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Acute coronary syndrome: a rare case of multiple endocrine neoplasia syndromes with pheochromocytoma and medullary thyroid carcinoma

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Cancer Biology & Medicine 2015年第3期12卷 255-258页

作者： Alessadro maloberti Paolo Meani Roberto Pirola Marisa Varrenti Marco Boniardi Anna Maria De Biase Paola Vallerio Edgardo Bonacina Giuseppe Mancia Paola Loli Cristina Giannattasio Health Science Department Milano-Bicocca University Cardiology IV "A. De Gasperis" DepartmentOspedale Niguarda Ca’Granda General Oncologic and Mini-invasive Surgery Department Niguarda Ca’ Granda Hospital Anatomy and Histology Department Niguarda Ca’ Granda Hospital Endocrine Unit Niguarda Ca’ Granda Hospital

Pheochromocytoma is a tumor arising from neuroectodermal chromaffin tissues in the adrenal gland or extra-adrenal paraganglia(paragangliomas). The prevalence of the tumor is 0.1%-0.6% in the hypertensive population, of which 10%-20% are malignant. Pheochromocytoma produces, stores, and secretes catecholamines, as well as leads to hypertensive crisis, arrhythmia, angina, and acute myocardial infarction without coronary artery diseases. We report a case of acute coronary syndrome(ACS) with a final diagnosis of multiple endocrine neoplasia with pheochromocytoma and medullary thyroid carcinoma(MTC).

关键词： Secondary hypertension pheochromocytoma echocardiography medullary thyroid carcinoma multiple endocrineneoplasia

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Correlation of molecular alterations with pathological features in hepatocellular carcinoma:Literature review and experience of an Italian center

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World Journal of Gastroenterology 2022年第25期28卷 2854-2866页

作者： Thais maloberti Antonio De Leo Viviana Sanza Elisa Gruppioni Annalisa Altimari Mattia Riefolo MichelaVisani Deborah Malvi Antonia D’Errico Giovanni Tallini Francesco Vasuri Dario de Biase Department of Experimental Diagnostic and Specialty MedicineUniversity of BolognaBologna 40138Italy Solid Tumor Molecular Pathology Laboratory IRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Department of Pathology IRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Department of Pharmacy and biotechnology(FaBiT) University of BolognaBologna 40138Italy

Hepatocellular carcinoma(HCC)represents the primary carcinoma of the liver and the fourth leading cause of cancer-related *** World Health Organization estimates an increase in cases in the coming *** risk factors of HCC are multiple,and the incidence in different countries is closely related to the different risk factors to which the population is *** molecular mechanisms that drive HCC tumorigenesis are extremely complex,but understanding this multistep process is essential for the identification of diagnostic,prognostic,and therapeutic *** development of multigenic nextgeneration sequencing panels through the parallel analysis of multiple markers can provide a landscape of the genomic status of the *** the literature and our preliminary data based on 36 HCCs,the most frequently altered genes in HCCs are TERT,CTNNB1,and *** the years,many groups have attempted to classify HCCs on a molecular basis,but a univocal classification has never been ***,statistically significant correlations have been found in HCCs between the molecular signature and morphologic features,and this leads us to think that it would be desirable to integrate the approach between anatomic pathology and molecular laboratories.

关键词： Hepatocarcinoma Mutation Next-generation sequencing Review TP53 CTNNB1 TERT

Molecular alterations in pancreatic tumors

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World Journal of Gastroenterology 2021年第21期27卷 2710-2726页

作者： Michela Visani Giorgia Acquaviva Antonio De Leo Viviana Sanza Lidia Merlo Thais maloberti Alba ABrandes Enrico Franceschi Monica Di Battista Michele Masetti Elio Jovine Sirio Fiorino Annalisa Pession Giovanni Tallini Dario de Biase Department of Experimental Diagnostic and Specialty MedicineUniversity of Bologna–Molecular Diagnostic UnitAzienda USL di BolognaBologna 40138Italy Division of Molecular Pathology Laboratory IRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Medical Oncology Department Azienda USL/IRCCS Istituto Delle Scienze Neurologiche di BolognaBologna 40139Italy Division of Surgery IRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40133Italy Internal Medicine Unit Budrio Hospital Azienda USLBologna 40133Italy Department of Pharmacy and Biotechnology University of BolognaBologna 40138Italy

