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Clinical features of acute esophageal mucosal lesions and reflux esophagitis Los Angeles classification grade D: A retrospective study

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World Journal of Gastrointestinal Surgery 2023年第3期15卷 408-419页

作者： Chikamasa Ichita Akiko Sasaki Sayuri shimizu Department of Gastroenterology Medicine Center Shonan Kamakura General HospitalKamakura 247-8533KanagawaJapan Department of Health Data Science Yokohama City UniversityYokohama 236–0027KanagawaJapan

BACKGROUND Acute esophageal mucosal lesions(AEMLs)are an underrecognized and largely unexplored *** findings are similar,and a higher percentage of AEML could be misdiagnosed as reflux esophagitis Los Angeles classification grade D(RE-D).These diseases could have different pathologies and require different *** To compare AEML and RE-D to confirm that the two diseases are different from each other and to clarify the clinical features of *** We selected emergency endoscopic cases of upper gastrointestinal bleeding with circumferential esophageal mucosal injury and classified them into AEML and RE-D groups according to the mucosal injury’s shape on the oral *** examined patient background,blood sampling data,comorbidities at onset,endoscopic characteristics,and outcomes in each *** Among the emergency cases,the AEML and RE-D groups had 105(3.1%)and 48(1.4%)cases,*** variables exhibited significantly different results,indicating that these two diseases are *** clinical features of AEML consisted of more comorbidities[risk ratio(RR):3.10;95%confidence interval(CI):1.68–5.71;P<0.001]and less endoscopic hemostasis compared with RE-D(RR:0.25;95%CI:0.10–0.63;P<0.001).Mortality during hospitalization was higher in the AEML group(RR:3.43;95%CI:0.82–14.40;P=0.094),and stenosis developed only in the AEML *** AEML and RE-D were clearly distinct diseases with different clinical *** may be more common than assumed,and the potential for its presence should be taken into account in cases of upper gastrointestinal bleeding with comorbidities.

关键词： Acute esophageal mucosal lesion Comorbidities Esophageal reflux Black esophagus Acute necrotizing esophagitis

Discrete Plane Segmentation and Estimation from a Point Cloud Using Local Geometric Patterns

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International Journal of Automation and computing 2008年第3期5卷 246-256页

作者： Yukiko Kenmochi Lilian Buzer Akihiro Sugimoto Ikuko shimizu Université Paris-Est Laboratoire d'Informatique de l'Institut Gaspard-MongeUMR CNRS 8049 A2SI-ESIEECité DescartesBP 9993162 Noisy-le-Grand CedexFrance Department of Computer Information and Communication SciencesTokyo University of Agriculture and Technology

This paper presents a method for segmenting a 3D point cloud into planar surfaces using recently obtained discretegeometry results. In discrete geometry, a discrete plane is defined as a set of grid points lying between two parallel planes with a small distance, called thickness. In contrast to the continuous case, there exist a finite number of local geometric patterns （LGPs） appearing on discrete planes. Moreover, such an LGP does not possess the unique normal vector but a set of normal vectors. By using those LGP properties, we first reject non-linear points from a point cloud, and then classify non-rejected points whose LGPs have common normal vectors into a planar-surface-point set. From each segmented point set, we also estimate the values of parameters of a discrete plane by minimizing its thickness.

关键词： Discrete plane image segmentation parameter estimation discrete geometry local geometric pattern (LGP)

Foreword to the Special Issue on Micro- and Nano-Metrology in Japan(I)

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Nanomanufacturing and Metrology 2021年第2期4卷 1-2页

作者： Yuki shimizu Yasuhiro Mizutani Masaki Michihata Department of Finemechanics Tohoku UniversitySendai 9808579Japan Department of Mechanical Engineering Osaka UniversitySuita 5650871Japan Department of Precision Engineering The University of TokyoBunkyo 1138654Japan

Micro-and nano-metrology occupies an important position in modern production engineering where higher-precision machining is required.A visualization of the process is indispensable for the creation of new technologies in stateof-the-art manufacturing that deals with the geometrical quantity in micrometers/*** micro-and nano-metrology is thus becoming more and more important as the platform of various manufacturing technologies,as well as strategic tools for responding to rapidly changing fabrication techniques in many scientific and industrial fields.

