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Clinical efficacy of a combination of Percoll continuous density gradient and swim-up techniques for semen processing in HIV-1 serodiscordant couples

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Asian Journal of Andrology 2017年第2期19卷 208-213页

作者： Osamu Inoue Naoaki Kuji Hiroe Ito Mitsutoshi Yamada Toshio Hamatani Aimi Oyadomari Shingo Kato Hideji Hanabusa Keiichi Isaka mamoru Tanaka Department of Obstetrics and Gynecology Keio University School of Medicine Tokyo 1608582 Japan Department of Obstetrics and Gynecology Tokyo Medical College Tokyo 1600023 Japan Department of Microbiology Keio University School of Medicine Tokyo 1608582 Japan Department of Hematology Ogikubo Hospital Tokyo 1670035 Japan

To evaluate the clinical efficacy of a procedure comprising a combination of Percoll continuous density gradient and modified swim-up techniques for the removal of human immunodeficiency virus type 1 （HIV-1） from the semen of HIV-1 infected males, a total of 129 couples with an HIV-1 positive male partner and an HIV-1 negative female partner （serodiscordant couples） who were treated at Keio University Hospital between January 2002 and April 2012 were examined. A total of 183 ejaculates from 129 HIV-1 infected males were processed. After swim-up, we successfully collected motile sperms at a recovery rate as high as 100.0% in cases of normozoospermia （126/126 ejaculates）, oligozoospermia （6/6）, and asthenozoospermia （36/36）. The recovery rate of oligoasthenozoospermia was 86.7% （13/15）. In processed semen only four ejaculates （4/181：2.2%） showed viral nucleotide sequences consistent with those in the blood of the infected males. After using these sperms, no horizontal infections of the female patients and no vertical infections of the newborns were observed. Furthermore, no obvious adverse effects were observed in the offspring. This protocol allowed us to collect HIV-1 negative motile sperms at a high rate, even in male factor cases. We concluded that our protocol is clinically effective both for decreasing HIV-1 infections and for yielding a healthy child.

关键词： assisted reproductive technology human immunodeficiency virus type 1 serodiscordant couPle viral nucleotide sequence

基于卷积神经网络的大尺寸气泡体积二维图像测定方法

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核动力工程 2021年第6期42卷 38-43页

作者：胡宁宁党卓然张牧昊唐可 mamoru Ishii 中国核动力研究设计院成都610213 成都理工大学核技术与自动化工程学院成都610059 普渡大学核工程学院美国西拉法叶IN 47907-2017

由于表面张力与惯性力作用,静止流场内较大尺寸气泡[500<气泡雷诺数(Re)<2000]形成不规则几何形状,造成二维图形处理方法等效球体或椭球获取三维体积的方式误差较大。此外,由于不规则界面的散射和反射,引起二维图像处理中边界模糊,难以... 详细信息

由于表面张力与惯性力作用,静止流场内较大尺寸气泡[500<气泡雷诺数(Re)<2000]形成不规则几何形状,造成二维图形处理方法等效球体或椭球获取三维体积的方式误差较大。此外,由于不规则界面的散射和反射,引起二维图像处理中边界模糊,难以辨识。本文以高速摄像机获得的静止流场内大尺寸气泡二维灰度图像作为卷积神经网络(CNN)的输入,以图像内气泡二维投影面积及实验获得三维体积训练网络,并用训练好的网络预测气泡体积。实验采用小气泡叠加法获得真实气泡体积,与网络预测结果进行对比。结果表明,该方法与传统图像处理方法相比,不需要对气泡形状进行假设,提高了对大尺寸气泡的适用性。

关键词：气泡等效体积直径卷积神经网络(CNN) 图像处理

Development of New Sliver Probe for Cooling Power Test of Polymer Quenchants

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材料热处理学报 2004年第5期25卷 437-442页

作者： Michiharu NARAZAKI mamoru TAJIMA Shigeru ASADA Katsumi ICHITANI Hideo YOKOTA Mitsugu TANAKA Youichi WATANABE Utsunomiya University Utsunomiya JapanKanagawa University Yokohama JapanNippon Grease Co. Ltd. Osaka JapanIdemitsu Kosan Co. Ltd. Chiba JapanNippon Oil Corporation Yokohama JapanNissho Engineering Co. Ltd. Kobe JapanNissan Motor Co. Ltd. Yokohama Japan

Working group on cooling power test of quenchants of Japanese Heat Treatment Society has studied on the new method for testing cooling power of aqueous quenchants. This method employed the cooling curve test of a new sliver rod probe, which has a metal-sheathed thermocouple at its geometrical center. The experimental study has clarified that the new silver probe has more excellent durability than the JIS silver probe employed for cooling power test of heat treating oils (JIS K 2242) and an aluminum alloy probe. Good repeatability and reproducibility of the cooling curves during polymer quenching have been confirmed. This new method is useful especially for cooling power test of aqueous quenchants used for solution heat treatment of aluminum alloys. This new silver rod probe is expected to be adopted for the revised version of JIS K 2242 as the cooling power test method for aqueous quenchants.

