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A special issue on Biophotonics in Europe

Frontiers of Optoelectronics 2017年第3期10卷 203-210页

作者： Valery V. TUCHIN Ekaterina BORISOVA malgorzata jedrzejewska-szczerska Martin J. LEAHY Francesco S. PAVONE Jurgen POPP Jose POZO Research-Educational Institute of Optics and Biophotonics Samtov State University (National Research University of Russia) 410012 Saratov Russia Interdisciplinary Laboratory of Biophotonics Tomsk State University (National Research University of Russia) 634050 Tomsk Russia Laboratory of-Laser Diagnostics of Technical and Living Systems Instituteof Precision Mechanics and Control of RAS 410028 Saratov Russia 4 Institute of Electronics Bulgarian Academy of Sciences Sofia Bulgaria Institute of Electronics Bulgarian Academy of Sciences Sofia Bulgaria Faculty of Electronics Telecommunicationand Informatics Gdafisk University of Technology Poland National Biophotonics and Imaging Platform Ireland Chair of Applied Physics School of Physics National University of Ireland Galway Ireland European Laboratory for Non Linear Spectroscopy (LENS) and University of Florence Sesto Fiorentino Italy Leibniz Institute of Photonic Tectmology Jena Institute of Physical chemistry & AbbeCenter of Photonics Friedrich Schiller University Jena Germany Technology and Innovation EPIC - European Photonics Industry Consortium Netherlands

Biophotonics is an emerging multidisciplinary research area, embracing all light-based technologies applied to the life sciences and medicine [1-6]. The expression itself is the combination of the Greek syllables ＂bios＂ standing for life and ＂phos＂ standing for light. Photonics is the technical term for all methodologies and technologies utilizing photons over the whole spectrum from X-ray over the ultraviolet, visible and the infrared to the terahertz region, and its interaction with any matter. Beyond this definition, biophotonics is a scientific discipline of remarkable societal importance. As a part of photonics, it has proved to be an important enabling technology for accelerated progress in medicine and biotechnology. It can do so, because it originated at the interface of the most innovative academic disciplines of the last century, i.e., photonics, biotechnology and nanotechnologies. This field of research brings together scientists from different professions, such as physicists, biologists, pharmacists, medical doctors, etc. To work on common projects, they need to understand the ideas and the techniques of their counterparts.

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WNT/β-catenin signaling in hepatocellular carcinoma:The aberrant activation,pathogenic roles,and therapeutic opportunities

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Genes & Diseases 2024年第2期11卷 727-746页

作者： Anna Gajos-Michniewicz malgorzata Czyz Department of Molecular Biology of Cancer Medical University of LodzLodz 92-215Poland

Hepatocellular carcinoma(HCC)is a liver cancer,highly heterogeneous both at the histopathological and molecular *** arises from hepatocytes as the result of the accumulation of numerous genomic alterations in various signaling pathways,including canonical WNT/β-catenin,AKT/mTOR,MAPK pathways as well as signaling associated with telomere maintenance,p53/cell cycle regulation,epigenetic modifiers,and oxidative *** role of WNT/β-catenin signaling in liver homeostasis and regeneration is well established,whereas in development and progression of HCC is extensively ***,we review recent advances in our understanding of how WNT/β-catenin signaling facilitates the HCC development,acquisition of stemness features,metastasis,and resistance to *** outline genetic and epigenetic alterations that lead to activated WNT/β-catenin signaling in *** discuss the pivotal roles of CTNNB1 mutations,aberrantly expressed non-coding RNAs and complexity of crosstalk between WNT/β-catenin signaling and other signaling pathways as challenging or advantageous aspects of therapy development and molecular stratification of HCC patients for treatment.

关键词： Cancer stem cells CTNNB1 mutations Liver cancer Non-coding RNA Tumor heterogeneity

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Blood equivalent phantom vs whole human blood, a comparative study

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Journal of Innovative Optical Health Sciences 2016年第2期9卷 70-78页

作者： K.Karpienko M.Gnyba D.Milewska M.S.Wrbel M.jedrzejewska-szczerska Department of Metrology and Optoelectronics Faculty of Electronics Telecommunications and Informatics Gdansk University of Technology 11/12 Narutowicza 80-233 GdanskPoland

Preclinical research of biomedical optoelectronic devices is often performed with the use of blood phantoms-a simplified physical model of *** aim of this study is the comparison and distinction between blood phantoms as well as whole human blood *** show how the use of such phantoms may in°uence the incorrect interpretation of measured *** the other hand,we highlight how the use of blood phantoms enables to investigate the phenomena that otherwise are almost impossible to be noticed.

