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Review on solar sail technology

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Astrodynamics 2019年第2期3卷 93-125页

作者： Shengping Gong malcolm macdonald School of Aerospace Engineering Tsinghua UniversityBeijing100084China Department of Mechanical&Aerospace Engineering University of StrathclydeGlasgouScotland

This paper reviews solar sail trajectory design and dynamics,attitude control,and structural *** the area of orbital dynamics,methods relevant to transfer trajectory design and non-Keplerian orbit generation are *** the area of attitude control,di erent control strategies,including utilisation of solar radiation pressure and conventional actuators,are ***,the methods of modelling structural dynamics during and after deployment are discussed,before considering possible future trends in developing of solar sailing missions.

关键词： solar sail orbit attitude structure

Regulation of toxins and bioregulators under the Chemical Weapons Convention and the Biological and Toxin Weapons Convention

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Journal of Biosafety and Biosecurity 2024年第2期6卷 99-112页

作者： Michael Crowley malcolm Dando Peace Studies and International Development University of BradfordBD71DPUK

In this paper we highlight how the apparent double coverage of toxins and bioregulators by both the Biological and Toxin Weapons Convention(BTWC)and the Chemical Weapons Convention(CWC)in fact masks a regulatory gap that has left such potentially dangerous agents neglected by both the control regimes during a period of rapid advances in relevant chemical,life and associated sciences and *** first review what toxins,bioregulators and other mid-spectrum agents are and why they are of such concern and then examine how they are regulated under the BTWC and *** paper then examines an illustrative range of contemporary chemical and life science research and associated activities of concern drawn from case study research on China,India,Iran,Russia,Syria and the United States,and assesses how the CWC and BTWC States Parties have inadequately addressed these *** then examine how both the CWC and BTWC Review Conferences failed to address these long-term challenges,and we end by providing a series of recommendations for how both regimes can be strengthened in this area.

关键词： Biological and Toxin Weapons Convention Chemical Weapons Convention Biotechnology Toxins Bioregulators Riot Control Agents Malodorants Delivery Systems

Gradient layered MXene/Fe_(3)O_(4)@CNTs/TOCNF ultrathin nanocomposite paper exhibiting effective electromagnetic shielding and multifunctionality

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Nano Research 2024年第9期17卷 8233-8242页

作者： Zhengkun Ma Jingzong He Shilin Liu Xiaoxuan Qie Meiheng Gan Ruonan Cheng Qilin Wu malcolm Xing State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China College of Chemistry and Chemical Engineering Donghua UniversityShanghai 201620China Department of Mechanical Engineering University of ManitobaWinnipegMB R3T 2N2Canada

As wearable electronic devices are rapidly developing,there is an urgent need for lightweight,flexible,and ultrathin multifunctional electromagnetic interference(EMI)shielding ***,the flexible ultrathin paper that combines efficient shielding and multifunctional integration remains a considerable ***,a novel MXene/Fe_(3)O_(4)@CNTs/TOCNF(MCT,MXene=transition metal carbide/carbonitride,CNTs=carbon nanotubes,TOCNF=TEMPO-oxidized cellulose nanofiber,TEMPO=2,2,6,6-tetramethylpiperidine-1-oxyl radical)nanocomposite paper with a multilayer electromagnetic gradient structure and electromagnetic dual losses was successfully prepared by a simple filtration *** from effective gradient design and adjusting the proportion of TOCNF,the composite paper(only 18μm)exhibits outstanding shielding effectiveness(SE)of 66 dB in the X-band,ultrahigh thickness-specific SE and surface-specific SE values of 3300 dB·mm-1 and 31,428 dB·cm^(2)·g^(-1)***,dehydroxylation treatment improves MCT paper's hydrophobicity,environmental stability,and mechanical strength,expanding its range of ***,the highly efficient Joule heating properties and hydrophobicity provide MCT additional de-icing *** also simulated the electromagnetic shielding effects of MCT composite paper,which was applied in *** study documents an innovative and intriguing material combination,providing a simple and effective manufacturing strategy for developing EMI shielding *** paper is highly suitable for outdoor portable or wearable electronic devices and has significant application potential in humid/severe cold environments.

关键词： cellulose fiber thin papers nanocomposites electromagnetic interference(EMI)shielding

SHARE-ENV:A Data Set to Advance Our Knowledge of the Environment−Wellbeing Relationship

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Environment & Health 2024年第2期2卷 95-104页

作者： Catarina Midões Enrica De Cian Giacomo Pasini Sara Pesenti malcolm N.Mistry Department of Economics Ca’Foscari University of Venice30121 VeneziaItaly Institute of Environmental Science and Technology of Universitat Autònoma de Barcelona 08193 Cerdanyola del VallèsBarcelonaSpain European Central Bank 60314 Frankfurt am MainGermany Environment and Health Modelling(EHM)Lab Department of Public HealthEnvironments and SocietyLondon School of Hygiene and Tropical Medicine(LSHTM)London WC1E 7HTUnited Kingdom