关键词： metrology becoming Japan

Interaction between Cd and Pb in the soil-plant system: a case study of an arid oasis soil-cole system

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Journal of Arid Land 2014年第1期6卷 59-68页

作者： ZhuanJun ZHAO ZhongRen NAN ZhaoWei WANG YiMing YANG Masayuki shimizu College of Resource & Environment Lanzhou University Department of Soil and Crop Science Colorado State University

The Hexi Corridor,our study area,is located in Northwest China and is also the most developed area of oasis farming in arid regions of Northwestern ***,the rapid development of metallurgy and chemical industries in this region poses a great threat to the accumulation of heavy metals in *** objectives of this study are(1)to determine the influence of heavy metals on plant growth;(2)to assess the translocation capability of heavy metals in soil-plant system;and(3)to investigate the interaction between heavy *** experiments were conducted on cole(Brassica campestris L.)grown in the arid oasis soils singly and jointly treated with cadmium(Cd)and lead(Pb).Nine treatments were applied into the *** the same planting conditions,three scenarios of Cd,Pb and Cd–Pb were designed to compare the interaction between Cd and *** results showed that the response of cole weights to Cd,Pb and Cd–Pb treatments was slight,while Cd and Pb uptakes in cole were more sensitive to the single effects of Cd and Pb concentration in soils from the lower treatment *** the influence of the single Cd,Pb and joint Cd–Pb treatments,Cd concentrations were lower in the cole roots than in the shoots,while for Pb,the results were *** studies revealed that the interaction of Cd and Pb could weaken the cole’s ability to uptake,concentrate and translocate heavy metals in arid oasis soils.

关键词： heavy metals interaction vegetables oasis soils arid regions Brassica campestris L.

Multichannel and high-density hybrid integrated light source with a laser diode array on a silicon optical waveguide platform for interchip optical interconnection

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Photonics Research 2014年第3期2卷 S0019-S0024页

作者： Takanori shimizu Nobuaki Hatori makoto Okano Masashige Ishizaka Yutaka Urino Tsuyoshi Yamamoto Masahiko Mori Takahiro Nakamura Yashuhiko Arakawa Institute for Photonics-Electronics Convergence System Technology(PECST) Japan Photonics Electronics Technology Research Association(PETRA) West 7SCR16-1 OnogawaTsukubaIbaraki 305-8569Japan National Institute of Advanced Industrial Science and Technology(AIST) West 7SCR16-1 OnogawaTsukubaIbaraki 305-8569Japan Institute of Industrial Science The University of Tokyo4-6-1 KomabaMeguroTokyo 153-8505Japan

A hybrid integrated light source was developed with a configuration in which a laser diode(LD)array was mounted on a silicon optical waveguide platform for interchip optical *** integrated light source is composed of 13-channel stripes with a pitch of 20 or 30μ*** output power of each LD in the 400 or 600-μm long LD array was over 40 mW at room temperature without *** output power uniformity was 1.3 dB including an LD array power *** use of a SiON waveguide with a spot size converter resulted in an optical coupling loss of 1 dB between an LD and SiON *** integrated light source including 52 output ports demonstrated a reduction in the footprint per *** also demonstrated a light source with over 100 output ports in which the number of output ports is increased by using a waveguide splitter and multichip *** integrated light sources are practical candidates for use with photonic integrated circuits for high-density optical interconnection.

关键词： waveguide interconnection optical

Analysis of Determinants for an Enhanced and Long-lasting Coastal Convective System by Means of a Case Study(26 July 2011)

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Advances in Atmospheric Sciences 2019年第12期36卷 1327-1339页

作者： Jung-Tae LEE Dong-In LEE Shingo shimizu Cheol-Hwan YOU New and Renewable Energy Resource Center Korea Institute of Energy ResearchDaejeon 34129Republic of Korea Department of Environmental Atmospheric Science Pukyong National UniversityBusan 48513Republic of Korea Storm Floodand Landslide Research DepartmentNational Research Institute for Earth Science and Disaster ResilienceTsukuba 305-0006Japan

A precipitation system developed continuously along the western coastline of the Korean Peninsula and created considerable precipitation both along the coast and inland on 26 July 2011. In this study, the causes for this nearshore convective system are investigated from observations and the results of model experiments. Three-dimensional radar fields clearly show that a change of wind at the surface border played an important role in the development of the nearshore convection system. The simulation results, which are very similar to the observations, show that the surface border generated and maintained the convergence zone. The roughness change enhanced the convergence, and the interaction between the deepening cold pool and downward flow maintained the convergence zone. The surface mechanical discontinuity affected by the roughness change between sea and land formed the convergence (gradient of wind stress), which induced momentum transfer to the upper layer. The cold pool created a steep gradient of potential temperature and provided the reason for the propagated convergence zone with the downward flow. The maximum value of the surface change factor, which comprises the influencing factors for the long-lasting convective system, reflects the enhancement of the system at the coast.

