and proteomics analysis from TBI patients and the TBI mouse model,we investigate a novel neutrophil phenotype and its associated effects on TBI outcome by neurological deficit scoring and behavioral *** also characterized the underlying mechanisms both invitro and invivo through molecular simulations,signaling detections,gene expression regulation assessments[including dual-luciferase reporter and chromatin immunoprecipitation(ChIP)assays],primary cultures or co-cultures of neutrophils and oligodendrocytes,intracellular iron,and lipid hydroperoxide concentration measurements,as well as forkhead box protein O1(FOXO1)conditional knockout ***:We identified that high expression of the FOXO1 protein was induced in neutrophils after TBI both in TBI patients and the TBI mouse *** of these FOXO1high neutrophils in the brain was detected not only in the acute phase but also in the chronic phase post-TBI,aggravating acute brain inflammatory damage and promoting late TBI-induced *** the acute stage,FOXO1 upregulated cytoplasmic Versican(VCAN)to interact with the apoptosis regulator B-cell lymphoma-2(BCL-2)-associated X protein(BAX),suppressing the mitochondrial translocation of BAX,which mediated the antiapoptotic effect companied with enhancing interleukin-6(IL-6)production of FOXO1high *** the chronic stage,the“FOXO1-transferrin receptor(TFRC)”mechanism contributes to FOXO1high neutrophil ferroptosis,disturbing the iron homeostasis of oligodendrocytes and inducing a reduction in myelin basic protein,which contributes to the progression of late depression afte

关键词： Traumatic brain injury(TBI) Neutrophil Forkhead box protein O1(FOXO1) Acute stage Chronic stage

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长期服用氯丙嗪引起双眼角膜内皮及晶状体色素沉着1例

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中华眼视光学与视觉科学杂志 2024年第4期26卷 305-306页

作者：田曼段兴翔杭州市余杭区第二人民医院眼科杭州311121

患者,女,74岁。因双眼视物模糊1年,于2023年4月6日至余杭区第二人民医院眼科就诊。患者既往高血压、糖尿病、冠心病病史,精神分裂症病史40余年,长期服用抗精神病药物氯丙嗪6年。自2017年开始连续服用抗精神病药物氯丙嗪400 mg,每日2次,... 详细信息

患者,女,74岁。因双眼视物模糊1年,于2023年4月6日至余杭区第二人民医院眼科就诊。患者既往高血压、糖尿病、冠心病病史,精神分裂症病史40余年,长期服用抗精神病药物氯丙嗪6年。自2017年开始连续服用抗精神病药物氯丙嗪400 mg,每日2次,2年后患者病情稳定,日剂量改为200 mg口服,每日2次至今。眼部检查:右眼裸眼视力(UCVA)0.3,左眼0.4.

关键词：抗精神病药物双眼视物模糊眼部检查精神分裂症医院眼科裸眼视力氯丙嗪色素沉着

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支气管镜下介入注药冷冻联合雾化吸入治疗气管支气管结核

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中国临床研究 2024年第10期37卷 1556-1559页

作者：徐元龙费贤树田曼南京中医药大学附属南京医院结核科江苏南京210000 南京医科大学附属儿童医院呼吸科江苏南京210008

目的分析对气管支气管结核(TBTB)采用支气管镜下介入注药冷冻联合雾化吸入方法治疗的临床疗效。方法选取2019年5月至2023年2月南京中医药大学附属南京医院收治的TBTB 60例患者为研究对象,采用中心随机法随机分为两组各30例,对照组采用... 详细信息

目的分析对气管支气管结核(TBTB)采用支气管镜下介入注药冷冻联合雾化吸入方法治疗的临床疗效。方法选取2019年5月至2023年2月南京中医药大学附属南京医院收治的TBTB 60例患者为研究对象,采用中心随机法随机分为两组各30例,对照组采用常规治疗联合雾化抗结核治疗,观察组在对照组基础上采用支气管镜下介入注药冷冻治疗。治疗3个月后比较两组患者痰菌转阴率、免疫功能相关指标[CD4^(+)、CD8^(+)、腺苷脱氨酶(ADA)]、炎症相关指标[γ-干扰素(IFN-γ)、白细胞介素-4(IL-4)、红细胞沉降率(ESR)]水平、症状缓解时间及不良反应。结果治疗3个月后,观察组患者IFN-γ、ESR水平和症状缓解时间显著低于对照组(P<0.05);痰菌转阴率、CD4^(+)、ADA和IL-4水平显著高于对照组(P<0.05)。观察组总不良反应发生率低于对照组,差异有统计学意义(10.00%vs 33.33%,χ^(2)=4.812,P<0.05)。结论支气管镜下介入注药冷冻联合雾化吸入抗结核治疗TBTB具有良好的临床疗效,可有效提高患者免疫功能,减轻其炎症反应,减少不良反应。