Climate change interacts with other environmental stressors and vulnerability *** places and,owing to socioeconomic conditions,some people,are far more at *** data behind current assessments of the environment−wellbeing nexus is coarse and regionally aggregated,when considering multiple regions/groups;or,when granular,comes from ad hoc samples with few *** assess the impacts of climate change,we require data that are granular and comprehensive,both in the variables and population *** build a publicly accessible data set,the SHARE-ENV data set,which fulfills these *** expand on EU representative,individual-level,longitudinal data(the SHARE survey),with environmental exposure information about temperature,radiation,precipitation,pollution,and flood *** illustrate through four simplified multilevel linear regressions,cross-sectional and longitudinal,how full-fledged studies can use SHARE-ENV to contribute to the *** studies would help assess climate impacts and estimate the effectiveness and fairness of several climate adaptation *** surveys can be expanded with environmental information to unlock different research avenues.

关键词： climate change risk environmental impacts climate adaptation population health longitudinal data

Reactive oxygen species promote endurance exercise-induced adaptations in skeletal muscles

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Journal of Sport and Health Science 2024年第6期13卷 780-792页

作者： Scott K.Powers Zsolt Radak Li Li Ji malcolm Jackson Department of Applied Physiology University of FloridaGainesvilleFL 32608USA Research Institute of Sport Science Hungarian University of Sport ScienceBudapest 1123Hungary Department of Kinesiology University of MinnesotaSt.PaulMN 55455USA Department of Musculoskeletal and Ageing Science Institute of Life Course and Medical SciencesUniversity of LiverpoolLiverpool L78TXUK

The discovery that contracting skeletal muscle generates reactive oxygen species(ROS)was first reported over 40 years *** prevailing view in the 1980s was that exercise-induced ROS production promotes oxidation of proteins and lipids resulting in muscle ***,a paradigm shift occurred in the 1990s as growing research revealed that ROS are signaling molecules,capable of activating transcriptional activators/coactivators and promoting exercise-induced muscle *** evidence supports the notion that reduction-oxidation(redox)signaling pathways play an important role in the muscle remodeling that occurs in response to endurance exercise *** review examines the specific role that redox signaling plays in this endurance exercise-induced skeletal muscle *** begin with a discussion of the primary sites of ROS production in contracting muscle fibers followed by a summary of the antioxidant enzymes involved in the regulation of ROS levels in the *** then discuss which redox-sensitive signaling pathways promote endurance exercise-induced muscle adaptation and debate the strength of the evidence supporting the notion that redox signaling plays an essential role in muscle adaptation to endurance exercise *** hopes of stimulating future research,we highlight several important unanswered questions in this field.

关键词： Antioxidants Mitochondrial biogenesis Radicals Redox signaling

Epigenetic silencing of BEND4,a novel DNA damage repair gene,is a synthetic lethal marker for ATM inhibitor in pancreatic cancer

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Frontiers of Medicine 2024年第4期18卷 721-734页

作者： Yuanxin Yao Honghui Lv Meiying Zhang Yuan Li James G.Herman malcolm V.Brock Aiai Gao Qian Wang Francois Fuks Lirong Zhang Mingzhou Guo Department of Gastroenterology and Hepatology the First Medical CenterChinese PLA General HospitalBeijing100853China Department of Pharmacology School of Basic Medical SciencesZhengzhou UniversityZhengzhou450001China Henan Institute of Advanced Technology Zhengzhou UniversityZhengzhou450001China UPMC Hillman Cancer Center University of Pittsburgh Medical CenterPittsburghPA15213USA Department of surgery School of MedicineJohns Hopkins School of MedicineBaltimoreMD21287USA Laboratory of Cancer Epigenetics Faculty of MedicineULB-Cancer Research Center(U-CRC)Universite Libre de Bruxelles(ULB)Brussels1070Belgium National Key Laboratory of Kidney Diseases the First Medical CenterChinese PLA General HospitalBeijing100853China

Synthetic lethality is a novel model for cancer *** understand the function and mechanism of BEN domain-containing protein 4(BEND4)in pancreatic cancer,eight cell lines and a total of 492 cases of pancreatic neoplasia samples were included in this ***-specific polymerase chain reaction,CRISPR/Cas9,immunoprecipitation assay,comet assay,and xenograft mouse model were ***4 is a new member of the BEN domain *** expression of BEND4 is regulated by promoter region *** is methylated in 58.1%(176/303)of pancreatic ductal adenocarcinoma(PDAC),33.3%(14/42)of intraductal papillary mucinous neoplasm,31.0%(13/42)of pancreatic neuroendocrine tumor,14.3%(3/21)of mucinous cystic neoplasm,4.3%(2/47)of solid pseudopapillary neoplasm,and 2.7%(1/37)of serous cystic ***4 methylation is significantly associated with late-onset PDAC(>50 years,P<0.01)and tumor differentiation(P<0.0001),and methylation of BEND4 is an independent poor prognostic marker(P<0.01)in ***,BEND4 plays tumor-suppressive roles in vitro and in ***,BEND4 involves non-homologous end joining signaling by interacting with Ku80 and promotes DNA damage *** of BEND4 increased the sensitivity of PDAC cells to ATM ***,the present study revealed an uncharacterized tumor suppressor BEND4 and indicated that methylation of BEND4 may serve as a potential synthetic lethal marker for ATM inhibitor in PDAC treatment.