关键词： coastal precipitation roughness convergence zone cold pool propagation downward flow

Azacitidine decreases reactive oxygen species production in peripheral white blood cells:A case report

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World Journal of Clinical Cases 2020年第22期8卷 5657-5662页

作者： Hidekazu Hasunuma Naomi shimizu Hiromitsu Yokota Ichiro Tatsuno Department of Blood Transfusion Toho University Medical Center Sakura HospitalSakura 2858741Japan Department of Hematology Toho University Medical Center Sakura HospitalSakura 2858741Japan Clinical Laboratory Program Education Development CenterFaculty of Science Toho UniversityFunabashi 2748510Japan Center for Diabetes Metabolism and EndocrinologyToho University Medical Center Sakura HospitalSakura 2858741Japan

BACKGROUND In myelodysplastic syndrome(MDS),oxidative stress is closely related to iron overload and DNA damage.A recent study suggested the possibility that increased oxidative stress causes not only iron overload but also disease progression of MDS with DNA *** present a case of MDS with decreased reactive oxygen species(ROS)production in peripheral white blood cells(WBCs)and decreased diacron-reactive oxygen metabolites(d-ROMs)in serum after azacitidine *** SUMMARY A 74-year-old man presented to the hematological department with the chief complaint of *** vital signs were within normal limits at admission with a heart rate of 80 bpm and blood pressure of 135/60 *** tests indicated pancytopenia,a WBC count of 2190 cells/μL,a hemoglobin level of 6.2 g/dL and a platelet count of 7.4×104/μ*** patient was diagnosed with MDS with fibrosis after a bone marrow *** case showed decreased ROS production in WBCs,d-ROMs in serum and Wilms’tumor 1 after azacitidine therapy,after which his hematopoiesis *** Azacitidine therapy can improve hematopoiesis and decrease ROS and d-ROM production.

关键词： Myelodysplastic syndrome Reactive oxygen species Diacron-reactive oxygen metabolites Ferritin Azacitidine Case report

Epigenetic therapeutics in dental pulp treatment: Hopes, challenges and concerns for the development of next-generation biomaterials

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Bioactive Materials 2023年第9期27卷 574-593页

作者： Henry F.Duncan Yoshifumi Kobayashi Michaela Kearney Emi shimizu Division of Restorative Dentistry&Periodontology Dublin Dental University HospitalTrinity College DublinUniversity of DublinLincoln PlaceDublinIreland Department of Oral Biology Rutgers School of Dental MedicineNewarkNJUSA

This opinion-led review paper highlights the need for novel translational research in vital-pulp-treatment(VPT),but also discusses the challenges in translating evidence to *** dentistry is expensive,invasive and relies on an outmoded mechanical understanding of dental disease,rather than employing a biological perspective that harnesses cell activity and the *** research has focussed on developing minimally-invasive biologically-based‘fillings’that preserve the dental pulp;research that is shifting the paradigm from expensive high-technology dentistry,with high failure rates,to smart restorations targeted at biological *** VPTs promote repair by recruiting odontoblast-like cells in a material-dependent ***,exciting opportunities exist for development of next-generation biomaterials targeted at regenerative processes in the dentin-pulp *** article analyses recent research using pharmacological-inhibitors to therapeutically-target histone-deacetylase(HDAC)enzymes in dental-pulp-cells(DPCs)that stimulate pro-regenerative effects with limited loss of ***,HDAC-inhibitors have the potential to enhance biomaterial-driven tissue responses at low concentration by influencing the cellular processes with minimal side-effects,providing an opportunity to develop a topically-placed,inexpensive bio-inductive pulp-capping *** positive results,clinical translation of these innovations requires enterprise to counteract regulatory obstacles,dental-industry priorities and to develop strong academic/industry *** aim of this opinion-led review paper is to discuss the potential role of therapeutically-targeting epigenetic modifications as part of a topical VPT strategy in the treatment of the damaged dental pulp,while considering the next steps,material considerations,challenges and future for the clinical development of epigenetic therapeutics or other‘smart’restora

关键词： Epigenetics Vital pulp treatment Histone deacetylase inhibitors Regenerative endodontics Pulp capping

Antimicrobial therapy using sulfamethoxazole trimethoprim for Kawasaki disease patients unresponsive to intravenous immunoglobulin

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Open Journal of Pediatrics 2011年第3期1卷 27-29页

作者： Satoru Nagata Yuichiro Yamashiro makoto Fujimori Yukihide Chiba Yoshikazu Ohtsuka Toshiaki shimizu 不详

Our previous study suggested that the production of superantigens and heat-shock protein 60 by small intestinal bacteria might play a role in Kawasaki disease (KD). We demonstrated that they were all resistant to commonly used antibiotics, except for sulamethoxazole trimethoprim (SMX-TMP). We used SMX-TMP for 7 cases of KD that were unresponsive to intravenous immunoglobulin (IVIG) and studied the antipyretic potency of this treatment. In 6 out of the 7 cases, we demonstrated that antipyretic potency was observed without side effects within 2 days of the initial administration. Antimicrobial therapy using SMX-TMP might represent a novel strategy for cases of KD that are unresponsive to IVIG.

关键词： Antimicrobial Therapy Intravenous Immunoglobulin Resistance Kawasaki Disease Sulfamethoxazole Trimethoprim