关键词：气管支气管结核支气管镜注药冷冻雾化

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Investigation of the shortest period Am type eclipsing binary TYC 6408–989–1

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Research in Astronomy and Astrophysics 2021年第3期21卷 107-116页

作者： Xiao-man tian School of Aeronautics Shandong Jiaotong University Jinan 250000China Center for Astronomical Mega-Science Chinese Academy of Sciences Beijing 100101China

The first BV bands photometric observations and the low-resolution spectrum of the shortest period Am type eclipsing binary TYC 6408-989-1 have been *** stellar atmospheric parameters of the primary star were obtained through the spectral fitting as follows:Teff=6990±117 K,log g=4.25±0.26 cm s^(-2),[Fe/H]=-0.45±0.03 *** original spectra obtained by European Southern Observatory(ESO)were processed with an IRAF package by *** on the ESO blue-violet spectra,TYC 6408-989-1 was concluded as a marginal Am(Am:)star with a spectral type of kA3 hF1 mA5Ⅳ-Ⅴidentified through the MKCLASS *** observed light curves were analyzed through the WilsonDevinney *** final photometric solutions show that TYC 6408-989-1 is a marginal contact binary with a low mass ratio(q=0.27).The temperature of the secondary component derived through the light curve analysis is significantly higher than main sequence *** addition,TYC 6408-989-1 is a poor thermal contact *** temperature differences between the two components is about 1800 ***6408-989-1 should be located in the oscillation stage predicted by the thermal relaxation oscillations theory(TRO)and will evolve into the shallow contact stage *** very short period(less than one day),marginal Am peculiarity and quite large rotational velocity(v sin i■160 km s^(-1))make TYC 6408-989-1 become a challenge to the cut-off of rotation velocities and periods of Am *** have collected the well known eclipsing Am binaries with absolute parameters from the literature.

关键词： stars:chemically peculiar stars:binaries:eclipsing stars:binaries:general(TYC 64089891) stars:evolution

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Expert consensus on the diagnosis and treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children

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World Journal of Pediatrics 2024年第9期20卷 901-914页

作者： Ying-Shuo Wang Yun-Lian Zhou Guan-Nan Bai Shu-Xian Li Dan Xu Li-Na Chen Xing Chen Xiao-Yan Dong Hong-Min Fu Zhou Fu Chuang-Li Hao Jian-Guo Hong En-Mei Liu Han-Min Liu Xiao-Xia Lu Zheng-Xiu Luo Lan-Fang Tang man tian Yong Yin Xiao-Bo Zhang Jian-Hua Zhang Hai-Lin Zhang De-Yu Zhao Shun-Ying Zhao Guo-Hong Zhu Ying-Xue Zou Quan Lu Yuan-Yuan Zhang Zhi-Min Chen Department of Pulmonology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Child Health Care Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Pediatric Pulmonology and Immunology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Pediatrics Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China Department of Pulmonology Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200062China Department of Pulmonary and Critical Care Medicine Kunming Children’s HospitalKunming 650034China Department of Respiratory Medicine Children’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Pulmonology Children’s Hospital of Soochow UniversitySuzhou 215003China Department of Pediatrics Shanghai General Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200080China Department of Respiratory Medicine Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430015China Department of Respiratory Medicine Children’s Hospital of Nanjing Medical UniversityNanjing 210008China Department of Respiratory Medicine Shanghai Children’s Medical CenterShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Respiratory Medicine Children’s Hospital of Fudan UniversityShanghai 201102China Department of Pediatric Pulmonology Xinhua HospitalShanghai Jiaotong University School of MedicineShanghai 201102China Department of Pediatric Respiratory Medicine The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027China National Clinical Research Center for Respiratory Diseases Beijing Children’s HospitalCapital Medical UniversityBeijing 100045China Departmen

