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Chinese Medicine 2011年第2期2卷 58-61页

作者： Masashi Ishihara Kiyoyuki Kitaichi Katsuhiko matsuura Hiroshi Nakamura Hisashi Tsurumi Hisataka Moriwaki Yoshinori Itoh 不详

A fifty-five-year-old male patient with malignant lymphoma who took oral valproic acid (VPA) tablets and itraconazole (ITZ) capsles received 3 courses of cancer chemotherapy, including 2 courses of a combination of rituximab/methotrexate/ifosphamide/etoposide/ carboplatin/ methylpredonisolon (R-IMVP16/CBDCA regimen) and subsequent one course of a combination of rituximab/ranimustine/citara bine/etoposide/merphalan (R-MEAM regimen). Plasma concentration of VPA dramatically decreased below the therapeutic concentration after the first and second chemotherapy and seizures appeared in both cases. Plasma concentration of ITZ was also lowered after the second chemotherapy course. At the third chemotherapy, Rikkunshi-to, a Japanese herbal medicine, was prescribed for 14 days. Plasma VPA concentration decreased, though to a lesser extent, after chemotherapy, in which the level was near the border of therapeutic concentration. No convulsion was observed. Therefore, care should be taken to monitor plasma drug concentration during cancer chemotherapy. Rikkunshi-to may be useful to alleviate the chemotherapy-induced decrease in plasma concentrations of orally administered drugs.

关键词： Cancer Chemotherapy Malignant Lymphoma Valproic Acid Therapeutic Drug Monitoring Convulsion Rikkunshi-to

Behavior of Motile Sperm in Taylor-Couette Flow: Effect of Shear Stress on the Behavior of Motile Sperm

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Open Journal of Fluid Dynamics 2013年第2期3卷 9-13页

作者： Yasutaka Hayamizu Toru Hyakutake Koji matsuura Shinichiro Yanase Shinichi Morita Shigeru Ohtsuka Takeshi Gonda Department of Mechanical Engineering Yonago National College of Technology Tottori Japan Graduate School of Engineering Yokohama National University Yokohama Japan Graduate School of Natural Science and Technology Okayama University Okayama Japan Research Core for Interdisciplinary Sciences Okayama University Okayama Japan

Infertility is often cited as one of the causes of a declining birthrate, which has become a serious social problem in recent years. Processes by which motile sperm can be safely and easily sorted are therefore important for infertility treatment. Therefore, as a new sorting method, microfluidic sperm sorter using the microfluidic system has been developed. To improve more separation efficiency of this device, it is necessary to know the behaviors of motile sperm in the microchannel where the sperm undergo shear flow. The previous study implied the necessity of the modeling of motile sperm in the shear flow. In the present study, therefore, we experimentally investigated the behavior of the motile sperm in the Taylor-Couette flow using PTV (Particle Tracking Velocimetry) method. The experimental results showed that the ascent of the shear stress led to the increase in the sperm velocity, and the direction of the sperm velocity was opposite to that of the flow.

关键词： Motile Sperm Taylor-Couette Flow Shear Stress PTV

Associations between Sensitivity to Cold, Menstruation-Related Symptoms and Handgrip Strength in Female University Students in Japan

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Health 2021年第5期13卷 526-537页

作者： Yukie matsuura Kiko Akamine Ayumi Murakami Tokimi Wada Honoka Atsumi Erina Kane Mizuki Yano Toshiyuki Yasui Department of Reproductive and Menopausal Medicine Graduate School of Biomedical Sciences Tokushima University Tokushima Japan Graduate School of Health Sciences Tokushima University Tokushima Japan Nursing Department Osaka Medical College Hospital Osaka Japan Nursing Department Tokushima University Hospital Tokushima Japan