关键词： Blood phantoms low-coherence interferometry absorption spectroscopy Raman spectroscopy

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从蛋白质环境引起的实际变化中剖析配体结构的误差

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上海大学学报（自然科学版） 2024年第2期30卷 229-242页

作者：乔琳琳李永乐郭聪 BICZYSKO malgorzata 上海大学理学院上海200444 上海大学量子与分子结构国际研究中心上海200444

配体构象应变能(ligand conformational strain energy,LCSE)是计算机辅助药物发现中考虑的一个重要参数.通过量子力学(quantum mechanical,QM)方法对自由态配体和蛋白质口袋中的结合态配体的结构进行计算并比较,可以获得配体构象应变能... 详细信息

配体构象应变能(ligand conformational strain energy,LCSE)是计算机辅助药物发现中考虑的一个重要参数.通过量子力学(quantum mechanical,QM)方法对自由态配体和蛋白质口袋中的结合态配体的结构进行计算并比较,可以获得配体构象应变能.然而,对配体构象应变能的合理范围以及计算方法仍然存在争议.选择8个柔性较大、特征结构模式多样的配体,这些结构的分辨率在高分辨率(0.86×10^(−10))与中等分辨率(3.10×10^(−10))之间,分别采用3种不同的量子力学方法:密度泛函(density functional theory,DFT)M062XD3、Hartree-Fock和GFN1-xTB,对8个配体进行逐步优化并计算配体能量,分析在结合态配体逐步优化到局域能量最小的自由态配体的过程中配体在结构和能量上的差异.量子力学计算结果显示,配体构象应变能小于6.0 kcal/mol,结合态配体结构中显著的几何参数误差是结合态和自由态配体结构的主要能量差异.因此,在分析配体构象应变能之前,对结合态配体结构进行精确实验测定非常重要.

关键词：蛋白质配体复合物应变能势能面密度泛函 Hartree-Fock GFN1-xTB

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美国的图论:第一个百年

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数学译林 2024年第1期43卷 69-72页

作者： malgorzata Marciniak 陆柱家(译) 童欣(校) 纽约城市大学LaGuardia社区学院不详

Robin Wilson,John ***,and David ***,Graph Theory in America:The First Hundred *** University Press,2023,320 pp.,$35.怀着极大的好奇心和夏天的热情,我把这本书拿在手里.对于精装本出版物来说,它相对较轻,非常适合在休闲度假或... 详细信息

关键词： Robin 图论 Princeton

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System supporting behavioral therapy for children with autism

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Journal of Innovative Optical Health Sciences 2015年第3期8卷 64-71页

作者： Małgorzata Je˛drzejewska-szczerska Katarzyna Karpienko Agnieszka Landowska Department of Metrology and Optoelectronics Faculty of Electronics Telecommunications and Informatics Gdansk University of Technology Gabriela Narutowicza Street 11/1280-233 GdanskPoland Department of Software Engineering Faculty of Electronics Telecommunications and InformaticsGdansk University of Technology Gabriela Narutowicza Street 11/1280-233 GdanskPoland

In this paper,a system supporting behavioral therapy for autistic children is *** system consists of sensors network,base station and a brooch indicating person's ernotional *** system can be used to measure values of physiological parameters that are associated with changes in the emotional *** the future,it can be useful to inform the autistic child and the therapist about the emotional state of the interlocutor objectively,on the basis of performed *** selected physiological parameters were chosen during the experiment which was designed and conducted by *** this experiment,a group of volunteers under con-trolld conditions was exposed to a stressful situation caused by the picture or *** each of the volunteers,a set of physiological parameters,was recorded,including:skin conductance,heart rate,peripheral temperature,respiration rate and *** bio statistical analysis allowved us to discern the proper plhysiological paraneters that are most associated to changes due to emotional state of a patient,such as:skin conductance,temperatures and res-piration *** allowed us to design electronic sensors network for supporting behavioral therapy for children with autism.

关键词： Autism spectrum disorder biomedical sensors physiological parameters sensor network.

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Hepatitis C virus infection in children in the era of directacting antiviral

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World Journal of Gastroenterology 2018年第24期24卷 2555-2566页

作者： malgorzata Pawlowska malgorzata Sobolewska-Pilarczyk Krzysztof Domagalski Department of Paediatric Infectious Diseases and Hepatology Faculty of MedicineCollegium MedicumNicolaus Copernicus University Centre For Modern Interdisciplinary Technologies Nicolaus Copernicus University

Hepatitis C virus(HCV) infection remains an important global health problem with chronic infection affecting approximately 11 million children worldwide. The emergence of direct-acting antiviral(DAA) therapies and the development of non-invasive methods for the determination of liver fibrosis will significantly improve the management of paediatric patients with chronic HCV infection in subsequent years. For paediatric patients, a new era of highly effective DAA agents is beginning, and the first results of available clinical trials are very promising. In this era, the identification and monitoring of patients continues to be an important issue. The availability of non-invasive serological and imaging methods to measure hepatic fibrosis enables the identification of patients with significant or advanced liver fibrosis stages. This article summarizes the current data on the epidemiology and progress of research aimed to evaluate the new therapies and non-invasive methods for liver injury in paediatric patients with chronic hepatitis C.