关键词：聚合物淬火剂动力试验冷却曲线银探测器

CO2 capture over molecular basket sorbents:Effects of SiO2 supports and PEG additive

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Journal of Energy Chemistry 2017年第5期26卷 1030-1038页

作者： Lin Zhang Xiaoxing Wang mamoru Fujii Linjun Yang Chunshan Song Key Laboratory of Energy Thermal Conversion and Control Ministry of EducationSchool of Energy and EnvironmentSoutheast UniversityNanjing 210096JiangsuChina Clean Fuels and Catalysis Program EMS Energy InstitutePSU-DUT Joint Center for Energy ResearchUSA Department of Energy&Mineral Engineering Pennsylvania State UniversityUniversity ParkPA 16802USA

The objective of this work is to study the influences of silica supports and PEG additive on the sorption performance of molecular basket sorbent（MBS） for COcapture consisting of polyethylenimine and one of the following supports: SBA-15（2-D structure）, TUD-1（3-D sponge-like structure） and fumed silica HS-5（3-D disordered structure）. Effects of the supports regarding pore structures and pore properties, the PEI loading amount as well as the sorption temperature were examined. Furthermore, polyethylene glycol（PEG） was introduced as an additive into the sorbents and its effect was investigated at different PEI loadings and sorption temperatures. The results suggest that the pore properties of MBS（after PEI loading） play a more important role in the COsorption capacity, rather than those of the supports *** with 3D pore structure exhibits higher COsorption capacity and amine efficiency than those with 2D-structured support. Among the sorbents studied, fumed silica（HS-5） based MBS showed the highest COsorption capacity in the temperature range of 30-95 °C, probably due to its unique interstitial pores formed by the aggregation of polymer-loaded SiOparticles. It was found that the temperature dependence is directly related to the PEI surface coverage layers. The more PEI surface coverage layers, the higher diffusion barrier for COand the stronger temperature dependence of COcapacity. 3D MBS exceeds 2D MBS at the same PEI coverage layers due to lower diffusion barrier. Adding PEG can significantly enhance the COsorption capacity and improve amine efficiency of all MBS, most likely by alleviating the diffusion barrier within PEI bulk layers through the inter-molecular interaction between PEI and PEG.

关键词： CO2 capture Molecular basket sorbents Mesoporous molecular sieve Polyethylenimine(PEI) Polyethylene glycol(PEG)

A combination treatment of entecavir and early-phase corticosteroid in severe exacerbation of chronic hepatitis B

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World Journal of Gastroenterology 2009年第13期15卷 1650-1652页

作者： Kazuyuki Matsumoto Yasuhiro Miyake Hirokazu Miyatake Masahiro Takahara Takayuki Imada Satoru Yagi Tatsuya Toyokawa Morihito Nakatsu Masaharu Ando mamoru Hirohata Department of Internal Medicine Mitoyo General Hospital Department of Molecular Hepatology Okayama University Graduate School of MedicineDentistry and Pharmaceutical Sciences

Of patients with severe exacerbation of chronic hepatitis B accompanied by jaundice and coagulopathy,20%-30%have a fatal *** this report,we describe 2 cases of severe exacerbation of chronic hepatitis B with jaundice and coagulopathy who were successfully treated with a combination of entecavir and *** both cases,rapid reductions in serum hepatitis B virus(HBV)-DNA levels were observed,and corticosteroid was stopped after serum HBV-DNA levels became *** treatment was ***,entecavir treatment reduced serum HBV-DNA levels rapidly,although the improvement in liver function was delayed by a few *** this time lag,liver cell injury continued and the disease *** suppressed the excessive host immune response and was useful for stopping progressive deterioration.A combination of entecavir and early-phase corticosteroid may be a useful treatment in severe exacerbation of chronic hepatitis B.

关键词： Acute exacerbation Chronic hepatitis B Corticosteroid Entecavir Hepatitis B virus Hepaticcoma

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WHEN STRUCTURES MOVE

WHEN STRUCTURES MOVE

Temperature Dependence of Electrical Properties of Organic Thin Film Transistors Based on pn Heterojuction and Their Applications in Temperature Sensors

International Symposium on New Olympics New Shell and Spatial Structures

作者： mamoru KAWAGUCHI Kawaguchi ＆ Engineers Yoyogi 3-2-7-601Tokyo 151-0053Japan

＜正＞Moving aspects of structures are taken up. In our daily structural design the structures are assumed to be immovable, and most of structural calculations are carried out on the basis of static principles. There are cases, however, where large movements are actually experienced by our structures due to different reasons. Many of them are due to excessive loading and unexpected instability, often leading to collapse of the structures. Some other cases are related to vibration where resonance of structures with external agencies such as earthquakes and wind is discussed. Self-excited oscillation sometimes produces catastrophic and spectacular motion of structures. Since the task of structural design is to realize safe and strong structures, we should be aware of such motions and the means to prevent or control them. Controlled motions can be obtained by adopting isolators to cope with the effects of earthquakes. Structures can be designed to be assembled on the ground and then hoisted to the position. In erection of such structures a big movement is observed as in Pantadome System. Finally those structures whose intended functions are movements are described with examples of rocking stones and a flying carp.