Background Mycoplasma pneumoniae(***)is a significant contributor to community-acquired pneumonia among *** 1968,when a strain of *** resistant to macrolide antibiotics was initially reported in Japan,macrolide-resistant ***(MRMP)has been documented in many countries worldwide,with varying incidence *** infections lead to a poor response to macrolide antibiotics,frequently resulting in prolonged fever,extended antibiotic treatment,increased hospitalization,intensive care unit admissions,and a significantly higher proportion of patients receiving glucocorticoids or second-line *** 2000,the global incidence of MRMP has gradually increased,especially in East Asia,which has posed a serious challenge to the treatment of *** infections in children and attracted widespread attention from ***,there is still no global consensus on the diagnosis and treatment of MRMP in *** We organized 29 Chinese experts majoring in pediatric pulmonology and epidemiology to write the world’s first consensus on the diagnosis and treatment of pediatric MRMP pneumonia,based on evidence *** evidence searches and reviews were conducted using electronic databases,including PubMed,Embase,Web of Science,CNKI,Medline,and the Cochrane *** used variations in terms for“macrolide-resistant”,“Mycoplasma pneumoniae”,“MP”,“***”,“pneumonia”,“MRMP”,“lower respiratory tract infection”,“Mycoplasma pneumoniae infection”,“children”,and“pediatric”.Results Epidemiology,pathogenesis,clinical manifestations,early identification,laboratory examination,principles of antibiotic use,application of glucocorticoids and intravenous immunoglobulin,and precautions for bronchoscopy are *** and rapid identification of gene mutations associated with MRMP is now available by polymerase chain reaction and fluorescent probe techniques in respiratory *** the resistance rate to mac

关键词： Child Macrolide-resistant Mycoplasma pneumoniae Recommendation Diagnosis Treatment

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Adsorption properties of Ⅴ(Ⅳ) on resin-activated carbon composite electrodes in capacitive deionization

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International Journal of Minerals,Metallurgy and Materials 2021年第11期28卷 1777-1787页

作者： Xiao-man tian Shen-xu Bao Yi-min Zhang School of Resources and Environmental Engineering Wuhan University of TechnologyWuhan 430070China Hubei Key Laboratory of Mineral Resources Processing and Environment Wuhan University of TechnologyWuhan 430070China Hubei Collaborative Innovation Center for High Efficient Utilization of Vanadium Resources Hubei Provincial Engineering Technology Research Center of High Efficient Cleaning Utilization for Shale Vanadium ResourceWuhan University of Science and TechnologyWuhan 430081China

Composite electrodes prepared by cation exchange resins and activated carbon(AC)were used to adsorb Ⅴ(Ⅳ)in capacitive deionization(CDI).The electrode made of middle resin size(D860/AC M)had the largest specific surface area and mesoporous content than two other composite *** analysis showed that D860/AC M presents higher specific capacitance and electrical double layer capacitor than the others,and significantly lower internal diffusion ***,D860/AC M exhibits the highest adsorption capacity and rate of Ⅴ(Ⅳ)among three *** intra-particle diffusion model fits well in the initial adsorption stage,while the liquid film diffusion model is more suitable for fitting at the later *** pseudo-second-order kinetic model is suited for the entire adsorption *** adsorption of Ⅴ(Ⅳ)on the composite electrode follows that of the Freundlich *** analysis indicates that the adsorption of Ⅴ(Ⅳ)is an exothermic process with entropy reduction,and the electric field force plays a dominant role in the CDI *** work aims to improve our understanding of the ion adsorption behaviors and mechanisms on the composite electrodes in CDI.

关键词： capacitive deionization composite electrode vanadium electrochemical behavior kinetics

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人工智能结合参与式教学法在临床实习带教中的应用

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海南医学 2024年第15期35卷 2276-2280页

作者：王言之田曼薛仁杰南京医科大学附属儿童医院呼吸科江苏南京210008 南京医科大学儿科学院江苏南京210008

实习是医学生从学校向医院过渡的重要阶段,不管是操作技能的锻炼还是诊疗思维的培养,每个实习医师的素质成长都离不开带教医师的指导。作为当前较热门的辅助工具,文心一言等预训练语言模型对教学新业态的冲击已得到关注。虽然人工智能... 详细信息

实习是医学生从学校向医院过渡的重要阶段,不管是操作技能的锻炼还是诊疗思维的培养,每个实习医师的素质成长都离不开带教医师的指导。作为当前较热门的辅助工具,文心一言等预训练语言模型对教学新业态的冲击已得到关注。虽然人工智能在文本生成、语言理解等方面有较大优势,但其引发的思维钝化及信任危机是不容忽视的问题。参与式教学法讲究“以学生为中心、师生共同参与”,一般从课前准备、过程学习、课后评价三个方面落实。将人工智能和参与式教学法有效融合,有助于引导学生从被动学习向主动学习转化,可弥补单一教学方法各自存在的缺陷,提高教学效果。

关键词：人工智能参与式教学法临床医学实习医师

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