关键词： biomarkers of liver injury adolescents epidemiology direct-acting antiviral Hepatitis C virus non-invasive methods children

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NO_(x) control for high-ash coal-fired power plants in India

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Clean Energy 2019年第1期3卷 24-33页

作者： malgorzata Wiatros-Motyka IEA Clean Coal Centre Apsley House176 Upper Richmond RoadLondonSW152SHUnited Kingdom

Many countries have strict emission limits for nitrogen oxides(NO_(x));thus NO_(x) control systems are widely *** has recently introduced NO_(x) emission limits,which require that pollution control technologies must be installed on most coal-fired ***,operational experience with NO_(x) control systems in India is limited to primary measures ***,Indian coals have a high level of inherent ash,which is also highly erosive and can influence the behaviour of some NO_(x) control systems and thus affect the selection *** measures for NO_(x) control from coal-fired power plants include low NO_(x) burners(LNBs),overfire air systems(OFA),fuel reburning,flue gas recirculation,fuel biasing,low excess air and combustion *** NO_(x) control includes selective catalytic reduction,selective non-catalytic reduction and multi-pollutant control *** of primary measures(LNBs and OFA)in India has been recommended to take place during next-scheduled plant outages;for many plants this could occur by ***,control strategies for individual plants will be needed to ascertain the appropriateness of installing post-combustion technologies or various combinations of NO_(x) control *** installation of secondary NO_(x) controls is not expected before test results from secondary controls on selected Indian power plants units are known.

关键词： high-ash coal NO_(x)controls SCR SNCR low NO_(x)burners overfire air India emission standards

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Emissions of fluorides from welding processes

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Journal of Environmental Sciences 2015年第11期27卷 179-183页

作者： malgorzata Szewczynska Emilia Pagowska Krystyna Pyrzynska Department of Chemical and Aerosol Hazards Central Institute for Labour Protection-National Research Institute Faculty of Chemistry University of Warsaw

The levels of fluoride airborne particulates emitted from welding processes were investigated. They were sampled with the patented IOM Sampler, developed by J. H Vincent and D. Mark at the Institute of Occupational Medicine（IOM）, personal inhalable sampler for simultaneous collection of the inhalable and respirable size fractions. Ion chromatography with conductometric detection was used for quantitative analysis. The efficiency of fluoride extraction from the cellulose filter of the IOM sampler was examined using the standard sample of urban air particle matter SRM-1648 a. The best results for extraction were obtained when water and the anionic surfactant N-Cetyl-N-N-Ntrimethylammonium bromide（CTAB） were used in an ultrasonic bath. The limits of detection and quantification for the whole procedure were 8 μg/L and 24 μg/L, respectively The linear range of calibration was 0.01–10 mg/L, which corresponds to 0.0001–0.1 mg of fluorides per m3 in collection of a 20 L air sample. The concentration of fluorides in the respirable fraction of collected air samples was in the range of 0.20–1.82 mg/m3, while the inhalable fraction contained 0.23–1.96 mg/m3 of fluorides during an eight-hour working day in the welding room.

关键词： Fluorides Particle size distribution Welding processes

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Cathepsin L, transmembrane peptidase/serine subfamily member 2/4, and other host proteases in COVID-19 pathogenesis – with impact on gastrointestinal tract

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World Journal of Gastroenterology 2021年第39期27卷 6590-6600页

作者： Izabela Berdowska malgorzata Matusiewicz Department of Biochemistry and Immunochemistry Wroclaw Medical UniversityWroclaw 50-368Lower SilesiaPoland

Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)seems to employ two routes of entrance to the host cell;via membrane fusion(with the cells expressing both angiotensin converting enzyme 2(ACE2)and transmembrane peptidase/serine subfamily member 2/4(TMPRSS2/4))or via receptor-mediated endocytosis(to the target cells expressing only ACE2).The second mode is associated with cysteine cathepsins(probably cathepsin L)involvement in the virus spike protein(S protein)proteolytic *** furin might activate the virus S protein enabling it to enter *** tract(GIT)involvement in SARS-CoV-2 infection is evident in a subset of coronavirus disease 2019(COVID-19)patients exhibiting GIT symptoms,such as diarrhea,and presenting viral-shedding in *** the abundance and co-localization of ACE2 and TMPRSS2 in the lower GIT(especially brush-border enterocytes),these two receptors seem to be mainly involved in SARS-CoV-2 invasion of the digestive ***,in vitro studies have demonstrated the virions capability of infection and replication in the human epithelial cells lining ***,also furin and cysteine cathepsins(cathepsin L)might participate in the activation of SARS-CoV-2 spike protein contributing to the virus invasiveness within ***,cathepsin L(due to its involvement in extracellular matrix components degradation and remodeling,the processes enhanced during SARS-CoV-2-induced inflammation)might be responsible for the dysregulation of absorption/digestion functions of GIT,thus adding to the observed in some COVID-19 patients symptoms such as diarrhea.

关键词： COVID-19 SARS-CoV-2 Angiotensin converting enzyme 2 Transmembrane peptidase/serine subfamily member 2/4 Cathepsin L Gastrointestinal tract

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