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Journal of Computer and Communications 2016年第5期4卷 10-15页

作者： Rongbin Ye Koji Ohta mamoru Baba Faculty of Engineering Iwate University Morioka Japan

Organic thin film transistors based on an F16CuPc/α6T pn heterojunction have been fabricated and analyzed to investigate the temperature dependence of electrical properties and apply in temperature sensors. The mobility follows a thermally activated hopping process. At temperatures over 200 K, the value of thermal activation energy (EA) is 40. 1 meV, similar to that of the single-layer device. At temperatures ranging from 100 to 200 K, we have a second regime with a much lower EA of 16.3 meV, where the charge transport is dominated by shallow traps. Similarly, at temperatures above 200 K, threshold voltage (VT) increases linearly with decreasing temperature, and the variations of VT of 0.185 V/K is larger than the variation of VT (~0.020 V/K) in the single layer devices. This result is due to the interface dipolar charges. At temperatures ranging from 100 K to 200 K, we have a second regime with much lower variations of 0.090 V/K. By studying gate voltage (VG)-dependence temperature variation factor (k), the maximum value of k (~0.11 dec/K) could be obtained at VG = 5 V. Furthermore, the pn heterojunction device could be characterized as a temperature sensor well working at low operating voltages.

关键词： Organic Thin Film Transistors pn Heterojunction Temperature Dependence Temperature Sensors

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静水中较大气泡运动特性实验研究

核动力工程 2015年第1期36卷 161-164页

作者：李仲春宋小明姜胜耀俞冀阳 mamoru Ishii 清华大学北京100084 中国核动力研究设计院核反应堆系统设计技术重点实验室成都610041 中国核动力研究设计院成都610041 普渡大学美国47906

对较大气泡在静水中的水力学特性、气泡上升速度、气泡形状与曳力系数等进行研究。气泡的产生是通过将特定体积的气泡存放在倒置的球帽杯中,然后释放到静水中。气泡的运动特性通过高速摄像仪捕捉,气泡相关运动参数通过数字图像处理程序... 详细信息

对较大气泡在静水中的水力学特性、气泡上升速度、气泡形状与曳力系数等进行研究。气泡的产生是通过将特定体积的气泡存放在倒置的球帽杯中,然后释放到静水中。气泡的运动特性通过高速摄像仪捕捉,气泡相关运动参数通过数字图像处理程序得到。实验得到不同尺寸气泡在静水中上升的特性,并将实验结果与现有的曳力模型进行比较,表明Tomiyama等关系式对于曳力以及气泡最终上升的预测比Ishii-Chawa模型好,较大气泡的形状具有一定的相似性。实验结果对存在较大气泡的两相流动特性以及相间交换特性有重要意义。

关键词：球帽型气泡运动特性曳力

Thermokarst Lake Changes in the Southern Fringe of Siberian Permafrost Region in Mongolia Using Corona, Landsat, and ALOS Satellite Imagery from 1962 to 2007

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Advances in Remote Sensing 2016年第4期5卷 215-231页

作者： Adiya Saruulzaya mamoru Ishikawa Yamkhin Jambaljav Graduate School of Environmental Science Hokkaido University Sapporo Japan Permafrost Department Institute of Geography and Geoecology Ulaanbaatar Mongolia

This study presents thermokarst lake changes at seven different sites in the continuous and isolated permafrost zones in Mongolia. Lakes larger than 0.1 ha were analyzed using Corona KH-4, KH-4A and KH-4B (1962-1968), Landsat ETM + (1999-2001), and ALOS/AVNIR-2 (2006-2007) satellite imagery. Between 1962 and 2007, the total number and area of lakes increased by +21% (347 to 420), and +7% (3680 ha to 3936 ha) in the continuous permafrost zone, respectively. These changes correspond to the appearance of 85 new lakes (166 ha) during the last 45 years. In contrast, lakes in the isolated permafrost zone have decreased by –42% (118 to 68) in number and –12% (422 ha to 371 ha) in area from 1962 to 2007. The changes in lake area and number are likely attributed to shifts in climate regimes and local permafrost conditions. Since 1962, the mean annual air temperature and potential evapotranspiration have increased significantly in the northern continuous permafrost zone compared to the southern isolated permafrost zone. Due to ongoing atmospheric warming without any significant trend in annual precipitation, patches of ice-rich subsurface have thawed, and the number and area of lakes have accordingly developed in the continuous permafrost zone. Shrinking of thermokarst lakes in the isolated permafrost zone may be due to disappearing permafrost, deepening of the active layer, and increased water loss through surface evaporation and subsurface drainage.

关键词： Thermokarst Lake Siberian Permafrost Region Mongolia Corona Landsat ALOS