Sensitivity to cold, which is a popular symptom in Japanese women, is associated with various symptoms such as shoulder stiffness and general fatigue. However, an association of sensitivity to cold with muscle strength has not been reported. The aim of the study was to clarify the associations of sensitivity to cold with handgrip strength and with menstruation-related symptoms in female university students in Japan. We recruited 278 female university students in Japan. Sensitivity to cold and menstruation-related symptoms including physical and psychological symptoms were assessed by using a self-administered questionnaire that we designed. Handgrip strength was measured by using a handgrip strength dynamometer. We received responses from 269 students. The prevalence rate of sensitivity to cold in the subjects was 54.3%. The students who had sensitivity to cold had a lower handgrip strength level (25.5 ± 3.8 kg) than did the students who did not have sensitivity to cold (26.7 ± 3.9 kg) (p = 0.017). Sensitivity to cold was associated with low body mass index. In addition, the students who had sensitivity to cold tended to have low back pain and constipation during menstruation. In conclusion, sensitivity to cold is an important symptom associated with muscle strength as well as menstruation-related symptoms for young women.

关键词： Sensitivity to Cold Menstruation-Related Symptoms Handgrip Strength Menstrual Phase Young Women

Duplication cyst of the small intestine found by double-balloon endoscopy:A case report

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World Journal of Gastroenterology 2008年第24期14卷 3924-3926页

作者： Haruei Ogino Toshiaki Ochiai Norimoto Nakamura Daisuke Yoshimura Teppei Kabemura Tetsuya Kusumoto Hiroshi matsuura Akihiko Nakashima Kuniomi Honda Kazuhiko Nakamura Department of Internal Medicine Saiseikai Fukuoka General Hospital Department of Surgery Saiseikai Fukuoka General Hospital Department of Pathology Saiseikai Fukuoka General Hospital Department of Medicine and Bioregulatory Science Graduate School of Medical SciencesKyushu University

A 35-year-old man was admitted due to bloody stool and anemia. The bleeding source could not be detected by esophagogastroduodenoscopy or colonoscopy. Double balloon endoscopy (DBE) revealed a diverticulum-like hole in which coagula stuck in the ileum at 1 meter on the oral side from the ileocecal valve. The adjacent mucosa just to the oral side of the hole was elevated like a submucosal tumor. The lesion was considered the source of bleeding and removed surgically. It was determined to be a cyst with an ileal structure on the mesenteric aspect accompanying gastric mucosa. The diagnosis was a duplication cyst of the ileum,which is a rare entity that can cause gastrointestinal bleeding. In the present case,DBE was used to fi nd the hemorrhagic duplication cyst in the ileum.

关键词： Duplication cyst Double-balloonendoscopy Small intestine bleeding

Study on Styrene Grafting onto Per-fluorinated Polymers Effects of Irradiated and Reaction Conditions

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Study on Styrene Grafting onto Per-fluorinated Polymers Effe...

Is Dose Adjustment Based on Several Factors of Body Size Descriptors Effective for Prevention of Thrombocytopenia by Linezolid Therapy in Hemodialysis Patients?

第6届辐射研究与辐射工艺学术年会

作者： Akio matsuura Tomoyuki Kakigi Saneto Asano Fumihiro Mutou Akihiro Oshima Masakazu Washio Advanced Research Institute for Science and Engineering Waseda University 3-4-1 Okubo Shinjuku Tokyo 169-8555 JAPAN

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Pharmacology & Pharmacy 2016年第10期7卷 417-423页

作者： Hideo Kato Mao Hagihara Yuka Yamagishi Yukihiro Hamada Jun Hirai Naoya Nishiyama Yusuke Koizumi Katsuhiko matsuura Hiroshige Mikamo Department of Infection Control and Prevention Aichi Medical University School of Medicine Nagakute Japan Department of Pharmacy Aichi Medical University School of Medicine Nagakute Japan

