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Effect of δ Phase on Hydrogen Embrittlement of Inconel 718 by Notch Tensile Tests

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Journal of Materials Science & Technology 2005年第2期21卷 256-260页

作者： LiufaLIU ChenLU WenjiangDING AkioHirose KojiroF.kobayashi SchoolofMaterialsScienceandEngineering ShanghaiJiaoTongUniversityShanghai200030China DepartmentofManufacturingScience GraduateSchoolOsakaUniversityYamadaoka2-1SuitaOsaka565-0871Japan

The effect of δ phase on the hydrogen embrittlement (HE) sensitivity of Inconel 718 was investigated by conducting notch tensile tests. Notch tensile specimens with various precipitation morphologies of δ phase were prepared with different heat treatments, and hydrogen was charged into the tensile specimens before tensile tests via a cathodic charging process. The loss of notch tensile strength (NTS) due to the charged hydrogen was used to evaluate the hydrogen embrittlement sensitivity. The results show that δ phase has deleterious effect on NTSs, and the fracture of hydrogen-charged specimens initiated near the notch surfaces. The loss of NTS caused by precharged hydrogen can be greatly decreased by dissolving δ phase. δ-free Inconel 718 alloy is proposed for the applications in hydrogen environments.

关键词： Superalloy Hydrogen embrittlement δ phase Inconel 718

Pathophysiology, diagnosis and treatment of intermittent claudication in patients with lumbar canal stenosis

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World Journal of Orthopedics 2014年第2期5卷 134-145页

作者： Shigeru kobayashi Department of Orthopaedics and Rehabilitation Medicine Faculty of Medical Sciences and the Research and Education Program for Life Science the University of Fukui Fukui 910-1193 Japan

Spinal nerve roots have a peculiar structure, different from the arrangements in the peripheral nerve. The nerve roots are devoid of lymphatic vessels but are immersed in the cerebrospinal fluid(CSF) within the subarachnoid space. The blood supply of nerve roots depends on the blood flow from both and peripheral direction(ascending) and the spinal cord direction(descending). There is no hypovascular region in the nerve root, although there exists a so-called water-shed of the bloodstream in the radicular artery itself. Increased mechanical compression promotes the disturbance of CSF flow, circulatory disturbance starting from the venous congestion and intraradicular edema formation resulting from the breakdown of the blood-nerve barrier. Although this edema may diffuse into CSF when the subarachnoid space is preserved, the endoneurial fluid pressure may increase when the area is closed by increased compression. On the other hand, the nerve root tissue has already degenerated under the compression and the numerous macrophages releasing various chemical mediators, aggravating radicular symptomsthat appear in the area of Wallerian degeneration. Prostaglandin E1(PGE1) is a potent vasodilator as well as an inhibitor of platelet aggregation and has therefore attracted interest as a therapeutic drug for lumbar canal stenosis. However, investigations in the clinical setting have shown that PGE1 is effective in some patients but not in others, although the reason for this is unclear.

关键词： Lumbar canal stenosis Cauda equine Nerve root Prostaglandin E1 Blood flow

Comprehensive review on small common bile duct stones

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World Journal of Gastroenterology 2023年第13期29卷 1955-1968页

作者： Sakue Masuda Kazuya Koizumi Kento Shionoya Ryuhei Jinushi Makomo Makazu Takashi Nishino Karen Kimura Chihiro Sumida Jun Kubota Chikamasa Ichita Akiko Sasaki Masahiro kobayashi makoto Kako Uojima Haruki Department of Gastroenterology Shonan Kamakura General HospitalKanagawa 247-8533Japan Department of Gastroenterology Kitasato University School of MedicineKanagawa 252-0375Japan

Common bile duct stones are among the most common conditions encountered by ***,it is well researched;however,some items,such as indications for endoscopic papillary balloon dilatation(EPBD),safety of EPBD and endoscopic sphincterotomy in patients receiving dual antiplatelet therapy or direct oral anticoagulant,selection strategy for retrieval balloons and baskets,lack adequate ***,the guidelines have been updated with new research,while others remain unchanged due to weak *** this review,we comprehensively summarize the standard methods in guidelines and new findings from recent studies on papillary dilation,stone retrieval devices,difficult-to-treat cases,troubleshooting during the procedure,and complicated cases of cholangitis,cholecystolithiasis,or distal biliary stricture.