Genetic alterations in pancreatic tumors can usually be classified in:(1)Mutational activation of oncogenes;(2)Inactivation of tumor suppressor genes;and(3)Inactivation of genome maintenance genes controlling the repair of DNA *** ultrasound-guided fine-needle aspiration has improved preoperative diagnosis,but the management of patients with a pancreatic lesion is still *** testing could help mainly in solving these“inconclusive”*** introduction of multi-gene analysis approaches,such as next-generation sequencing,has provided a lot of useful information on the molecular characterization of pancreatic *** types of pancreatic tumors(e.g.,pancreatic ductal adenocarcinomas,intraductal papillary mucinous neoplasms,solid pseudopapillary tumors)are characterized by specific molecular *** aim of this review is to summarize the main molecular alterations found in pancreatic tumors.

关键词： Pancreatic tumors Molecular alterations Pancreatic ductal adenocarcinomas Intraductal papillary mucinous neoplasm Mutations Molecular markers

24h动态中心动脉收缩压和左心室质量的关系:一项前瞻性多中心研究

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中华高血压杂志 2017年第11期25卷 1004-1004页

作者：黄洁叶鹏 Weber T Wassertheurer S Schmidt-Trucks?ss A Rodilla E Ablasser C Jankowski P Lorenza Muiesan M Giannattasio C Mang C Wilkinson I Kellermair J Hametner B Pascual JM Zweiker R Czarnecka D Paini A Salvetti M maloberti a McEniery C

研究者在7个欧洲中心中调查左心室质量与肱动脉诊室血压以及肱动脉压和中心动脉动态收缩压之间的关系。使用校准的示波装置测量，经平均压／舒张压校准和转换函数计算中心动脉收缩压。由不知道血压值的单个操作者通过M型超声心动图测定... 详细信息

研究者在7个欧洲中心中调查左心室质量与肱动脉诊室血压以及肱动脉压和中心动脉动态收缩压之间的关系。使用校准的示波装置测量，经平均压／舒张压校准和转换函数计算中心动脉收缩压。由不知道血压值的单个操作者通过M型超声心动图测定左心室质量。研究者调查了未使用抗高血压药物的受试者289人（女性137人，平均年龄50．8岁）。

关键词：左心室质量动脉收缩压前瞻性多中心研究 M型超声心动图抗高血压药物肱动脉压计算中心平均年龄

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预测20年总死亡与心血管病死亡风险增加的尿酸阈值

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中华高血压杂志 2020年第1期28卷 99-99页

作者： Virdis A Masi S Casiglia E Tikhonoff V Cicero AFG Ungar A Rivasi G Salvetti M Barbagallo CM Bombelli M Dell'Oro R Bruno B Lippa L D'Elia L Verdecchia P MallamaciF Cirillo M Rattazzi M Cirillo P Gesualdo L Mazza A Giannattasio C maloberti a Volpe M Tocci G GeorgiopoulosG Iaccarino G Nazzaro P Parati G Palatini P Galletti F Ferri C Desideri G Viazzi F Pontremoli R Muiesan ML Grassi G Borghi C 赵狄(摘译) 刘莉(审校) 不详

目前识别心血管病风险不同分层的血清尿酸水平仍未确定。采用基于人群的大数据,研究人员评估了总死亡和与心血管病死亡(cardiovascular mortality,CVM)风险增加的血清尿酸水平。尿酸与心脏健康(uric acid right for heart health,URRAH... 详细信息

目前识别心血管病风险不同分层的血清尿酸水平仍未确定。采用基于人群的大数据,研究人员评估了总死亡和与心血管病死亡(cardiovascular mortality,CVM)风险增加的血清尿酸水平。尿酸与心脏健康(uric acid right for heart health,URRAH)研究是一项收集意大利几个基于大型人群纵向研究大数据的多中心回顾性观察性研究(随访20年),患者均在意大利高血压协会的高血压诊所就诊。

关键词：心血管病尿酸水平死亡风险

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