Previous study suggested that low body weight was one of the risk factors of thrombocytopenia induced by linezolid in non-hemodialysis patients. However, there have been little investigations for the linezolid-induced thrombocytopenia in hemodialysis patients. This study was to evaluate the association between several factors of body size descriptors and thrombocytopenia in hemodialysis-patients. No factor of body size descriptors showed significant correlation with linezolid-induced thrombocytopenia (patients with thrombocytopenia vs patients without thrombocytopenia: body weight;60.0 kg vs 55.3 kg, p = 0.82: body mass indices;21.1 kg/m2 vs 21.2 mg/m2, p = 0.44: ideal body weight;61.2 kg vs 59.5 kg, p = 0.21: lean body weight;50.1 kg vs 45.7 kg, p = 0.64: dosage amount;20.0 mg/kg vs 21.7 mg/kg, p = 0.74: body surface area;1.65 m2 vs 1.54 m2, p = 0.43). There were not significant differences in the body size descriptors between linezolid therapy for more than 14 days and for less than 13 days (more than 14 days vs less than 13 days: body weight;53.5 kg vs 56.8 kg, p = 0.75: body mass indices;20.9 kg/m2 vs 21.1 mg/m2, p = 0.47: ideal body weight;60.3 kg vs 59.9 kg, p = 0.17: lean body weight;44.3 kg vs 47.7 kg, p = 0.56: dosage amount;22.4 mg/kg vs 21.1 mg/kg, p = 0.67: body surface area;1.51 m2 vs 1.59 m2, p = 0.37). Our data suggested that dosage adjustment of linezolid based on body weight was not recommended in hemodialysis-patients.

关键词： Linezolid Thrombocytopenia Body Weight

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太平洋邮船公司从上海到美国的定期航班

近代中国 2012年第1期 101-119页

作者：松浦章日本关西大学东西学术研究所关西大学亚洲文化中心关西大学文学部

一1847年,容闳首次前往美国留学。1828年11月17日,他生于广东南屏镇(近澳门),其少年时代就读于澳门的马礼逊(Morri—son Schoo1)学校。1847年,他获得了一个偶然的机会可以前往美国留学。容闳所搭乘的前往美国的航船,是从广州的黄埔港出... 详细信息

一1847年,容闳首次前往美国留学。1828年11月17日,他生于广东南屏镇(近澳门),其少年时代就读于澳门的马礼逊(Morri—son Schoo1)学校。1847年,他获得了一个偶然的机会可以前往美国留学。容闳所搭乘的前往美国的航船,是从广州的黄埔港出发的阿立芬特兄弟公司(The Olyphant Brother Co.)的亨特利思(Huntress)号帆船。

关键词：希利美国黄埔港澳门公司上海大西洋那岛

关于用相转化法制备的反渗透、超过滤和微孔膜表面孔形成机理的讨论

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湿法冶金 1992年第3期11卷 24-30,41页

作者：祝振鑫 T.matsuura 核工业北京化工冶金研究院加拿大国家研究院环化所

本文对反渗透、超过滤和微孔膜表面孔的形成机理进行了讨论,提出了三种不同起源的孔,网络孔起源于聚合物聚集体网络内聚合物链段之间的空间,聚集体孔起源于聚合物聚集体之间的间隙空间,而相分离孔则起源于液-液相分离时出现的、由聚合... 详细信息

本文对反渗透、超过滤和微孔膜表面孔的形成机理进行了讨论,提出了三种不同起源的孔,网络孔起源于聚合物聚集体网络内聚合物链段之间的空间,聚集体孔起源于聚合物聚集体之间的间隙空间,而相分离孔则起源于液-液相分离时出现的、由聚合物聚集体的团聚体包围起来的,大的贫聚合物相。为了设计某种用于特定分离目的的膜,需要适当调节上述三种不同起源的孔的比例,并控制其尺寸。

关键词：微孔膜相转化法表面孔形成机理

Genetic Polymorphisms in ADH1B and ALDH2 Are Associated with Colorectal Tumors in Japan: A Case-Control Study

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Journal of Cancer Therapy 2015年第12期6卷 1054-1062页