关键词： Choledocholithotomy Choledocholithiasis Common bile duct stones Endoscopic papillary balloon dilation Endoscopic sphincterotomy Small common bile duct stones

Control of gonadal maturation and sex in grouper

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Aquaculture and Fisheries 2022年第5期7卷 519-524页

作者： Yasuhisa kobayashi Laboratory for Aquatic Biology Department of FisheriesFaculty of AgricultureKindai UniversityNakamachi 3327-204Nara631-0052Japan

Protogynous groupers,belonging to the subfamily Epinephelinae,are among the most crucial fishery targets in the Asian ***,several grouper species are cultured,providing seed for the aquaculture ***,cultivation grouper larvae are ***,the improvement of aquaculture technology of grouper production is *** managing the reproduction and sex of the target parent fish is vital to enhance the efficiency of *** paper reviews new technologies for induction of gonadal maturation and control of sex in *** dynamics of androgen-producing cells,which are essential for a sex change,are also discussed.

关键词： Grouper Sex change Protogynous Gonadal maturation Androgen Estrogen

Design and Synthesis of 6α-Corticosteroid Haptens and Their Bovine Serum Albumin (BSA) Conjugates

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Chinese Chemical Letters 2003年第3期14卷 259-262页

作者： Pi SUN Norihiro kobayashi Junichi GOTO Graduate School of Pharmaceurical Sciences Tohoku UniversityAobayamaAoba-kuSendai 980-8578Japan

The site of attachment of protein carrier to corticosteroids has great influence on the specificity of produced antibody. In order to obtain highly specific and accurate antibodies for bioimmunoassay determination of cortisol, different tether lengths of 6-corticosteroid haptens and their BSA conjugates were designed and synthesized.

关键词： Cortisol hapten monocolonal antibody bioimmunoassay.

Comprehensive review on endoscopic ultrasound-guided tissue acquisition techniques for solid pancreatic tumor

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World Journal of Gastroenterology 2023年第12期29卷 1863-1874页

作者： Sakue Masuda Kazuya Koizumi Kento Shionoya Ryuhei Jinushi Makomo Makazu Takashi Nishino Karen Kimura Chihiro Sumida Jun Kubota Chikamasa Ichita Akiko Sasaki Masahiro kobayashi makoto Kako Uojima Haruki Department of Gastroenterology Shonan Kamakura General HospitalKanagawa 247-8533Japan Department of Gastroenterology Internal MedicineKitasato University School of MedicineKanagawa 252-0375Japan

Pancreatic ductal adenocarcinoma is speculated to become the second leading cause of cancer-related mortality by 2030,a high mortality rate considering the number of *** and chemotherapy are the main treatment options,but they are burdensome for patients.A clear histological diagnosis is needed to determine a treatment plan,and endoscopic ultrasound(EUS)-guided tissue acquisition(TA)is a suitable technique that does not worsen the cancer-specific prognosis even for lesions at risk of needle tract *** the development of personalized medicine and precision treatment,there has been an increasing demand to increase cell counts and collect specimens while preserving tissue structure,leading to the development of the fine-needle biopsy(FNB)***-FNB is rapidly replacing EUS-guided fine-needle aspiration(FNA)as the procedure of choice for EUS-TA of pancreatic ***,EUS-FNA is sometimes necessary where the FNB needle cannot penetrate small hard lesions,so it is important clinicians are familiar with *** these recent developments,we present an up-to-date review of the role of EUS-TA in pancreatic ***,technical aspects,such as needle caliber,negative pressure,and puncture methods,for obtaining an adequate specimen in EUS-TA are discussed.