关键词： BEND4 DNA methylation synthetic lethality NHEJ pathway

Spontaneous mutations and mutational responses to penicillin treatment in the bacterial pathogen Streptococcus pneumoniae D39

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Marine Life Science & Technology 2024年第3期6卷 198-211页

作者： Wanyue Jiang Tongtong Lin Jiao Pan Caitlyn ERivera Clayton Tincher Yaohai Wang Yu Zhang Xiang Gao Yan Wang Ho‑Ching T.Tsui malcolm E.Winkler Michael Lynch Hongan Long Institute of Evolution and Marine Biodiversity KLMMEOcean University of ChinaQingdao 266003China Laboratory for Marine Biology and Biotechnology Laoshan LaboratoryQingdao 266237China Department of Biology Indiana UniversityBloomingtonIN 47405USA School of Mathematics Science Ocean University of ChinaQingdao 266000China State Key Laboratory of Microbial Technology Microbial Technology InstituteSchool of Life ScienceShandong UniversityQingdao 266237China Biodesign Center for Mechanisms of Evolution Arizona State UniversityTempeAZ 85281USA

Bacteria with functional DNA repair systems are expected to have low mutation rates due to strong natural selection for genomic ***,our study of the wild-type Streptococcus pneumoniae D39,a pathogen responsible for many common diseases,revealed a high spontaneous mutation rate of 0.02 per genome per cell division in mutation-accumulation(MA)*** rate is orders of magnitude higher than that of other non-mutator bacteria and is characterized by a high mutation bias in the A/T *** high mutation rate may have resulted from a reduction in the overall efficiency of selection,conferred by the tiny effective population size in *** line with this,*** D39 also exhibited the lowest DNA mismatch-repair(MMR)efficiency among *** with the antibiotic penicillin did not elevate the mutation rate,as penicillin did not induce DNA damage and *** lacks a stress response *** findings suggested that the MA results are applicable to within-host scenarios and provide insights into pathogen evolution.

关键词： Neutral evolution Mutation spectrum Antibiotics DNA mismatch repair Oxidative damage repair

The use of hydrogel microspheres as cell and drug delivery carriers for bone,cartilage,and soft tissue regeneration

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Biomaterials Translational 2024年第3期5卷 236-256页

作者： Chung-Hsun Lin Jesse RSrioudom Wei Sun malcolm Xing Su Yan Le Yu Jian Yang Department of Biomedical Engineering The Pennsylvania State UniversityUniversity ParkPAUSA Department of Bioengineering University of PennsylvaniaPhiladelphiaPAUSA Leicester International Institute Dalian University of TechnologyPanjinLiaoning ProvinceChina Department of Mechanical Engineering University of ManitobaWinnipegCanada Division of Biological and Biomedical Systems University of Missouri-Kansas CityKansas CityMOUSA Biomedical Engineering Program Westlake UniversityHangzhouZhejiang ProvinceChina Research Centre for Industries of the Future Westlake UniversityHangzhouZhejiang ProvinceChina

Bone,cartilage,and soft tissue regeneration is a complex process involving many cellular activities across various cell *** remain the“gold standard”for the regeneration of these ***,the use of autografts is associated with many disadvantages,including donor scarcity,the requirement of multiple surgeries,and the risk of *** development of tissue engineering techniques opens new avenues for enhanced tissue ***,the expectations of tissue engineering scaffolds have gone beyond merely providing physical support for cell *** scaffolds should also provide biological cues to actively boost tissue *** a new type of injectable biomaterial,hydrogel microspheres have been increasingly recognised as promising therapeutic carriers for the local delivery of cells and drugs to enhance tissue *** to traditional tissue engineering scaffolds and bulk hydrogel,hydrogel microspheres possess distinct advantages,including less invasive delivery,larger surface area,higher transparency for visualisation,and greater flexibility for ***,we review the materials characteristics of hydrogel microspheres and compare their fabrication approaches,including microfluidics,batch emulsion,electrohydrodynamic spraying,lithography,and mechanical ***,based on the different requirements for bone,cartilage,nerve,skin,and muscle tissue regeneration,we summarize the applications of hydrogel microspheres as cell and drug delivery carriers for the regeneration of these ***,hydrogel microspheres are regarded as effective therapeutic delivery carriers to enhance tissue regeneration in regenerative ***,significant effort is required before hydrogel microspheres become widely accepted as commercial products for clinical use.

关键词： drug delivery fabrication techniques hydrogel microspheres microgels tissue regeneration

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2024年全球经济压力点

商业周刊（中文版） 2024年第2期 4-5页

作者： malcolm Scott Enda Curran 易语(译) 不详

全球经济2023年经受了以往罕有的考验:通胀和几十年来最激进的货币紧缩行动,欧洲和中东的战火以及中美之间日益加深的摩擦,所有这一切都迫使企业对供应链和安全进行重新考量。

关键词：供应链货币紧缩通胀全球经济