作者： Akiko Shiotani Hideki Ishikawa Michihiro Mutoh Tatsuya Takeshita Tomiyo Nakamura Kanehisa Morimoto Toshiyuki Sakai Keiji Wakabayashi Nariaki matsuura Department of Molecular Pathology Osaka University Graduate School of Medicine & Health Science Osaka Japan Department of Molecular-Targeting Cancer Prevention Kyoto Prefectural University of Medicine Kyoto Japan Epidemiology and Prevention Division Research Center for Cancer Prevention and Screening National Cancer Center Tokyo Japan Department of Public Health Wakayama Medical University School of Medicine Wakayama Japan Department of Food Nutrition Faculty of Agriculture Ryukoku University Shiga Japan Department of Hygiene and Preventive Medicine Osaka University Graduate School of Medicine Osaka Japan Graduate Division of Nutritional and Environmental Sciences University of Shizuoka Shizuoka Japan

Background: Unlike with esophageal cancer, acetaldehyde levels and genetic polymorphisms in alcohol dehydrogenase have not yet been shown to be contributing factors for colorectal cancer (CRC). This study aimed to clarify the mechanism of CRC development related to alcohol consumption and to the presence of genetic polymorphisms in the alcohol dehydrogenase, ADH1B and aldehyde dehydrogenase, ALDH2. Methods: This was a case-control study (221 cases and 179 controls) in patients with adenomas and intramucosal tumors who underwent endoscopic removal of all tumors. The amount of alcohol consumption was determined using a self-recorded questionnaire, and the tumor information was obtained from colonoscopy results. Blood samples were taken to analyze the following polymorphisms: ALDH2 Glu504Lys and ADH1B His48Arg. Results: The polymorphisms in ADH1B and ALDH2 had little influence on the development of colorectal adenoma or intramucosal cancer. Patients with ALDH2 (Glu/Glu) were more tolerant of alcohol than those with ALDH2 (Glu/Lys and Lys/Lys). Next, we examined certain combinations of the ADH1B genotypes. In the ALDH2 (Glu/Glu) group, an increased risk (OR = 3.4;95% CI 1.4 - 8.4;P = 0.009) was observed among moderate/heavy drinkers with ADH1B (His/His). In the ALDH2 (Glu/Lys and Lys/Lys) group, an increased risk (OR = 4.2;95% CI 1.1 - 16.7;P = 0.041) was found among moderate/heavy drinkers with ADH1B (Arg/His and Arg/Arg). Conclusions: ADH1B and ALDH2 activity may be involved in the development of CRC.

关键词： Genetic Polymorphisms Colorectal Tumor Alcohol Intake Alcohol Dehydrogenase-1B Aldehyde Dehydrogenase-2

20世纪初青岛与上海的轮船航路——以“信利号”航运活动为中心的考察

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西南交通大学学报（社会科学版） 2019年第3期20卷 1-9页

作者：松浦章关西大学东西学术研究所日本大阪5648680

德国1898～1914年占领山东的胶州湾,青岛逐渐发展成近代化城市。德占时期青岛的建设对东亚的轮船航运产生了重要影响,青岛也因此发展成山东海运的重要窗口。根据1909～1910年《青岛官报》的记载,德占时期,上海轮船Singlee号曾经频繁从... 详细信息

德国1898～1914年占领山东的胶州湾,青岛逐渐发展成近代化城市。德占时期青岛的建设对东亚的轮船航运产生了重要影响,青岛也因此发展成山东海运的重要窗口。根据1909～1910年《青岛官报》的记载,德占时期,上海轮船Singlee号曾经频繁从青岛入港。该船属于中国商业轮船公司,中文名"信利号",专门从事上海和青岛之间的轮船运输,其航行的最大目的是购买胶济铁路沿线出产的煤炭。这一时期,也正是德国建好胶济铁路、大量"开发"沿线丰富煤矿资源的时期。从信利号的频繁航行可以看出,山东是上海重要的煤炭供给地,20世纪初期上海和青岛间的轮船航路是两地煤炭运输的干线航路。

关键词：航运德占时期青岛上海 “信利号”轮船煤炭运输胶济铁路