关键词： Endoscopic ultrasound-guided fine needle biopsy Endoscopic ultrasoundguided tissue acquisition Personalized medicine Genomic profiling test Pancreatic cancer Puncture procedure

Understanding the biology of urothelial cancer metastasis

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Asian Journal of Urology 2016年第4期3卷 211-222页

作者： Takashi kobayashi Department of Urology Kyoto University Graduate School of MedicineKyotoJapan

Management of unresectable urothelial cancer(UC)has been a clinical challenge for *** drug resistance is a key issue,precise understanding of biology of UC metastasis is another challenge for the improvement of treatment outcome of UC *** of the cell biology concepts including epithelial-mesenchymal transition(EMT)and cancer stemness seems to explain UC *** genetics based on gene expression profiling,next generation sequencing,and explosion of non-coding RNA world has opened the door to intrinsic molecular subtyping of *** steps include,based on the recently accumulated understanding,the establishment of novel disease models representing UC metastasis in various experimental platforms,particularly in vivo animal ***,novel knowledge molecular genetics has not been fully linked to the modeling of UC *** understanding of bladder carcinogenesis is needed particularly with regard to cell of origin related to tumor characteristics including driver gene alterations,pathological differentiations,and metastatic *** we will be able to establish better disease models,which will consequently lead us to further understanding of biology and eventually the development of novel therapeutic strategies for UC metastasis.

关键词： Urothelial carcinoma Metastasis Epithelialmesenchymal transition Animal models

Fluorescence detection of Europiumdoped very small superparamagnetic iron oxide nanoparticles in murine hippocampal slice cultures

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Neural Regeneration Research 2018年第4期13卷 637-638页

作者： Martin Pohland Yuske kobayashi Jana Glumm Institute of Cell Biology and Neurobiology Center for Anatomy Charite -Universitaitsmedizin Berlin Berlin Germany Department of Interventional and Diagnostic Radiology and Nuclear Medicine Universitatsklinikum Hamburg-EppendorfHamburg Germany Department of neurosurgery HELIOS Klinikum Berlin BuchBerlin Germany

In the late 1980s,superparamagnetic iron oxide nanoparticles（SPIO）moved into focus as contrast agents in magnetic resonance imaging（MRI）,due to their strong relaxivity and resulting higher resolution of *** the time,no one anticipated their high potential in basic research or for medical diagnostic andtreatment. Since then, SPIO have been evaluated notonly as spe- cific markers for MRI, but also for cell labeling and tracking （Li et al., 2013）.

关键词： Eu Fluorescence detection of Europiumdoped very small superparamagnetic iron oxide nanoparticles in murine hippocampal slice cultures

Extraction of yarn positional information from three-dimensional CT image of textile fabric using a yarn model for its structure analysis

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仪器仪表学报 2008年第8期29卷 1569-1576页

作者： Toshihiro Shinohara Jun-ya Takayama Shinji Ohyama Akira kobayashi School of Biology-Oriented Science and Technology Kinki University Kinokawa-shi Wakayama-kenJapan Graduate School of Science and Engineering Tokyo Institute of Technology1-12-1 Meguro-kuTokyoJapan Faculty of University Evaluation and Research National Institution for Academic Degrees and UniversityEvaluation Kodaira-shi TokyoJapan

This paper proposes a novel method for analyzing a textile fabric structure to extract positional information regarding each yarn using three-dimensional X-ray computed tomography(3D CT) *** relationship among the yarns can be reconstructed using the extracted yarn positional *** this paper,a sequence of points on the center line of each yarn of the sample is defined as the yarn positional information,since the sequence can be regarded as the representative position of the *** sequence is extracted by tracing the *** yarn is traced by estimating the yarn center and direction and correlating the yarn part of the 3D CT image with a 3D yarn model,which is moved along the estimated yarn *** trajectory of the center of the yarn model corresponds to the positional information of the *** application of the proposed method is shown by experimentally applying the proposed method to a 3D CT image of a double-layered woven ***,the experimental results for a plain knitted fabric show that this method can be applied to even knitted fabrics.

关键词：纺织品 CT影像分析方法物理结构